Takashi Ueyama

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. pmc Is gastrectomy-induced high turnover of bone with hyperosteoidosis and increase of mineralization a typical osteomalacia?
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan
    PLoS ONE 8:e65685. 2013
  2. pmc Brain regions responsible for tinnitus distress and loudness: a resting-state FMRI study
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Graduate School of Wakayama Medical University, Wakayama, Japan
    PLoS ONE 8:e67778. 2013
  3. ncbi request reprint Molecular mechanism of emotional stress-induced and catecholamine-induced heart attack
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Wakayama, Japan
    J Cardiovasc Pharmacol 41:S115-8. 2003
  4. ncbi request reprint Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors: a possible animal model of 'tako-tsubo' cardiomyopathy
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Japan
    Circ J 66:712-3. 2002
  5. ncbi request reprint Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by indirect action on the nervous system and by direct action on the heart
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Wakayama, Japan
    Circ J 71:565-73. 2007
  6. ncbi request reprint Estrogen attenuates the emotional stress-induced cardiac responses in the animal model of Tako-tsubo (Ampulla) cardiomyopathy
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Wakayama, Japan
    J Cardiovasc Pharmacol 42:S117-9. 2003
  7. ncbi request reprint Estrogen-producing steroidogenic pathways in parietal cells of the rat gastric mucosa
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 8509, Japan
    Life Sci 74:2327-37. 2004
  8. ncbi request reprint Emotional stress-induced Tako-tsubo cardiomyopathy: animal model and molecular mechanism
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Ann N Y Acad Sci 1018:437-44. 2004
  9. doi request reprint Catecholamines and estrogen are involved in the pathogenesis of emotional stress-induced acute heart attack
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Ann N Y Acad Sci 1148:479-85. 2008
  10. ncbi request reprint Gastric parietal cells: potent endocrine role in secreting estrogen as a possible regulator of gastro-hepatic axis
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 8509, Japan
    Endocrinology 143:3162-70. 2002

Collaborators

Detail Information

Publications37

  1. pmc Is gastrectomy-induced high turnover of bone with hyperosteoidosis and increase of mineralization a typical osteomalacia?
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan
    PLoS ONE 8:e65685. 2013
    ..These results suggest that chronic systemic inflammation might underlie the GX-induced pathological changes in bone...
  2. pmc Brain regions responsible for tinnitus distress and loudness: a resting-state FMRI study
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Graduate School of Wakayama Medical University, Wakayama, Japan
    PLoS ONE 8:e67778. 2013
    ..The regions for distress and depressive state are known to be related to depression, while the regions for tinnitus loudness are known to be related to the default mode network and integration of multi-sensory information. ..
  3. ncbi request reprint Molecular mechanism of emotional stress-induced and catecholamine-induced heart attack
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Wakayama, Japan
    J Cardiovasc Pharmacol 41:S115-8. 2003
    ..Activation of alpha-adrenoceptors and beta-adrenoceptors is the primary trigger of emotional stress-induced molecular changes in the heart...
  4. ncbi request reprint Emotional stress induces transient left ventricular hypocontraction in the rat via activation of cardiac adrenoceptors: a possible animal model of 'tako-tsubo' cardiomyopathy
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Japan
    Circ J 66:712-3. 2002
    ..Together with results of previous studies, activation of cardiac adrenoceptors in the absence of ischemia-reperfusion is proposed as the primary cause of this syndrome...
  5. ncbi request reprint Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by indirect action on the nervous system and by direct action on the heart
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Wakayama, Japan
    Circ J 71:565-73. 2007
    ..Takotsubo cardiomyopathy is triggered by emotional or physical stress especially in post-menopausal women. A reduction in estrogen levels following menopause might underlie the high incidence of takotsubo cardiomyopathy...
  6. ncbi request reprint Estrogen attenuates the emotional stress-induced cardiac responses in the animal model of Tako-tsubo (Ampulla) cardiomyopathy
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Wakayama, Japan
    J Cardiovasc Pharmacol 42:S117-9. 2003
    ..However, heart rate in stress was significantly higher in OVX than in OVX + E rats. In summary, these data suggest that increase of serum estradiol levels can diminish the pathological changes in the heart induced by emotional stress...
  7. ncbi request reprint Estrogen-producing steroidogenic pathways in parietal cells of the rat gastric mucosa
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 8509, Japan
    Life Sci 74:2327-37. 2004
    ..These results indicate that parietal cells of rat stomach convert circulating progesterone and/through androstenedione and testosterone to synthesize both estrone and 17beta-estradiol, which then enter the liver via the portal vein...
  8. ncbi request reprint Emotional stress-induced Tako-tsubo cardiomyopathy: animal model and molecular mechanism
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Ann N Y Acad Sci 1018:437-44. 2004
    ..Sequential gene expression can be considered as an adaptive response to stress. Activation of alpha- or beta-adrenoceptors is the primary trigger of emotional stress-induced cardiac changes...
  9. doi request reprint Catecholamines and estrogen are involved in the pathogenesis of emotional stress-induced acute heart attack
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Ann N Y Acad Sci 1148:479-85. 2008
    ..These data suggest that reduction of estrogen levels following menopause might be involved in the primary cause of takotsubo cardiomyopathy both by indirect action on the nervous system and by direct action on the heart...
  10. ncbi request reprint Gastric parietal cells: potent endocrine role in secreting estrogen as a possible regulator of gastro-hepatic axis
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 8509, Japan
    Endocrinology 143:3162-70. 2002
    ..These findings indicate that gastric parietal cells play a potent endocrine role in secreting estrogen that may function as a regulator of the gastro-hepatic axis...
  11. doi request reprint Cardiac and vascular gene profiles in an animal model of takotsubo cardiomyopathy
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama, 641 8509, Japan
    Heart Vessels 26:321-37. 2011
    ..Activation of α1-adrenoceptor in the blood vessels or activation of β1-adrenoceptors in the heart were mainly responsible for emotional stress-induced alteration of cardiac and vascular gene profiles...
  12. ncbi request reprint Emotional stress activates MAP kinase in the rat heart
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical University, Japan
    Life Sci 69:1927-34. 2001
    ..Thus, emotional stress activates the alpha1-adrenoceptor-mediated MAP kinase pathway, whereas the pathway of the response mediated by the beta-adrenoceptor remains unknown...
  13. ncbi request reprint Estrogen alters c-Fos response to immobilization stress in the brain of ovariectomized rats
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 8509, Japan
    Brain Res 1084:67-79. 2006
    ..These data suggest that neuronal activities in these areas are influenced bidirectionally by systemic estrogen level...
  14. ncbi request reprint Stress-induced elevation of the ST segment in the rat electrocardiogram is normalized by an adrenoceptor blocker
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Clin Exp Pharmacol Physiol 27:384-6. 2000
    ..4. These results suggest that direct activation of cardiac adrenoceptors by stress may result in angina-like ECG changes...
  15. ncbi request reprint Emotional stress induces immediate-early gene expression in rat heart via activation of alpha- and beta-adrenoceptors
    T Ueyama
    Department of Anatomy, Wakayama Medical College, Wakayama 641 8509, Japan
    Am J Physiol 277:H1553-61. 1999
    ....
  16. ncbi request reprint Effects of ethanol on the stress-induced expression of NGFI-A mRNA in the rat brain
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Alcohol 18:171-6. 1999
    ..Regional differences in the expression of NGFI-A mRNA may be important for the complex interactions between ethanol and stress...
  17. ncbi request reprint Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neurosci Res 28:103-10. 1997
    ..Our results provide, some new information that may be relevant to the pathogenesis of stress-induced disturbances of memory and learning...
  18. ncbi request reprint Upregulation of heme oxygenase-1 in an animal model of Takotsubo cardiomyopathy
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Circ J 73:1141-6. 2009
    ..Disturbance of the coronary microcirculation and catecholamine intoxication, which may be responsible for the pathogenesis of takotsubo cardiomyopathy, could trigger an oxidative stress response in the heart...
  19. ncbi request reprint AP-1 expression in ethanol-treated corneal epithelium in vivo
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 39:84-91. 2007
    ..The purpose of the current study was to examine if the ethanol exposure during laser epithelial keratomileusis (LASEK) may stimulate or damage the corneal epithelial cells...
  20. ncbi request reprint Polaprezinc (Zinc L-carnosine) is a potent inducer of anti-oxidative stress enzyme, heme oxygenase (HO)-1 - a new mechanism of gastric mucosal protection
    Kazuki Ueda
    2nd Department of Internal Medicine, Wakayama Medical University, Japan
    J Pharmacol Sci 110:285-94. 2009
    ..These data indicate for the first time that PZ is an effective inducer of HO-1 in the stomach. PZ-induced HO-1 functions as a part of the mucosal protective effects of PZ...
  21. doi request reprint Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions
    Kazuki Ueda
    Second Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Am J Physiol Gastrointest Liver Physiol 295:G460-9. 2008
    ..Pretreatment with ZnPP also aggravated AGML. The sequential HNE-Nrf2-HO-1 pathway in the gastric mucosal cells and the macrophages is involved in an adaptive mechanism against oxidative stress after AGML...
  22. ncbi request reprint Transcriptional activation in lens epithelial cells following an ocular blunt trauma
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Kimiidera, Wakayama 641 0012, Japan
    J Cataract Refract Surg 31:1226-30. 2005
    ..To determine whether an ocular blunt trauma activates anterior ocular segment (cornea and lens) by examining the expression patterns of c-fos and c-jun mRNAs in these tissues of an eye of adult rat following a blunt trauma...
  23. pmc Nrf2-inducing anti-oxidation stress response in the rat liver--new beneficial effect of lansoprazole
    Yasunobu Yamashita
    2nd Department of Internal Medicine, Wakayama Medical University Graduate School of Medicine, Wakayama, Japan
    PLoS ONE 9:e97419. 2014
    ..e. the AhR/Cyp1a1/Nrf2 pathway in hepatocytes. ..
  24. ncbi request reprint [Emotion, amygdala, and autonomic nervous system]
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Japan
    Brain Nerve 64:1113-9. 2012
    ..As estrogen receptor α, estrogen receptor β, and androgen receptor are expressed in the medial amygdala, sex steroids may modulate the autonomic nervous activities...
  25. ncbi request reprint Semaphorin 4A induces growth cone collapse of hippocampal neurons in a Rho/Rho-kinase-dependent manner
    Kazunori Yukawa
    Department of Physiology, Wakayama Medical University, Wakayama 641 8509, Japan
    Int J Mol Med 16:115-8. 2005
    ..Thus, our data indicated that Sema4A could function as a chemo-repulsive cue by activating a receptor whose signal is transmitted to Rho-kinase and induced growth cone collapse of hippocampal neurons...
  26. ncbi request reprint STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy
    Kazunori Yukawa
    Department of Physiology, Wakayama Medical University, Wakayama 641 8509, Japan
    Int J Mol Med 15:225-30. 2005
    ..Our findings also suggest that the STAT6 pathway may have a promotive effect on renal fibrosis by activating collagen synthesis following ureteral obstruction...
  27. ncbi request reprint The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy
    Kazunori Yukawa
    Department of Physiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Int J Mol Med 15:73-8. 2005
    ..Thus, our results suggest that the kinase domain deleted by gene targeting plays a suppressive role for the development of renal fibrosis through inhibition of the tubular epithelial-to-mesenchymal transition in a mouse model of COU...
  28. ncbi request reprint Immobilization stress induces c-fos and c-jun immediate early genes expression in the heart
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Life Sci 59:339-47. 1996
    ....
  29. ncbi request reprint Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat
    E Senba
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neurosci Res 29:183-207. 1997
    ..IEG expression in the peripheral organs may provide a molecular basis for stress-induced psychosomatic disorders...
  30. ncbi request reprint Persistent median artery in the hand: a report with a brief review of the literature
    Yoshihiro Tsuruo
    Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Anat Sci Int 81:242-52. 2006
    ..The present study reports an unusual variation of the persistent median artery in the hand and briefly reviews the literature about the median artery...
  31. ncbi request reprint Cyclooxygenase 2 expression in rat corneas after ethanol exposure
    Takeshi Miyamoto
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama City, Wakayama, Japan
    J Cataract Refract Surg 32:1736-40. 2006
    ..To evaluate the effects of ethanol exposure of the cornea on inflammation in corneal epithelium...
  32. ncbi request reprint [Limbic system and autonomic nervous system]
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University School of Medicine
    Rinsho Shinkeigaku 50:1003-6. 2010
    ..Estrogen attenuated the stress-induced c-Fos expression in medial amygdaloid nucleus, paraventricular hypothalamic nucleus; these same regions contain central sympathetic neurons and neurons with immunoreactive estrogen receptors...
  33. ncbi request reprint Distinct gene expression in the stomach following stress and alcohol exposure
    T Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan
    Kaibogaku Zasshi 76:435-41. 2001
    ..These data provide new insights into cellular mechanisms that occur during the pathogenesis of acute gastric mucosal lesions...
  34. ncbi request reprint Expression of c-fos, heat shock protein 70, neurotrophins, and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate
    Y Kinoshita
    Department of Neurological Surgery, Wakayama Medical University, Wakayama City, Japan
    J Neurotrauma 18:435-45. 2001
    ..Intravenous infusion of magnesium sulfate (25 mg/kg) decreased both the infarct volume and upregulation of these mRNAs, suggesting its therapeutic potential...
  35. ncbi request reprint Distribution of neurons expressing alpha 1G subunit mRNA of T-type voltage-dependent calcium channel in adult rat central nervous system
    M Kase
    Department of Anatomy, Kansai Medical University, Moriguchi, Osaka, Japan
    Neurosci Lett 268:77-80. 1999
    ..The cells expressing alpha1G were widely distributed in the central nervous system. The distribution seemed to be restricted to neurons, and exhibited a specific pattern in the cerebellum, thalamus, hippocampus and cerebral cortex...
  36. ncbi request reprint No involvement of the nerve growth factor gene locus in hypertension in spontaneously hypertensive rats
    Kiyomitsu Nemoto
    Department of Molecular Toxicology and COE Program in the 21 st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Hypertens Res 28:155-63. 2005
    ....
  37. ncbi request reprint A brief regional ischemic-reperfusion enhances propofol-induced depression in left ventricular function of in situ rat hearts
    Naoya Kuzumoto
    Departments of Anesthesiology and Physiology II, Nara Medical University, 840 Shijo Cho, Kashihara, Nara 634 8521, Japan
    Anesthesiology 101:879-87. 2004
    ....