E Senba

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. ncbi request reprint [Descending facilitation in chronic stress and chronic pain state]
    Emiko Senba
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8509 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:29-35. 2008
  2. ncbi request reprint The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers
    Emiko Senba
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Neurosci Res 50:257-62. 2004
  3. ncbi request reprint Sensory afferent processing in multi-responsive DRG neurons
    E Senba
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Prog Brain Res 113:387-410. 1996
  4. ncbi request reprint Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat
    E Senba
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neurosci Res 29:183-207. 1997
  5. ncbi request reprint Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor
    S Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 8509, Japan
    Neuroscience 133:797-806. 2005
  6. ncbi request reprint Expression of mKirre in the developing sensory pathways: its close apposition to nephrin-expressing cells
    Y Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 150:880-6. 2007
  7. ncbi request reprint Activation of central 5HT2A receptors reduces the craniofacial nociception of rats
    K Okamoto
    Department of Physiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, 641 8509, Japan
    Neuroscience 147:1090-102. 2007
  8. ncbi request reprint TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons
    S Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, Wakayama, 641 8509 Japan
    Neuroscience 130:223-8. 2005
  9. ncbi request reprint Expression of mKirre, a mammalian homolog of Drosophila kirre, in the developing and adult mouse brain
    S Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8509, Japan
    Neuroscience 133:615-24. 2005
  10. ncbi request reprint The effects of acute and chronic restraint stress on activation of ERK in the rostral ventromedial medulla and locus coeruleus
    Hiroki Imbe
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City 641 8509, Japan
    Pain 112:361-71. 2004

Collaborators

Detail Information

Publications80

  1. ncbi request reprint [Descending facilitation in chronic stress and chronic pain state]
    Emiko Senba
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8509 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:29-35. 2008
    ..Systemic enhancement of pain and hyperalgesia induced by unilateral joint inflammation may have been caused by the central sensitization and descending facilitation...
  2. ncbi request reprint The immunosuppressant FK506 activates capsaicin- and bradykinin-sensitive DRG neurons and cutaneous C-fibers
    Emiko Senba
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Neurosci Res 50:257-62. 2004
    ..These findings, taken together, indicate that FK506 application on inflamed skin may activate nociceptive C-fibers, which bear bradykinin receptors and capsaicin-sensitive heat transducer of TRP family, TRPV1...
  3. ncbi request reprint Sensory afferent processing in multi-responsive DRG neurons
    E Senba
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Prog Brain Res 113:387-410. 1996
    ..In order to understand this mechanism, it is basically important to identify various receptor mRNAs in DRG neurons, precise localization of receptor proteins, site of synthesis and route of supply of ligands for these receptors...
  4. ncbi request reprint Stress-induced expression of immediate early genes in the brain and peripheral organs of the rat
    E Senba
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neurosci Res 29:183-207. 1997
    ..IEG expression in the peripheral organs may provide a molecular basis for stress-induced psychosomatic disorders...
  5. ncbi request reprint Up-regulated phosphorylation of signal transducer and activator of transcription 3 and cyclic AMP-responsive element binding protein by peripheral inflammation in primary afferent neurons possibly through oncostatin M receptor
    S Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 8509, Japan
    Neuroscience 133:797-806. 2005
    ..Among them, the up-regulation of p-STAT3 and p-CREB may be induced possibly through OSMR...
  6. ncbi request reprint Expression of mKirre in the developing sensory pathways: its close apposition to nephrin-expressing cells
    Y Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 150:880-6. 2007
    ..These results suggest that mKirre may be involved in the establishment of the pathway from sensory organs to the brain not only in a homophilic manner but also with its heterophilic interaction to nephrin...
  7. ncbi request reprint Activation of central 5HT2A receptors reduces the craniofacial nociception of rats
    K Okamoto
    Department of Physiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, 641 8509, Japan
    Neuroscience 147:1090-102. 2007
    ..These results suggest that 5HT2A receptors in the Vc/C2 region mediate antinociceptive effects in the craniofacial nociception...
  8. ncbi request reprint TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons
    S Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, Wakayama, 641 8509 Japan
    Neuroscience 130:223-8. 2005
    ..These results suggest that TRPV2 is expressed predominantly in the NT-3-dependent subpopulation of DRG neurons throughout development and in adult mice...
  9. ncbi request reprint Expression of mKirre, a mammalian homolog of Drosophila kirre, in the developing and adult mouse brain
    S Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8509, Japan
    Neuroscience 133:615-24. 2005
    ..The spatiotemporal expression pattern of mKirre mRNA suggests important roles of mKirre in later developmental processes, especially the synapse formation...
  10. ncbi request reprint The effects of acute and chronic restraint stress on activation of ERK in the rostral ventromedial medulla and locus coeruleus
    Hiroki Imbe
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City 641 8509, Japan
    Pain 112:361-71. 2004
    ..05]. These findings suggest that chronic restraint stress-induced activation of ERK in the RVM and the suppression in the LC may be involved in the modulation of the pain threshold by chronic stress...
  11. ncbi request reprint Emotional stress induces immediate-early gene expression in rat heart via activation of alpha- and beta-adrenoceptors
    T Ueyama
    Department of Anatomy, Wakayama Medical College, Wakayama 641 8509, Japan
    Am J Physiol 277:H1553-61. 1999
    ....
  12. ncbi request reprint Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns
    T Bando
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 142:1263-71. 2006
    ..These findings suggest that IL-31 and OSM may thus have redundant functions in the development of OSMRbeta-expressing neurons...
  13. ncbi request reprint Postnatal differentiation of local networks in the nucleus of the tractus solitarius
    Y Kawai
    Department of Anatomy and Neurobiology, Wakayama Medical College, 811 1 Kimiidera, 641 8509, Wakayama, Japan
    Neuroscience 100:109-14. 2000
    ....
  14. ncbi request reprint Characterization of TROY-expressing cells in the developing and postnatal CNS: the possible role in neuronal and glial cell development
    Tomoko Hisaoka
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 8509, Japan
    Eur J Neurosci 23:3149-60. 2006
    ..These findings suggest that the signaling from TROY regulates neuronal differentiation at least in part...
  15. ncbi request reprint Effects of ethanol on the stress-induced expression of NGFI-A mRNA in the rat brain
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Alcohol 18:171-6. 1999
    ..Regional differences in the expression of NGFI-A mRNA may be important for the complex interactions between ethanol and stress...
  16. doi request reprint Characterization of Foxp2-expressing cells in the developing spinal cord
    Y Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1, Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 162:1150-62. 2009
    ....
  17. ncbi request reprint Galectin-1 is involved in the potentiation of neuropathic pain in the dorsal horn
    Hiroki Imbe
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama 640 0012, Japan
    Brain Res 993:72-83. 2003
    ..These data suggest that endogenous galectin-1 may potentiate neuropathic pain after the peripheral nerve injury at least partly by increasing SPR in the dorsal horn...
  18. ncbi request reprint Expression of oncostatin M receptor beta in a specific subset of nociceptive sensory neurons
    Shinobu Tamura
    Department of Anatomy and Neurobiology, Wakay ama Medical University, 811 1 Kimiidera, Wakayama, Japan, 641 8509
    Eur J Neurosci 17:2287-98. 2003
    ....
  19. ncbi request reprint Immobilization stress induces c-fos and c-jun immediate early genes expression in the heart
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Life Sci 59:339-47. 1996
    ....
  20. doi request reprint The forkhead transcription factors, Foxp1 and Foxp2, identify different subpopulations of projection neurons in the mouse cerebral cortex
    T Hisaoka
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 166:551-63. 2010
    ....
  21. ncbi request reprint Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing olfactory system
    Tomoko Hisaoka
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Glia 45:313-24. 2004
    ..Thus, TROY was expressed in some specific subsets of glial cells in the olfactory bulb, including OECs, suggesting that TROY may play some roles in the developing and adult olfactory system...
  22. ncbi request reprint Induction of brain-derived neurotrophic factor by leptin in the ventromedial hypothalamus
    T Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 139:1107-15. 2006
    ....
  23. ncbi request reprint Effects of local anaesthesia on formalin-induced Fos expression in the rat dorsal horn
    A Tokunaga
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neuroreport 6:2301-4. 1995
    ..No significant difference was observed between EB and LB group. These findings suggested that the early and late phase contribute in concert to the induction of genetic changes in dorsal horn neurones after formalin injection...
  24. ncbi request reprint Expression of interleukin-6 receptor, leukemia inhibitory factor receptor and glycoprotein 130 in the murine cerebellum and neuropathological effect of leukemia inhibitory factor on cerebellar Purkinje cells
    Y Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical School, 811 1, Kimiidera, Wakayama City, 641 0012, Wakayama, Japan
    Neuroscience 100:841-8. 2000
    ..The present results suggest that the leukemia inhibitory factor affects cerebellar functions through Purkinje cells...
  25. ncbi request reprint Stress-induced elevation of the ST segment in the rat electrocardiogram is normalized by an adrenoceptor blocker
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Clin Exp Pharmacol Physiol 27:384-6. 2000
    ..4. These results suggest that direct activation of cardiac adrenoceptors by stress may result in angina-like ECG changes...
  26. ncbi request reprint Foxp1 gene expression in projection neurons of the mouse striatum
    S Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Neuroscience 124:261-7. 2004
    ..The expression pattern of Foxp1 mRNA suggests that Foxp1 may play a role in the development and formation of a circuit in the basal ganglia, which is involving the matrix neurons...
  27. ncbi request reprint Immobilization stress reduced the expression of neurotrophins and their receptors in the rat brain
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neurosci Res 28:103-10. 1997
    ..Our results provide, some new information that may be relevant to the pathogenesis of stress-induced disturbances of memory and learning...
  28. ncbi request reprint Characterization of TROY/TNFRSF19/TAJ-expressing cells in the adult mouse forebrain
    Tomoko Hisaoka
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1, Kimiidera, Wakayama, Japan
    Brain Res 1110:81-94. 2006
    ..Thus, TROY was expressed in uncommitted precursor cells and astroglial lineage cells, suggesting that TROY plays some roles in the regulation of gliogenesis in the adult CNS...
  29. ncbi request reprint 5-HT2A receptor subtype in the peripheral branch of sensory fibers is involved in the potentiation of inflammatory pain in rats
    Keiichiro Okamoto
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Pain 99:133-43. 2002
    ..These findings suggest that 5-HT2A receptors are mainly expressed in CGRP-synthesizing small DRG neurons and may be involved in the potentiation of inflammatory pain in the periphery...
  30. ncbi request reprint Spontaneous synaptogenesis in ex vivo sympathetic ganglion and the blockade by serum treatment
    Y Kawai
    Department of Anatomy and Neurobiology, Wakayama Medical College, Wakayama 641 8509, Japan
    J Comp Neurol 424:670-8. 2000
    ..These results suggest that dendrites of SCG neurons rapidly develop and exhibit local efferent characteristics that underlie the inhibitory synaptic transmission once they are subjected to serum deprivation...
  31. ncbi request reprint Persistent monoarthritis of the temporomandibular joint region enhances nocifensive behavior and lumbar spinal Fos expression after noxious stimulation to the hindpaw in rats
    Keiichiro Okamoto
    Department of Physiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Exp Brain Res 170:358-67. 2006
    ....
  32. ncbi request reprint Electrophysiological and morphological characteristics of nucleus tractus solitarii neurons projecting to the ventrolateral medulla
    Y Kawai
    Department of Anatomy and Neurobiology, Wakayama Medical College, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Brain Res 877:374-8. 2000
    ..It is concluded that the projection from the NTS to the VLM is mediated mostly by medium to large neurons that are inhibited locally by GABAergic interneurons within the NTS...
  33. ncbi request reprint Expression of c-fos, heat shock protein 70, neurotrophins, and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate
    Y Kinoshita
    Department of Neurological Surgery, Wakayama Medical University, Wakayama City, Japan
    J Neurotrauma 18:435-45. 2001
    ..Intravenous infusion of magnesium sulfate (25 mg/kg) decreased both the infarct volume and upregulation of these mRNAs, suggesting its therapeutic potential...
  34. ncbi request reprint Fasting-induced activation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus
    Y Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Neuroendocrinol 16:105-12. 2004
    ..These results suggest that ERK and p38 are differentially activated by fasting in distinct regions of the hypothalamus depending on the condition of energy balance...
  35. ncbi request reprint Emotional stress activates MAP kinase in the rat heart
    T Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical University, Japan
    Life Sci 69:1927-34. 2001
    ..Thus, emotional stress activates the alpha1-adrenoceptor-mediated MAP kinase pathway, whereas the pathway of the response mediated by the beta-adrenoceptor remains unknown...
  36. doi request reprint Involvement of descending facilitation from the rostral ventromedial medulla in the enhancement of formalin-evoked nocifensive behavior following repeated forced swim stress
    Hiroki Imbe
    Department of Physiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, 641 8509, Japan
    Brain Res 1329:103-12. 2010
    ..These findings suggest that the descending facilitation from the RVM may be involved in the enhancement of formalin-evoked nocifensive behavior following the forced swim stress...
  37. ncbi request reprint AP-1 expression in ethanol-treated corneal epithelium in vivo
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 39:84-91. 2007
    ..The purpose of the current study was to examine if the ethanol exposure during laser epithelial keratomileusis (LASEK) may stimulate or damage the corneal epithelial cells...
  38. doi request reprint Detailed expression pattern of Foxp1 and its possible roles in neurons of the spinal cord during embryogenesis
    Yoshihiro Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
    Dev Neurosci 31:511-22. 2009
    ..These results suggest that Foxp1 may play some important roles in the determination of neuronal fates of the ventral spinal cord, possibly through the suppression of Lhx3 expression...
  39. ncbi request reprint Activation of ERK in the rostral ventromedial medulla is involved in hyperalgesia during peripheral inflammation
    Hiroki Imbe
    Department of Physiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, 641 8509, Japan
    Brain Res 1187:103-10. 2008
    ..3% vs. baseline, n=7) was significantly longer than that in the control group (52.0%+/-3.6% vs. baseline, n=8). These findings suggest that activation of ERK in the RVM contributes to thermal hyperalgesia during peripheral inflammation...
  40. doi request reprint Perturbed intraepithelial differentiation of corneal epithelium in c-Fos-null mice
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Jpn J Ophthalmol 52:1-7. 2008
    ..We examined the role of c-Fos in the differentiation of corneal epithelial cells by using c-Fos-deficient (c-fos (-/-)) mice...
  41. doi request reprint Activation of ERK in the locus coeruleus following acute noxious stimulation
    Hiroki Imbe
    Department of Physiology, Wakayama Medical University, Wakayama City, Japan
    Brain Res 1263:50-7. 2009
    ..The activation of ERK in the LC may be involved in the plasticity of the descending pain modulatory systems following acute noxious stimulation...
  42. ncbi request reprint TROY, a novel member of the tumor necrosis factor receptor superfamily in the central nervous system
    Yoshihiro Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama 641 8509, Japan
    Ann N Y Acad Sci 1126:A1-10. 2008
    ..Thus, TROY was expressed in some specific subsets of glial cells in the olfactory bulb, including OECs, and may play some roles in the developing and adult olfactory system...
  43. doi request reprint Expression of kin of irregular chiasm-like 3/mKirre in proprioceptive neurons of the dorsal root ganglia and its interaction with nephrin in muscle spindles
    Tadasuke Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
    J Comp Neurol 511:92-108. 2008
    ....
  44. ncbi request reprint Effects of peripheral inflammation on activation of ERK in the rostral ventromedial medulla
    Hiroki Imbe
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, 641 8509, Japan
    Brain Res 1063:151-8. 2005
    ..7% +/- 1.4%) [P < 0.01]. These findings suggest that inflammation-induced activation of ERK in the RVM may be involved in the plasticity in the descending pain modulatory system following inflammation...
  45. ncbi request reprint Molecular mechanism of emotional stress-induced and catecholamine-induced heart attack
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, Wakayama, Japan
    J Cardiovasc Pharmacol 41:S115-8. 2003
    ..Activation of alpha-adrenoceptors and beta-adrenoceptors is the primary trigger of emotional stress-induced molecular changes in the heart...
  46. ncbi request reprint AP-1 (c-Fos/c-Jun) is required for corneal epithelial spreading
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 241:327-9. 2003
    ..Antisense-oligonucleotide (AS) c-fos-null mice were used for this purpose...
  47. ncbi request reprint Expression of AP-1 (c-fos/c-jun) in developing mouse corneal epithelium
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, 641 0012 Wakayama, Japan
    Graefes Arch Clin Exp Ophthalmol 241:330-3. 2003
    ..AP-1 consists of Fos family and Jun family proteins...
  48. ncbi request reprint Expression of oncostatin M in hematopoietic organs
    Shinobu Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, Japan
    Dev Dyn 225:327-31. 2002
    ..Our data revealed that eosinophil progenitors and eosinophils as well as PMNs are also an important cellular source of OSM in mice...
  49. ncbi request reprint Essential function of oncostatin m in nociceptive neurons of dorsal root ganglia
    Yoshihiro Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical University, Wakayama, 641 8509 Japan
    J Neurosci 24:1941-7. 2004
    ..Thus, OSM plays an essential role in the development of a subtype of nociceptive neurons in the DRGs...
  50. ncbi request reprint Expression of c-Fos and c-Jun in developing mouse lens
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama, Japan
    Ophthalmic Res 36:226-30. 2004
    ..They were not detected in an adult mouse lens. The expression pattern of the AP-1 transcription factor in equatorial epithelium may suggest its role in fiber differentiation...
  51. ncbi request reprint Expression of a member of tumor necrosis factor receptor superfamily, TROY, in the developing mouse brain
    Tomoko Hisaoka
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1, Kimiidera, Wakayama, 641 8509, Japan
    Brain Res Dev Brain Res 143:105-9. 2003
    ..Its spatial and temporal expression patterns suggest that TROY plays some important roles in neurogenesis of embryonic stages...
  52. ncbi request reprint Increase of galanin-like immunoreactivity in rat hypothalamic arcuate neurons after peripheral nerve injury
    Hiroki Imbe
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City 641 8509, Japan
    Neurosci Lett 368:102-6. 2004
    ..6 +/- 1.0; P < 0.05). These data suggest that the galanin-ergic neurons in the Arc may be involved in the functional modulation of descending pain modulation system following peripheral nerve injury...
  53. ncbi request reprint Transcription activation in lens epithelial cells after anterior capsule rubbing in rats. expression of c-Fos
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan
    J Cataract Refract Surg 29:1601-4. 2003
    ..To determine whether lens epithelial cells (LECs) are transcriptionally activated after a foreign body is attached to the anterior lens surface...
  54. ncbi request reprint Distinct gene expression in the stomach following stress and alcohol exposure
    T Ueyama
    Department of Anatomy and Cell Biology, Wakayama Medical University, 811-1 Kimiidera, Wakayama 641-8509, Japan
    Kaibogaku Zasshi 76:435-41. 2001
    ..These data provide new insights into cellular mechanisms that occur during the pathogenesis of acute gastric mucosal lesions...
  55. ncbi request reprint Halothane but not isoflurane attenuates interleukin 1beta-induced nitric oxide synthase in vascular smooth muscle
    H Maeda
    Department of Anesthesia, Wakayama Medical College, Japan
    Anesthesiology 95:492-9. 2001
    ..Thus, these findings suggest that halothane may have some sites to affect nitric oxide-signaling pathway...
  56. ncbi request reprint Expression of transcription factor AP-1 in rat lens epithelial cells during wound repair
    K Shirai
    Department of Ophthalmology, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Exp Eye Res 73:461-8. 2001
    ..e. 30 min post-injury, suggesting that AP-1 may play important roles in regulating lens cell behavior during lens wound repair in rats...
  57. ncbi request reprint Noradrenaline-mediated lateral inhibition in the sympathetic ganglion
    Y Kawai
    Department of Anatomy and Neurobiology, Wakayama Medical College, Japan
    Neurosci Lett 238:87-9. 1997
    ..Electron microscopic observations confirmed that these cells received synapses of intrinsic type. It was concluded that some SCG neurons were under an inhibitory control from neighboring neurons via noradrenergic synapses...
  58. ncbi request reprint Blockade of peripheral 5HT3 receptor attenuates the formalin-induced nocifensive behavior in persistent temporomandibular joint inflammation of rat
    Keiichiro Okamoto
    Department of Anatomy and Neurobiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City 640 0012, Japan
    Neurosci Lett 367:259-63. 2004
    ....
  59. ncbi request reprint Developmental expression pattern of oncostatin M receptor beta in mice
    Shinobu Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, 641 0012 Wakayama, Japan
    Mech Dev 115:127-31. 2002
    ..After birth, its gene expression became detectable in the other organs, such as lymph node, bone, heart, kidney, small intestine, nasal cavity, and lung...
  60. ncbi request reprint Localization of oncostatin M receptor beta in adult and developing CNS
    S Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, 641 8509, Wakayama, Japan
    Neuroscience 119:991-7. 2003
    ..Our results suggest that OSM contributes to the development of specific subpopulations of both neurons and astrocytes in the murine CNS...
  61. ncbi request reprint Disappearance of desmosomal components in rat corneal epithelium during wound healing
    Y Okada
    Department of Ophthalmology, Wakayama Medical College, Wakayama, Japan
    Ophthalmologica 215:61-5. 2001
    ....
  62. ncbi request reprint Expression pattern of the winged-helix/forkhead transcription factor Foxp1 in the developing central nervous system
    Shinobu Tamura
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Gene Expr Patterns 3:193-7. 2003
    ..In neonates, its gene expression was persisted in these motor-related regions...
  63. ncbi request reprint Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly
    Shuji Murakami
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8509, Japan
    Neurosci Res 53:129-39. 2005
    ..Repetitive stress-induced reduction of BDNF may partly contribute to the neuronal atrophy/death and reduction of hippocampal volume observed both in animals and humans suffering chronic stress and/or depression...
  64. pmc Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons
    Tadasuke Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    J Biol Chem 285:37884-94. 2010
    ..These results suggest that leptin-induced NREBP is an important regulator of GHS-R expression in the hypothalamus and provides a novel molecular link between leptin and ghrelin signaling...
  65. ncbi request reprint Contribution of peripheral 5-HT2A or 5-HT3 receptors to Fos expression in the trigeminal spinal nucleus produced by acute injury to the masseter muscle during persistent temporomandibular joint inflammation in rats
    K Okamoto
    Department of Physiology, Wakayama Medical University, Wakayama City 641 8509, Japan
    Neuroscience 143:597-606. 2006
    ..These results suggest that peripheral 5-HT2A and 5-HT3 receptors contribute to nociceptive processing in the masseter muscle in TMJ inflammatory conditions...
  66. ncbi request reprint Induction of synaptosomal-associated protein-23 kD (SNAP-23) by various cytokines
    Y Morikawa
    Department of Anatomy and Neurobiology, Wakayama Medical School, Wakayama, Japan
    Blood 92:129-35. 1998
    ..Constitutive expression of SNAP-23 was seen in various tissues, including heart, lung, kidney, liver, spleen, and small intestine. Possible involvement of SNAP-23 in cytokine signal transduction is discussed...
  67. ncbi request reprint In vivo activation of STAT3 signaling in satellite cells and myofibers in regenerating rat skeletal muscles
    Katsuya Kami
    Department of Health Science, Osaka University of Health and Sport Sciences, Wakayama, Japan
    J Histochem Cytochem 50:1579-89. 2002
    ..These findings suggest that activation of STAT3 signaling is an important molecular event that induces the successful regeneration of injured skeletal muscles...
  68. ncbi request reprint Subcellular localization of glucose transporter 4 in the hypothalamic arcuate nucleus of ob/ob mice under basal conditions
    Tadasuke Komori
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Brain Res 1049:34-42. 2005
    ..We discuss the possibility of novel pathways which induce the translocation of GLUT4 in the arcuate nucleus of ob/ob mice...
  69. ncbi request reprint Attenuation of fasting-induced phosphorylation of mitogen-activated protein kinases (ERK/p38) in the mouse hypothalamus in response to refeeding
    Eiko Ueyama
    Department of Anatomy and Neurobiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Neurosci Lett 371:40-4. 2004
    ..Thus, refeeding rapidly reduced the fasting-induced phosphorylation of ERK, p38, and CREB, suggesting that the activation of these signal molecules in the hypothalamus is precisely regulated with feeding status...
  70. ncbi request reprint Central serotonin 3 receptors play an important role in the modulation of nociceptive neural activity of trigeminal subnucleus caudalis and nocifensive orofacial behavior in rats with persistent temporomandibular joint inflammation
    K Okamoto
    Department of Physiology, Wakayama Medical University, Kimiidera 811 1, Wakayama City 641 8509, Japan
    Neuroscience 135:569-81. 2005
    ....
  71. ncbi request reprint Distribution and colocalization of NGF and GDNF family ligand receptor mRNAs in dorsal root and nodose ganglion neurons of adult rats
    Hitoshi Kashiba
    Department of Physiology, Kansai College of Oriental Medicine, 2 11 1 Wakaba, Kumatori, Sennan, Osaka 590 0433, Japan
    Brain Res Mol Brain Res 110:52-62. 2003
    ..In contrast, NG neurons were suggested to be divided into two major groups; one group depends on brain-derived neurotrophic factor (BDNF)/neurotrophin-4/5 (NT-4/5), and the other depends on both BDNF/NT-4/5 and GDNF...
  72. pmc Acute suppression, but not chronic genetic deficiency, of c-fos gene expression impairs long-term memory in aversive taste learning
    Yasunobu Yasoshima
    Department of Behavioral Physiology, Graduate School of Human Sciences, Osaka University, 1 2 Yamada oka, Suita 565 0871, Japan
    Proc Natl Acad Sci U S A 103:7106-11. 2006
    ....
  73. ncbi request reprint Stress-induced hyperalgesia: animal models and putative mechanisms
    Hiroki Imbe
    Department of Oral Anatomy, Osaka Dental University, Hirakata City, 573 1121, Japan
    Front Biosci 11:2179-92. 2006
    ..These stress-induced hyperalgesia models may contribute to a better understanding of chronic pain and provide a more rational basis for drug therapies in a variety of pain syndromes...
  74. ncbi request reprint Effects of peripheral inflammation on activation of p38 mitogen-activated protein kinase in the rostral ventromedial medulla
    Hiroki Imbe
    Department of Oral Anatomy, Osaka Dental University, Kuzuhahanazono cho 8 1, Hirakata City, 573 1121, Japan
    Brain Res 1134:131-9. 2007
    ..05]. These findings suggest that inflammation-induced activation of p38 MAPK in the RVM may be involved in the plasticity in the descending pain modulatory system following inflammation...
  75. ncbi request reprint Changes in estrogen receptors alpha and beta expression in the brain of mice exposed prenatally to bisphenol A
    Keisuke Kawai
    Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, Japan
    Regul Toxicol Pharmacol 47:166-70. 2007
    ..Exposure to bisphenol A may have changed the expression of ERs in the brain, but did not directly affect serotonin neurons in the DRN...
  76. pmc Mammalian twisted gastrulation is essential for skeleto-lymphogenesis
    Tetsuya Nosaka
    Division of Hematopoietic Factors, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Mol Cell Biol 23:2969-80. 2003
    ..Although lymphopenia in TSG-deficient mice would partly be ascribed to systemic effects of runtiness and wasting, our findings may also provide a clue for understanding the pathogenesis of human dwarfism with combined immunodeficiency...
  77. ncbi request reprint Increased body weight in mice lacking mu-opioid receptors
    Wenhua Han
    Division of Psychobiology, Tokyo Institute of Psychiatry, Kamikitazawa, Tokyo, Japan
    Neuroreport 17:941-4. 2006
    ..Our results suggest that the up-regulated expression of neuropeptide Y mRNA might contribute to the increased weights of adult mu-opioid receptor knockout mice...
  78. ncbi request reprint Expression of mitochondrial tricarboxylate carrier TCC mRNA and protein in the rat brain
    Shin ichi Miyake
    Department of Anatomy and Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Brain Res Mol Brain Res 100:67-73. 2002
    ..Our results suggest that this tricarboxylate carrier protein may contribute to biosynthesis and bioenergetics in neuronal cells in brain...
  79. ncbi request reprint [Molecular medicine of pain--current topics and perspectives]
    Emiko Senba
    Nihon Ronen Igakkai Zasshi 42:392-8. 2005
  80. ncbi request reprint Effects of amitriptyline and gabapentin on bilateral hyperalgesia observed in an animal model of unilateral axotomy
    Tsuneo Yasuda
    Division of Pharmacology, Drug Safety and Metabolism, Otsuka Pharmaceutical Factory, Inc, 115 Tateiwa, Muya cho, Naruto, Tokushima 772 8601, Japan
    Pain 115:161-70. 2005
    ....