Shizuya Saika

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. doi request reprint Wakayama symposium: modulation of wound healing response in the corneal stroma by osteopontin and tenascin-C
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ocul Surf 11:12-5. 2013
  2. ncbi request reprint TGF beta in fibroproliferative diseases in the eye
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Front Biosci (Schol Ed) 1:376-90. 2009
  3. ncbi request reprint Therapeutic effects of adenoviral gene transfer of bone morphogenic protein-7 on a corneal alkali injury model in mice
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Lab Invest 85:474-86. 2005
  4. ncbi request reprint TGF-beta signal transduction in corneal wound healing as a therapeutic target
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Cornea 23:S25-30. 2004
  5. ncbi request reprint Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation
    Shizuya Saika
    Departments of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Exp Eye Res 79:147-56. 2004
  6. ncbi request reprint Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Lab Invest 84:1245-58. 2004
  7. ncbi request reprint Relationship between posterior capsule opacification and intraocular lens biocompatibility
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Prog Retin Eye Res 23:283-305. 2004
  8. ncbi request reprint Protein expression pattern of collagen type XV in mouse cornea
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 242:432-6. 2004
  9. pmc Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Am J Pathol 164:651-63. 2004
  10. ncbi request reprint Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 45:100-9. 2004

Collaborators

Detail Information

Publications107 found, 100 shown here

  1. doi request reprint Wakayama symposium: modulation of wound healing response in the corneal stroma by osteopontin and tenascin-C
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ocul Surf 11:12-5. 2013
    ..In conclusion, osteopontin or tenascin-C, α9 integrin ligands, play an important role in stromal healing (or fibrosis) and neovascularization in mouse cornea...
  2. ncbi request reprint TGF beta in fibroproliferative diseases in the eye
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Front Biosci (Schol Ed) 1:376-90. 2009
    ..Blocking Smad signal by chemical or natural inhibitors or anti-Smad gene introduction effectively suppress fibrogenic reaction; inhibition of both fibroblast-myofibroblast conversion or EMT. Such strategies can be clinically tested...
  3. ncbi request reprint Therapeutic effects of adenoviral gene transfer of bone morphogenic protein-7 on a corneal alkali injury model in mice
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Lab Invest 85:474-86. 2005
    ..These data suggest that overexpression of BMP-7 is an effective strategy for treatment of ocular alkali burns...
  4. ncbi request reprint TGF-beta signal transduction in corneal wound healing as a therapeutic target
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Cornea 23:S25-30. 2004
    ..Possible benefits of preserving non-Smad cascades in treating problems in corneal wound healing by manipulating TGF-beta signals have been suggested...
  5. ncbi request reprint Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation
    Shizuya Saika
    Departments of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Exp Eye Res 79:147-56. 2004
    ..In contrast, in post-operative lens cells differentiating to fiber cells, its expression levels decline. Further study is needed to clarify the roles of TSP-1 in modulating lens cell phenotype expression...
  6. ncbi request reprint Smad3 is required for dedifferentiation of retinal pigment epithelium following retinal detachment in mice
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Lab Invest 84:1245-58. 2004
    ..The results suggest that blocking the Smad3 pathway might be beneficial in prevention/treatment of PVR...
  7. ncbi request reprint Relationship between posterior capsule opacification and intraocular lens biocompatibility
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Prog Retin Eye Res 23:283-305. 2004
    ..Other factors affecting the biological and mechanical outcome of IOL implantation are its composition, surface properties and shape...
  8. ncbi request reprint Protein expression pattern of collagen type XV in mouse cornea
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 242:432-6. 2004
    ..Its COOH-terminal peptide has an anti-angiogenic effect and its distribution in avascular tissue of cornea is of interest...
  9. pmc Smad3 signaling is required for epithelial-mesenchymal transition of lens epithelium after injury
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Am J Pathol 164:651-63. 2004
    ..The results suggest that blocking the Smad3 pathway might be beneficial in inhibiting capsular fibrosis after injury and/or surgery...
  10. ncbi request reprint Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 45:100-9. 2004
    ..e., Smad and p38 mitogen-activated kinase [MAPK]) in regulation of cell migration and proliferation of healing mouse corneal epithelium...
  11. ncbi request reprint Histology of anterior capsule opacification with a polyHEMA/HOHEXMA hydrophilic hydrogel intraocular lens compared to poly(methyl methacrylate), silicone, and acrylic lenses
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Cataract Refract Surg 29:1198-203. 2003
    ..Extracellular matrix accumulation appeared immature and less with a polyHEMA/HOHEXMA hydrogel IOL...
  12. pmc Therapeutic effect of topical administration of SN50, an inhibitor of nuclear factor-kappaB, in treatment of corneal alkali burns in mice
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Pathol 166:1393-403. 2005
    ..An acceleration of epithelial cell proliferation by SN50 treatment was found to depend on TNF-alpha/JNK signaling. In conclusion, topical application of SN50 is effective in treating corneal alkali burns in mice...
  13. pmc Expression of Smad7 in mouse eyes accelerates healing of corneal tissue after exposure to alkali
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Pathol 166:1405-18. 2005
    ..Together these data suggest that overexpression of Smad7 may have effects beyond those of simply blocking Smad3/TGF-beta signaling and may represent an effective new strategy for treatment of ocular burns...
  14. ncbi request reprint Inhibition of p38MAP kinase suppresses fibrotic reaction of retinal pigment epithelial cells
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama 641 0012, Japan
    Lab Invest 85:838-50. 2005
    ..Gene transfer of DN-p38MAPK attenuated the post-retinal detachment fibrotic reaction of the retinal pigment epithelium in vivo in mice, supporting its effectiveness in preventing/treating PVR...
  15. ncbi request reprint Epithelial-mesenchymal transition as a therapeutic target for prevention of ocular tissue fibrosis
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Endocr Metab Immune Disord Drug Targets 8:69-76. 2008
    ..EMT-related signal transduction cascades, i. e., TGFbeta/Smad, are a target to prevent or treat unfavorable ocular tissue fibrosis, e. g., fibrotic diseases in the crystalline lens or retina, as well as possibly in other organs...
  16. doi request reprint Fibrotic disorders in the eye: targets of gene therapy
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Prog Retin Eye Res 27:177-96. 2008
    ..Modulation of signal transduction molecules, e.g., Smad and mitogen-activated protein kinases, by gene transfer and other technology is beneficial and can be an important treatment regiment to overcome (prevent or treat) these diseases...
  17. ncbi request reprint Yin and yang in cytokine regulation of corneal wound healing: roles of TNF-alpha
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimidera, Wakayama 641 0012, Japan
    Cornea 26:S70-4. 2007
    ..Further studies are needed to determine if anti-TNF-alpha strategies might be effective in the treatment of ocular surface inflammatory or allergic disorders...
  18. ncbi request reprint Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice
    Shizuya Saika
    Dept of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Physiol Cell Physiol 293:C75-86. 2007
    ..Together, these data suggest that overexpression of PPARgamma may represent an effective new strategy for treatment of ocular surface burns...
  19. ncbi request reprint Effect of Smad7 gene overexpression on transforming growth factor beta-induced retinal pigment fibrosis in a proliferative vitreoretinopathy mouse model
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Arch Ophthalmol 125:647-54. 2007
    ..To determine the effects of Smad7 gene transfer in the prevention of fibrogenic responses by the retinal pigment epithelium, a major cause of proliferative vitreoretinopathy after retinal detachment, in mice...
  20. ncbi request reprint Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Lab Invest 87:130-8. 2007
    ..An in vitro experiment shows OPN facilitates cell adhesion of lens epithelial cell line. OPN is required for activation of Smad2/3 signal in an injured lens epithelium and lens cell EMT...
  21. pmc Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Pathol 168:1848-60. 2006
    ....
  22. ncbi request reprint TGFbeta pathobiology in the eye
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Lab Invest 86:106-15. 2006
    ..The present paper reviews recent progress concerning the roles of TGFbeta signaling in the pathology of the eye...
  23. ncbi request reprint Adenoviral gene transfer of BMP-7, Id2, or Id3 suppresses injury-induced epithelial-to-mesenchymal transition of lens epithelium in mice
    Shizuya Saika
    Dept of Ophthalmology, Wakayama Medical Univ, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Am J Physiol Cell Physiol 290:C282-9. 2006
    ..Gene transfer of BMP-7, Id2, or Id3 delayed injury-induced EMT of lens epithelial cells and subsequent sealing of the capsular break with fibrous tissue in mice...
  24. ncbi request reprint Response of lens epithelial cells to injury: role of lumican in epithelial-mesenchymal transition
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 44:2094-102. 2003
    ....
  25. ncbi request reprint Expression of transcription factor AP-1 in rat lens epithelial cells during wound repair
    K Shirai
    Department of Ophthalmology, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Exp Eye Res 73:461-8. 2001
    ..e. 30 min post-injury, suggesting that AP-1 may play important roles in regulating lens cell behavior during lens wound repair in rats...
  26. ncbi request reprint Collagens XII and XIV (FACITs) in capsular opacification and in cultured lens epithelial cells
    S Saika
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Curr Eye Res 23:463-8. 2001
    ....
  27. pmc Latent TGFbeta binding protein-1 and fibrillin-1 in human capsular opacification and in cultured lens epithelial cells
    S Saika
    Department of Ophthalmology, Wakayama Medical University School of Medicine, 811 1 Kimidera, Wakayama, 641 8509, Japan
    Br J Ophthalmol 85:1362-6. 2001
    ..The aim of the study was to further clarify the mechanism of TGFbeta1 deposition in ECM of capsular opacification...
  28. ncbi request reprint Epithelial repair: roles of extracellular matrix
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical College, Japan
    Cornea 21:S23-9. 2002
    ..3) Expression of keratan sulfate proteoglycan (KSPG) proteins in corneal epithelium was examined during repair after injury in wild-type and lumican-null mice...
  29. ncbi request reprint Accumulation of latent transforming growth factor-beta binding protein-1 and TGF beta 1 in extracellular matrix of filtering bleb and of cultured human subconjunctival fibroblasts
    S Saika
    Department of Ophthalmology, Wakayama Medical College, 811 1 Kimiidera, Wakayama, 641 8509, Japan
    Graefes Arch Clin Exp Ophthalmol 239:234-41. 2001
    ..To examine immunohistochemically whether extracellular matrix (ECM) of the filtering bleb and of cultured human subconjunctival fibroblasts contains latent TGF beta binding protein-1 (LTBP-1) and TGF beta...
  30. ncbi request reprint Osteopontin: a component of matrix in capsular opacification and subcapsular cataract
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 44:1622-8. 2003
    ..To examine whether tissues of human capsular opacification and subcapsular cataract contain osteopontin, an adhesive matrix protein, and whether mouse lens epithelium expresses osteopontin after injury...
  31. ncbi request reprint Lens epithelial cell regeneration of a capsule-like structure during postoperative healing in rabbits
    S Saika
    Department of Ophthalmology, Wakayama Medical College, 811 1 Kimiidera, Wakayama, 641 8509, Japan
    J Cataract Refract Surg 27:1076-8. 2001
    ..To determine whether lens epithelial cells (LECs) can regenerate the lens capsule during healing after lens extraction and intraocular lens (IOL) implantation.Setting: Department of Ophthalmology, Wakayama Medical College, Japan...
  32. ncbi request reprint Surgical posterior vitreous detachment combined with gas/air tamponade for treating macular edema associated with branch retinal vein occlusion: retinal tomography and visual outcome
    S Saika
    Department of Ophthalmology, Wakayama Medical University, School of Medicine, Kimiidera, Japan
    Graefes Arch Clin Exp Ophthalmol 239:729-32. 2001
    ..To assess the effectiveness of surgical posterior vitreous detachment (PVD) together with gas/air tamponade in treating visual impairment from macular edema associated with branch retinal vein occlusion (BRVO-macular edema)...
  33. ncbi request reprint Comparison of Scheimpflug images of posterior capsule opacification and histological findings in rabbits and humans
    S Saika
    Department of Ophthalmology, Wakayama Medical College, 811 1 Kimiidera, Wakayama, 641 8509, Japan
    J Cataract Refract Surg 27:1088-92. 2001
    ..To compare the posterior capsule opacification in Scheimpflug photographic images produced by an electronic anterior eye segment analysis system with the histopathological findings in rabbits and humans...
  34. ncbi request reprint Smad translocation and growth suppression in lens epithelial cells by endogenous TGFbeta2 during wound repair
    S Saika
    Department of Ophthalmology, Wakayama 641 0012, Japan
    Exp Eye Res 72:679-86. 2001
    ..Nuclear translocation of Smads in lens epithelial cells is transient even with continuous exposure to TGFbeta2...
  35. ncbi request reprint Immunolocalization of c-Fos and c-Jun in rat ocular surface epithelium
    S Saika
    Department of Ophthalmology, Wakayama Medical College, Wakayama, Japan
    Ophthalmic Res 32:9-12. 2000
    ..The corneal epithelium lacked immunoreactivity for either protein. AP1 may have an important role in the maintenance of homeostasis of limbal and conjunctival epithelia...
  36. ncbi request reprint Multiple retinal holes in the macular region: a case report
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Japan
    Graefes Arch Clin Exp Ophthalmol 240:578-9. 2002
    ..To describe the first case of multiple retinal holes in the macular region successfully treated with vitrectomy...
  37. ncbi request reprint Expression of involucrin by ocular surface epithelia of patients with benign and malignant disorders
    S Saika
    Department of Ophthalmology, Wakayama Medical College, Wakayama, 641 8509, Japan
    Curr Eye Res 21:877-85. 2000
    ..malignant disorders. Expression of cytokeratins was also examined to provide further information relative to the epithelial differentiation...
  38. pmc TGFbeta-Smad signalling in postoperative human lens epithelial cells
    S Saika
    Department of Ophthalmology, Wakayama Medical University, Japan
    Br J Ophthalmol 86:1428-33. 2002
    ..Smads3/4 are involved in signal transduction between transforming growth factor beta (TGFbeta) cell surface receptors and gene promoters. Nuclear localisation of Smads indicates achievement of endogenous TGFbeta signalling in cells...
  39. ncbi request reprint Lens epithelial cell death after cataract surgery
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimidera, Wakayama 641 0012, Japan
    J Cataract Refract Surg 28:1452-6. 2002
    ..To determine whether lens epithelial cells (LECs) undergo apoptosis during healing after cataract surgery to further characterize the healing process of the postoperative lens capsule...
  40. ncbi request reprint Transient adenoviral gene transfer of Smad7 prevents injury-induced epithelial-mesenchymal transition of lens epithelium in mice
    Shizuya Saika
    Department Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Lab Invest 84:1259-70. 2004
    ..We conclude that gene transfer of Smad7 in mice prevents injury-induced EMT of lens epithelial cells and sealing of the capsular break with fibrous tissue...
  41. ncbi request reprint Inhibition of p38MAP kinase suppresses fibrogenic reaction in conjunctiva in mice
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 13:1730-9. 2007
    ..To examine the effects of blocking p38 mitogen-activated protein kinase (MAPK) on post-injury conjunctival scarring in mice. Its effects on the behaviors of cultured subconjunctival fibroblasts were also investigated...
  42. ncbi request reprint A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Mol Vis 12:681-91. 2006
    ....
  43. doi request reprint JNK MAPK signaling contributes in vivo to injury-induced corneal epithelial migration
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 42:185-92. 2009
    ..Furthermore, in vitro the relative contribution was determined by the JNK/SAPK pathway to that of its p38 and ERK MAPK counterparts in mediating injury-induced increases in cell migration...
  44. doi request reprint Impaired angiogenic response in the corneas of mice lacking osteopontin
    Norihito Fujita
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Invest Ophthalmol Vis Sci 51:790-4. 2010
    ..Cell culture study was also conducted to clarify the effects of OPN in transforming growth factor (TGF) beta1-driven cell signaling and expression of vascular endothelial growth factor (VEGF)...
  45. doi request reprint Corneal wound healing in an osteopontin-deficient mouse
    Ken ichi Miyazaki
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 49:1367-75. 2008
    ..To investigate the effects of loss of osteopontin (OPN) in the healing of the injured cornea in mice. Cell culture study was also conducted to clarify the effects of OPN in fibroblast behaviors...
  46. doi request reprint Suppression of injury-induced conjunctiva scarring by peroxisome proliferator-activated receptor gamma gene transfer in mice
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 50:187-93. 2009
    ..Its effects on fibrogenic reaction of cultured human subconjunctival fibroblasts (hSCFs) were also evaluated...
  47. ncbi request reprint Emodin suppression of ocular surface inflammatory reaction
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 48:5013-22. 2007
    ..To determine whether a Chinese herbal medicine component, emodin, suppresses inflammatory/fibrogenic reaction in cultured subconjunctival fibroblasts and reduces injury-induced increases in ocular surface inflammation in mice...
  48. ncbi request reprint Genipin suppresses subconjunctival fibroblast migration, proliferation and myofibroblast transdifferentiation
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 38:355-60. 2006
    ....
  49. ncbi request reprint Fibroblast growth factor 2: roles of regulation of lens cell proliferation and epithelial-mesenchymal transition in response to injury
    Takeshi Tanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 10:462-7. 2004
    ..To examine the role of fibroblast growth factor 2 (FGF2) in regulating lens cell proliferation and epithelial-mesenchymal transition (EMT) in response to injury...
  50. ncbi request reprint Genipin suppression of fibrogenic behaviors of the alpha-TN4 lens epithelial cell line
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Cataract Refract Surg 32:1727-35. 2006
    ....
  51. doi request reprint Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Curr Eye Res 33:559-65. 2008
    ..To investigate the effect of tetrandrine on activation of human subconjunctival fibroblasts (SCFs) in vitro...
  52. ncbi request reprint Sonic hedgehog expression and role in healing corneal epithelium
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Japan
    Invest Ophthalmol Vis Sci 45:2577-85. 2004
    ..To examine the expression pattern and roles of Sonic hedgehog (Shh) in healing corneal epithelium...
  53. ncbi request reprint Endogenous TNFalpha suppression of neovascularization in corneal stroma in mice
    Shuko Fujita
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Invest Ophthalmol Vis Sci 48:3051-5. 2007
    ..To examine the role of tumor necrosis factor alpha (TNFalpha) in stromal neovascularization in injured cornea in vivo and in cytokine-enhanced vessel-like endothelial cell tube formation in vitro...
  54. ncbi request reprint TNFalpha suppression of corneal epithelium migration
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 13:1428-35. 2007
    ..To evaluate the role of tumor necrosis factor alpha (TNFalpha) in regulation of corneal epithelial cell migration...
  55. pmc Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C
    Sai Ichi Tanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 16:1194-205. 2010
    ..Tenascin-C is a component of the extracellular matrix in patients having post-operative capsular opacification...
  56. ncbi request reprint Expression of cyclooxygenase-2 in corneal cells after photorefractive keratectomy and laser in situ keratomileusis in rabbits
    Takeshi Miyamoto
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Cataract Refract Surg 30:2612-7. 2004
    ..To compare the expression pattern of cyclooxygenase-2 (COX-2) in rabbit corneal cells after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) with the same refractive correction...
  57. pmc TRPV1 involvement in inflammatory tissue fibrosis in mice
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Am J Pathol 178:2654-64. 2011
    ..In conclusion, absence or blocking of TRPV1 suppressed inflammation and fibrosis/scarring during healing of alkali-burned mouse cornea. TRPV1 is a potential drug target for improving the outcome of inflammatory/fibrogenic wound healing...
  58. ncbi request reprint Interleukin-7 modulates extracellular matrix production and TGF-beta signaling in cultured human subconjunctival fibroblasts
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Curr Eye Res 31:491-9. 2006
    ..IL-7 is capable of inducing Smad7, an inhibitory Smad that interferes with TGF-beta/Smad signal...
  59. pmc Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium
    Takayoshi Sumioka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 14:2272-81. 2008
    ..To understand the role of TGF-beta related signals in the repair of a corneal endothelium defect and also to evaluate the therapeutic effect of Smad7 gene transfer on injury induced fibrosis of the corneal endothelium in rats...
  60. ncbi request reprint Gene transfer of Smad7 modulates injury-induced conjunctival wound healing in mice
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 12:841-51. 2006
    ..Herein, we examined the effects of Smad7 gene introduction on post-injury conjunctival wound healing in mice. Its effects on the cultured human subconjunctival fibroblasts (SCFs) were also investigated...
  61. doi request reprint Connective tissue growth factor modulates extracellular matrix production in human subconjunctival fibroblasts and their proliferation and migration in vitro
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Jpn J Ophthalmol 52:8-15. 2008
    ..TGFbeta1 is the major factor involved in bleb scarring following filtration surgery...
  62. doi request reprint Impaired cornea wound healing in a tenascin C-deficient mouse model
    Takayoshi Sumioka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Lab Invest 93:207-17. 2013
    ..These results indicate that tenascin C modulates wound healing-related fibrogenic gene expression in ocular fibroblasts and is required for primary healing of the corneal stroma...
  63. ncbi request reprint Cellular fibronectin, but not collagens, disappears in the central posterior capsules during healing after lens extraction and IOL implantation in rabbits
    Sai Ichi Tanaka
    Department of Ophthalmology, Wakayama Medical College, Wakayama, Japan
    Jpn J Ophthalmol 46:147-52. 2002
    ..The study was conducted also to compare the extracellular matrix components in rabbit capsules with those previously reported in the human eye...
  64. pmc Targeted disruption of TGF-beta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    Misako Sato
    Department of Pathology, Wakayama Medical University, Wakayama, Japan
    J Clin Invest 112:1486-94. 2003
    ..Together the data demonstrate that the Smad3 pathway is central to the pathogenesis of interstitial fibrosis and suggest that inhibitors of this pathway may have clinical application in the treatment of obstructive nephropathy...
  65. ncbi request reprint AP-1 expression in ethanol-treated corneal epithelium in vivo
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 39:84-91. 2007
    ..The purpose of the current study was to examine if the ethanol exposure during laser epithelial keratomileusis (LASEK) may stimulate or damage the corneal epithelial cells...
  66. ncbi request reprint Biological compatibility of polymethyl methacrylate, hydrophilic acrylic and hydrophobic acrylic intraocular lenses
    Walid Barbour
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 37:255-61. 2005
    ..The aim of this study was to add animal eye experimental implantation data regarding cellular reaction on the anterior surface of IOLs...
  67. ncbi request reprint Effects of the matrix metalloproteinase inhibitor GM6001 on the destruction and alteration of epithelial basement membrane during the healing of post-alkali burn in rabbit cornea
    Tadashi Kato
    Department of Ophthalmology, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Jpn J Ophthalmol 50:90-5. 2006
    ..To examine the alteration in structure and matrix composition of epithelial basement membrane (BM) during the healing of alkali-burned rabbit cornea, and the roles of matrix metalloproteinases (MMPs) in these alterations...
  68. ncbi request reprint Histological observation of complete closure of anterior capsulotomy in 2 cases
    Sai Ichi Tanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    J Cataract Refract Surg 30:1374-7. 2004
    ..The finding indicates that phenotypic modulation in lens epithelial cell to contractile cell type and accumulation of matrix are involved in closure of the anterior capsulotomy window...
  69. pmc The use of sintered bone in spinal surgery
    A Minamide
    Department of Orthopaedic Surgery, Wakayama Medical College, Wakayama City, Japan
    Eur Spine J 10:S185-8. 2001
    ..Our observations warrant further clinical investigation of the use of sintered bone as an effective spinal arthrodesis, especially in patients who have fragile vertebrae, as in osteoporosis...
  70. ncbi request reprint Expression patterns of beta1-related alpha integrin subunits in murine lens during embryonic development and wound healing
    Walid Barbour
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Curr Eye Res 29:1-10. 2004
    ..To study the expression patterns of b1-related alpha integrin subunits in murine lens epithelial cells, comparing embryonic fiber differentiation with injury-induced epithelial mesenchymal transition (EMT)...
  71. ncbi request reprint [Investigation of mechanism of cell proliferation regulation and its clinical application]
    Yoshitaka Ohnishi
    Department of Ophthalmology, Wakayama Medical University, Japan
    Nihon Ganka Gakkai Zasshi 109:865-83; discussion 884. 2005
    ..e., epithelial-mesenchymal transition. These cellular activities can be controlled by modulation of growth factor signaling by employing such strategy including gene introduction...
  72. ncbi request reprint Brown haze in an Allergan SI-40NB silicone intraocular lens
    Takeshi Tanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    J Cataract Refract Surg 30:250-2. 2004
    ..Although the exact cause of this complication is unknown, water incorporated into the material may have had a role in the development of the sphere-like structures...
  73. ncbi request reprint An experimental approach to spinal fusion using sintered bovine bone in a pig model
    A Minamide
    Department of Orthopaedic Surgery, Wakayama Medical College, Wakayama City, Japan
    J Spinal Disord 13:156-64. 2000
    ..The sintered bovine bone with its moderate strength tended to adjust to the bone stiffness of the host bone in the specimens as new bone grew...
  74. ncbi request reprint Experimental spinal fusion using sintered bovine bone coated with type I collagen and recombinant human bone morphogenetic protein-2
    A Minamide
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 24:1863-70; discussion 1871-2. 1999
    ....
  75. ncbi request reprint Effects of sintered bovine bone on cell proliferation, collagen synthesis, and osteoblastic expression in MC3T3-E1 osteoblast-like cells
    T Matsumoto
    Department of Orthopedic Surgery, Wakayama Medical College, Wakayama City, Japan
    J Orthop Res 17:586-92. 1999
    ....
  76. ncbi request reprint Mechanical compression of the lumbar nerve root alters pain-related behaviors induced by the nucleus pulposus in the rat
    M Kawakami
    Department of Orthopaedic Surgery, Wakayama Medical College, Wakayama City, Japan
    J Orthop Res 18:257-64. 2000
    ..It is possible that mechanical constriction of the nerve root alters the pain-related behavior elicited by chemical factors from the nucleus pulposus...
  77. ncbi request reprint Effects of basic fibroblast growth factor on spontaneous resorption of herniated intervertebral discs. An experimental study in the rabbit
    A Minamide
    Department of Orthopaedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 24:940-5. 1999
    ....
  78. ncbi request reprint Evaluation of carriers of bone morphogenetic protein for spinal fusion
    A Minamide
    Department of Orthopaedic Surgery, Wakayama Medical College, Wakayama City, Wakayama, Japan
    Spine (Phila Pa 1976) 26:933-9. 2001
    ..Posterolateral lumbar transverse process fusion in a rabbit model was performed using two different carriers for recombinant human morphogenetic protein-2, one having a porous structure and the other being a Type I collagen sheet...
  79. ncbi request reprint Posterior endoscopic surgery for lumbar disc herniation with contralateral symptoms - a report of two cases
    Y Nakagawa
    Department of Orthopaedic Surgery, Wakayama Medical University, Wakayama, Japan
    Minim Invasive Neurosurg 49:282-5. 2006
    ..After that, through the same approach, the nerve root of the opposite (symptomatic) side should be decompressed...
  80. ncbi request reprint Effects of steroid and lipopolysaccharide on spontaneous resorption of herniated intervertebral discs. An experimental study in the rabbit
    A Minamide
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 23:870-6. 1998
    ..Lipopolysaccharide accelerated the replacement of grafted intervertebral disc by fibrous tissue, which suggests the resorption of the disc in the epidural space of the rabbit, whereas high-dose steroid suppressed the replacement...
  81. ncbi request reprint Impaired cutaneous wound healing with excess granulation tissue formation in TNFalpha-null mice
    Maki Shinozaki
    Department of Critical Care Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Arch Dermatol Res 301:531-7. 2009
    ..In conclusion, lacking TNFalpha potentiates Smad-mediated fibrogenic reaction in healing dermis and retards reepithelialization in a healing mouse cutaneous wound...
  82. ncbi request reprint Transcription activation in lens epithelial cells after anterior capsule rubbing in rats. expression of c-Fos
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan
    J Cataract Refract Surg 29:1601-4. 2003
    ..To determine whether lens epithelial cells (LECs) are transcriptionally activated after a foreign body is attached to the anterior lens surface...
  83. ncbi request reprint Topical exposure of mitomycin C reduces opacification of the residual anterior lens capsule and lenticular regeneration after vitrectomy and lensectomy in rabbits
    Takeshi Miyamoto
    Department of Ophthalmology, Wakayama Medical University, 811 1, Kimiidera, 641 0012 Wakayama, Japan
    Graefes Arch Clin Exp Ophthalmol 242:327-31. 2004
    ..To examine the effect of topical administration of mitomycin C (MMC) on the opacification of residual anterior lens capsule in a vitrectomized/lensectomized eye...
  84. ncbi request reprint Expression of AP-1 (c-fos/c-jun) in developing mouse corneal epithelium
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, 641 0012 Wakayama, Japan
    Graefes Arch Clin Exp Ophthalmol 241:330-3. 2003
    ..AP-1 consists of Fos family and Jun family proteins...
  85. doi request reprint Perturbed intraepithelial differentiation of corneal epithelium in c-Fos-null mice
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Jpn J Ophthalmol 52:1-7. 2008
    ..We examined the role of c-Fos in the differentiation of corneal epithelial cells by using c-Fos-deficient (c-fos (-/-)) mice...
  86. ncbi request reprint [Effects of surface modification of intraocular lenses on foreign body reaction ]
    Yasuhiko Okajima
    Department of Ophthalmology, Nihon University School of Medicine, Japan
    Nihon Ganka Gakkai Zasshi 109:267-73. 2005
    ..In order to improve biocompatibility, we investigated the effects of surface modification by 2-methacryloyloxyethyl phosphorylcholine (MPC) on the foreign body reaction of intraocular lens (IOLs)...
  87. doi request reprint Immunohistochemical observation of anterior subcapsular cataract in eye with spontaneously regressed retinoblastoma
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    J Cataract Refract Surg 36:503-7. 2010
    ..Histology of the fibrous anterior subcapsular opacification tissue showed the possibility of epithelial-mesenchymal transition of the lens epithelial cells in the secondary cataract following a spontaneously regressed retinoblastoma...
  88. ncbi request reprint Neurotrophic keratopathy; its pathophysiology and treatment
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Histol Histopathol 25:771-80. 2010
    ..Targeting TRP channel in the cornea is expected to contribute to the development of a new treatment method for neurotrophic keratopathy. Further study and clinical trial are need to establish this new treatment strategy...
  89. ncbi request reprint AP-1 (c-Fos/c-Jun) is required for corneal epithelial spreading
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 241:327-9. 2003
    ..Antisense-oligonucleotide (AS) c-fos-null mice were used for this purpose...
  90. pmc Therapeutic potential of trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 16:2964-73. 2010
    ....
  91. ncbi request reprint Cyclooxygenase 2 expression in rat corneas after ethanol exposure
    Takeshi Miyamoto
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama City, Wakayama, Japan
    J Cataract Refract Surg 32:1736-40. 2006
    ..To evaluate the effects of ethanol exposure of the cornea on inflammation in corneal epithelium...
  92. ncbi request reprint Effects of interferon-gamma on human subconjunctival fibroblasts in the presence of TGFbeta1: reversal of TGFbeta-stimulated collagen production
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 241:116-24. 2003
    ..IFN-gamma reportedly up-regulates Smad7, an inhibitory mediator of TGFbeta-Smad signaling, and blocks TGFbeta effects...
  93. ncbi request reprint Wound healing in rabbit corneas after photorefractive keratectomy and laser in situ keratomileusis
    Takeshi Miyamoto
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    J Cataract Refract Surg 29:153-8. 2003
    ..To compare the wound-healing process in the rabbit cornea after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) with the same refractive correction...
  94. doi request reprint Expression pattern of sonic hedgehog and effect of topical mitomycin C on its expression in human ocular surface neoplasms
    Kyoko Fujita
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Jpn J Ophthalmol 52:190-4. 2008
    ..To examine if the cells of human ocular surface neoplasms express sonic hedgehog (Shh) and the effects of topical mitomycin C on its expression...
  95. ncbi request reprint Histology and immunohistochemistry of fibrous posterior capsule opacification in an infant
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    J Cataract Refract Surg 30:523-6. 2004
    ..The presumed LECs amid the ECM were positive for vimentin and alpha-smooth muscle actin. Histology of the fibrous PCO tissue from this infant was similar to that in adult patients...
  96. ncbi request reprint Treatment of eyelid epithelial neoplasm by targeting sonic hedgehog signaling: an experimental study
    Ken ichi Miyazaki
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Jpn J Ophthalmol 50:305-11. 2006
    ..To evaluate the effect of cyclopamine, an inhibitor of the Sonic hedgehog (Shh) signal, on the growth of an epithelial neoplasm...
  97. ncbi request reprint Transcriptional activation in lens epithelial cells following an ocular blunt trauma
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Kimiidera, Wakayama 641 0012, Japan
    J Cataract Refract Surg 31:1226-30. 2005
    ..To determine whether an ocular blunt trauma activates anterior ocular segment (cornea and lens) by examining the expression patterns of c-fos and c-jun mRNAs in these tissues of an eye of adult rat following a blunt trauma...
  98. ncbi request reprint Growth factor deposition in anterior subcapsular cataract
    Iku Ishida
    Department of Ophthalmology, Wakayama Medical University, Wakayama 641 8509, Japan
    J Cataract Refract Surg 31:1219-25. 2005
    ..To characterize immunohistochemically the distribution of growth factors and extracellular matrix (ECM) components in an anterior subcapsular cataract (ASC) and to determine the role of growth factors in the development of ASC...
  99. ncbi request reprint Expression of c-Fos and c-Jun in developing mouse lens
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama, Japan
    Ophthalmic Res 36:226-30. 2004
    ..They were not detected in an adult mouse lens. The expression pattern of the AP-1 transcription factor in equatorial epithelium may suggest its role in fiber differentiation...
  100. pmc Sonic hedgehog: its expression in a healing cornea and its role in neovascularization
    Kyoko Fujita
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Mol Vis 15:1036-44. 2009
    ..To examine if sonic hedgehog (Shh) is involved in tissue neovascularization by using cell culture and an animal cornea...
  101. ncbi request reprint Sintered bone implantation for the treatment of benign bone tumours in the hand
    Y Taniguchi
    Department of Orthopaedic Surgery, Wakayama Medical College, Japan
    J Hand Surg Br 24:109-12. 1999
    ..Sintered bone was not absorbed, and lucent zones around the implants or other abnormal findings were not observed. Bone union was achieved in all patients who had pathological fractures before surgery...