Yuka Okada

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. ncbi Neurotrophic keratopathy; its pathophysiology and treatment
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Histol Histopathol 25:771-80. 2010
  2. ncbi Effects of topical antiglaucoma medications on corneal epithelium as evaluated by gene expression patterns
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Cornea 26:S46-54. 2007
  3. ncbi Expression of AP-1 (c-fos/c-jun) in developing mouse corneal epithelium
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, 641 0012 Wakayama, Japan
    Graefes Arch Clin Exp Ophthalmol 241:330-3. 2003
  4. ncbi AP-1 (c-Fos/c-Jun) is required for corneal epithelial spreading
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 241:327-9. 2003
  5. ncbi AP-1 expression in ethanol-treated corneal epithelium in vivo
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 39:84-91. 2007
  6. ncbi Perturbed intraepithelial differentiation of corneal epithelium in c-Fos-null mice
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Jpn J Ophthalmol 52:1-7. 2008
  7. ncbi TRPV1 involvement in inflammatory tissue fibrosis in mice
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Am J Pathol 178:2654-64. 2011
  8. ncbi JNK MAPK signaling contributes in vivo to injury-induced corneal epithelial migration
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 42:185-92. 2009
  9. ncbi Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice
    Shizuya Saika
    Dept of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Physiol Cell Physiol 293:C75-86. 2007
  10. ncbi Emodin suppression of ocular surface inflammatory reaction
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 48:5013-22. 2007

Collaborators

Detail Information

Publications66

  1. ncbi Neurotrophic keratopathy; its pathophysiology and treatment
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Histol Histopathol 25:771-80. 2010
    ..Targeting TRP channel in the cornea is expected to contribute to the development of a new treatment method for neurotrophic keratopathy. Further study and clinical trial are need to establish this new treatment strategy...
  2. ncbi Effects of topical antiglaucoma medications on corneal epithelium as evaluated by gene expression patterns
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Cornea 26:S46-54. 2007
    ....
  3. ncbi Expression of AP-1 (c-fos/c-jun) in developing mouse corneal epithelium
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, 641 0012 Wakayama, Japan
    Graefes Arch Clin Exp Ophthalmol 241:330-3. 2003
    ..AP-1 consists of Fos family and Jun family proteins...
  4. ncbi AP-1 (c-Fos/c-Jun) is required for corneal epithelial spreading
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 241:327-9. 2003
    ..Antisense-oligonucleotide (AS) c-fos-null mice were used for this purpose...
  5. ncbi AP-1 expression in ethanol-treated corneal epithelium in vivo
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 39:84-91. 2007
    ..The purpose of the current study was to examine if the ethanol exposure during laser epithelial keratomileusis (LASEK) may stimulate or damage the corneal epithelial cells...
  6. ncbi Perturbed intraepithelial differentiation of corneal epithelium in c-Fos-null mice
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Jpn J Ophthalmol 52:1-7. 2008
    ..We examined the role of c-Fos in the differentiation of corneal epithelial cells by using c-Fos-deficient (c-fos (-/-)) mice...
  7. ncbi TRPV1 involvement in inflammatory tissue fibrosis in mice
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Am J Pathol 178:2654-64. 2011
    ..In conclusion, absence or blocking of TRPV1 suppressed inflammation and fibrosis/scarring during healing of alkali-burned mouse cornea. TRPV1 is a potential drug target for improving the outcome of inflammatory/fibrogenic wound healing...
  8. ncbi JNK MAPK signaling contributes in vivo to injury-induced corneal epithelial migration
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 42:185-92. 2009
    ..Furthermore, in vitro the relative contribution was determined by the JNK/SAPK pathway to that of its p38 and ERK MAPK counterparts in mediating injury-induced increases in cell migration...
  9. ncbi Effect of overexpression of PPARgamma on the healing process of corneal alkali burn in mice
    Shizuya Saika
    Dept of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Physiol Cell Physiol 293:C75-86. 2007
    ..Together, these data suggest that overexpression of PPARgamma may represent an effective new strategy for treatment of ocular surface burns...
  10. ncbi Emodin suppression of ocular surface inflammatory reaction
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 48:5013-22. 2007
    ..To determine whether a Chinese herbal medicine component, emodin, suppresses inflammatory/fibrogenic reaction in cultured subconjunctival fibroblasts and reduces injury-induced increases in ocular surface inflammation in mice...
  11. ncbi Genipin suppresses subconjunctival fibroblast migration, proliferation and myofibroblast transdifferentiation
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ophthalmic Res 38:355-60. 2006
    ....
  12. ncbi Corneal wound healing in an osteopontin-deficient mouse
    Ken ichi Miyazaki
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 49:1367-75. 2008
    ..To investigate the effects of loss of osteopontin (OPN) in the healing of the injured cornea in mice. Cell culture study was also conducted to clarify the effects of OPN in fibroblast behaviors...
  13. ncbi Genipin suppression of fibrogenic behaviors of the alpha-TN4 lens epithelial cell line
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Cataract Refract Surg 32:1727-35. 2006
    ....
  14. ncbi Tetrandrine suppresses activation of human subconjunctival fibroblasts in vitro
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Curr Eye Res 33:559-65. 2008
    ..To investigate the effect of tetrandrine on activation of human subconjunctival fibroblasts (SCFs) in vitro...
  15. ncbi TNFalpha suppression of corneal epithelium migration
    Yuka Okada
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 13:1428-35. 2007
    ..To evaluate the role of tumor necrosis factor alpha (TNFalpha) in regulation of corneal epithelial cell migration...
  16. ncbi Role of p38 MAP kinase in regulation of cell migration and proliferation in healing corneal epithelium
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 45:100-9. 2004
    ..e., Smad and p38 mitogen-activated kinase [MAPK]) in regulation of cell migration and proliferation of healing mouse corneal epithelium...
  17. ncbi Epithelial-mesenchymal transition as a therapeutic target for prevention of ocular tissue fibrosis
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Endocr Metab Immune Disord Drug Targets 8:69-76. 2008
    ..EMT-related signal transduction cascades, i. e., TGFbeta/Smad, are a target to prevent or treat unfavorable ocular tissue fibrosis, e. g., fibrotic diseases in the crystalline lens or retina, as well as possibly in other organs...
  18. ncbi A new model of anterior subcapsular cataract: involvement of TGFbeta/Smad signaling
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Mol Vis 12:681-91. 2006
    ....
  19. ncbi Effect of Smad7 gene overexpression on transforming growth factor beta-induced retinal pigment fibrosis in a proliferative vitreoretinopathy mouse model
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Arch Ophthalmol 125:647-54. 2007
    ..To determine the effects of Smad7 gene transfer in the prevention of fibrogenic responses by the retinal pigment epithelium, a major cause of proliferative vitreoretinopathy after retinal detachment, in mice...
  20. ncbi Fibrotic disorders in the eye: targets of gene therapy
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Prog Retin Eye Res 27:177-96. 2008
    ..Modulation of signal transduction molecules, e.g., Smad and mitogen-activated protein kinases, by gene transfer and other technology is beneficial and can be an important treatment regiment to overcome (prevent or treat) these diseases...
  21. ncbi Impaired cornea wound healing in a tenascin C-deficient mouse model
    Takayoshi Sumioka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Lab Invest 93:207-17. 2013
    ..These results indicate that tenascin C modulates wound healing-related fibrogenic gene expression in ocular fibroblasts and is required for primary healing of the corneal stroma...
  22. ncbi Sonic hedgehog expression and role in healing corneal epithelium
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Japan
    Invest Ophthalmol Vis Sci 45:2577-85. 2004
    ..To examine the expression pattern and roles of Sonic hedgehog (Shh) in healing corneal epithelium...
  23. ncbi Impaired angiogenic response in the corneas of mice lacking osteopontin
    Norihito Fujita
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Invest Ophthalmol Vis Sci 51:790-4. 2010
    ..Cell culture study was also conducted to clarify the effects of OPN in transforming growth factor (TGF) beta1-driven cell signaling and expression of vascular endothelial growth factor (VEGF)...
  24. ncbi Therapeutic potential of trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface
    Ai Kitano
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 16:2964-73. 2010
    ....
  25. ncbi Inhibitory effect of blocking TGF-beta/Smad signal on injury-induced fibrosis of corneal endothelium
    Takayoshi Sumioka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 14:2272-81. 2008
    ..To understand the role of TGF-beta related signals in the repair of a corneal endothelium defect and also to evaluate the therapeutic effect of Smad7 gene transfer on injury induced fibrosis of the corneal endothelium in rats...
  26. ncbi Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C
    Sai Ichi Tanaka
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Mol Vis 16:1194-205. 2010
    ..Tenascin-C is a component of the extracellular matrix in patients having post-operative capsular opacification...
  27. ncbi Impaired cutaneous wound healing with excess granulation tissue formation in TNFalpha-null mice
    Maki Shinozaki
    Department of Critical Care Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Arch Dermatol Res 301:531-7. 2009
    ..In conclusion, lacking TNFalpha potentiates Smad-mediated fibrogenic reaction in healing dermis and retards reepithelialization in a healing mouse cutaneous wound...
  28. ncbi Transforming growth factor beta signal transduction: a potential target for maintenance/restoration of transparency of the cornea
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Eye Contact Lens 36:286-9. 2010
    ..g., Smad and mitogen-activated protein kinases, by gene transfer and other technology provides a new concept of prevention/treatment of unfavorable fibrogenesis in the cornea...
  29. ncbi Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Lab Invest 87:130-8. 2007
    ..An in vitro experiment shows OPN facilitates cell adhesion of lens epithelial cell line. OPN is required for activation of Smad2/3 signal in an injured lens epithelium and lens cell EMT...
  30. ncbi Protein expression pattern of collagen type XV in mouse cornea
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 242:432-6. 2004
    ..Its COOH-terminal peptide has an anti-angiogenic effect and its distribution in avascular tissue of cornea is of interest...
  31. ncbi Expression of c-Fos and c-Jun in developing mouse lens
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, School of Medicine, Kimiidera, Wakayama, Japan
    Ophthalmic Res 36:226-30. 2004
    ..They were not detected in an adult mouse lens. The expression pattern of the AP-1 transcription factor in equatorial epithelium may suggest its role in fiber differentiation...
  32. ncbi Cyclooxygenase 2 expression in rat corneas after ethanol exposure
    Takeshi Miyamoto
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama City, Wakayama, Japan
    J Cataract Refract Surg 32:1736-40. 2006
    ..To evaluate the effects of ethanol exposure of the cornea on inflammation in corneal epithelium...
  33. ncbi Loss of tumor necrosis factor alpha potentiates transforming growth factor beta-mediated pathogenic tissue response during wound healing
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Am J Pathol 168:1848-60. 2006
    ....
  34. ncbi Impaired angiogenic response in the cornea of mice lacking tenascin C
    Takayoshi Sumioka
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Invest Ophthalmol Vis Sci 52:2462-7. 2011
    ..Cell culture study was also conducted to clarify the roles of TNC in the expression of vascular endothelial growth factor (VEGF) and transforming growth factor (TGF)β1 in fibroblasts and macrophages...
  35. ncbi TGF beta in fibroproliferative diseases in the eye
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Front Biosci (Schol Ed) 1:376-90. 2009
    ..Blocking Smad signal by chemical or natural inhibitors or anti-Smad gene introduction effectively suppress fibrogenic reaction; inhibition of both fibroblast-myofibroblast conversion or EMT. Such strategies can be clinically tested...
  36. ncbi Expression of cyclooxygenase-2 in corneal cells after photorefractive keratectomy and laser in situ keratomileusis in rabbits
    Takeshi Miyamoto
    Department of Ophthalmology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Cataract Refract Surg 30:2612-7. 2004
    ..To compare the expression pattern of cyclooxygenase-2 (COX-2) in rabbit corneal cells after photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK) with the same refractive correction...
  37. ncbi Expression pattern of sonic hedgehog and effect of topical mitomycin C on its expression in human ocular surface neoplasms
    Kyoko Fujita
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Jpn J Ophthalmol 52:190-4. 2008
    ..To examine if the cells of human ocular surface neoplasms express sonic hedgehog (Shh) and the effects of topical mitomycin C on its expression...
  38. ncbi Transcription activation in lens epithelial cells after anterior capsule rubbing in rats. expression of c-Fos
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan
    J Cataract Refract Surg 29:1601-4. 2003
    ..To determine whether lens epithelial cells (LECs) are transcriptionally activated after a foreign body is attached to the anterior lens surface...
  39. ncbi Immunohistochemical observation of anterior subcapsular cataract in eye with spontaneously regressed retinoblastoma
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    J Cataract Refract Surg 36:503-7. 2010
    ..Histology of the fibrous anterior subcapsular opacification tissue showed the possibility of epithelial-mesenchymal transition of the lens epithelial cells in the secondary cataract following a spontaneously regressed retinoblastoma...
  40. ncbi Histology and immunohistochemistry of fibrous posterior capsule opacification in an infant
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    J Cataract Refract Surg 30:523-6. 2004
    ..The presumed LECs amid the ECM were positive for vimentin and alpha-smooth muscle actin. Histology of the fibrous PCO tissue from this infant was similar to that in adult patients...
  41. ncbi Wakayama symposium: modulation of wound healing response in the corneal stroma by osteopontin and tenascin-C
    Shizuya Saika
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Ocul Surf 11:12-5. 2013
    ..In conclusion, osteopontin or tenascin-C, α9 integrin ligands, play an important role in stromal healing (or fibrosis) and neovascularization in mouse cornea...
  42. ncbi Effects of interferon-gamma on human subconjunctival fibroblasts in the presence of TGFbeta1: reversal of TGFbeta-stimulated collagen production
    Osamu Yamanaka
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    Graefes Arch Clin Exp Ophthalmol 241:116-24. 2003
    ..IFN-gamma reportedly up-regulates Smad7, an inhibitory mediator of TGFbeta-Smad signaling, and blocks TGFbeta effects...
  43. ncbi [Investigation of mechanism of cell proliferation regulation and its clinical application]
    Yoshitaka Ohnishi
    Department of Ophthalmology, Wakayama Medical University, Japan
    Nippon Ganka Gakkai Zasshi 109:865-83; discussion 884. 2005
    ..e., epithelial-mesenchymal transition. These cellular activities can be controlled by modulation of growth factor signaling by employing such strategy including gene introduction...
  44. ncbi Transcriptional activation in lens epithelial cells following an ocular blunt trauma
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Kimiidera, Wakayama 641 0012, Japan
    J Cataract Refract Surg 31:1226-30. 2005
    ..To determine whether an ocular blunt trauma activates anterior ocular segment (cornea and lens) by examining the expression patterns of c-fos and c-jun mRNAs in these tissues of an eye of adult rat following a blunt trauma...
  45. ncbi Endogenous osteopontin involvement in laser-induced choroidal neovascularization in mice
    Norihito Fujita
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    Invest Ophthalmol Vis Sci 52:9310-5. 2011
    ....
  46. ncbi Topical exposure of mitomycin C reduces opacification of the residual anterior lens capsule and lenticular regeneration after vitrectomy and lensectomy in rabbits
    Takeshi Miyamoto
    Department of Ophthalmology, Wakayama Medical University, 811 1, Kimiidera, 641 0012 Wakayama, Japan
    Graefes Arch Clin Exp Ophthalmol 242:327-31. 2004
    ..To examine the effect of topical administration of mitomycin C (MMC) on the opacification of residual anterior lens capsule in a vitrectomized/lensectomized eye...
  47. ncbi Cell adhesion on explanted intraocular lenses part 2: experimental study of a surface-modified IOL in rabbits
    Nobuyuki Ishikawa
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    J Cataract Refract Surg 37:1339-42. 2011
    ..To develop a hydrophobic acrylic IOL with a hydrophilic, anti-cell adhesive surface characteristic...
  48. ncbi Treatment of eyelid epithelial neoplasm by targeting sonic hedgehog signaling: an experimental study
    Ken ichi Miyazaki
    Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, Japan
    Jpn J Ophthalmol 50:305-11. 2006
    ..To evaluate the effect of cyclopamine, an inhibitor of the Sonic hedgehog (Shh) signal, on the growth of an epithelial neoplasm...
  49. ncbi Growth factor deposition in anterior subcapsular cataract
    Iku Ishida
    Department of Ophthalmology, Wakayama Medical University, Wakayama 641 8509, Japan
    J Cataract Refract Surg 31:1219-25. 2005
    ..To characterize immunohistochemically the distribution of growth factors and extracellular matrix (ECM) components in an anterior subcapsular cataract (ASC) and to determine the role of growth factors in the development of ASC...
  50. ncbi Cellular fibronectin, but not collagens, disappears in the central posterior capsules during healing after lens extraction and IOL implantation in rabbits
    Sai-Ichi Tanaka
    Department of Ophthalmology, Wakayama Medical College, Wakayama, Japan
    Jpn J Ophthalmol 46:147-52. 2002
    ..Cellular fibronectin may play a role in the early wound healing process in the postoperative posterior capsule because the immunoreactivity in the central posterior capsule disappears in the later phase of healing...
  51. ncbi Cell adhesion on explanted intraocular lenses: part 1: analysis of explanted IOLs
    Nobuyuki Ishikawa
    Department of Ophthalmology, Wakayama Medical University, Wakayama, Japan
    J Cataract Refract Surg 37:1333-8. 2011
    ..To determine whether cell adhesion on an intraocular lens (IOL) in Japanese patients is affected by the optic material...
  52. ncbi A patient with corneal epithelial disorder that developed after administration of a latanoprost generic, but not a brand-name drug, eye drop
    Yukihisa Takada
    Department of Ophthalmology, School of Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Case Rep Ophthalmol Med 2012:536746. 2012
    ..Conclusions. This clinical history strongly suggested the association between a generic drug, Latanoprost eye drops, and the development of corneal epithelial disorder...
  53. ncbi Histopathological features in a case of peters' anomaly with acquired corneal staphyloma
    Kumi Shirai
    Department of Ophthalmology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Case Rep Ophthalmol Med 2011:418048. 2011
    ..The cells labeled by antibodies against αSMA were scattered in the entire corneal stroma. As judged by the histological findings, the eye with the central corneal staphyloma was diagnosed as Peters' anomaly...
  54. ncbi Tumor necrosis factor alpha-gene therapy for an established murine melanoma using RGD (Arg-Gly-Asp) fiber-mutant adenovirus vectors
    Yuka Okada
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women's University, Koshien, Nishinomiya, Hyogo 663-8179, Japan
    Jpn J Cancer Res 93:436-44. 2002
    ..Ad-RGD-TNFalpha required one-tenth the dosage of Ad-TNFalpha to induce an equal therapeutic effect. These results suggest that alpha(v)-integrin-targeted Ad will be a very powerful tool for the advancement of melanoma gene therapy...
  55. ncbi Fiber-mutant technique can augment gene transduction efficacy and anti-tumor effects against established murine melanoma by cytokine-gene therapy using adenovirus vectors
    Yuka Okada
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Kyuban-cho, Koshien, Nishinomiya, Hyogo 663-8179, Japan
    Cancer Lett 177:57-63. 2002
    ..These results suggested that the fiber-mutant for altering Ad-tropism is a very potent technology for advancing gene therapy for melanoma...
  56. ncbi Transcriptional targeting of RGD fiber-mutant adenovirus vectors can improve the safety of suicide gene therapy for murine melanoma
    Yuka Okada
    Research Institute for Microbial Diseases, Osaka University, Japan
    Cancer Gene Ther 12:608-16. 2005
    ..These results indicate that AdRGD combined with transcriptional regulation using Tyr or TERT promoter is a potentially useful and safe vector system for suicide gene therapy for melanoma...
  57. ncbi Optimization of antitumor efficacy and safety of in vivo cytokine gene therapy using RGD fiber-mutant adenovirus vector for preexisting murine melanoma
    Yuka Okada
    Department of Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women's University, 11-68 Kyuban-cho, Koshien, Nishinomiya, Hyogo 663-8179, Japan
    Biochim Biophys Acta 1670:172-80. 2004
    ....
  58. ncbi Gene transduction efficiency and maturation status in mouse bone marrow-derived dendritic cells infected with conventional or RGD fiber-mutant adenovirus vectors
    Naoki Okada
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Cancer Gene Ther 10:421-31. 2003
    ..AdRGD-infection caused greater induction of maturation than conventional Ad-infection, irrespective of the type of transgene inserted...
  59. ncbi Immunological properties and vaccine efficacy of murine dendritic cells simultaneously expressing melanoma-associated antigen and interleukin-12
    Naoki Okada
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Cancer Gene Ther 12:72-83. 2005
    ....
  60. ncbi High glucose up-regulates lipopolysaccharide-stimulated inflammatory cytokine production via c-jun N-terminal kinase in the monocytic cell line THP-1
    Hirotaka Iwata
    Department of Pathophysiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    J Endotoxin Res 13:227-34. 2007
    ..Therefore, we suggest that this may be one of the mechanisms by which sub-clinical infection by Gram-negative bacteria promotes atherosclerosis in diabetic subjects...
  61. ncbi Effective tumor targeted gene transfer using PEGylated adenovirus vector via systemic administration
    Jian Qing Gao
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    J Control Release 122:102-10. 2007
    ..PEGylation of Ad achieved tumor targeting through the EPR effect, and these attributes suggest that systemic injection of PEG-Ad has great potential as an anti-tumor treatment...
  62. ncbi Anti-tumor activity of chemokine is affected by both kinds of tumors and the activation state of the host's immune system: implications for chemokine-based cancer immunotherapy
    Naoki Okada
    Department of Biopharmaceutics, Kyoto Pharmaceutical University, 5 Nakauchi cho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    Biochem Biophys Res Commun 317:68-76. 2004
    ..Altogether, our results suggest that the tumor-suppressive activity of chemokine-gene immunotherapy is greatly influenced by the kind of tumor and the activation state of the host's immune system...
  63. ncbi TERT promoter-driven adenovirus vector for cancer gene therapy via systemic injection
    Xinglei Yao
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6, Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 362:419-24. 2007
    ..Our results suggest that Adv in which transgene expression is driven by the TERT promoter are a promising prototype of tumor-targeting vectors for effective and safe cancer gene therapy...
  64. ncbi Exaggerated vascular and renal pathology in endothelin-B-receptor-deficient rats with subtotal nephrectomy
    Naoko Tazawa
    Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Osaka, Japan
    J Cardiovasc Pharmacol 44:S467-70. 2004
    ....
  65. ncbi Complementation of placental defects and embryonic lethality by trophoblast-specific lentiviral gene transfer
    Yuka Okada
    Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita, Osaka 565 0871, Japan
    Nat Biotechnol 25:233-7. 2007
    ..Ectopic expression of Mapk11 also complemented Mapk14 deficiency during placentation...
  66. ncbi [Development and evaluation of a novel placenta-specific gene manipulation method using lentiviral vectors]
    Yuka Okada
    Research Institute for Microbial Diseases, Osaka University, Suita City, Japan
    Yakugaku Zasshi 128:1007-11. 2008
    ..This technology provides a powerful system for gene manipulation exclusively in placental organogenesis with implications for the treatment of placental dysfunction...