Takehiko Maeda

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. pmc Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama 641 0012, Japan
    Proc Natl Acad Sci U S A 106:13076-81. 2009
  2. ncbi Increment of activated serine/threonine protein phosphatase in brain membrane fraction synchronized with antinociceptive effect of morphine in mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama, Japan
    Biol Pharm Bull 33:1011-4. 2010
  3. ncbi Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama, Japan
    J Pharmacol Sci 108:341-7. 2008
  4. ncbi Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama, Japan
    Neuropsychopharmacology 32:1133-40. 2007
  5. pmc Involvement of serine/threonine protein phosphatases sensitive to okadaic acid in restraint stress-induced hyperlocomotion in cocaine-sensitized mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Japan
    Br J Pharmacol 148:405-12. 2006
  6. ncbi Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Brain Res 1056:191-9. 2005
  7. ncbi Electrophysiological characteristic of corticoaccumbens synapses in rat mesolimbic system reconstructed using organotypic slice cultures
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Brain Res 1015:34-40. 2004
  8. ncbi Involvement of peripheral mechanism in the verapamil-induced potentiation of morphine analgesia in mice
    Norifumi Shimizu
    Department of Pharmacology, Wakayama Medical University, Wakayama 641 8509, Japan
    J Pharmacol Sci 95:452-7. 2004
  9. ncbi Negative relationship between morphine analgesia and P-glycoprotein expression levels in the brain
    Wakako Hamabe
    Department of Pharmacology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Pharmacol Sci 105:353-60. 2007
  10. doi Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Anesth Analg 109:1305-11. 2009

Collaborators

Detail Information

Publications34

  1. pmc Leptin derived from adipocytes in injured peripheral nerves facilitates development of neuropathic pain via macrophage stimulation
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama 641 0012, Japan
    Proc Natl Acad Sci U S A 106:13076-81. 2009
    ..This report shows that adipocytes associated with primary afferent neurons may be involved in the development of neuropathic pain through adipokine secretion...
  2. ncbi Increment of activated serine/threonine protein phosphatase in brain membrane fraction synchronized with antinociceptive effect of morphine in mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama, Japan
    Biol Pharm Bull 33:1011-4. 2010
    ..These results suggest that the translocation of PP5 to the membrane fraction is, at least in part, involved in the antinociceptive effect of morphine in mice...
  3. ncbi Pioglitazone attenuates tactile allodynia and thermal hyperalgesia in mice subjected to peripheral nerve injury
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama, Japan
    J Pharmacol Sci 108:341-7. 2008
    ..This suggests that pioglitazone alleviates neuropathic pain through attenuation of proinflammatory cytokine upregulation by PPARgamma stimulation...
  4. ncbi Peroxisome proliferator-activated receptor gamma activation relieves expression of behavioral sensitization to methamphetamine in mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama, Japan
    Neuropsychopharmacology 32:1133-40. 2007
    ..These results suggest that PPARgamma has a significant role in the expression of behavioral sensitization to METH in mice...
  5. pmc Involvement of serine/threonine protein phosphatases sensitive to okadaic acid in restraint stress-induced hyperlocomotion in cocaine-sensitized mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Japan
    Br J Pharmacol 148:405-12. 2006
    ..There may be intracellular mechanisms mediating psychostimulant cross-sensitization to stress underlying the spontaneous recurrence of its psychosis...
  6. ncbi Morphine has an antinociceptive effect through activation of the okadaic-acid-sensitive Ser/Thr protein phosphatases PP 2 A and PP5 estimated by tail-pinch test in mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Brain Res 1056:191-9. 2005
    ..These results suggest that PP 2 A and PP5 are involved in the antinociceptive effect of morphine in mice...
  7. ncbi Electrophysiological characteristic of corticoaccumbens synapses in rat mesolimbic system reconstructed using organotypic slice cultures
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Brain Res 1015:34-40. 2004
    ....
  8. ncbi Involvement of peripheral mechanism in the verapamil-induced potentiation of morphine analgesia in mice
    Norifumi Shimizu
    Department of Pharmacology, Wakayama Medical University, Wakayama 641 8509, Japan
    J Pharmacol Sci 95:452-7. 2004
    ..1 and 1 mg/kg). These findings suggest that peripheral mechanisms partially contribute to morphine analgesia and mediate the potentiation of morphine analgesia by verapamil...
  9. ncbi Negative relationship between morphine analgesia and P-glycoprotein expression levels in the brain
    Wakako Hamabe
    Department of Pharmacology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Pharmacol Sci 105:353-60. 2007
    ..These results indicate that the individual differences in morphine analgesia may be due to some functional or quantitative differences in individual P-gp in BCECs, acting at the BBB...
  10. doi Activation of extracellular signal-regulated kinase in sciatic nerve contributes to neuropathic pain after partial sciatic nerve ligation in mice
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Anesth Analg 109:1305-11. 2009
    ..In this study, we investigated whether pERK in injured sciatic nerve contributes to neuropathic pain induced by partial sciatic nerve ligation (PSL) in mice...
  11. doi Macrophage inflammatory protein-1alpha mediates the development of neuropathic pain following peripheral nerve injury through interleukin-1beta up-regulation
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Pain 149:305-15. 2010
    ..In conclusion, we propose a novel critical molecule MIP-1alpha derived from macrophages and Schwann cells that appears to play a crucial role in the development of neuropathic pain induced by PSL...
  12. ncbi Role of pharmacokinetic effects in the potentiation of morphine analgesia by L-type calcium channel blockers in mice
    Norifumi Shimizu
    Department of Pharmacology, Wakayama Medical University, Japan
    J Pharmacol Sci 94:240-5. 2004
    ..These results suggest that increases in morphine concentration in peripheral blood may be, at least in part, involved in the ability of L-type CCBs to potentiate the analgesic effect of morphine...
  13. ncbi Suppressive effect of imipramine on vincristine-induced mechanical allodynia in mice
    Fumihiro Saika
    Department of Pharmacology, Wakayama Medical University
    Biol Pharm Bull 32:1231-4. 2009
    ....
  14. ncbi Involvement of spinal Met-enkephalin in nicotine-induced antinociception in mice
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Brain Res 1189:70-7. 2008
    ..c.) administration. These results suggest that nicotine has an antinociceptive effect by promoting the release of Met-ENK, but not dynorphins and endorphins, from activated opioidergic neurons in spinal cord...
  15. ncbi Activation of spinal anti-analgesic system following electroacupuncture stimulation in rats
    Yohji Fukazawa
    Department of Pharmacology, Wakayama Medical University, Japan
    J Pharmacol Sci 99:408-14. 2005
    ....
  16. doi CC-chemokine MIP-1α in the spinal cord contributes to nerve injury-induced neuropathic pain
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Neurosci Lett 484:17-21. 2010
    ..t.) elicited long-lasting tactile allodynia and thermal hyperalgesia in naïve mice. These results suggest that peripheral nerve injury elicits the up-regulation of spinal MIP-1α and CCR1 to participate in neuropathic pain...
  17. ncbi The critical role of invading peripheral macrophage-derived interleukin-6 in vincristine-induced mechanical allodynia in mice
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Eur J Pharmacol 592:87-92. 2008
    ..These results suggest that the invading peripheral macrophage-derived IL-6 plays a critical role in vincristine-induced mechanical allodynia...
  18. ncbi Activation of spinal cholecystokinin and neurokinin-1 receptors is associated with the attenuation of intrathecal morphine analgesia following electroacupuncture stimulation in rats
    Yohji Fukazawa
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Wakayama 641 8509, Japan
    J Pharmacol Sci 104:159-66. 2007
    ....
  19. ncbi P-glycoprotein ATPase activating effect of opioid analgesics and their P-glycoprotein-dependent antinociception in mice
    Wakako Hamabe
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8509, Japan
    Pharmacol Biochem Behav 85:629-36. 2006
    ..These results suggest that P-gp ATPase activity may be, at least in part, involved in the antinociceptive potencies of those opioid analgesics that are substrates for P-gp...
  20. doi Pharmacological relationship between nicotinic and opioid systems in analgesia and corticosterone elevation
    Akihiro Yamamoto
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Life Sci 89:956-61. 2011
    ..Here, we investigated crosstalk between the endogenous opioid system and nicotinic acetylcholine receptors (nAChRs), specifically in nicotine-induced analgesia and activation of the hypothalamic-pituitary-adrenal (HPA) axis...
  21. ncbi Up-regulation of tumor necrosis factor-alpha in spinal cord contributes to vincristine-induced mechanical allodynia in mice
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Neurosci Lett 445:140-3. 2008
    ..These results suggest that VCR treatments elicited the activation of glial cells in spinal cord, and up-regulated TNF-alpha in these cells may play an important role in VCR-induced mechanical allodynia...
  22. doi Activation of nicotinic acetylcholine receptors on bone marrow-derived cells relieves neuropathic pain accompanied by peripheral neuroinflammation
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Neurochem Int 61:1212-9. 2012
    ..Activation of nAChRs on immune cells may relieve neuropathic pain accompanied by the suppression of neuroinflammation...
  23. doi The critical role of spinal ceramide in the development of partial sciatic nerve ligation-induced neuropathic pain in mice
    Yuka Kobayashi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Biochem Biophys Res Commun 421:318-22. 2012
    ..Therefore, we conclude that spinal ceramide may play a crucial role in PSL-induced neuropathic pain through the activation of microglia...
  24. doi Leptin enhances CC-chemokine ligand expression in cultured murine macrophage
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Biochem Biophys Res Commun 384:311-5. 2009
    ..Therefore, a new paradigm of leptin-mediated chemokine expression may lead to the clarification of complex immune systems in future...
  25. ncbi Effects of diltiazem and MK-801 on morphine analgesia and pharmacokinetics in mice
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    Neurosci Lett 326:216-8. 2002
    ....
  26. ncbi Possible involvement of endogenous opioid system located downstream of α7 nicotinic acetylcholine receptor in mice with physical dependence on nicotine
    Keiko Ueno
    Department of Pharmacology, Wakayama Medical University School of Medicine, Japan
    J Pharmacol Sci 124:47-53. 2014
    ..Thus, a physical dependence on NIC was in part mediated by the activation of the endogenous opioid system, located downstream of α7 nAChR. ..
  27. doi Epigenetic augmentation of the macrophage inflammatory protein 2/C-X-C chemokine receptor type 2 axis through histone H3 acetylation in injured peripheral nerves elicits neuropathic pain
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Wakayama 641 0012, Japan
    J Pharmacol Exp Ther 340:577-87. 2012
    ....
  28. ncbi Naloxone-precipitated morphine withdrawal elicits increases in c-fos mRNA expression in restricted regions of the infant rat brain
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Japan
    Jpn J Pharmacol 90:270-5. 2002
    ....
  29. doi Involvement of inflammatory mediators in neuropathic pain caused by vincristine
    Norikazu Kiguchi
    Department of Pharmacology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Int Rev Neurobiol 85:179-90. 2009
    ..These agents could increase the tolerability of vincristine when used for the treatment of leukemia and lymphoma...
  30. ncbi HMGB1 as a potential therapeutic target for neuropathic pain
    Takehiko Maeda
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    J Pharmacol Sci 123:301-5. 2013
    ..Here, we overview the characteristics of HMGB1 as a pro-inflammatory mediator and show the promise of HMGB1 as a therapeutic target for neuropathic pain. ..
  31. doi PPAR and Pain
    Takehiko Maeda
    Department of Pharmacology, Wakayama Medical University, Wakayama 641 0012, Japan
    Int Rev Neurobiol 85:165-77. 2009
    ..The effects of PPAR ligands on neuroinflammation in animal models suggest their possible use for treating human inflammatory pain and neuropathic pain...
  32. ncbi Evaluation of a novel aminopeptidase N inhibitor, in vitro, using two assay systems
    Luqing Shang
    Department of Pharmacology, Wakayama Medical University, Wakayama City, Wakayama, Japan
    J Enzyme Inhib Med Chem 23:198-205. 2008
    ..08 and 7.79 respectively. These results suggest that AHPA-Val has good activity as an APNI and that these two assay systems are useful for evaluating the potency of novel APNIs...
  33. ncbi The algogenic-induced nociceptive flexion test in mice: studies on sensitivity of the test and stress on animals
    Makoto Inoue
    Division of Molecular Pharmacology and Neuroscience, Nagasaki University Graduate School of Biomedical Sciences, 1 14 Bunkyo machi, Nagasaki 852 8521, Japan
    Brain Res Bull 60:275-81. 2003
    ..Altogether, these findings indicate that the ANF test is a highly sensitive and less stressful technique to study in vivo mechanisms of pain at the peripheral nerve ending...
  34. ncbi Pharmacological differences between Liu-Jun-Zi-Tang, a traditional Chinese herbal medicine, and domperidone on isolated guinea-pig ileum
    Masanobu Ozaki
    Department of Toxicology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biol Pharm Bull 29:1349-54. 2006
    ..These findings suggest that Liu-Jun-Zi-Tang has milder effects on histamine-induced disorders than domperidone. In other words, domperidone has a more potent effect on histamine-induced disorders...