Tomoyoshi Kondo

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. ncbi request reprint Levodopa therapy from the neuroprotection viewpoint. From a clinical outlook
    Tomoyoshi Kondo
    Dept of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    J Neurol 252:IV32-IV36. 2005
  2. doi request reprint Dopamine dysregulation syndrome. Hypothetical application of reward system stimulation for the treatment of anhedonia in Parkinson's disease patients
    Tomoyoshi Kondo
    Dept of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Neurol 255:14-8. 2008
  3. doi request reprint Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 15:30-5. 2009
  4. pmc Ephrin-A1-mediated dopaminergic neurogenesis and angiogenesis in a rat model of Parkinson's disease
    Xuefeng Jing
    Department of Molecular Cell Biology and Molecular Medicine, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
    PLoS ONE 7:e32019. 2012
  5. ncbi request reprint [Amyotrophic lateral sclerosis associated with extrapyramidal symptoms or signs]
    Kiwa Hama
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 58:779-84. 2006
  6. ncbi request reprint ALS-like skin changes in mice on a chronic low-Ca/Mg high-Al diet
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8510, Japan
    J Neurol Sci 219:7-14. 2004
  7. doi request reprint Immunohistochemical expression of IGF-I and GSK in the spinal cord of Kii and Guamanian ALS patients
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, Wakayama City, Wakayama Prefecture, Japan
    Neuropathology 29:548-58. 2009
  8. ncbi request reprint Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Neurosci Lett 401:146-9. 2006
  9. ncbi request reprint Expression of insulin-like growth factor-II and leukemia inhibitory factor antibody immunostaining on the ionized calcium-binding adaptor molecule 1-positive microglias in the spinal cord of amyotrophic lateral sclerosis patients
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, College of Medicine, Wakayama City, Japan
    Neuropathology 27:257-68. 2007
  10. doi request reprint Survival rate of patients with amyotrophic lateral sclerosis in Wakayama Prefecture, Japan, 1966 to 2005
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, Wakayama City, Japan
    J Neurol Sci 268:95-101. 2008

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Levodopa therapy from the neuroprotection viewpoint. From a clinical outlook
    Tomoyoshi Kondo
    Dept of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    J Neurol 252:IV32-IV36. 2005
    ..From these results, it can be speculated that levodopa exerts some neuroprotective effects as long as the dose is not excessively high...
  2. doi request reprint Dopamine dysregulation syndrome. Hypothetical application of reward system stimulation for the treatment of anhedonia in Parkinson's disease patients
    Tomoyoshi Kondo
    Dept of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Neurol 255:14-8. 2008
    ..Understanding the mechanism of DDS may help in the development of this type of approach...
  3. doi request reprint Effects of zonisamide on c-Fos expression under conditions of tacrine-induced tremulous jaw movements in rats: a potential mechanism underlying its anti-parkinsonian tremor effect
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 15:30-5. 2009
    ..To examine the mechanisms underlying the anti-tremor effect of zonisamide in rats under conditions of tacrine-induced tremulous jaw movements (TJMs)...
  4. pmc Ephrin-A1-mediated dopaminergic neurogenesis and angiogenesis in a rat model of Parkinson's disease
    Xuefeng Jing
    Department of Molecular Cell Biology and Molecular Medicine, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Japan
    PLoS ONE 7:e32019. 2012
    ..We conclude that activation of EphA receptor-mediated signaling by clustered ephrin-A1-Fc from within the lateral ventricle could potentially be utilized in the treatment of neurodegenerative diseases such as Parkinson's disease...
  5. ncbi request reprint [Amyotrophic lateral sclerosis associated with extrapyramidal symptoms or signs]
    Kiwa Hama
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 58:779-84. 2006
    ..8%. The incidence of extrapyramidal signs is more frequent than expected by chance, suggesting that the degeneration of basal ganglia and/or substantia nigra may not be so rare in ALS...
  6. ncbi request reprint ALS-like skin changes in mice on a chronic low-Ca/Mg high-Al diet
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8510, Japan
    J Neurol Sci 219:7-14. 2004
    ..This is the first report of skin changes in animal models similar to those of ALS. We speculate that environmental factors such as chronic low-Ca/Mg high-Al condition play some causative role in the pathogenesis of Kii-ALS...
  7. doi request reprint Immunohistochemical expression of IGF-I and GSK in the spinal cord of Kii and Guamanian ALS patients
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, Wakayama City, Wakayama Prefecture, Japan
    Neuropathology 29:548-58. 2009
    ....
  8. ncbi request reprint Intragastric proteasome inhibition induces alpha-synuclein-immunopositive aggregations in neurons in the dorsal motor nucleus of the vagus in rats
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Neurosci Lett 401:146-9. 2006
    ..This might also implicate that Lewy body formation in the DMV in PD is possibly related to peroral invasion of environmental toxins that inhibit ubiquitin-proteasome system function...
  9. ncbi request reprint Expression of insulin-like growth factor-II and leukemia inhibitory factor antibody immunostaining on the ionized calcium-binding adaptor molecule 1-positive microglias in the spinal cord of amyotrophic lateral sclerosis patients
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, College of Medicine, Wakayama City, Japan
    Neuropathology 27:257-68. 2007
    ..Neuroprotective and/or neurotoxic effects of microglia on motor neurons should be further studied...
  10. doi request reprint Survival rate of patients with amyotrophic lateral sclerosis in Wakayama Prefecture, Japan, 1966 to 2005
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, Wakayama City, Japan
    J Neurol Sci 268:95-101. 2008
    ..Bulbar palsy onset and age at onset were expected as predictors of the survival rate...
  11. ncbi request reprint Effects of zonisamide on experimental tremors in rats
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 14:33-6. 2008
    ..To study the effect of zonisamide on experimental tremors in rats...
  12. ncbi request reprint [Effect of zonisamide on resting tremor resistant to antiparkinsonian medication]
    Ichiro Nakanishi
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 55:685-9. 2003
    ..A more detailed random examination should be carried out...
  13. ncbi request reprint A species-specific difference in the effects of harmaline on the rodent olivocerebellar system
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Brain Res 1068:94-101. 2006
    ..Recognition of these species-specific differences in the response of the olivocerebellar system to harmaline is an important consideration for experimental analysis of the rodent model of tremors...
  14. ncbi request reprint Increased writing activity in Parkinson's disease: a punding-like behavior?
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama, Japan 641 8510
    Parkinsonism Relat Disord 11:323-5. 2005
    ....
  15. ncbi request reprint [A patient with multiple system atrophy presenting prolonged levodopa-responsive parkinsonism and off-dystonia of the trunk]
    Ichiro Nakanishi
    Department of Neurology, Wakayama Medical University, Kimiidera 811 1, Wakayama City, 641 8510, Japan
    No To Shinkei 55:605-8. 2003
    ..In patients with MSA, disproportionate antecollis is common before levodopa treatment, and levodopa induced off-dystonia of his trunk is very rare...
  16. ncbi request reprint Retrograde dopaminergic neuron degeneration following intrastriatal proteasome inhibition
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Neurosci Lett 380:93-8. 2005
    ..These results reveal that intrastriatal proteasome inhibition sufficiently induces retrograde dopaminergic neuronal degeneration with abundant accumulation of alpha-synuclein in the SN...
  17. ncbi request reprint Expression of FKBP12 and ryanodine receptors (RyRs) in the spinal cord of MND patients
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, College of Medicine, Wakayama City, Japan
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:94-9. 2005
    ..Further study of the correlation between RyR and FKBP12 should contribute to clarifying the mechanisms of neurodegeneration in MND, including calcium-induced neuronal loss...
  18. ncbi request reprint Changes in the incidence of amyotrophic lateral sclerosis in Wakayama, Japan
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, Wakayama City, Japan
    Amyotroph Lateral Scler Other Motor Neuron Disord 6:155-63. 2005
    ..However, a high incidence of ALS persisted among males in Wakayama prefecture, especially in the Kozagawa and Koza areas. Some environmental factors and gender specificity may be related to the decreased incidence of ALS in focus areas...
  19. ncbi request reprint Stereotyped behaviors or punding after quetiapine administration in Parkinson's disease
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 10:177-80. 2004
    ....
  20. doi request reprint Alteration of eating behaviors in patients with Parkinson's disease: possibly overlooked?
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, Wakayama, Japan
    Neurocase 14:480-4. 2008
    ..Since dopamine is closely involved in acquisition of food preferences, dietary changes with/without compulsive eating may be a manifestation of an alteration of appetitive behaviors due to excessive dopaminergic neurotransmission...
  21. doi request reprint Transcranial sonography of the substantia nigra and MIBG myocardial scintigraphy: complementary role in the diagnosis of Parkinson's disease
    Yoshinori Kajimoto
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 15:270-2. 2009
    ..Since TCS and MIBG myocardial scintigraphy can distinctively detect PD-related pathological phenomenon, it is expected that the combination of these tests could contribute to an accurate diagnosis of PD...
  22. ncbi request reprint Cerebellar ataxia and leukoencephalopathy associated with cobalamin deficiency
    Shuhei Morita
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Wakayama 641 8510, Japan
    J Neurol Sci 216:183-4. 2003
    ..Brain magnetic resonance imaging (MRI) demonstrated a diffuse leukoencephalopathy. Six months after the initiation of methylcobalamin therapy, there were clinical improvement and reduction in the MRI abnormalities...
  23. ncbi request reprint Cerebellar atrophy in a patient with anorexia nervosa
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, Wakayama 641 8510, Japan
    Int J Eat Disord 36:238-41. 2004
    ..Reversible cerebral atrophy (pseudoatrophy) is observable in patients with anorexia nervosa. However, it is extremely rare to see marked cerebellar atrophy...
  24. ncbi request reprint T2-low signal intensity in the cortex in multiple system atrophy
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    J Neurol Sci 211:85-8. 2003
    ..The cortical T2-low signal intensity in MSA might reflect the spread of degenerative processes in the cortex...
  25. ncbi request reprint [Three patients with Parkinson's disease whose therapeutic levels were successfully improved after administration of quetiapine for suppression of psychosis]
    Rieko Kodama
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    No To Shinkei 55:413-7. 2003
    ....
  26. ncbi request reprint [Translation and linguistic validation of the Japanese version of the wearing-off questionnaires(WOQ-19 and WOQ-9)]
    Tomoyoshi Kondo
    Department of Neurology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Brain Nerve 63:1285-92. 2011
    ..We thus developed a linguistically validated Japanese version of the WOQ-19 and the WOQ-9. (Received: February 3, 2011, Accepted: March 29, 2011)...
  27. doi request reprint White matter hyperintensities in patients with multiple system atrophy
    Maiko Umoto
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 18:17-20. 2012
    ..Although white matter hyperintensities (WMHs) are prevalent in the elderly, the clinical significance and the underlying pathophysiological mechanisms of WMHs in neurodegenerative disorders have not been fully clarified...
  28. ncbi request reprint Effect of zonisamide on essential tremor: a pilot crossover study in comparison with arotinolol
    Shuhei Morita
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 11:101-3. 2005
    ..A controlled trial of this drug in the future would be valuable...
  29. ncbi request reprint [A patient with probable dementia with Lewy bodies, who showed catatonia induced by donepezil: a case report]
    Shuhei Morita
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 56:881-4. 2004
    ..After treatment with trihexiphenizil, she had improvement of motor abnormalities and worsened parkinsonism. It is important to recognize that donepezil may induce catatonia on the patients of parkinsonism with severe dementia...
  30. ncbi request reprint Hair loss induced by dopamine agonist: case report and review of the literature
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 10:51-2. 2003
    ..Although the pathophysiological mechanism underlying the hair loss is unclear, hair loss may be possibly overlooked, and should be noted as a possible side effect of the dopaminergic therapy...
  31. doi request reprint Effects of T-type calcium channel blockers on a parkinsonian tremor model in rats
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Pharmacol Biochem Behav 97:656-9. 2011
    ..The present results suggest that T-type calcium channels in the CNS may be a suitable target for developing new therapeutic strategies for treating parkinsonian tremor...
  32. ncbi request reprint Effects of subchronic treatment with selegiline on L-DOPA-induced increase in extracellular dopamine level in rat striatum
    Kouichi Adachi
    Department of Neurology, Wakayama Medical University, Wakayama, Japan
    J Pharmacol Sci 101:286-92. 2006
    ..A dose-dependent decrease in DA level was observed, indicating that DA level in selegiline-treated rats can be controlled by L-DOPA dose...
  33. ncbi request reprint The role of exogenous risk factors in amyotrophic lateral sclerosis in Wakayama, Japan
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, Wakayama City, Japan
    Amyotroph Lateral Scler 8:150-6. 2007
    ..54, 95% CI 0.30-0.98). In conclusion, CS/SSM, surgical treatment for CS/SSM and occupation at onset are suspected to be risk factors for developing/triggering or worsening ALS...
  34. ncbi request reprint Familial hemifacial spasm: report of cases and review of literature
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    J Neurol Sci 193:97-102. 2002
    ..Clarifying the role of genetic susceptibility in pathophysiological mechanisms underlying hemifacial spasm is an important approach toward better understanding of the pathogenesis of cranial rhizopathies...
  35. ncbi request reprint Bell's palsy-induced blepharospasm
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    J Neurol 249:452-4. 2002
    ..Another speculation is that abnormal afferent input from the paralyzed side contributes to the abnormal sensitization of the blink reflex, thereby facilitating the induction of abnormal facial motor outputs such as blepharospasm...
  36. doi request reprint Avoidance of swallowing saliva: a symptom related to aberrant basal ganglia functions?
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, Wakayama, Japan
    Neurocase 19:232-5. 2013
    ..OCD-like behavior may be induced in association with pathological conditions in which aberrant basal ganglia functions are present...
  37. ncbi request reprint Chronic inflammatory demyelinating polyneuropathy associated with primary biliary cirrhosis
    Ken Ya Murata
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, Wakayama 641 8510, Japan Electronic address
    J Clin Neurosci 20:1799-801. 2013
    ....
  38. doi request reprint T-type calcium channel as a new therapeutic target for tremor
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    Cerebellum 10:563-9. 2011
    ..Based on both basic and clinical studies, the possibility is emerging that T-type calcium channel blockers that transit into the central nervous system may have therapeutic potentials for tremor disorders...
  39. doi request reprint Hiccups in Parkinson's disease: an overlooked non-motor symptom?
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    Parkinsonism Relat Disord 16:249-51. 2010
    ..Although hiccups may be a non-motor symptom of Parkinson's disease (PD), they have attracted little research attention to date...
  40. ncbi request reprint [Echogenicity of the substantia nigra in Parkinson's disease: its relation to clinical findings]
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, Japan
    No To Shinkei 58:199-204. 2006
  41. ncbi request reprint Initial therapy for Parkinson's disease: levodopa vs. dopamine receptor agonists
    Tomoyoshi Kondo
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0035, Japan
    J Neurol 249:II25-9. 2002
    ..Although the patient's conditions should be considered in the selsction of a drug, DA agonist therapy is recommended as the initial therapy for Parkinson's disease...
  42. doi request reprint Transcranial sonography in relation to SPECT and MIBG
    Yoshinori Kajimoto
    Department of Neurology, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Int Rev Neurobiol 90:48-62. 2010
    ..We briefly review data regarding the clinical significance of these functional imaging studies in the diagnosis of PD, and discuss the diagnostic potential of the combining TCS of the SN with other functional imaging tools...
  43. ncbi request reprint Nuclear localization of glyceraldehyde-3-phosphate dehydrogenase is not involved in the initiation of apoptosis induced by 1-Methyl-4-phenyl-pyridium iodide (MPP+)
    Rieko Kodama
    Department of Neurology, Institute of Advanced Medicine, Wakayama Medical University, Japan
    Genes Cells 10:1211-9. 2005
    ..Thus, we have concluded that a simple nuclear localization of GAPDH does not induce apoptosis, and that MPP+-induced apoptosis is not caused by nuclear translocation of GAPDH...
  44. ncbi request reprint Sensorimotor hemiparesis with secondary cervical dystonia following lateral caudal medullary infarction without signs and symptoms of Wallenberg syndrome
    Yoshinori Kajimoto
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    J Neurol Sci 219:167-8. 2004
    ..It is clinically important to recognize that the lateral caudal medullary infarction appears without signs and symptoms of lower cranial nerve palsies commonly involved in Wallenberg syndrome...
  45. ncbi request reprint Oxidative stress and microglial activation in substantia nigra following striatal MPP+
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    Neuroreport 15:1039-44. 2004
    ..We hope that this model will be useful in developing a disease modifying therapy of Parkinson's disease...
  46. ncbi request reprint Neurosyphilis with mesiotemporal magnetic resonance imaging abnormalities
    Kiwa Hama
    Department of Neurology, Wakayama Medical University, Wakayama
    Intern Med 47:1813-7. 2008
    ..Appropriate diagnosis and commencing adequate treatment are needed for a good prognosis; thus, neurosyphilis should be included in the differential diagnosis of mesiotemporal magnetic resonance imaging abnormalities...
  47. ncbi request reprint [A case of the familial essential myoclonus and epilepsy presenting behavioral arrest]
    Shuhei Morita
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 55:345-8. 2003
    ..From symptomatological as well as genetic aspects, FEME has been suggested to be heterogeneous. We propose that this unique akinetorigid attack might be a new clinical phenotype of FEME...
  48. ncbi request reprint Bicycle sign for differential diagnosis of parkinsonism: is it of use in a hilly country like Japan?
    Hideto Miwa
    Department of Neurology, Wakayama Medical University, Wakayama, Japan
    J Parkinsons Dis 1:167-8. 2011
    ..The present study suggested that "bicycle sign" could contribute to earlier and better differential diagnosis of parkinsonism in a hilly country like Japan. ..
  49. ncbi request reprint [Unilateral multiple cranial nerve palsies mimicking Garcin syndrome as an atypical symptom of brainstem encephalitis: a case report]
    Shuhei Morita
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 55:341-4. 2003
    ....
  50. ncbi request reprint [A case of spinocerebellar ataxia 6 accompanied with schizophrenia]
    Ichiro Nakanishi
    Department of Neurology, Psychiatry, Wakayama, Wakayama Medical University, 811 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 56:49-52. 2004
    ..Therefore, the schizophrenic symptoms, association of which with SCA 6 has previously reported in a few cases, may represent rare clinical features of the channelopathy associated with the mutation in the CACNA1A gene...
  51. ncbi request reprint FKBP12 immunoreactivity in the human spinal cord of motor neuron disease patients
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, College of Medicine, Wakayama City, Kimiidera, Japan
    Neuropathology 22:269-74. 2002
    ..It is speculated that the decrease in FKBP12 (N-19) plays some causative role in the development of neurodegeneration in MND. Further investigation of FKBP12 and ligands may help elucidate the pathogenesis of MND...
  52. ncbi request reprint [Transient improvement of writing tremor by holding breath in volition: a case report]
    Shuhei Morita
    Department of Neurology, Wakayama Medical University, 2 1 1 Kimiidera, Wakayama City 641 8510, Japan
    No To Shinkei 54:1055-8. 2002
    ..Although the pathophysiological relationship between primary writing tremor and writer's cramp are unclear, the unique characters of this tremor may suggest that a focal task-specific tremor and essential tremor can co-exist...
  53. ncbi request reprint Chronic low-Ca/Mg high-Al diet induces neuronal loss
    Tameko Kihira
    Department of Neurology, Wakayama Medical University, Wakayama City, Japan
    Neuropathology 22:171-9. 2002
    ..Environmental factors such as a low-Ca/Mg high Al exposure might be one of the risk factors for the development of neuronal degeneration of ALS in the Kii Peninsula...
  54. ncbi request reprint [Inclusion body myositis associated with chronic thyroiditis, Sjögren's syndrome and autoimmune cholangitis]
    Kiwa Hama
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 56:503-7. 2004
    ..Although the pathogenic backgrounds underlying IBM are likely heterogeneous, an autoimmune-mediated mechanism may be related to the pathogenesis of IBM in the present patient...
  55. ncbi request reprint [The frontal assessment battery at bed side(FAB) in patients with Parkinson's disease]
    Rieko Takagi
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, Wakayama 641 8510, Japan
    No To Shinkei 54:897-902. 2002
    ..In the PD patients, there was no correlation between the FAB scores and their age or duration of the illness. The FAB is likely to be useful and convenient battery for assessing frontal lobe function at bedside in the PD patients...
  56. ncbi request reprint [Generalized muscle weakness mimicking periodic paralysis in a patient with toluene abuse]
    Shiduka Kamiyoshi
    Department of Neurlogy, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 54:427-30. 2002
    ....
  57. ncbi request reprint [Speech-related tremor of lips: a focal task-specific tremor]
    Shuhei Morita
    Department of Neurology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8510, Japan
    No To Shinkei 54:327-9. 2002
    ..Administration of a beta-blocker and consumption of small amount of alcohol could effectively improve the tremor, possibly suggesting that this type of tremor might be a clinical variant of essential tremor...
  58. ncbi request reprint Transcranial sonography of the substantia nigra in Japanese patients with Parkinson's disease or atypical parkinsonism: clinical potential and limitations
    Masae Okawa
    Department of Neurology, Wakayama Medical University
    Intern Med 46:1527-31. 2007
    ..However, TCS of the SN has not been applied in Japanese patients, and its clinical potential has not been determined...
  59. ncbi request reprint p53 protein, interferon-gamma, and NF-kappaB levels are elevated in the parkinsonian brain
    Makio Mogi
    Department of Medicinal Biochemistry, School of Pharmacy, Aichi Gakuin University, Nagoya 464 8650, Japan
    Neurosci Lett 414:94-7. 2007
    ....
  60. ncbi request reprint [Benefit of L-DOPA-without-DCI (decarboxylase inhibitor) therapy on wearing-off phenomenon in advanced stages of Parkinson's disease patients]
    Masaya Hironishi
    Department of Neurology, Shingu City Medical Center, Hachibuse 18 7, Shingu city 647 0072, Japan
    No To Shinkei 54:127-32. 2002
    ..No adverse event was observed. Levodopa-without-DCI-therapy was effective for controlling motor fluctuation in patients of Parkinson's disease in advanced stages...
  61. ncbi request reprint Nutritional status and risk of amyotrophic lateral sclerosis in Japan
    Kazushi Okamoto
    Department of Public Health, Aichi Prefectural College of Nursing and Health, Nagoya, Japan
    Amyotroph Lateral Scler 8:300-4. 2007
    ..58 (95%CI 0.40-0.96) for polyunsaturated fatty acids (PUFAs). Our findings suggest that high intakes of carbohydrate and low intakes of fat and some kinds of fatty acids may, when combined, increased the risk of ALS...
  62. ncbi request reprint [Diagnosis and therapy for patients with Parkinson's disease (discussion)]
    Koichi Okamoto
    Nihon Naika Gakkai Zasshi 92:1493-511. 2003
  63. ncbi request reprint Ropinirole is effective on motor function when used as an adjunct to levodopa in Parkinson's disease: STRONG study
    Yoshikuni Mizuno
    Department of Neurology, Juntendo University School of Medicine, Bunkyo, Tokyo, Japan
    Mov Disord 22:1860-5. 2007
    ..The results showed that ropinirole was more effective than placebo in improving motor function and ADL when used as an adjunct to levodopa in patients with advanced Parkinson's disease...
  64. ncbi request reprint Placebo-controlled, double-blind dose-finding study of entacapone in fluctuating parkinsonian patients
    Yoshikuni Mizuno
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Mov Disord 22:75-80. 2007
    ..In conclusion, both entacapone 100 and 200 mg were equally effective in increasing on time of PD patients with wearing-off fluctuations, although the safety and tolerability profile appeared more favorable for the 100-mg dose...
  65. ncbi request reprint [Comment on guidelines for treatment of Parkinson's disease]
    Tomoyoshi Kondo
    Department of Neurology, Wakayama Medical University
    Rinsho Shinkeigaku 44:830-2. 2004
    ....
  66. ncbi request reprint Chorea in motor neuron disease
    Hideto Miwa
    Mov Disord 17:1397. 2002
  67. ncbi request reprint [Parkinson's disease, familial Parkinson's disease]
    Tomoyoshi Kondo
    Department of Neurology, Wakayama Medical University
    Nihon Rinsho 62:97-101. 2004
  68. ncbi request reprint [How Parkinson's disease patients recognize Parkinson's disease therapeutic guideline?]
    Masaya Hironishi
    Department of Neurology, Shingu Municipal Medical Center, Hachibuse 18 7, Shingu shi, Wakayama 647 0072, Japan
    No To Shinkei 58:413-7. 2006
    ..A plain-language explanation manual of the PGL for PD patients, if published, would be helpful to the patients' understanding of PD therapy and to building cooperation between patients and physicians...
  69. ncbi request reprint [Pure dysarthria caused by a small cortical infarction]
    Shuhei Morita
    Department of Neurology, Wakayama Medical University
    No To Shinkei 58:534-5. 2006
  70. ncbi request reprint Drug discarding: a problematic therapeutic event in Parkinson's disease
    Hideto Miwa
    Mov Disord 22:293. 2007
  71. ncbi request reprint [Validation of the Japanese version of the Parkinson's Disease Questionnaire]
    Junko Kohmoto
    Department of Neurology, Wakayama Medical University
    Rinsho Shinkeigaku 43:71-6. 2003
    ..It evaluates the dysfunction of daily living and quality of life. We developed the Japanese-translated version of PDQ-39 and examined the validity of the PDQ-39 in Japanese PD patients...
  72. ncbi request reprint [Drug induced dyskinesia]
    Tomoyoshi Kondo
    Nihon Naika Gakkai Zasshi 96:1621-6. 2007
  73. ncbi request reprint Mutation analysis of the PINK1 gene in 391 patients with Parkinson disease
    Ryuya Kumazawa
    Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan
    Arch Neurol 65:802-8. 2008
    ..To determine the frequency, distribution, and clinical features of Parkinson disease (PD) with PINK1 mutations...
  74. ncbi request reprint [Long-term treatment of Parkinson's disease patients with selegiline hydrochloride (FPF 1100): outcome of 5-year treatment]
    Tomoyoshi Kondo
    Department of Neurology, Juntendo University School of Medicine, Japan
    No To Shinkei 54:1041-8. 2002
    ..This study may assure tolerability of selegiline hydrochloride in a long-term treatment of Parkinson's disease patients...
  75. ncbi request reprint Psychological adjustment has a greater effect on health-related quality of life than on severity of disease in Parkinson's disease
    Yoshimi Suzukamo
    Department of Epidemiology and Health Care Research, Graduate School of Medicine and Public Health, Kyoto University, Kyoto, Japan
    Mov Disord 21:761-6. 2006
    ..This finding suggests that, in addition to any suppression of the progression of symptoms, psychological intervention may also be effective in enhancing the HRQL of patients with PD...