Masakazu Ichinose

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. ncbi [Chronic hepatitis C in hemodialysis patients]
    Hiroto Tanaka
    Third Department of Internal Medicine, Wakayama Medical University
    Nihon Rinsho 62:645-8. 2004
  2. ncbi A case of primary lung cancer producing alpha-fetoprotein
    Toshiyuki Yamagata
    Division of Clinical Oncology and Palliative Medicine, Wakayama Medical University, Wakayama City, Japan
    Can Respir J 11:504-6. 2004
  3. ncbi Agents against cytokine synthesis or receptors
    Toshiyuki Yamagata
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Kimiidera 811 1 Wakayama 641 8509, Japan
    Eur J Pharmacol 533:289-301. 2006
  4. pmc Efficacy and safety of inhaled formoterol 4.5 and 9 μg twice daily in Japanese and European COPD patients: phase III study results
    Miron A Bogdan
    Clinica Medic Or, Calea Vitan no 106, Postcode 031298, Bucharest, Romania
    BMC Pulm Med 11:51. 2011
  5. doi Differences of inflammatory mechanisms in asthma and COPD
    Masakazu Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Allergol Int 58:307-13. 2009
  6. doi Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD
    Masakazu Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Respir Med 104:267-74. 2010
  7. doi Tiotropium 5microg via Respimat and 18microg via HandiHaler; efficacy and safety in Japanese COPD patients
    M Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Respir Med 104:228-36. 2010
  8. ncbi Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    J Allergy Clin Immunol 118:84-90. 2006
  9. ncbi 2. Advances in pharmacotherapy for COPD
    Masakazu Ichinose
    The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama
    Intern Med 46:81-4. 2007
  10. ncbi Cytokine-directed therapy in asthma
    Masakazu Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Japan
    Curr Drug Targets Inflamm Allergy 3:263-9. 2004

Detail Information

Publications83

  1. ncbi [Chronic hepatitis C in hemodialysis patients]
    Hiroto Tanaka
    Third Department of Internal Medicine, Wakayama Medical University
    Nihon Rinsho 62:645-8. 2004
  2. ncbi A case of primary lung cancer producing alpha-fetoprotein
    Toshiyuki Yamagata
    Division of Clinical Oncology and Palliative Medicine, Wakayama Medical University, Wakayama City, Japan
    Can Respir J 11:504-6. 2004
    ..It has also been reported that some primary lung tumours produce AFP. However, these tumours are mainly poorly differentiated adenocarcinomas or large cell carcinomas. A lung carcinoid that produces AFP is extremely rare...
  3. ncbi Agents against cytokine synthesis or receptors
    Toshiyuki Yamagata
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Kimiidera 811 1 Wakayama 641 8509, Japan
    Eur J Pharmacol 533:289-301. 2006
    ..As many cytokines are involved in the pathophysiology of inflammatory lung diseases, inhibitory agents of the synthesis of multiple cytokines may be more useful tools. Several such agents are now in clinical development...
  4. pmc Efficacy and safety of inhaled formoterol 4.5 and 9 μg twice daily in Japanese and European COPD patients: phase III study results
    Miron A Bogdan
    Clinica Medic Or, Calea Vitan no 106, Postcode 031298, Bucharest, Romania
    BMC Pulm Med 11:51. 2011
    ..This study evaluated the efficacy and safety of the long-acting β₂-agonist formoterol in patients with moderate-to-severe COPD...
  5. doi Differences of inflammatory mechanisms in asthma and COPD
    Masakazu Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Allergol Int 58:307-13. 2009
    ..These distinct inflammatory patterns in both diseases seem to cause pathological differences in asthma and COPD...
  6. doi Additive effects of transdermal tulobuterol to inhaled tiotropium in patients with COPD
    Masakazu Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Respir Med 104:267-74. 2010
    ..However, there are no reports on the efficacy of tulobuterol combined with an anticholinergic. In this study, we investigated the efficacy and safety of transdermal tulobuterol combined with inhaled tiotropium in COPD...
  7. doi Tiotropium 5microg via Respimat and 18microg via HandiHaler; efficacy and safety in Japanese COPD patients
    M Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Wakayama, Japan
    Respir Med 104:228-36. 2010
    ..To compare the efficacy and safety of tiotropium inhaled via Respimat Soft Mist Inhaler, a multidose propellant-free inhaler and HandiHaler, a single-dose dry powder inhaler, in a phase 2 study of Japanese COPD patients...
  8. ncbi Airway cytokine expression measured by means of protein array in exhaled breath condensate: correlation with physiologic properties in asthmatic patients
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama City, Wakayama 641 0012, Japan
    J Allergy Clin Immunol 118:84-90. 2006
    ..Simultaneous monitoring of airway inflammation and physiology might be useful for asthma management...
  9. ncbi 2. Advances in pharmacotherapy for COPD
    Masakazu Ichinose
    The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama
    Intern Med 46:81-4. 2007
    ..In this review, I describe briefly the current recommendation for pharmacological therapy of stable COPD according to the global and Japanese guidelines for COPD...
  10. ncbi Cytokine-directed therapy in asthma
    Masakazu Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Japan
    Curr Drug Targets Inflamm Allergy 3:263-9. 2004
    ....
  11. ncbi Efficacy and safety of formoterol in Japanese patients with COPD
    Yoshiaki Minakata
    The Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Intern Med 47:217-23. 2008
    ..This study evaluated the efficacy and safety of the formoterol Turbuhaler at dosages of 4.5, 9 and 18 microg bid compared with placebo in Japanese patients with COPD...
  12. ncbi Inflamatory mechanisms in bronchial asthma and COPD
    Masakazu Ichinose
    Third Department of Internal Medicine, Wakayama Medical University, Kimiidera, Japan
    Tohoku J Exp Med 200:1-6. 2003
    ..In this review, I describe some inflammatory molecules that seem to be involved in the inflammatory process in each disease...
  13. ncbi Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways
    M Ichinose
    Third Dept of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Eur Respir J 22:457-61. 2003
    ..This intervention may be useful in the future management of chronic obstructive pulmonary disease...
  14. pmc Increase of nitrosative stress in patients with eosinophilic pneumonia
    Kanako Furukawa
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama, Wakayama 641 0012, Japan
    Respir Res 12:81. 2011
    ..We hypothesized that nitrosative stress markers including Calv, inducible type of NO synthase (iNOS), and 3-nitrotyrosine (3-NT), are upregulated in EP...
  15. ncbi Increase of 27-hydroxycholesterol in the airways of patients with COPD: possible role of 27-hydroxycholesterol in tissue fibrosis
    Takashi Kikuchi
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama, Japan
    Chest 142:329-37. 2012
    ..The aim of this study was to assess the production of 27-OHC in the airways of patients with COPD and to elucidate the possible role of 27-OHC in the tissue fibrosis of COPD...
  16. doi Clinical application of exhaled breath condensate analysis in asthma: prediction of FEV1 improvement by steroid therapy
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama 641 8509, Japan
    Respiration 78:393-8. 2009
    ..Exhaled breath condensate (EBC) measurements have recently been reported to be useful for the detection of inflammatory molecules in the airways. However, the clinical relevance of EBC analysis in asthma therapy has not been determined yet...
  17. doi The possible role of hematopoietic cell kinase in the pathophysiology of COPD
    Satoru Yanagisawa
    Third Department of Internal Medicine, School of Medicine, Wakayama Medical University, Wakayama, Japan
    Chest 135:94-101. 2009
    ..Although the overexpression of Hck causes emphysema-like histologic changes in mice, its expression and activity in patients with COPD are unclear...
  18. doi Peroxynitrite augments fibroblast-mediated tissue remodeling via myofibroblast differentiation
    Tomohiro Ichikawa
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama, Japan
    Am J Physiol Lung Cell Mol Physiol 295:L800-8. 2008
    ..01) and inhibited by anti-TGF-beta antibody. These results suggest that RNS can affect the differentiation to myofibroblasts and excessive ECM production via a NF-kappaB-TGF-beta(1)-dependent pathway...
  19. pmc Oxidative stress enhances toll-like receptor 3 response to double-stranded RNA in airway epithelial cells
    Akira Koarai
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Am J Respir Cell Mol Biol 42:651-60. 2010
    ..Modulation of this pathway may be a therapeutic target for viral-induced exacerbations of COPD...
  20. doi 25-hydroxycholesterol promotes fibroblast-mediated tissue remodeling through NF-κB dependent pathway
    Tomohiro Ichikawa
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Exp Cell Res 319:1176-86. 2013
    ....
  21. pmc 25-Hydroxycholesterol enhances cytokine release and Toll-like receptor 3 response in airway epithelial cells
    Akira Koarai
    Third Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Respir Res 13:63. 2012
    ..In the present study, we examined whether 25-HC affects the release of cytokines and also modulates the responses of toll-like receptor 3 (TLR3) in airway epithelial cells...
  22. doi Molecular mechanism of the additive effects of leukotriene modifier in asthmatic patients receiving steroid therapy
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Allergol Int 58:89-96. 2009
    ..We evaluated the additive effects of LM with ICS on pulmonary function and airway inflammation in asthmatics with or without AR...
  23. doi Cigarette smoke augments the expression and responses of toll-like receptor 3 in human macrophages
    Akira Koarai
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Respirology 17:1018-25. 2012
    ..However, the effects of cigarette smoke on TLR3 remain unclear. In this study, it was examined whether cigarette smoke affects the expression and responses of TLR3 in human macrophages...
  24. pmc Oxidative stress augments toll-like receptor 8 mediated neutrophilic responses in healthy subjects
    Satoru Yanagisawa
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Respir Res 10:50. 2009
    ..However, it remains unknown whether TLR8 signaling is potentiated by oxidative stress. The aim of this study is to examine whether oxidative stress modulates TLR8 signaling in vitro...
  25. ncbi High COPD prevalence in patients with liver disease
    Yoshiaki Minakata
    The Third Department of Internal Medicine, Wakayama Medical University, Wakayama
    Intern Med 49:2687-91. 2010
    ..In this study, we investigated the prevalence of COPD in patients with liver diseases by recruiting a large number of patients, and also investigated was the effect of hepatitis virus infection on COPD prevalence...
  26. ncbi Prevalence of COPD in primary care clinics: correlation with non-respiratory diseases
    Yoshiaki Minakata
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Intern Med 47:77-82. 2008
    ..The aim of the present study was to determine whether or not COPD is different among patients already suffering from other diseases...
  27. doi Difference in time-course of improvement in asthma control measures between budesonide and budesonide/formoterol
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Pulm Pharmacol Ther 26:189-94. 2013
    ..The present study provides evidence that ICS/LABA combination therapy results in a more rapid improvement in asthma symptoms, lung function, and airway inflammation compared to ICS monotherapy in steroid-naive patients with asthma...
  28. doi Increased 25-hydroxycholesterol concentrations in the lungs of patients with chronic obstructive pulmonary disease
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama, Japan
    Respirology 17:533-40. 2012
    ..The aim of this study was to assess the production of 25-HC in the airways and to elucidate the role of 25-HC in neutrophil infiltration in the airways of patients with chronic obstructive pulmonary disease (COPD)...
  29. doi Inhibitory effects of theophylline on the peroxynitrite-augmented release of matrix metalloproteinases by lung fibroblasts
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama, Japan
    Am J Physiol Lung Cell Mol Physiol 302:L764-74. 2012
    ....
  30. doi Exhaled nitric oxide cutoff values for asthma diagnosis according to rhinitis and smoking status in Japanese subjects
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Japan
    Allergol Int 60:331-7. 2011
    ..Furthermore, there is no detailed study that investigated the cutoff values that takes into account patient factors that influence the FE(NO) levels...
  31. ncbi Two cases of asthma in handicapped elderly persons in which assisted inhalation therapy was effective
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Allergol Int 55:347-51. 2006
    ....
  32. ncbi Peak expiratory flow variability adjusted by forced expiratory volume in one second is a good index for airway responsiveness in asthmatics
    Kazuto Matsunaga
    The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama
    Intern Med 47:1107-12. 2008
    ..An accurate index that shows the degree of AHR may be obtained by combining the index of airway lability with the parameters that represent airway caliber...
  33. doi Validation of a compact motion sensor for the measurement of physical activity in patients with chronic obstructive pulmonary disease
    Akihito Sugino
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Respiration 83:300-7. 2012
    ..Objectives: The validity of the Actimarker was evaluated in COPD patients...
  34. doi Poor sensitivity of symptoms in early detection of COPD
    Keiichiro Akamatsu
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama, Japan Wakayama, Japan
    COPD 5:269-73. 2008
    ....
  35. doi Reduced level of physical activity in Japanese patients with chronic obstructive pulmonary disease
    Yoshiaki Minakata
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan Electronic address
    Respir Investig 52:41-8. 2014
    ..However, a detailed understanding of the PA in Japanese patients with COPD is lacking. We evaluated the levels of PA in terms of intensity in Japanese patients with COPD and evaluated the factors, which could influence the PA...
  36. ncbi Validation of the triaxial accelerometer for the evaluation of physical activity in Japanese patients with COPD
    Masae Kanda
    The Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Japan
    Intern Med 51:369-75. 2012
    ..We initially evaluated the reproducibility of the DAM in Japanese healthy subjects. Next, the within-subject repeatability and the determinants of physical activity were investigated in Japanese COPD patients...
  37. ncbi Overexpression of CD-11b and CXCR1 on circulating neutrophils: its possible role in COPD
    Toshiyuki Yamagata
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Chest 132:890-9. 2007
    ..The aim of the present study was to investigate the surface expression of molecules in circulating neutrophils and to clarify their possible role in the airflow limitation of COPD...
  38. pmc The influence of free 3-nitrotyrosine and saliva on the quantitative analysis of protein-bound 3-nitrotyrosine in sputum
    Kazuhito Ueshima
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Anal Chem Insights 2:1-7. 2007
    ..Furthermore, the influence of salivary contamination on the measurement of protein-bound 3-NT in induced sputum by means of HPLC-ECD was very small and could be negligible...
  39. doi Activation of Toll-like receptor 3 augments myofibroblast differentiation
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama, Wakayama, Japan
    Am J Respir Cell Mol Biol 40:654-62. 2009
    ..01) and they were inhibited by anti-TGF-beta antibody. These results suggest that activation of TLR3 can affect the differentiation to myofibroblasts and enhance ECM production via the NF-kappaB-TGF-beta(1)-dependent pathway...
  40. doi Relationship between alveolar nitric oxide concentration in exhaled air and small airway function in COPD
    Tsunahiko Hirano
    Third Department of Internal Medicine, School of Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0012, Japan
    J Breath Res 7:046002. 2013
    ..Airway inflammation, including excess nitric oxide generation in the peripheral airways, might be related to the pathophysiology of COPD...
  41. doi Persistent elevation of exhaled nitric oxide and modification of corticosteroid therapy in asthma
    Tsunahiko Hirano
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 0012, Japan
    Respir Investig 51:84-91. 2013
    ..However, improvement in residual airway inflammation and pulmonary function through modification of corticosteroid therapy has not been proven...
  42. doi Reference ranges for exhaled nitric oxide fraction in healthy Japanese adult population
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University, Japan
    Allergol Int 59:363-7. 2010
    ..In healthy adults, there have been a few studies of the reference ranges for FE(NO) in Caucasians. A community study in other regions may reveal any possible ethnic differences in the FE(NO) levels...
  43. ncbi Nitrative stress in refractory asthma
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama, Japan
    J Allergy Clin Immunol 121:355-60. 2008
    ..Recent reports showed that nitrative stress induced tissue remodeling in vitro, which is associated with a component of refractoriness in asthma. However, there is no report that nitrative stress is involved in refractory asthma...
  44. ncbi Deletion of the kinase domain in death-associated protein kinase attenuates tubular cell apoptosis in renal ischemia-reperfusion injury
    Masanori Kishino
    Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    J Am Soc Nephrol 15:1826-34. 2004
    ..54 +/- 0.34 mg/dl versus 0.87 +/- 0.24 mg/dl at 40 h after ischemia). Thus, these results indicate that deletion of the kinase domain from DAPK molecule can attenuate tubular cell apoptosis and renal dysfunction after IR injury...
  45. doi Natural history and risk factors of obstructive changes over a 10-year period in severe asthma
    Kazuto Matsunaga
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Respir Med 107:355-60. 2013
    ..However, the natural history and risk factors of obstructive change for such asthmatic patients have not been fully elucidated...
  46. ncbi Adjuvant chemotherapy with tegafur/uracil administration after transcatheter arterial chemoembolization for advanced hepatocellular carcinoma
    Hiroki Ueda
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama City 641 0012, Japan
    Oncol Rep 19:1355-61. 2008
    ..In conclusion, UFT administration after TACE was an effective treatment and showed no severe adverse events. This regimen may have an adjuvant role and antiangiogenic function in advanced HCC...
  47. doi Nitrative stress in inflammatory lung diseases
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama, Wakayama 641 0012, Japan
    Nitric Oxide 25:138-44. 2011
    ..In the present paper, we review the physiological and pathophysiological effects of NO and NO-related molecules in the respiratory system and in inflammatory lung diseases...
  48. doi N-acetyl-L-cysteine inhibits TGF-beta1-induced profibrotic responses in fibroblasts
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, 811 1 Kimiidera, Wakayama, Wakayama 641 0012, Japan
    Pulm Pharmacol Ther 22:487-91. 2009
    ..TGF-beta(1) has been reported to decrease the intracellular glutathione level and stimulate the production of reactive oxygen species...
  49. doi The regulation of amiloride-sensitive epithelial sodium channels by tumor necrosis factor-alpha in injured lungs and alveolar type II cells
    Toshiyuki Yamagata
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, 811 1, Kimiidera, Wakayama 641 8509, Japan
    Respir Physiol Neurobiol 166:16-23. 2009
    ..4, TNF-alpha 1.9 microA/cm(2)). These data suggest that TNF-alpha may affect the pathophysiology of acute lung injury and pulmonary edema through the inhibition of alveolar liquid clearance and sodium transport...
  50. doi Stratifying a risk for an increased variation of airway caliber among the clinically stable asthma
    Atsushi Hayata
    Third Department of Internal Medicine, Wakayama Medical University, School of Medicine, Wakayama, Japan
    Allergol Int 62:343-9. 2013
    ..The objective of this study is to examine a predictive marker for increased variation of PEF in patients with clinically stable asthma...
  51. pmc Improvement of Airflow Limitation by Fluticasone Propionate/Salmeterol in Chronic Obstructive Pulmonary Disease: What is the Specific Marker?
    Keiichiro Akamatsu
    Third Department of Internal Medicine, School of Medicine, Wakayama Medical University Wakayama, Japan
    Front Pharmacol 2:36. 2011
    ..Conclusion: Combining FE(NO) and specific IgE may be a useful marker for predicting the response to ICS/LABA on airflow limitation in COPD...
  52. ncbi Angioimmunoblastic lymphadenopathy with dysproteinaemia accompanied by pleural effusion
    Toshiyuki Yamagata
    Division of Clinical Oncology and Palliative Medicine, Wakayama Medical University, Wakayama City, Wakayama, Japan
    Respirology 10:124-7. 2005
    ..Cytologically, atypical plasma cells, and T-cell predominant lymphocytes were also present. These findings are likely to be characteristic of pleural effusions associated with AILD and may prove to be a useful marker for diagnosis...
  53. ncbi [Case of successful pregnancy and childbirth in a rheumatoid arthritis patient treated with etanercept]
    Kanako Furukawa
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 36:47-51. 2013
    ..This case is considered important because, to the best of our knowledge, this may be the first report of a planned pregnancy and childbirth in a patient under administration of a biological preparation...
  54. doi Oxidative and nitrative stress in bronchial asthma
    Hisatoshi Sugiura
    Third Department of Internal Medicine, Wakayama Medical University School of Medicine, Wakayama City, Wakayama, Japan
    Antioxid Redox Signal 10:785-97. 2008
    ..This review describes the rapidly accruing data linking oxidative and nitrative events to the pathogenesis of bronchial asthma...
  55. ncbi Combination hepatic arterial infusion therapy is effective for ocular melanoma metastasis to the liver
    Hiroki Ueda
    Third Department of Internal Medicine, Wakayama Medical University, Kimiidera 811 1, Wakayama City 641 0012, Japan
    Oncol Rep 14:1543-6. 2005
    ..Combination HAI therapy may have a potent therapeutic effect on malignant melanoma metastasis to the liver, and our regimen using DAV and CDDP may be beneficial to the improvement of prognosis without serious side effects...
  56. ncbi Deletion of the kinase domain in death-associated protein kinase attenuates renal tubular cell apoptosis in chronic obstructive uropathy
    Kazunori Yukawa
    Department of Physiology, Wakayama Medical University, Wakayama 641 8509, Japan
    Int J Mol Med 13:515-20. 2004
    ..Thus, these results indicate that the part of the kinase domain deleted by the gene targeting is crucial for the execution of tubular cell apoptosis, but is not essential for interstitial cell apoptosis in a COU model in mice...
  57. ncbi STAT6 deficiency inhibits tubulointerstitial fibrosis in obstructive nephropathy
    Kazunori Yukawa
    Department of Physiology, Wakayama Medical University, Wakayama 641 8509, Japan
    Int J Mol Med 15:225-30. 2005
    ..Our findings also suggest that the STAT6 pathway may have a promotive effect on renal fibrosis by activating collagen synthesis following ureteral obstruction...
  58. ncbi The kinase domain of death-associated protein kinase is inhibitory for tubulointerstitial fibrosis in chronic obstructive nephropathy
    Kazunori Yukawa
    Department of Physiology, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Int J Mol Med 15:73-8. 2005
    ..Thus, our results suggest that the kinase domain deleted by gene targeting plays a suppressive role for the development of renal fibrosis through inhibition of the tubular epithelial-to-mesenchymal transition in a mouse model of COU...
  59. ncbi Rapid intrahepatic tumor seeding after percutaneous ethanol injection therapy for hepatocellular carcinoma
    Hiroto Tanaka
    The Third Department of Internal Medicine, Wakayama Medical University
    Intern Med 47:411-4. 2008
    ..We successfully performed emergency TAE, but the patient died of liver failure. Rapid seeding of multiple intrahepatic tumors after PEIT is a rare event, but such a possibility must be kept in mind...
  60. doi Antifibrotic effect of edaravone in rat liver cirrhosis induced by dimethylnitrosamine
    Hiroto Tanaka
    3rd Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 0015, Japan
    Clin Exp Med 9:229-33. 2009
    ..This study showed that EDA reduces liver fibrosis in a rat of cirrhosis induced by DMN. These data suggest that the reduction of liver fibrosis by EDA may be induced by the suppression of activated hepatic stellate cells...
  61. pmc Estimation of protein intake using urinary urea nitrogen in patients with early-stage liver cirrhosis
    Yohei Kida
    The Third Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City, 641 8509, Japan
    Hepatol Int 1:382-6. 2007
    ..However, it has never been done on the basis of urinary urea nitrogen (UUN). The aim of this study, therefore, is to determine the usefulness of the estimated protein intake (EPI) based on UUN in patients with LC...
  62. doi Multiple symptoms of higher brain dysfunction caused by Marchiafava-Bignami disease in a patient with dermatomyositis
    Kanako Furukawa
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Rheumatol Int 31:109-12. 2011
    ..5 months after admission. There has been no report of a case of DM with MBD. This report may provide useful data with regard to the mechanisms of central nervous system (CNS) disorders in patients with DM...
  63. ncbi A case of polymyositis with a significantly high level of KL-6 associated with pancreatic cancer
    Yohei Kida
    Third Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    Mod Rheumatol 17:262-4. 2007
    ....
  64. ncbi [Epidemiology of COPD in Japan]
    Yoshiaki Minakata
    Third Department of Internal Medicine, Wakayama Medical University
    Nihon Rinsho 69:1721-6. 2011
    ..8 % of COPD patients, and the prevalence of COPD is high in heart failure, ischemic heart failure and liver diseases. The effort to decrease the mortality of COPD in Japan is necessary...
  65. ncbi [Levels of serum ascorbate and its metabolites in hemodialysis patients]
    Hiroko Hirano
    Third Department of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Nihon Jinzo Gakkai Shi 46:426-33. 2004
    ..AA deficiency in HD patients may result in high TBARS levels, which reflect increased oxidative stress. Adequate AA supplementation should therefore be considered in such patients...
  66. ncbi Hepatic encephalopathy with status epileptics: a case report
    Hiroto Tanaka
    Third Department of Internal Medicine, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 0015, Japan
    World J Gastroenterol 12:1793-4. 2006
    ..Thus, we diagnosed the patient as hepatic encephalopathy with status epilepticus. We consider the status epilepticus of this patient to a rare and interesting finding in hepatic encephalopathy...
  67. ncbi Underdiagnosis and undertreatment of COPD in primary care settings
    Tsuneyuki Takahashi
    Division of Respiratory and Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai, Japan
    Respirology 8:504-8. 2003
    ..The aim of this study was to improve the detection of COPD in a primary care setting and to evaluate the subsequent management of these patients by general practitioners...
  68. doi Validation of symptom-based COPD questionnaires in Japanese subjects
    Tomotaka Kawayama
    Division of Respirology, Neurology and Rheumatology, Kurume University School of Medicine, Kurume, Japan
    Respirology 13:420-6. 2008
    ..Symptom-based questionnaires may be helpful in diagnosing patients with COPD. The aim of this study was to determine whether two COPD questionnaires designed in Western countries were applicable to Japanese and other Asian patients...
  69. ncbi Quantitative assessment of protein-bound tyrosine nitration in airway secretions from patients with inflammatory airway disease
    Hisatoshi Sugiura
    Division of Respiratory and Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Free Radic Res 38:49-57. 2004
    ..More importantly, they show that increased RNS production in the airways seems to contribute in a critical way to the pathogenesis of COPD, and that the effects of RNS in airways may differ in asthma and COPD...
  70. ncbi Decreased expression of antioxidant enzymes and increased expression of chemokines in COPD lung
    Masafumi Tomaki
    Division of Respiratory and Infectious Diseases, Tohoku University Graduate School of Medicine, 1 1, Seiryo machi, Aoba ku, Sendai 980 8574, Japan
    Pulm Pharmacol Ther 20:596-605. 2007
    ....
  71. doi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  72. ncbi Disruption of L-histidine decarboxylase reduces airway eosinophilia but not hyperresponsiveness
    Akira Koarai
    Division of Respiratory and Infectious Diseases and Department of Cellular Pharmacology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Am J Respir Crit Care Med 167:758-63. 2003
    ..Furthermore, allergen-induced airway hyperresponsiveness appeared to occur independently of airway eosinophilia in our present model...
  73. ncbi Clinical efficacy and safety of transdermal tulobuterol in the treatment of stable COPD: an open-label comparison with inhaled salmeterol
    Yoshinosuke Fukuchi
    Department of Respiratory Medicine, Juntendo University School of Medicine, Hongo, Tokyo, Japan
    Treat Respir Med 4:447-55. 2005
    ..The tulobuterol patch (Hokunalin) is a transdermal patch preparation of the beta2-adrenoceptor agonist (beta2-agonist) tulobuterol designed to yield sustained beta(2)-agonistic effects for 24 hours when applied once daily...
  74. ncbi Increased liver temperature efficiently augments human cellular immune response: T-cell activation and possible monocyte translocation
    Yohei Kida
    Department of Immunology, Kinki University School of Medicine, Osaka Sayama, Osaka, Japan
    Cancer Immunol Immunother 55:1459-69. 2006
    ..These results suggest that heating of the liver may efficiently induce cellular immune responses to liver cancers...
  75. ncbi [A multicenter, open-label, randomized comparison of suppressive effects on asthmatic inflammation of lower airways and improved effects on health-related QOL between HFA-BDP and fluticasone propionate]
    Hiroyuki Ohbayashi
    Tohno Kousei Hospital, Japan
    Arerugi 56:577-86. 2007
    ....
  76. ncbi Cytokine-mediated xanthine oxidase upregulation in chronic obstructive pulmonary disease's airways
    Yuichi Komaki
    Division of Respiratory and Infectious Diseases, Tohoku University Graduate School of Medicine, Sendai 980 8574, Japan
    Pulm Pharmacol Ther 18:297-302. 2005
    ..Because the XO activity was significantly correlated with the degree of airway obstruction, these cytokine-XO production pathways may play a key role in the inflammation of COPD...
  77. ncbi Importance of assistance by caregivers for inhaled corticosteroid therapy in elderly patients with asthma
    Kazuto Matsunaga
    J Am Geriatr Soc 54:1626-7. 2006
  78. ncbi [Chemotherapy of chronic obstructive pulmonary disease]
    Masakazu Ichinose
    Nihon Naika Gakkai Zasshi 96:483-9. 2007
  79. ncbi [New development of pharmacotherapy--physiological basis and future possibility]
    Masakazu Ichinose
    Wakayama Medical University
    Nihon Rinsho 65:689-95. 2007
    ..In future, we need COPD specific anti-inflammatory agents, including histone deacetylase (HDAC) activator...
  80. ncbi COPD in Japan: the Nippon COPD Epidemiology study
    Yoshinosuke Fukuchi
    Department of Respiratory Medicine, Juntendo University, Tokyo, Japan
    Respirology 9:458-65. 2004
    ..Despite high smoking rates, few prevalence studies of COPD have been performed in Asia. The Nippon COPD Epidemiology (NICE) Study used spirometry to measure prevalence of airflow limitation in Japanese adults...
  81. ncbi [New development in drug therapy for COPD]
    Masakazu Ichinose
    Nihon Naika Gakkai Zasshi 94:1794-8. 2005
  82. ncbi Long-term use of corticosteroid eye drops delays the spontaneous remission of pulmonary sarcoidosis
    Masayuki Nara
    Department of Respiratory and Infectious Diseases, Postgraduate Division, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Tohoku J Exp Med 202:275-82. 2004
    ..These findings suggest the possibility that the topical corticosteroid therapy influenced the clinical course of pulmonary sarcoidosis, inducing some delay in the spontaneous remission in the longterm course...
  83. ncbi [Chronic obstructive pulmonary disease (COPD) burden in Japan--confronting COPD Japan survey]
    Masakazu Ichinose
    Kurume University
    Nihon Kokyuki Gakkai Zasshi 45:927-35. 2007
    ....