Muneki Hotomi

Summary

Affiliation: Wakayama Medical University
Country: Japan

Publications

  1. pmc Maternal immunization with pneumococcal surface protein A protects against pneumococcal infections among derived offspring
    Masamitsu Kono
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama City, Wakayama, Japan
    PLoS ONE 6:e27102. 2011
  2. pmc PspA family distribution, antimicrobial resistance and serotype of Streptococcus pneumoniae isolated from upper respiratory tract infections in Japan
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama Shi, Wakayama, Japan
    PLoS ONE 8:e58124. 2013
  3. pmc Evaluation of a rapid immunochromatographic ODK-0901 test for detection of pneumococcal antigen in middle ear fluids and nasopharyngeal secretions
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    PLoS ONE 7:e33620. 2012
  4. ncbi request reprint Nasopharyngeal carriage of drug-resistant Streptococcus pneumoniae in children with acute otitis media evaluated by polymerase chain reaction-based genotyping of penicillin-binding proteins
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Japan
    Acta Otolaryngol 122:72-7. 2002
  5. ncbi request reprint Intranasal immunization with recombinant outer membrane protein P6 induces specific immune responses against nontypeable Haemophilus influenzae
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama Shi, Wkayama 641 0032, Japan
    Int J Pediatr Otorhinolaryngol 65:109-16. 2002
  6. doi request reprint Protection of pneumococcal infection by maternal intranasal immunization with pneumococcal surface protein A
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Adv Otorhinolaryngol 72:121-5. 2011
  7. ncbi request reprint Genotyping of Streptococcus pneumoniae and Haemophilus influenzae isolated from paired middle ear fluid and nasopharynx by pulsed-field gel electrophoresis
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama Shi, Wakayama, Japan
    ORL J Otorhinolaryngol Relat Spec 66:233-40. 2004
  8. ncbi request reprint Antimicrobial resistance in Haemophilus influenzae isolated from the nasopharynx among Japanese children with acute otitis media
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Acta Otolaryngol 126:130-7. 2006
  9. doi request reprint Distribution of fibronectin-binding protein genes (prtF1 and prtF2) and streptococcal pyrogenic exotoxin genes (spe) among Streptococcus pyogenes in Japan
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8509, Japan
    J Infect Chemother 15:367-73. 2009
  10. ncbi request reprint Antimicrobial resistance of Haemophilus influenzae isolated from the nasopharynx of Japanese children with acute otitis media
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Acta Otolaryngol 126:240-7. 2006

Collaborators

Detail Information

Publications56

  1. pmc Maternal immunization with pneumococcal surface protein A protects against pneumococcal infections among derived offspring
    Masamitsu Kono
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama City, Wakayama, Japan
    PLoS ONE 6:e27102. 2011
    ..The current findings strongly suggest that maternal immunization with PspA is an attractive strategy against pneumococcal infections during early childhood...
  2. pmc PspA family distribution, antimicrobial resistance and serotype of Streptococcus pneumoniae isolated from upper respiratory tract infections in Japan
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama Shi, Wakayama, Japan
    PLoS ONE 8:e58124. 2013
    ..In the present study, we evaluated the distribution of the pneumococcal capsular type and surface protein A (PspA) family of pneumococcal isolates from upper respiratory tract infections in Japan...
  3. pmc Evaluation of a rapid immunochromatographic ODK-0901 test for detection of pneumococcal antigen in middle ear fluids and nasopharyngeal secretions
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    PLoS ONE 7:e33620. 2012
    ..The ODK-0901 test may provide a rapid and highly sensitive evaluation of the presence of S. pneumoniae and thus may be a promising method of identifying pneumococci in MEFs and NPSs...
  4. ncbi request reprint Nasopharyngeal carriage of drug-resistant Streptococcus pneumoniae in children with acute otitis media evaluated by polymerase chain reaction-based genotyping of penicillin-binding proteins
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Japan
    Acta Otolaryngol 122:72-7. 2002
    ..Strains with mutations in the three PBP genes were often isolated from children < or = 2 years old. Evaluation of mutations in PBP genes using PCR will prove useful for studying the epidemiology of antibiotic resistance...
  5. ncbi request reprint Intranasal immunization with recombinant outer membrane protein P6 induces specific immune responses against nontypeable Haemophilus influenzae
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama Shi, Wkayama 641 0032, Japan
    Int J Pediatr Otorhinolaryngol 65:109-16. 2002
    ..This study was designed to investigate the specific mucosal immunity induced by intranasal immunization of recombinant P6 (rP6) with cholera toxin (CT)...
  6. doi request reprint Protection of pneumococcal infection by maternal intranasal immunization with pneumococcal surface protein A
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Adv Otorhinolaryngol 72:121-5. 2011
    ..Current findings suggest that maternal intranasal immunization with PspA is an attractive procedure against pneumococcal infections in early childhood...
  7. ncbi request reprint Genotyping of Streptococcus pneumoniae and Haemophilus influenzae isolated from paired middle ear fluid and nasopharynx by pulsed-field gel electrophoresis
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama Shi, Wakayama, Japan
    ORL J Otorhinolaryngol Relat Spec 66:233-40. 2004
    ..In children with AOM, the nasopharynx could have been colonized by a virulent strain of bacteria that replaced the benign, commensal bacteria and then progressed to the middle ear, where they caused AOM...
  8. ncbi request reprint Antimicrobial resistance in Haemophilus influenzae isolated from the nasopharynx among Japanese children with acute otitis media
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Acta Otolaryngol 126:130-7. 2006
    ..High prevalence of penicillin-binding protein (PBP) gene mutated (PGM) strains of H. influenzae should be taken into account when treating otitis media in children...
  9. doi request reprint Distribution of fibronectin-binding protein genes (prtF1 and prtF2) and streptococcal pyrogenic exotoxin genes (spe) among Streptococcus pyogenes in Japan
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8509, Japan
    J Infect Chemother 15:367-73. 2009
    ..These genes (i.e., the prtF1, prtF2, and spe genes) may enable host-bacteria interaction, and internalization in the host cell, but may not enable infection complications such as invasive diseases...
  10. ncbi request reprint Antimicrobial resistance of Haemophilus influenzae isolated from the nasopharynx of Japanese children with acute otitis media
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Acta Otolaryngol 126:240-7. 2006
    ..A high prevalence of penicillin-binding protein gene-mutated (PGM) strains of Haemophilus influenzae should be taken into account when treating otitis media in children...
  11. pmc An application of outer membrane protein p6-specific enzyme-linked immunosorbent assay for detection of haemophilus influenzae in middle ear fluids and nasopharyngeal secretions
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    PLoS ONE 8:e71774. 2013
    ..Consequently, diagnosis using the P6-ELISA should be based on an overall evaluation, including the results of other related examinations and clinical symptoms to prevent misleading conclusions in clinical setting. ..
  12. ncbi request reprint High prevalence of Streptococcus pneumoniae with mutations in pbp1a, pbp2x, and pbp2b genes of penicillin-binding proteins in the nasopharynx in children in Japan
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    ORL J Otorhinolaryngol Relat Spec 68:139-45. 2006
    ..Among the numerous mutations in pbp genes that alter the affinity for beta-lactams, the decreased affinity of PBP1A, 2X and 2B is especially important in the development of resistances to beta-lactams...
  13. doi request reprint Formation of biofilm by Haemophilus influenzae isolated from pediatric intractable otitis media
    Satomi Moriyama
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Japan
    Auris Nasus Larynx 36:525-31. 2009
    ..The aims of this study are to evaluate biofilm formation by nontypeable Haemophilus influenzae (NTHi) isolated from children with acute otitis media (AOM) and its relation with clinical outcome of the disease...
  14. doi request reprint Clinical and microbiological impact of human bocavirus on children with acute otitis media
    Levent Bekir Beder
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama shi 641 0012, Wakayama, Japan
    Eur J Pediatr 168:1365-72. 2009
    ..In conclusion, HBoV may worsen the clinical symptoms and prolong the clinical outcome of AOM in pediatric population. Finally, HBoV may prime the secondary bacterial infection in the middle ear in favor of S. pneumoniae...
  15. ncbi request reprint Protection against systemic fatal pneumococcal infection by maternal intranasal immunization with pneumococcal surface protein A (PspA)
    Toshiki Katsurahara
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8509, Japan
    J Infect Chemother 14:393-8. 2008
    ..These findings suggest that maternal intranasal immunization with PspA could be an attractive procedure to employ against pneumococcal infections in early childhood...
  16. ncbi request reprint Evaluation of mutations in penicillin binding protein-3 gene of non-typeable Haemophilus influenzae isolated from the nasopharynx of children with acute otitis media
    Akihiro Sakai
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Acta Otolaryngol 125:180-3. 2005
    ..The high prevalence of BLNAR strains should be taken into account in the treatment of AOM in young children...
  17. doi request reprint Nontypeable Haemophilus influenzae isolated from intractable acute otitis media internalized into cultured human epithelial cells
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama, Japan
    Auris Nasus Larynx 37:137-44. 2010
    ..The aim of this study is to examine the internalization of nontypeable Haemophilus influenzae (NTHi) into human epithelial cells...
  18. ncbi request reprint Macrolide-resistant genes of Streptococcus pyogenes isolated from the upper respiratory tract by polymerase chain reaction
    Dewan S Billal
    Department of Otolaryngology Head and Neck Surgery, Japan
    J Infect Chemother 10:115-20. 2004
    ..pyogenes-related diseases. Physicians and researchers need to take into consideration the macrolide resistance of some strains of S. pyogenes...
  19. ncbi request reprint A recombinant P4 protein of Haemophilus influenzae induces specific immune responses biologically active against nasopharyngeal colonization in mice after intranasal immunization
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama shi 641 0032, Japan
    Vaccine 23:1294-300. 2005
    ..The use of an intranasal vaccine composed of the different surface protein antigens is an attractive strategy for the development of a vaccine against NTHi...
  20. pmc Serotype distribution and penicillin resistance of Streptococcus pneumoniae isolates from middle ear fluids of pediatric patients with acute otitis media in Japan
    Muneki Hotomi
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama 640 8501, Japan
    J Clin Microbiol 46:3808-10. 2008
    ..Serotypes 19F and 23F occurred most frequently among PRSP strains. The 7-valent pneumococcal conjugate vaccine (PCV) showed better coverage of PRSP strains (87.0%). The 7-valent PCV may reduce the prevalence of PRSP in Japan...
  21. ncbi request reprint Increase of macrolide-resistant Streptococcus pneumoniae-expressing mefE or ermB gene in the nasopharynx among children with otitis media
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama 641 0012, Japan
    Laryngoscope 115:317-20. 2005
    ..To evaluate prevalence of macrolide resistant strains and the genotypes of the resistance among Streptococcus pneumoniae isolated from the nasopharynx of children with otitis media...
  22. pmc Genetic characteristics and clonal dissemination of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae strains isolated from the upper respiratory tract of patients in Japan
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama, 641 8509, Japan
    Antimicrob Agents Chemother 51:3969-76. 2007
    ..influenzae among medical centers in Japan. The gBLNAR strains show a remarkable prevalence among H. influenzae isolates, with the prevalence increasing with time. This fact should be taken into account when treating URT infections...
  23. doi request reprint Haemophilus influenzae and Haemophilus haemolyticus in tonsillar cultures of adults with acute pharyngotonsillitis
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama Shi, Wakayama, 640 8501, Japan
    Auris Nasus Larynx 37:594-600. 2010
    ..The aim of this study was to evaluate the clinical implication of Haemophilus haemolyticus, one of the closest relative of Haemophilus influenzae, on acute pharyngotonsillitis...
  24. ncbi request reprint Determination of pneumococcal serotypes/genotypes in nasopharyngeal secretions of otitis media children by multiplex PCR
    Dewan S Billal
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama Shi, Wakayama, 641 8509, Japan
    Eur J Pediatr 167:401-7. 2008
    ..The relatively minor populations in the nasopharynx may be determined using molecular techniques...
  25. ncbi request reprint [Current status of PRSP and BLNAR]
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University
    Nihon Rinsho 65:441-7. 2007
  26. ncbi request reprint Maternal intranasal immunization with outer membrane protein P6 maintains specific antibody level of derived offspring
    Kazuma Yamauchi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1, Kimiidera, Wakayama Shi, Wakayama 641 8509, Japan
    Vaccine 24:5294-9. 2006
    ..It can supply protective antibodies via transplacental transfer during pregnancy and via breast milk after birth...
  27. ncbi request reprint Current status of antimicrobial susceptibility of clinical isolates of Streptococcus pyogenes in Japan: report of a countrywide surveillance study
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 0012, Japan
    J Infect Chemother 11:48-51. 2005
    ..Strains having ermB were resistant to TEL (MIC, > or = 8 microg/ml), while strains having ermTR were susceptible to TEL. Physicians and researchers need to take into consideration the macrolide resistance of some strains of S. pyogenes...
  28. ncbi request reprint Efficacy of a novel oral carbapenem, tebipenem pivoxil (TBM-PI), against experimental otitis media caused by penicillin resistant Streptococcus pneumoniae in chinchilla
    Muneki Hotomi
    Infection and Immunity Research Center, Wakayama Medical University, Wakayama, Japan
    Vaccine 25:2478-84. 2007
    ..01). Quantitative cultures in the middle ear effusions at day 5 of the TBM-PI group yielded 3.5+/-2.4log(10)CFUs/ml. TBM-PI is a promising antibiotic for the treatment of acute otitis media...
  29. ncbi request reprint Functions of tonsils in the mucosal immune system of the upper respiratory tract using a novel animal model, Suncus murinus
    Masaki Suzumoto
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera 811 1, Wakayama shi 641 0032, Wakayama, Japan
    Acta Otolaryngol 126:1164-70. 2006
    ..Our results also indicated a significant difference in roles of immune responses among individual tonsillar organs, suggesting functional sub-compartmentalization...
  30. doi request reprint A scoring system for management of acute pharyngo-tonsillitis in adults
    Masaki Suzumoto
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Wakayama shi, Wakayama 641 8510, Japan
    Auris Nasus Larynx 36:314-20. 2009
    ..The aim of this study was to develop and evaluate a scoring system for the management of acute pharyngo-tonsillitis...
  31. doi request reprint Loss of erythromycin resistance genes from strains of Streptococcus pyogenes that have developed resistance to levofloxacin
    Dewan Sakhawat Billal
    Department of Otolaryngology, Wakayama Medical University, Japan
    Diagn Microbiol Infect Dis 64:225-8. 2009
    ..Erythromycin resistance was fully restored by transconjugation with respective parent strains with either mefA- or ermTR-mediated mechanisms...
  32. pmc Streptococcus pneumoniae isolates from middle ear fluid and nasopharynx of children with acute otitis media exhibit phase variation
    Jun Arai
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    J Clin Microbiol 49:1646-9. 2011
    ..The fraction of the opaque colonies was significantly higher in middle ear isolates than in nasopharyngeal isolates. The difference is probably the result of the pneumococci adapting to differential selective environments...
  33. pmc Household transmission of Streptococcus pneumoniae among siblings with acute otitis media
    Jun Shimada
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimidera, Wakayama City, Wakayama 641 0012, Japan
    J Clin Microbiol 40:1851-3. 2002
    ..This study demonstrated person-to-person transmission of S. pneumoniae, especially drug-resistant strains, among siblings with AOM...
  34. ncbi request reprint Treatment and outcome of severe and non-severe acute otitis media
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Eur J Pediatr 164:3-8. 2005
    ..In a similar manner, children with non-severe disease who failed to improve without antibiotics were younger (40.7 months versus 54.8 months, P < 0.05) and more often colonized with pathogens (75.0% versus 33.4%, P < 0.05)...
  35. ncbi request reprint Evaluation of serotypes of Streptococcus pneumoniae isolated from otitis media patients by multiplex polymerase chain reaction
    Dewan S Billal
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    ORL J Otorhinolaryngol Relat Spec 68:135-8. 2006
    ....
  36. ncbi request reprint Rapid identification of nontypeable and serotype b Haemophilus influenzae from nasopharyngeal secretions by the multiplex PCR
    Dewan S Billal
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Int J Pediatr Otorhinolaryngol 71:269-74. 2007
    ..Detection of this pathogen from nasopharyngeal secretions (NPS) is important...
  37. ncbi request reprint Clinical bacteriology and immunology in acute otitis media in children
    Noboru Yamanaka
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama 641 8509, Japan
    J Infect Chemother 14:180-7. 2008
    ..The failure to develop a good antibody response to common antigens such as PspA and P6 may enable the pathogen to cause persistent or recurrent disease...
  38. ncbi request reprint In vitro induction and selection of fluoroquinolone-resistant mutants of Streptococcus pyogenes strains with multiple emm types
    Dewan S Billal
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8510, Japan
    J Antimicrob Chemother 59:28-34. 2007
    ....
  39. doi request reprint Minimal biofilm eradication concentration of antimicrobial agents against nontypeable Haemophilus influenzae isolated from middle ear fluids of intractable acute otitis media
    Shin Takei
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1, Kimiidera, Wakayama, Wakayama, 640 8500, Japan
    J Infect Chemother 19:504-9. 2013
    ..e., high MBECs, to suppress the biofilm formation of NTHi. In contrast, fluoroquinolones followed by macrolides showed lower MBECs. MBEC would be a good parameter to infer the efficacies of antimicrobials against NTHi in biofilm...
  40. ncbi request reprint Factors associated with clinical outcomes in acute otitis media
    Muneki Hotomi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Ann Otol Rhinol Laryngol 113:846-52. 2004
    ..05). Age, severity of disease at presentation, and nasopharyngeal colonization patterns were proven to be important determinants of outcome in AOM...
  41. doi request reprint A comparison of conventional and molecular microbiology in detecting differences in pneumococcal colonization in healthy children and children with upper respiratory illness
    Masashi Ogami
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama Shi, Wakayama, Japan
    Eur J Pediatr 169:1221-5. 2010
    ..Future studies should incorporate real-time PCR technology along with CM to fully understand the epidemiology of colonization in health and illness...
  42. doi request reprint Clonal spread of beta-lactamase-producing amoxicillin-clavulanate-resistant (BLPACR) strains of non-typeable Haemophilus influenzae among young children attending a day care in Japan
    Makoto Ito
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Int J Pediatr Otorhinolaryngol 74:901-6. 2010
    ..We investigated the nasopharyngeal carriage status of these resistant strains among children attending a same day care center during a 10-year period...
  43. ncbi request reprint [A new scoring system for assessing the severity of adult acute rhinosinusitis]
    Noboru Yamanaka
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama
    Nihon Jibiinkoka Gakkai Kaiho 113:687-98. 2010
    ....
  44. doi request reprint Clinical scoring system of acute pharyngotonsillitis
    Akihisa Togawa
    Department of Otolaryngology, Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Adv Otorhinolaryngol 72:139-41. 2011
    ..The aim of this study was to evaluate clinical outcomes of acute pharyngo-tonsillitis by a scoring system and the impact of causative pathogens...
  45. ncbi request reprint Tonsillitis index: an objective tool for quantifying the indications for tonsillectomy for recurrent acute tonsillitis
    Keiji Fujihara
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, 811 1 Kimiidera, Wakayama City 641 8509, Japan
    Int J Pediatr Otorhinolaryngol 69:1515-20. 2005
    ..TI may be a useful tool for surgical decision making...
  46. doi request reprint Pathogenic role of tonsillar lymphocytes in associated with HSP60/65 in Pustulosis palmaris et plantaris
    Masaki Hayashi
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Kimiidera, Wakayama Shi, Japan
    Auris Nasus Larynx 36:578-85. 2009
    ....
  47. ncbi request reprint T-lymphocyte maturation-associated protein gene as a candidate metastasis suppressor for head and neck squamous cell carcinomas
    Levent Bekir Beder
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Cancer Sci 100:873-80. 2009
    ..LOH and hypermethylation appeared to be important mechanisms for inactivation of MAL function...
  48. doi request reprint Role of miR-200c/miR-141 in the regulation of epithelial-mesenchymal transition and migration in head and neck squamous cell carcinoma
    Shunji Tamagawa
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University, Wakayama, Japan
    Int J Mol Med 33:879-86. 2014
    ..Furthermore, our data suggest that the promoter hypermethylation of ZEB1 and ZEB2 may play an essential role and may overshadow the effects of the miR-200 family in the regulation of EMT during carcinogenesis...
  49. ncbi request reprint [Molecular-biological and immunological approaches against intractable acute otitis media in children]
    Noboru Yamanaka
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical University
    Kansenshogaku Zasshi 77:595-605. 2003
  50. ncbi request reprint [Roles of beta-catenin overexpression and adenomatous polyposis coli mutation in head and neck cancer]
    Shin Takei
    Department of Otolaryngology Head and Neck Surgery, Wakayama Medical College, Wakayama
    Nihon Jibiinkoka Gakkai Kaiho 106:692-9. 2003
    ..Regarding the beta-catein mutation, non of the 31 samples exhibited a gene mutation in beta-catenin exon 3. Thus, the rate of APC and beta-catenin mutation in head and neck cancer may be very low...
  51. pmc Brain regions responsible for tinnitus distress and loudness: a resting-state FMRI study
    Takashi Ueyama
    Department of Anatomy and Cell Biology, Graduate School of Wakayama Medical University, Wakayama, Japan
    PLoS ONE 8:e67778. 2013
    ..The regions for distress and depressive state are known to be related to depression, while the regions for tinnitus loudness are known to be related to the default mode network and integration of multi-sensory information. ..
  52. ncbi request reprint Recent advances in otitis media. 6. Vaccine
    G Scott Giebink
    Department of Pediatrics, University of Minnesota Medical School, Minneapolis, USA
    Ann Otol Rhinol Laryngol Suppl 194:86-103. 2005
  53. pmc Nasal colonization with Streptococcus pneumoniae includes subpopulations of surface and invasive pneumococci
    David E Briles
    Department of Microbiology, University of Alabama at Birmingham, USA
    Infect Immun 73:6945-51. 2005
    ..Although this speculation is unproven, the observation that there are separate populations of pneumococci during colonization may help guide future attempts to understand the biology of nasal colonization by this pathogen...
  54. pmc Can the Etest correctly determine the MICs of beta-lactam and cephalosporin antibiotics for beta-lactamase-negative ampicillin-resistant Haemophilus influenzae?
    Dewan Sakhawat Billal
    Antimicrob Agents Chemother 51:3463-4. 2007
  55. pmc Prevalence of Streptococcus invasive locus (sil) and its relationship with macrolide resistance among group A Streptococcus strains
    Dewan Sakhawat Billal
    J Clin Microbiol 46:1563-4. 2008
  56. pmc PIR-B-deficient mice are susceptible to Salmonella infection
    Ikuko Torii
    Department of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294 3300, USA
    J Immunol 181:4229-39. 2008
    ..These findings suggest that the disruption of PIR-A and PIR-B balance affects their regulatory roles in host defense to bacterial infection...