Affiliation: Wakayama Medical University
- Combined small-cell carcinoma of the stomach: p53 and K-ras gene mutational analysis supports a monoclonal origin of three histological componentsBo Han
Department of Pathology, Wakayama Medical University, Wakayama 641 8509, Japan
Int J Exp Pathol 86:213-8. 2005..Our results strongly support a hypothesis that the combined SmCC of stomach in this case was of monoclonal origin...
- Myoepithelial carcinoma arising in an adenomyoepithelioma of the breast: case report with immunohistochemical and mutational analysisBo Han
Department of Pathology, Wakayama Medical University, Kimiidera, Wakayama, Japan
Pathol Int 56:211-6. 2006..No mutations in exons 1 and 2 of the K-, H-, and N-ras genes were identified in any of the neoplastic component. To the authors' knowledge this is the first report of a mutation in the p53 gene in a malignant AME of the breast...
- Calcitonin targets extracellular signal-regulated kinase signaling pathway in human cancersMisa Nakamura
Department of Pathology, Wakayama Medical University, Kimiidera 811 1, Wakayama 641 0012, Japan
J Mol Endocrinol 39:375-84. 2007..These novel findings indicate that CT may be used to target ERK in the treatment of cancer...
- Calcitonin inhibits invasion of breast cancer cells: involvement of urokinase-type plasminogen activator (uPA) and uPA receptorBo Han
Department of Pathology, Wakayama Medical University, Wakayama 641-8509, Japan
Int J Oncol 28:807-14. 2006..To the best of our knowledge, this is the first report describing a direct effect of CT on breast cancer cell invasion. Our data might suggest a close link between CT signaling, the uPA-mediated pathway, and breast cancer invasion...
- Expression of calcitonin receptor in rat mammary gland during lactationAiko Ishii
Department of Pathology, Wakayama Medical University, Wakayama, Japan
Endocr J 53:317-24. 2006..These results suggest that up-regulation of CTR during lactation may contribute to inhibition of mammary epithelial cell proliferation...
- Urokinase-type plasminogen activator system and breast cancer (Review)Bo Han
Department of Pathology, Wakayama Medical University, Kimiidera 811-1, Wakayama 641-8509, Japan
Oncol Rep 14:105-12. 2005..Correlations of the uPA system with other informative markers of breast cancer are also discussed...
- Adrenomedullin: a tumor progression factor via angiogenic controlMisa Nakamura
Department of Pathology, Wakayama Medical University, 811 1 Kimiidera, Wakayama, 641 8509, Japan
Curr Cancer Drug Targets 6:635-43. 2006..The major focus of this review will be on the role of ADM in cancer, with emphasis on its utility in diagnostic and prognostic terms, along with its relevance as a therapeutic target...
- Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancerScott A Tomlins
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
Nature 448:595-9. 2007..Furthermore, the identification of androgen-repressed and insensitive 5' fusion partners may have implications for the anti-androgen treatment of advanced prostate cancer...
- Heterogeneity of TMPRSS2 gene rearrangements in multifocal prostate adenocarcinoma: molecular evidence for an independent group of diseasesRohit Mehra
Michigan Center for Translational Pathology, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA
Cancer Res 67:7991-5. 2007..Understanding this molecular heterogeneity is critical to the future development and utility of diagnostic and prognostic PCA biomarkers...
- Central malignant salivary gland tumors of the jaw: retrospective clinical analysis of 22 casesYi Li
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University, Chengdu, China
J Oral Maxillofac Surg 66:2247-53. 2008..As a review of central malignant salivary gland tumor cases in Southwest China in the past 20 years, this study provided the clinical, radiologic, and pathologic information of these rare lesions...