K Yoshimura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Aesthetic Plast Surg 32:48-55; discussion 56-7. 2008
  2. doi request reprint Numerical measurement of viable and nonviable adipocytes and other cellular components in aspirated fat tissue
    Hirotaka Suga
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Plast Reconstr Surg 122:103-14. 2008
  3. ncbi request reprint Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 208:64-76. 2006
  4. ncbi request reprint Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection
    Daisuke Matsumoto
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Tissue Eng 12:3375-82. 2006
  5. doi request reprint Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    Breast J 16:169-75. 2010
  6. ncbi request reprint Clinical trial of bleaching treatment with 10% all-trans retinol gel
    Kotaro Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Dermatol Surg 29:155-60; discussion 160. 2003
  7. doi request reprint Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Dermatol Surg 34:1178-85. 2008
  8. doi request reprint Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Regen Med 4:265-73. 2009
  9. ncbi request reprint Differential expression of heparin-binding EGF-like growth factor (HB-EGF) mRNA in normal human keratinocytes induced by a variety of natural and synthetic retinoids
    Kotaro Yoshimura
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Exp Dermatol 12:28-34. 2003
  10. ncbi request reprint Cosmetic color improvement of the nipple-areola complex by optimal use of tretinoin and hydroquinone
    Kotaro Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Graduate School of Medicine, Japan
    Dermatol Surg 28:1153-7; discussion 1158. 2002

Collaborators

Detail Information

Publications63

  1. pmc Cell-assisted lipotransfer for cosmetic breast augmentation: supportive use of adipose-derived stem/stromal cells
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    Aesthetic Plast Surg 32:48-55; discussion 56-7. 2008
    ..Lipoinjection is a promising treatment but has some problems, such as unpredictability and a low rate of graft survival due to partial necrosis...
  2. doi request reprint Numerical measurement of viable and nonviable adipocytes and other cellular components in aspirated fat tissue
    Hirotaka Suga
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Plast Reconstr Surg 122:103-14. 2008
    ..A reliable method with which to assay viability and number of adipocytes and other cellular components in adipose tissue remains to be established...
  3. ncbi request reprint Characterization of freshly isolated and cultured cells derived from the fatty and fluid portions of liposuction aspirates
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    J Cell Physiol 208:64-76. 2006
    ..These results suggest that liposuction-derived cells may be useful and valuable for cell-based therapies...
  4. ncbi request reprint Cell-assisted lipotransfer: supportive use of human adipose-derived cells for soft tissue augmentation with lipoinjection
    Daisuke Matsumoto
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Tissue Eng 12:3375-82. 2006
    ..These findings may partly explain why transplanted aspirated fat does not survive well and suggest clinical potential of the CAL method for soft tissue augmentation...
  5. doi request reprint Progenitor-enriched adipose tissue transplantation as rescue for breast implant complications
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, Bunkyo ku, Tokyo, Japan
    Breast J 16:169-75. 2010
    ..These preliminary results suggest that CAL is a suitable methodology for the replacement of breast implants...
  6. ncbi request reprint Clinical trial of bleaching treatment with 10% all-trans retinol gel
    Kotaro Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Dermatol Surg 29:155-60; discussion 160. 2003
    ..Although an aggressive use of tretinoin along with hydroquinone enables an efficient treatment of hyperpigmented skin lesions, irritant dermatitis remains to be solved...
  7. doi request reprint Cell-assisted lipotransfer for facial lipoatrophy: efficacy of clinical use of adipose-derived stem cells
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Dermatol Surg 34:1178-85. 2008
    ..Lipoinjection is a promising treatment, but its efficacy in recontouring facial lipoatrophy remains to be established...
  8. doi request reprint Adipose-derived stem/progenitor cells: roles in adipose tissue remodeling and potential use for soft tissue augmentation
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Regen Med 4:265-73. 2009
    ..A novel transplantation strategy, termed cell-assisted lipotransfer, involves the enrichment of adipose progenitor cells in grafts; preliminary results suggest this approach to be safe and effective...
  9. ncbi request reprint Differential expression of heparin-binding EGF-like growth factor (HB-EGF) mRNA in normal human keratinocytes induced by a variety of natural and synthetic retinoids
    Kotaro Yoshimura
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Exp Dermatol 12:28-34. 2003
    ..The capacity of retinoids to upregulate HB-EGF may be an important index for investigation and development of an ideal synthetic retinoid, which has maximum benefits and minimum side-effects..
  10. ncbi request reprint Cosmetic color improvement of the nipple-areola complex by optimal use of tretinoin and hydroquinone
    Kotaro Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Graduate School of Medicine, Japan
    Dermatol Surg 28:1153-7; discussion 1158. 2002
    ..A successful treatment to improve the color of nipple-areola complex (NAC) has never been reported, although the number of women seeking the more attractively colored NAC is not small...
  11. ncbi request reprint Effects of all-trans retinoic acid on melanogenesis in pigmented skin equivalents and monolayer culture of melanocytes
    K Yoshimura
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1, Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
    J Dermatol Sci 27:S68-75. 2001
    ..The role of RA in bleaching treatments appears to be in other specific actions, such as promotion of keratinocytes proliferation and acceleration of epidermal turnover...
  12. ncbi request reprint Experience with a strong bleaching treatment for skin hyperpigmentation in Orientals
    K Yoshimura
    Department of Plastic, Reconstructive, and Aesthetic Surgery, University of Tokyo, Japan
    Plast Reconstr Surg 105:1097-108; discussion 1109-10. 2000
    ....
  13. ncbi request reprint Myosin heavy chain expression in skeletal muscle autografts under neural or aneural conditions
    K Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Japan
    J Surg Res 75:135-47. 1998
    ....
  14. ncbi request reprint A regenerative change during muscle adaptation to denervation in rats
    K Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Tokyo, 113, Japan
    J Surg Res 81:139-46. 1999
    ....
  15. ncbi request reprint Surgical correction of cryptotia with superiorly based superficial mastoid fascia and skin paddle
    K Yoshimura
    Department of Plastic, Reconstructive, and Aesthetic Surgery at the University of Tokyo, Japan
    Plast Reconstr Surg 105:836-41. 2000
    ..The procedure was performed in eight auricles in a total of seven patients with cryptotia. A satisfactory contour and protrusion of the auricle were maintained postoperatively, leaving the scar within the auricular sulcus...
  16. ncbi request reprint Correlation between age and the secretions of melanocyte-stimulating cytokines in cultured keratinocytes and fibroblasts
    M Okazaki
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Dermatol 153:23-9. 2005
    ..The chief cellular components of the skin other than melanocytes are keratinocytes and fibroblasts, and the influences of age-related changes in those cells on skin pigmentation have not been elucidated...
  17. ncbi request reprint Usefulness of a narrow-band reflectance spectrophotometer in evaluating effects of depigmenting treatment
    K Yoshimura
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
    Aesthetic Plast Surg 25:129-33. 2001
    ....
  18. doi request reprint Cellular and molecular features of lipoma tissue: comparison with normal adipose tissue
    H Suga
    Department of Plastic Surgery, University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Dermatol 161:819-25. 2009
    ..Involvement of adipose-derived stem/progenitor/stromal cells (ASCs) in the development of lipomas has been suggested, but the pathogenesis and pathophysiology of this tumour remain unclear...
  19. ncbi request reprint The mechanism of epidermal hyperpigmentation in café-au-lait macules of neurofibromatosis type 1 (von Recklinghausen's disease) may be associated with dermal fibroblast-derived stem cell factor and hepatocyte growth factor
    M Okazaki
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo 7 3 1, Hongo, Tokyo 3 86SS, Japan
    Br J Dermatol 148:689-97. 2003
    ..The mechanism of the accentuated melanization in café-au-lait macules (CALMs) in patients with neurofibromatosis type 1 (NF1; von Recklinghausen's disease) has not been elucidated...
  20. doi request reprint Preserved proliferative capacity and multipotency of human adipose-derived stem cells after long-term cryopreservation
    Koichi Gonda
    Department of Plastic Surgery, University of Tokyo School of Medicine, Japan
    Plast Reconstr Surg 121:401-10. 2008
    ....
  21. ncbi request reprint Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide
    S Homma
    Dept of Respiratory Medicine, Toranomon Hospital, Toranomon 2 2 2, Minato ku, Tokyo, 105 8470, Japan
    Eur Respir J 25:200-4. 2005
    ..In conclusion, more attention needs to be paid to the possible toxic effects of indium compounds, and maximum healthcare measures should be taken to protect industry workers from these toxicities...
  22. pmc Chemically charging the pore constriction opens the mechanosensitive channel MscL
    K Yoshimura
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo 113 0033, Japan
    Biophys J 80:2198-206. 2001
    ..These results support the view that exposure of hydrophobic surfaces to a hydrophilic environment during channel opening serves as the barrier to gating...
  23. ncbi request reprint Pretreatment with topical all-trans-retinoic acid is beneficial for wound healing in genetically diabetic mice
    Y Kitano
    Department Plastic and Reconstructive Surgery, School of Medicine, University of Tokyo
    Arch Dermatol Res 293:515-21. 2001
    ..It is known that cutaneous wounds of db/db mice show delayed wound healing due to impaired wound contraction, delayed granulation tissue formation and underexpression of keratinocyte growth factor (KGF)...
  24. ncbi request reprint The sensitivity of chlamydomonas photoreceptor is optimized for the frequency of cell body rotation
    K Yoshimura
    Department of Biological Sciences, Graduate School of Science, University of Tokyo, Hongo, Tokyo, 113 0033 Japan
    Plant Cell Physiol 42:665-72. 2001
    ..These characteristic kinetics of the PRC should be important for Chlamydomonas cells to extract information from the signals generated by the cell body rotation...
  25. doi request reprint Influences of centrifugation on cells and tissues in liposuction aspirates: optimized centrifugation for lipotransfer and cell isolation
    Masakazu Kurita
    Department of Plastic Surgery, University of Tokyo School of Medicine, Japan
    Plast Reconstr Surg 121:1033-41; discussion 1042-3. 2008
    ..This study was performed to investigate quantitatively the effects of centrifugation on liposuction aspirates to optimize centrifugal conditions for fat transplantation and isolation of adipose-derived stem cells...
  26. ncbi request reprint Craniofacial anomalies of the cultured mouse embryo induced by inhibition of sonic hedgehog signaling: an animal model of holoprosencephaly
    Takashi Nagase
    Department of Plastic and Reconstructive Surgery, University Hospital, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Craniofac Surg 16:80-8. 2005
    ..The authors consider that these facial anomalies represent milder phenotypes of holoprosencephaly...
  27. ncbi request reprint Digital artery perforator flaps for fingertip reconstructions
    Isao Koshima
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Plast Reconstr Surg 118:1579-84. 2006
  28. doi request reprint Functional implications of CD34 expression in human adipose-derived stem/progenitor cells
    Hirotaka Suga
    Department of Plastic Surgery, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Stem Cells Dev 18:1201-10. 2009
    ..Loss of CD34 expression may be related to the physiological process of commitment and/or differentiation from immature status into specific lineages such as adipose, bone, or smooth muscle...
  29. ncbi request reprint Tretinoin reverses upregulation of matrix metalloproteinase-13 in human keloid-derived fibroblasts
    Gentaro Uchida
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Exp Dermatol 12:35-42. 2003
    ..The present results suggest that tretinoin may be clinically useful to improve the chronic inflammation seen in keloids and prevent expansion of keloid tissues into circumferential normal skin...
  30. ncbi request reprint Repeated treatment protocols for melasma and acquired dermal melanocytosis
    Kotaro Yoshimura
    Department of Plastic Surgery, University of Tokyo, School of Medicine, Tokyo, Japan
    Dermatol Surg 32:365-71. 2006
    ..Melasma and acquired dermal melanocytosis (ADM; acquired bilateral nevus of Ota-like macules) are both seen most commonly symmetrically on the face of women with darker skin and are also known as difficult conditions to treat...
  31. ncbi request reprint Rapid expansion of human adipose-derived stromal cells preserving multipotency
    H Suga
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Cytotherapy 9:738-45. 2007
    ..We investigated the effects of an endothelial growth medium (EGM-2) on ASC, focusing on proliferation and differentiation potentials...
  32. ncbi request reprint Identification of myelinated motor and sensory axons in a regenerating mixed nerve
    Y Kawasaki
    Department of Plastic, Reconstructive, and Aesthetic Surgery, University of Tokyo, Tokyo, Japan
    J Hand Surg Am 25:104-11. 2000
    ..The results suggest that the myelinated sensory axons regenerate faster in the early stage of nerve regeneration and that regeneration of the myelinated motor axons is prominent in the subsequent stage. (J Hand Surg 2000; 25A:104-111...
  33. ncbi request reprint A clinical trial of topical bleaching treatment with nanoscale tretinoin particles and hydroquinone for hyperpigmented skin lesions
    Katsujiro Sato
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Dermatol Surg 33:937-44. 2007
    ..Although combined use of tretinoin (all-trans-retinoic acid; atRA) and hydroquinone improves various hyperpigmented lesions, the pharmacologic instability of atRA and atRA-induced irritant dermatitis are difficult unsolved problems...
  34. ncbi request reprint Reversible adipose tissue enlargement induced by external tissue suspension: possible contribution of basic fibroblast growth factor in the preservation of enlarged tissue
    Harunosuke Kato
    Department of Plastic Surgery, University of Tokyo, Tokyo, Japan
    Tissue Eng Part A 16:2029-40. 2010
    ....
  35. doi request reprint CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity
    Satoshi Nishimura
    Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Nat Med 15:914-20. 2009
    ..These results support the notion that CD8(+) T cells have an essential role in the initiation and propagation of adipose inflammation...
  36. doi request reprint IFATS collection: Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanism
    Hirotaka Suga
    Department of Plastic Surgery, University of Tokyo, Japan
    Stem Cells 27:238-49. 2009
    ..This study revealed a functional role for ASCs in the response to injury and provides new insight into the therapeutic potential of ASCs...
  37. ncbi request reprint Angiogenesis within the developing mouse neural tube is dependent on sonic hedgehog signaling: possible roles of motor neurons
    Takashi Nagase
    Department of Plastic and Reconstructive Surgery, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Genes Cells 10:595-604. 2005
    ..These results suggest that the neural tube angiogenesis is dependent on Shh signaling, and mediated, at least in part, by the Ang-1 positive motor neurons...
  38. ncbi request reprint Combined therapy using Q-switched ruby laser and bleaching treatment with tretinoin and hydroquinone for acquired dermal melanocytosis
    Akira Momosawa
    Department of Plastic and Reconstructive Surgery, University of Tokyo, Japan
    Dermatol Surg 29:1001-7. 2003
    ....
  39. doi request reprint A therapeutic strategy based on histological assessment of hyperpigmented skin lesions in Asians
    Masakazu Kurita
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    J Plast Reconstr Aesthet Surg 62:955-63. 2009
    ..Based on pathological features and our extensive clinical experience with hyperpigmented skin, we propose a therapeutic strategy for treating hyperpigmented skin lesions, which may be particularly useful in Asian populations...
  40. ncbi request reprint Investigation of the pharmacokinetics of cyclosporine in patients following long-term administration after a kidney transplant: comparison of Neoral and Sandimmune
    S Takahara
    Osaka University, Graduate School of Medicine, Faculty of Medicine, Urology Department, Suita, Japan
    Transplant Proc 36:456S-460S. 2004
    ..53181). During the period of the study, there was no acute rejection episode, onset of adverse drug reaction symptoms, or marked change in laboratory test values...
  41. ncbi request reprint Efficacious pleurodesis with OK-432 and doxorubicin against malignant pleural effusions
    K Kishi
    Dept of Respiratory Medicine, Respiratory Center, Toranomon Hospital, Tokyo, Japan
    Eur Respir J 24:263-6. 2004
    ..Pleurodesis using both OK-432 and doxorubicin showed high efficacy for controlling malignant pleural effusions caused by lung cancer...
  42. ncbi request reprint Cisplatin, vincristine, methotrexate, peplomycin, etoposide (COMPE) therapy for disseminated germ cell testicular tumors
    K Yoshimura
    Department of Urology, Cancer Institute Hospital, Tokyo, Japan
    Int J Urol 4:47-51. 1997
    ..This paper reports a trial of a cisplatin-based (COMPE) combination chemotherapy regimen based on synchronization theory...
  43. ncbi request reprint Angle-splitting ostectomy followed by face lift for elderly patients with prominent mandibular angles
    Takashi Nagase
    Department of Plastic Surgery, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Plast Reconstr Surg 115:633-40; discussion 641-2. 2005
    ..Subsequent face lifts can improve skin redundancy and lead to better cosmetic results...
  44. doi request reprint TGF-beta is specifically expressed in human dermal papilla cells and modulates hair folliculogenesis
    Keita Inoue
    Department of Plastic Surgery, University of Tokyo School of Medicine, Hongo, Bunkyo ku, Tokyo, Japan
    J Cell Mol Med 13:4643-56. 2009
    ..These results suggest an important role for TGF-beta(2) in hair follicle morphogenesis and provide insights into the establishment of future cell therapies for hair regrowth by transplanting expanded DPCs...
  45. ncbi request reprint Differential expression of stem-cell-associated markers in human hair follicle epithelial cells
    Keita Inoue
    Department of Plastic Surgery, University of Tokyo, Tokyo, Japan
    Lab Invest 89:844-56. 2009
    ..We showed that K15, CD200, CD34, and CD271 were useful biomarkers for characterizing freshly isolated human follicular epithelial cells in diverse stages of differentiation...
  46. ncbi request reprint Surgical correction of retracted nostril rim with auricular composite grafts and anchoring suspention
    Toshitsugu Hirohi
    Ritz Cosmetic Surgery Clinic, Tokyo, 6F 3 1 7, Kamiosaki, Shinagawa ku, Tokyo 141 0021, Japan
    Aesthetic Plast Surg 27:418-22. 2003
    ..The presented method merits consideration as a standard operative approach for correction of retracted nostril rim...
  47. ncbi request reprint Effects of subepithelial fibroblasts on epithelial differentiation in human skin and oral mucosa: heterotypically recombined organotypic culture model
    Mutsumi Okazaki
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Plast Reconstr Surg 112:784-92. 2003
    ..In epithelial differentiation, however, the intrinsic control by epithelial cells may still be stronger than extrinsic regulation by mesenchymal fibroblasts...
  48. ncbi request reprint Elevated expression of hepatocyte and keratinocyte growth factor in cultured buccal-mucosa-derived fibroblasts compared with normal-skin-derived fibroblasts
    Mutsumi Okazaki
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 30:108-15. 2002
    ..Our study suggests that increased expression of HGF and KGF by buccal mucosal fibroblasts may partly be responsible for the faster wound healing with less scar formation in the oral cavity compared with normal skin...
  49. doi request reprint Adipose tissue remodeling in lipedema: adipocyte death and concurrent regeneration
    Hirotaka Suga
    Department of Plastic Surgery, University of Tokyo Graduate School of Medicine, Bunkyo ku, Tokyo, Japan
    J Cutan Pathol 36:1293-8. 2009
    ..The confinement to the lower extremities and the difference from systemic obesity warrants further elucidation in future studies...
  50. doi request reprint Arterial embolization and skin necrosis of the nasal ala following injection of dermal fillers
    Keita Inoue
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Plast Reconstr Surg 121:127e-128e. 2008
  51. ncbi request reprint Simultaneous reconstruction of breast and well-projected nipple after expansion of mammary skin
    Kotaro Yoshimura
    Department of Plastic Surgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Scand J Plast Reconstr Surg Hand Surg 39:77-84. 2005
    ..Its disadvantages are the relatively weak blood supply of the flaps, and difficulty in calculating the position of the nipple. The procedure may be beneficial for selected cases...
  52. ncbi request reprint Influences of preservation at various temperatures on liposuction aspirates
    Daisuke Matsumoto
    Department of Plastic Surgery, University of Tokyo School of Medicine, Japan
    Plast Reconstr Surg 120:1510-7. 2007
    ..The aim of this study was to assess degeneration of aspirated fat during preservation and optimize the preservation method for lipoaspirates...
  53. ncbi request reprint Epidermal hyperpigmentation in non-syndromic solitary cafe-au-lait macules may be associated with increased secretion of endothelin-1 by lesional keratinocytes
    Mutsumi Okazaki
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Scand J Plast Reconstr Surg Hand Surg 39:213-7. 2005
    ..It may be that the increased secretion of ET-1 by epidermal keratinocytes has a role in the accentuated epidermal melanisation seen in non-syndromic macules...
  54. ncbi request reprint Neurospheres from human adipose tissue transplanted into cultured mouse embryos can contribute to craniofacial morphogenesis: a preliminary report
    Takashi Nagase
    Clinical Research Center, National Hospital Organization Murayama Medical Center, Tokyo, Japan
    J Craniofac Surg 18:49-53; discussion 60-1. 2007
    ..Although preliminary, our results support an idea that ASC-derived neurospheres have properties of neural progenitors in vitro and in vivo...
  55. ncbi request reprint Anti-androgenic therapy using oral spironolactone for acne vulgaris in Asians
    Katsujiro Sato
    Department of Plastic Surgery, University of Tokyo School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Aesthetic Plast Surg 30:689-94. 2006
    ..Obtaining this race-specific information is important because Westerners and Asians respond differently to hormone therapy. This study aimed to examine the efficacy and safety of oral spironolactone used to treat acne in Asians...
  56. ncbi request reprint Induction of hard keratin expression in non-nail-matrical keratinocytes by nail-matrical fibroblasts through epithelial-mesenchymal interactions
    Mutsumi Okazaki
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Plast Reconstr Surg 111:286-90. 2003
    ..In addition, it is possible that lost nails could be reconstructed with grafts of "tissue-engineered" nail equivalent...
  57. ncbi request reprint Lower face reduction with full-thickness marginal ostectomy of mandibular corpus-angle followed by corticectomy
    Toshitsugu Hirohi
    Ritz Cosmetic Surgery Clinic Tokyo, Shinagawa ku, Tokyo, Japan
    J Plast Reconstr Aesthet Surg 63:1251-9. 2010
    ..In addition, the limited mobility of the oscillating saw leads to semi-vertical ostectomy, and leaves unnatural mandibular contours, such as loss of the mandibular angle...
  58. ncbi request reprint Construction of pigmented skin equivalent and its application to the study of congenital disorders of pigmentation
    Mutsumi Okazaki
    Department of Plastic and Reconstructive Surgery, Graduate School of Medicine, University of Tokyo, Japan
    Scand J Plast Reconstr Surg Hand Surg 39:339-43. 2005
    ..Our results suggested that our pigmented skin equivalent is useful for the study of congenital hyperpigmentary disorders, although insufficient differentiation of keratinocytes might be a disadvantage...
  59. ncbi request reprint Characterization of wound drainage fluids as a source of soluble factors associated with wound healing: comparison with platelet-rich plasma and potential use in cell culture
    Emiko Aiba-Kojima
    Department of Plastic Surgery, University of Tokyo Hospital, Tokyo, Japan
    Wound Repair Regen 15:511-20. 2007
    ..SPRP and DF are economical ready-made mixtures of serum and autologous soluble factors, and may be differentially useful for regenerative therapies...
  60. doi request reprint Evaluation of animal models for the hair-inducing capacity of cultured human dermal papilla cells
    Keita Inoue
    Department of Plastic Surgery, University of Tokyo School of Medicine, Tokyo, Japan
    Cells Tissues Organs 190:102-10. 2009
    ..For translational research on cell therapies for hair regrowth with cultured human DP cells (hDPCs), a model to evaluate the capacity of hDPCs to induce hair formation is inevitable...
  61. ncbi request reprint Defects in aortic fusion and craniofacial vasculature in the holoprosencephalic mouse embryo under inhibition of sonic hedgehog signaling
    Takashi Nagase
    Clinical Research Center, National Hospital Organization Murayama Medical Center, 2 37 1 Gakuen, Musashimurayama City, Tokyo 208 0011, Japan
    J Craniofac Surg 17:736-44. 2006
    ..These results suggest that Shh signaling is essential for some aspects of embryonic angiogenesis, and that pathophysiology of holoprosencephaly may involve, at least in part, the Shh-dependent angiogenesis...
  62. ncbi request reprint Phosphorylated retinoid X receptor alpha loses its heterodimeric activity with retinoic acid receptor beta
    Kotaro Yoshimura
    Department of Medicine, Gifu University Graduate School of Medicine, Gifu, 501 1194, Japan
    Cancer Sci 98:1868-74. 2007
    ..In conclusion, the inhibition of RXRalpha phosphorylation and the restoration of its original function as a master regulator of nuclear receptors might therefore be an effective strategy for controlling cancer cell growth...
  63. pmc Participation of bone marrow-derived cells in fibrotic changes in denervated skeletal muscle
    Yasushi Mochizuki
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi cho, Kodaira, Tokyo 187 8502, Japan
    Am J Pathol 166:1721-32. 2005
    ..These findings identify elementary targets that may regulate the migration, homing, differentiation, and function of BM-DCs, leading to amelioration of the excessive fibrosis of denervated skeletal muscle...