Research Topics
Genomes and Genes
| Tadashi YoshidaSummaryAffiliation: University of Tokyo Country: Japan Publications
| Collaborators
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Detail Information
Publications
Kruppel-like factor 4 contributes to high phosphate-induced phenotypic switching of vascular smooth muscle cells into osteogenic cellsTadashi Yoshida
Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo 160 8582, Japan
J Biol Chem 287:25706-14. 2012..Klf4 was also induced markedly in the calcified aorta of adenine-induced uremic rats. Results provide novel evidence that Klf4 mediates high phosphate-induced conversion of SMCs into osteogenic cells...- Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardationTadashi Yoshida
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
J Biol Chem 285:21175-84. 2010..In vivo chromatin immunoprecipitation assays on the heart revealed that Klf4 bound to the promoter region of the Gata4 gene. Results provide novel evidence that Klf4 plays a key role in late fetal and/or postnatal cardiac development... - Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migrationOlga A Cherepanova
Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA
Circ Res 104:609-18. 2009.... - Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiationYueting Shang
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
J Cell Biol 181:461-73. 2008..Our results demonstrate that Pitx2 functions to regulate the early stages of SMC differentiation... 
Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expressionQiong Gan
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
Circ Res 101:883-92. 2007..Results also indicate that the MCAT element-mutated SM alpha-actin promoter-enhancer is a useful tool to direct gene expression selectively in differentiated SMCs...- Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipidsTadashi Yoshida
Dept of Molecular Physiology and Biological Physics, Univ of Virginia, MR5 Room 1226, 415 Lane Road, Charlottesville, VA 22908, USA
Am J Physiol Cell Physiol 295:C1175-82. 2008..Coimmunoprecipitation assays showed that Klf4 interacted with HDAC5. Results provide evidence that Klf4, Elk-1, and HDACs coordinately mediate POVPC-induced suppression of SMC differentiation marker genes... - Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cellsTadashi Yoshida
Department of Molecular Physiology and Biological Physics, University of Virginia, MR5 Room 1220, 415 Lane Road, PO Box 801394, Charlottesville, VA 22908, USA
Arterioscler Thromb Vasc Biol 24:1596-601. 2004..The aim of the present study was to determine whether myocardin alone is sufficient to induce SMC lineage in multipotential stem cells as evidenced by activation of the entire SMC differentiation program... - PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteinsKeiko Kawai-Kowase
Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Road, MR5, Room 1220, P O Box 801394, Charlottesville, VA 22908, USA
Mol Cell Biol 25:8009-23. 2005..These results provide novel evidence that PIAS1 modulates transcriptional activation of SMC marker genes through cooperative interactions with both SRF and class I bHLH proteins... - 5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivoJennifer A Hendrix
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
J Clin Invest 115:418-27. 2005.... - Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promotersTadashi Yoshida
Dept of Molecular Physiology and Biological Physics, Univ of Virginia, MR5 Rm 1220, 415 Lane Road, Charlottesville, VA 22908, USA
Am J Physiol Cell Physiol 292:C886-95. 2007.... - Myocardin and Prx1 contribute to angiotensin II-induced expression of smooth muscle alpha-actinTadashi Yoshida
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
Circ Res 94:1075-82. 2004..Taken together, these results support a model in which Ang II-induced increases in expression of SM alpha-actin are mediated through Prx1-dependent increases in SRF binding to CArG elements and subsequent recruitment of myocardin... - Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injuryTadashi Yoshida
Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908, USA
Circ Res 102:1548-57. 2008..Taken together, we have demonstrated that Klf4 plays a critical role in regulating expression of SMC differentiation markers and proliferation of SMCs in vivo in response to vascular injury... - The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodiesLi Jin
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
J Biol Chem 284:2121-30. 2009..All together, these results suggest that Palladin is essential for expression of the full complement of contractile proteins necessary for optimal force development of SMCs derived from EBs... - Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cellsQiong Gan
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
Stem Cells 25:2-9. 2007..Finally, we consider how these rapid histone modification exchanges become progressively more stable as ESCs undergo differentiation and maturation into specialized cell lineages... - MCAT elements and the TEF-1 family of transcription factors in muscle development and diseaseTadashi Yoshida
Department of Molecular Physiology and Biological Physics, University of Virginia, MR5 Room 1226, 415 Lane Road, Charlottesville, Virginia 22908, USA
Arterioscler Thromb Vasc Biol 28:8-17. 2008.... - Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitroNataliya A Pidkovka
University of Virginia, Cardiovascular Research Center, Department of Molecular Physiology and Biophysics, 415 Lane Road, Charlottesville, VA 22908, USA
Circ Res 101:792-801. 2007..These results may have important novel implications for the mechanisms by which oxPLs contribute to the pathogenesis of atherosclerosis... - Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genesTadashi Yoshida
Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908 0736, USA
Circ Res 92:856-64. 2003..Taken together, results provide compelling evidence that myocardin plays a key role as a transcriptional coactivator of SMC marker genes through CArG-dependent mechanisms... - Telomere length of normal leukocytes is affected by a functional polymorphism of hTERTYumiko Matsubara
Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
Biochem Biophys Res Commun 341:128-31. 2006..0117). These findings suggest that the functional (-1327)T/C polymorphism of hTERT is associated with leukocyte telomere length in normal individuals... - Molecular determinants of vascular smooth muscle cell diversityTadashi Yoshida
Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA
Circ Res 96:280-91. 2005.... 
A case-control study of calciphylaxis in Japanese end-stage renal disease patientsMatsuhiko Hayashi
Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan
Nephrol Dial Transplant 27:1580-4. 2012..Since no systematic studies of calciphylaxis have ever been performed in Japan, we conducted a nationwide survey and a case-control study to identify the characteristics of calciphylaxis in the Japanese dialysis population...