Tadashi Yoshida

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Smooth muscle-selective inhibition of nuclear factor-κB attenuates smooth muscle phenotypic switching and neointima formation following vascular injury
    Tadashi Yoshida
    Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan
    J Am Heart Assoc 2:e000230. 2013
  2. pmc Kruppel-like factor 4 contributes to high phosphate-induced phenotypic switching of vascular smooth muscle cells into osteogenic cells
    Tadashi Yoshida
    Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 287:25706-14. 2012
  3. pmc Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 285:21175-84. 2010
  4. pmc Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration
    Olga A Cherepanova
    Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA
    Circ Res 104:609-18. 2009
  5. ncbi request reprint Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression
    Qiong Gan
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Circ Res 101:883-92. 2007
  6. pmc Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
    Yueting Shang
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 181:461-73. 2008
  7. pmc Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids
    Tadashi Yoshida
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, MR5 Room 1226, 415 Lane Road, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 295:C1175-82. 2008
  8. ncbi request reprint Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, MR5 Room 1220, 415 Lane Road, PO Box 801394, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 24:1596-601. 2004
  9. pmc The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies
    Li Jin
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:2121-30. 2009
  10. pmc PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins
    Keiko Kawai-Kowase
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Road, MR5, Room 1220, P O Box 801394, Charlottesville, VA 22908, USA
    Mol Cell Biol 25:8009-23. 2005

Collaborators

Detail Information

Publications37

  1. pmc Smooth muscle-selective inhibition of nuclear factor-κB attenuates smooth muscle phenotypic switching and neointima formation following vascular injury
    Tadashi Yoshida
    Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan
    J Am Heart Assoc 2:e000230. 2013
    ..Although activation of the nuclear factor-κB (NF-κB) pathway in vessels has been shown to be critical for the progression of vascular diseases, the cell-autonomous role of NF-κB within SMCs has not been fully understood...
  2. pmc Kruppel-like factor 4 contributes to high phosphate-induced phenotypic switching of vascular smooth muscle cells into osteogenic cells
    Tadashi Yoshida
    Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 287:25706-14. 2012
    ..Klf4 was also induced markedly in the calcified aorta of adenine-induced uremic rats. Results provide novel evidence that Klf4 mediates high phosphate-induced conversion of SMCs into osteogenic cells...
  3. pmc Smooth and cardiac muscle-selective knock-out of Kruppel-like factor 4 causes postnatal death and growth retardation
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Biol Chem 285:21175-84. 2010
    ..In vivo chromatin immunoprecipitation assays on the heart revealed that Klf4 bound to the promoter region of the Gata4 gene. Results provide novel evidence that Klf4 plays a key role in late fetal and/or postnatal cardiac development...
  4. pmc Oxidized phospholipids induce type VIII collagen expression and vascular smooth muscle cell migration
    Olga A Cherepanova
    Department of Molecular Physiology and Biological Physics, University of Virginia, Robert M Berne Cardiovascular Research Center, Charlottesville, VA 22908, USA
    Circ Res 104:609-18. 2009
    ....
  5. ncbi request reprint Smooth muscle cells and myofibroblasts use distinct transcriptional mechanisms for smooth muscle alpha-actin expression
    Qiong Gan
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Circ Res 101:883-92. 2007
    ..Results also indicate that the MCAT element-mutated SM alpha-actin promoter-enhancer is a useful tool to direct gene expression selectively in differentiated SMCs...
  6. pmc Pitx2 is functionally important in the early stages of vascular smooth muscle cell differentiation
    Yueting Shang
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Cell Biol 181:461-73. 2008
    ..Our results demonstrate that Pitx2 functions to regulate the early stages of SMC differentiation...
  7. pmc Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids
    Tadashi Yoshida
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, MR5 Room 1226, 415 Lane Road, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 295:C1175-82. 2008
    ..Coimmunoprecipitation assays showed that Klf4 interacted with HDAC5. Results provide evidence that Klf4, Elk-1, and HDACs coordinately mediate POVPC-induced suppression of SMC differentiation marker genes...
  8. ncbi request reprint Forced expression of myocardin is not sufficient for induction of smooth muscle differentiation in multipotential embryonic cells
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, MR5 Room 1220, 415 Lane Road, PO Box 801394, Charlottesville, VA 22908, USA
    Arterioscler Thromb Vasc Biol 24:1596-601. 2004
    ..The aim of the present study was to determine whether myocardin alone is sufficient to induce SMC lineage in multipotential stem cells as evidenced by activation of the entire SMC differentiation program...
  9. pmc The actin-associated protein Palladin is required for development of normal contractile properties of smooth muscle cells derived from embryoid bodies
    Li Jin
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Biol Chem 284:2121-30. 2009
    ..All together, these results suggest that Palladin is essential for expression of the full complement of contractile proteins necessary for optimal force development of SMCs derived from EBs...
  10. pmc PIAS1 activates the expression of smooth muscle cell differentiation marker genes by interacting with serum response factor and class I basic helix-loop-helix proteins
    Keiko Kawai-Kowase
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Road, MR5, Room 1220, P O Box 801394, Charlottesville, VA 22908, USA
    Mol Cell Biol 25:8009-23. 2005
    ..These results provide novel evidence that PIAS1 modulates transcriptional activation of SMC marker genes through cooperative interactions with both SRF and class I bHLH proteins...
  11. pmc 5' CArG degeneracy in smooth muscle alpha-actin is required for injury-induced gene suppression in vivo
    Jennifer A Hendrix
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 115:418-27. 2005
    ....
  12. ncbi request reprint Platelet-derived growth factor-BB represses smooth muscle cell marker genes via changes in binding of MKL factors and histone deacetylases to their promoters
    Tadashi Yoshida
    Dept of Molecular Physiology and Biological Physics, Univ of Virginia, MR5 Rm 1220, 415 Lane Road, Charlottesville, VA 22908, USA
    Am J Physiol Cell Physiol 292:C886-95. 2007
    ....
  13. ncbi request reprint Myocardin and Prx1 contribute to angiotensin II-induced expression of smooth muscle alpha-actin
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    Circ Res 94:1075-82. 2004
    ..Taken together, these results support a model in which Ang II-induced increases in expression of SM alpha-actin are mediated through Prx1-dependent increases in SRF binding to CArG elements and subsequent recruitment of myocardin...
  14. pmc Conditional deletion of Krüppel-like factor 4 delays downregulation of smooth muscle cell differentiation markers but accelerates neointimal formation following vascular injury
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, 415 Lane Rd, Charlottesville, VA 22908, USA
    Circ Res 102:1548-57. 2008
    ..Taken together, we have demonstrated that Klf4 plays a critical role in regulating expression of SMC differentiation markers and proliferation of SMCs in vivo in response to vascular injury...
  15. doi request reprint High glucose concentration does not modulate the formation of arterial medial calcification in experimental uremic rats
    Tadashi Yoshida
    Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan
    J Vasc Res 50:512-20. 2013
    ..Results suggest that glucose concentration does not directly modulate high phosphate-induced SMC phenotypic switching and arterial medial calcification...
  16. pmc Induction of T-cell activation or anergy determined by the combination of intensity and duration of T-cell receptor stimulation, and sequential induction in an individual cell
    Tomohiro Yamamoto
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Immunology 121:383-91. 2007
    ..We also show that the calcineurin signal controlled the induction of activation or anergy depending on the activity. This study contributes to better understanding of the precise mechanism for inducing T-cell anergy...
  17. ncbi request reprint Concise review: epigenetic mechanisms contribute to pluripotency and cell lineage determination of embryonic stem cells
    Qiong Gan
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    Stem Cells 25:2-9. 2007
    ..Finally, we consider how these rapid histone modification exchanges become progressively more stable as ESCs undergo differentiation and maturation into specialized cell lineages...
  18. ncbi request reprint Regulation of T cell activation and anergy by the intensity of the Ca²+ signal in cooperation with other signals
    Yu Adachi
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Biosci Biotechnol Biochem 74:1788-93. 2010
    ....
  19. ncbi request reprint Oral administration of IL-12 abrogates the induction but not the maintenance of oral tolerance
    Tadashi Yoshida
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Int Arch Allergy Immunol 140:306-14. 2006
    ..IL-12 induced by food factors may also affect the induction of oral tolerance. In this study we examined the effect of the oral administration of IL-12 on the induction and maintenance of oral tolerance...
  20. doi request reprint Multifunctionalities of oleyl-branched oligosaccharide phosphate from potato starch with a high phosphate content
    Taichi Ikehara
    Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Agric Food Chem 59:4962-8. 2011
    ..These results show that OA-BOS-P could be a useful material with novel emulsifying, Ca(2+)-binding, and starchy food-controlling properties...
  21. doi request reprint An increased number of CD4+CD25+ cells induced by an oral administration of Lactobacillus plantarum NRIC0380 are involved in antiallergic activity
    Tadashi Yoshida
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Int Arch Allergy Immunol 162:283-9. 2013
    ..We therefore examined in detail the antiallergic activity of Treg cells obtained from mice that had been fed NRIC0380...
  22. ncbi request reprint Myocardin is a key regulator of CArG-dependent transcription of multiple smooth muscle marker genes
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, PO Box 800736, Charlottesville, VA 22908 0736, USA
    Circ Res 92:856-64. 2003
    ..Taken together, results provide compelling evidence that myocardin plays a key role as a transcriptional coactivator of SMC marker genes through CArG-dependent mechanisms...
  23. ncbi request reprint Contribution of the net charge to the regulatory effects of amino acids and epsilon-poly(L-lysine) on the gelatinization behavior of potato starch granules
    Azusa Ito
    Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Biosci Biotechnol Biochem 70:76-85. 2006
    ..The amino acids and PL were easily retained by the swollen potato starch granules according to replacement of the outer solution of the starch granules...
  24. ncbi request reprint Improved physical and biochemical features of a collagen membrane by conjugating with soluble egg shell membrane protein
    Tamao Ino
    Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    Biosci Biotechnol Biochem 70:865-73. 2006
    ....
  25. ncbi request reprint Introducing site-specific glycosylation using protein engineering techniques reduces the immunogenicity of β-lactoglobulin
    Yoshiyuki Tatsumi
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Biosci Biotechnol Biochem 76:478-85. 2012
    ..We conclude that site-specific glycosylation is an effective method to reduce the immunogenicity of BLG, and that masking of epitopes by high-mannose chains is effective to reduce immunogenicity...
  26. ncbi request reprint Effect of sorbed water on the thermal stability of soybean protein
    Hiroshi Tsukada
    Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan
    Biosci Biotechnol Biochem 70:2096-103. 2006
    ....
  27. ncbi request reprint MCAT elements and the TEF-1 family of transcription factors in muscle development and disease
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, MR5 Room 1226, 415 Lane Road, Charlottesville, Virginia 22908, USA
    Arterioscler Thromb Vasc Biol 28:8-17. 2008
    ....
  28. pmc Deletion of Krüppel-like factor 4 in endothelial and hematopoietic cells enhances neointimal formation following vascular injury
    Tadashi Yoshida
    Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, 160 8582, Japan
    J Am Heart Assoc 3:e000622. 2014
    ..Because Klf4 is also expressed in non-SMCs including endothelial cells (ECs), we determined if Tie2 promoter-dependent deletion of Klf4 in ECs and hematopoietic cells affected injury-induced neointimal formation...
  29. ncbi request reprint Lactobacillus plantarum NRIC1832 enhances IL-10 production from CD4⁺ T cells in vitro
    Sayo Noguchi
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Biosci Biotechnol Biochem 76:1925-31. 2012
    ....
  30. ncbi request reprint Oxidized phospholipids induce phenotypic switching of vascular smooth muscle cells in vivo and in vitro
    Nataliya A Pidkovka
    University of Virginia, Cardiovascular Research Center, Department of Molecular Physiology and Biophysics, 415 Lane Road, Charlottesville, VA 22908, USA
    Circ Res 101:792-801. 2007
    ..These results may have important novel implications for the mechanisms by which oxPLs contribute to the pathogenesis of atherosclerosis...
  31. ncbi request reprint Telomere length of normal leukocytes is affected by a functional polymorphism of hTERT
    Yumiko Matsubara
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Biochem Biophys Res Commun 341:128-31. 2006
    ..0117). These findings suggest that the functional (-1327)T/C polymorphism of hTERT is associated with leukocyte telomere length in normal individuals...
  32. ncbi request reprint Molecular determinants of vascular smooth muscle cell diversity
    Tadashi Yoshida
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA
    Circ Res 96:280-91. 2005
    ....
  33. ncbi request reprint Role of Krüppel-like factor 4 and its binding proteins in vascular disease
    Tadashi Yoshida
    Apheresis and Dialysis Center, School of Medicine, Keio University
    J Atheroscler Thromb 21:402-13. 2014
    ..This article summarizes the role of KLF4 in vascular disease with a particular focus on in vivo studies and reviews recent progress in our understanding of the regulatory mechanisms involved in KLF4- mediated gene transcription...
  34. ncbi request reprint Reduced T cell response to beta-lactoglobulin by conjugation with acidic oligosaccharides
    Tadashi Yoshida
    Department of Applied Biological Science, Tokyo University of Agriculture and Technology, Tokyo, Japan
    J Agric Food Chem 53:6851-7. 2005
    ..Our observations indicate that the method used in this study could be applied to various protein allergens to achieve reduced allergenicity with multiple improvements in their properties...
  35. ncbi request reprint Interfacial behavior of fatty-acylated sericin prepared by lipase-catalyzed solid-phase synthesis
    Masato Ogino
    Department of Applied Biological Science, Faculty of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan
    Biosci Biotechnol Biochem 70:66-75. 2006
    ....
  36. doi request reprint Efficacy of high-dose intravenous immunoglobulin therapy in Japanese patients with steroid-resistant polymyositis and dermatomyositis
    Eizo Saito
    Department of Rheumatology, Toho University Ohashi Medical Center, Tokyo, Japan
    Mod Rheumatol 18:34-44. 2008
    ..8%) during the study period, but none of the adverse reactions were considered to be serious or required emergency treatment. In conclusion, the present study indicates that IVIG therapy is effective for steroid-resistant PM/DM...
  37. doi request reprint A case-control study of calciphylaxis in Japanese end-stage renal disease patients
    Matsuhiko Hayashi
    Apheresis and Dialysis Center, School of Medicine, Keio University, Tokyo, Japan
    Nephrol Dial Transplant 27:1580-4. 2012
    ..Since no systematic studies of calciphylaxis have ever been performed in Japan, we conducted a nationwide survey and a case-control study to identify the characteristics of calciphylaxis in the Japanese dialysis population...