Haruhiko Yoshida

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi Use of a gastric juice-based PCR assay to detect Helicobacter pylori infection in culture-negative patients
    H Yoshida
    Second Department of Internal Medicine, University of Tokyo, Japan
    J Clin Microbiol 36:317-20. 1998
  2. ncbi Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Japan
    Ann Intern Med 131:174-81. 1999
  3. ncbi Determination of the optimal cut-off value for the [13C]-urea breath test based on a Helicobacter pylori-specific polymerase chain reaction assay
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Bunkyo, Japan
    J Gastroenterol Hepatol 15:155-60. 2000
  4. ncbi Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
    Haruhiko Yoshida
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, and Department of Gastroenterology and Hepatology, Kanto Central Hospital, Tokyo, Japan
    Hepatology 54:532-40. 2011
  5. ncbi Benefit of interferon therapy in hepatocellular carcinoma prevention for individual patients with chronic hepatitis C
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gut 53:425-30. 2004
  6. ncbi Interferon therapy prolonged life expectancy among chronic hepatitis C patients
    Haruhiko Yoshida
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Bunkyo, Tokyo, Japan
    Gastroenterology 123:483-91. 2002
  7. ncbi The effect of Helicobacter pylori eradication on reducing the incidence of gastric cancer
    Keiji Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Clin Gastroenterol 42:279-83. 2008
  8. ncbi Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Gastroenterol 107:569-77; quiz 578. 2012
  9. ncbi Management of occluded uncovered metallic stents in patients with malignant distal biliary obstructions using covered metallic stents
    Osamu Togawa
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Gastroenterol 42:546-9. 2008
  10. ncbi Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1570-5. 2011

Detail Information

Publications111 found, 100 shown here

  1. ncbi Use of a gastric juice-based PCR assay to detect Helicobacter pylori infection in culture-negative patients
    H Yoshida
    Second Department of Internal Medicine, University of Tokyo, Japan
    J Clin Microbiol 36:317-20. 1998
    ..The PCR assay is recommended to confirm the H. pylori status of culture-negative peptic-ulcer patients...
  2. ncbi Interferon therapy reduces the risk for hepatocellular carcinoma: national surveillance program of cirrhotic and noncirrhotic patients with chronic hepatitis C in Japan. IHIT Study Group. Inhibition of Hepatocarcinogenesis by Interferon Therapy
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Japan
    Ann Intern Med 131:174-81. 1999
    ..Previous studies on the effect of interferon therapy on the incidence of hepatocellular carcinoma have not sufficiently assessed degree of liver fibrosis, a major risk factor for hepatocellular carcinoma...
  3. ncbi Determination of the optimal cut-off value for the [13C]-urea breath test based on a Helicobacter pylori-specific polymerase chain reaction assay
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Bunkyo, Japan
    J Gastroenterol Hepatol 15:155-60. 2000
    ..7% at 20 min had the longest distance, being separated by 3.16 SD from the two mean values. Using this cut-off value, the urea breath test showed 100% specificity and 98% sensitivity for the diagnosis of Helicobacter pylori infection...
  4. ncbi Effect of vitamin K2 on the recurrence of hepatocellular carcinoma
    Haruhiko Yoshida
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, and Department of Gastroenterology and Hepatology, Kanto Central Hospital, Tokyo, Japan
    Hepatology 54:532-40. 2011
    ..CONCLUSION: Efficacy of vitamin K2 in suppressing HCC recurrence was not confirmed in this double-blind, randomized, placebo-controlled study...
  5. ncbi Benefit of interferon therapy in hepatocellular carcinoma prevention for individual patients with chronic hepatitis C
    H Yoshida
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gut 53:425-30. 2004
    ..Interferon therapy for chronic hepatitis C, in general, has been shown to prevent HCC...
  6. ncbi Interferon therapy prolonged life expectancy among chronic hepatitis C patients
    Haruhiko Yoshida
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Bunkyo, Tokyo, Japan
    Gastroenterology 123:483-91. 2002
    ..The effects of interferon therapy in chronic hepatitis C patients on survival are unclear. Our objective was to analyze survival among a large cohort of chronic hepatitis C patients...
  7. ncbi The effect of Helicobacter pylori eradication on reducing the incidence of gastric cancer
    Keiji Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    J Clin Gastroenterol 42:279-83. 2008
    ..017) between the groups, but not for undifferentiated cancer (P=0.847). The results of the current study suggest that the eradication of H. pylori infection reduces the incidence of gastric cancer...
  8. ncbi Radiofrequency ablation for hepatocellular carcinoma: 10-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Am J Gastroenterol 107:569-77; quiz 578. 2012
    ..However, there has been no report on 10-year outcome of RFA. The objective of this study was to report a 10-year consecutive case series at a tertiary referral center...
  9. ncbi Management of occluded uncovered metallic stents in patients with malignant distal biliary obstructions using covered metallic stents
    Osamu Togawa
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Clin Gastroenterol 42:546-9. 2008
    ..Currently, there is no consensus on the management of occluded EMSs. We evaluated the efficacy of a covered EMS as a second endoprosthesis in patients with an occluded EMS...
  10. ncbi Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration
    Kosuke Sakitani
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:1570-5. 2011
    ..We aimed to elucidate the association between gastric cancer risk and the distribution of precancerous lesions in the stomach by histological analyses...
  11. ncbi Hepatocellular carcinoma with extrahepatic metastasis: clinical features and prognostic factors
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer 117:4475-83. 2011
    ..The objective of this study was to further elucidate the clinical course and prognostic determinants of patients with this disease...
  12. ncbi Percutaneous radiofrequency ablation for hepatocellular carcinoma. An analysis of 1000 cases
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Cancer 103:1201-9. 2005
    ..8%, 75.6%, 62.4%, 53.7%, and 38.2% for nonnaive patients, respectively. CONCLUSIONS: The authors confirmed the safety and efficacy of RFA for HCC in a large-scale series and long-term prognosis was satisfactory...
  13. ncbi Evaluation of molecular targeted cancer drug by changes in tumor marker doubling times
    Kenichiro Enooku
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:71-8. 2012
    ..We evaluated the usefulness of tumor marker doubling time (DT) as an efficacy indicator of a molecular targeted anticancer agent...
  14. ncbi Evaluation of transcatheter arterial embolization prior to percutaneous tumor ablation in patients with hepatocellular carcinoma: a randomized controlled trial
    Masatoshi Akamatsu
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Liver Int 24:625-9. 2004
    ..We continued the study after the introduction of RFA and compared TAE combined with RFA (TAE/RFA) with RFA only...
  15. ncbi Obesity is an independent risk factor for hepatocellular carcinoma development in chronic hepatitis C patients
    Takamasa Ohki
    Department of Gastroenterology, University of Tokyo, Hongo, Tokyo, Japan
    Clin Gastroenterol Hepatol 6:459-64. 2008
    ..The aim of this study was to investigate the relationship between body weight and risk of hepatocarcinogenesis in chronic hepatitis C patients...
  16. ncbi Systemic combination therapy of intravenous continuous 5-fluorouracil and subcutaneous pegylated interferon alfa-2a for advanced hepatocellular carcinoma
    Koji Uchino
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:1152-9. 2012
    ....
  17. ncbi Assessment of liver stiffness in patients after living donor liver transplantation by transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Japan
    Scand J Gastroenterol 44:1115-20. 2009
    ..The aim of this study was to evaluate the usefulness of transient elastography for the assessment of fibrosis in patients after living donor LT...
  18. ncbi Sustained viral response prolonged survival of patients with C-viral hepatocellular carcinoma
    Masatoshi Akamatsu
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Liver Int 26:536-42. 2006
    ..We conducted this retrospective study to evaluate the position of interferon therapy in the curative treatment of hepatitis C virus-associated hepatocellular carcinoma (HCC)...
  19. ncbi Gain of GRHL2 is associated with early recurrence of hepatocellular carcinoma
    Yasuo Tanaka
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 49:746-57. 2008
    ..The aim of this study is to identify genomic changes that might be implicated in hepatocellular carcinoma (HCC) progression, and evaluate the associations with clinico-pathological features...
  20. ncbi Assessment of the risk factors for colonic diverticular hemorrhage
    Atsuo Yamada
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Dis Colon Rectum 51:116-20. 2008
    ..Studies about risk factors, other than nonsteroidal anti-inflammatory drugs, for colonic diverticular hemorrhage are limited. We conducted the present study to elucidate their significance as a risk factor...
  21. ncbi A randomized controlled trial of radiofrequency ablation with ethanol injection for small hepatocellular carcinoma
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 129:122-30. 2005
    ..Percutaneous radiofrequency ablation is a recently introduced treatment for hepatocellular carcinoma, whereas ethanol injection is now a standard therapy. We compared their long-term outcomes...
  22. ncbi Value of post-vascular phase (Kupffer imaging) by contrast-enhanced ultrasonography using Sonazoid in the detection of hepatocellular carcinoma
    Eriko Goto
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 47:477-85. 2012
    ....
  23. ncbi The effectiveness of liraglutide in nonalcoholic fatty liver disease patients with type 2 diabetes mellitus compared to sitagliptin and pioglitazone
    Takamasa Ohki
    Department of Gastroenterology, Mitsui Memorial Hospital, Kanda Izumicho 1, Chiyoda ku, Tokyo, Japan
    ScientificWorldJournal 2012:496453. 2012
    ..04; 95% CI 1.12-73.1, P = 0.04). CONCLUSIONS. Administration of liraglutide improved T2DM but also improvement of liver inflammation, alteration of liver fibrosis, and reduction of body weight...
  24. ncbi Percutaneous ethanol injection for hepatocellular carcinoma: 20-year outcome and prognostic factors
    Shuichiro Shiina
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Liver Int 32:1434-42. 2012
    ..Ethanol injection is the best-known image-guided percutaneous ablation for hepatocellular carcinoma (HCC) and a well-tolerated, inexpensive procedure with few adverse effects. However, there have been few reports on its long-term results...
  25. ncbi Efficacy and safety of low-pressured and short-time dilation in endoscopic papillary balloon dilation for bile duct stone removal
    Takeshi Tsujino
    Departments of Gastroenterology, Japanese Red Cross Medical Center, Tokyo, Japan
    J Gastroenterol Hepatol 23:867-71. 2008
    ..Pancreatitis after EPBD is believed to be related to papillary damage after balloon dilation. We changed the dilation method to a theoretically less hazardous one. This modified dilation method was compared with the initial method...
  26. ncbi Prediction of hepatocellular carcinoma development by plasma ADAMTS13 in chronic hepatitis B and C
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    Cancer Epidemiol Biomarkers Prev 20:2204-11. 2011
    ....
  27. ncbi Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses
    Yoku Hayakawa
    Department of Gastroenterology, University of Tokyo, Tokyo 113 8655, Japan
    Gastroenterology 138:1055-67.e1-4. 2010
    ..Apoptosis signal-regulating kinase 1 (ASK1) is a MAPK kinase kinase; little is known about the role of ASK1 in colonic disease. We assessed the involvement of ASK1 in the development of intestinal inflammation and CAC...
  28. ncbi Recurrent hepatocellular carcinoma has an increased risk of subsequent recurrence after curative treatment
    Noriyo Yamashiki
    Department of Gastroenterology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 22:2155-60. 2007
    ..The aim of this study was to evaluate the difference in the risk for subsequent recurrence, if any, between primary and recurrent cases...
  29. ncbi Hepatocellular carcinoma in viral hepatitis: improving standard therapy
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Best Pract Res Clin Gastroenterol 22:1137-51. 2008
    ..Prevention of HCC recurrence, or tertiary prevention, is one of the most challenging tasks in current hepatology...
  30. ncbi Risk assessment for delayed hemorrhagic complication of colonic polypectomy: polyp-related factors and patient-related factors
    Hirotsugu Watabe
    Department of Gastroenterology, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan 113-8655
    Gastrointest Endosc 64:73-8. 2006
    ..CONCLUSIONS: Hypertension is a significant risk factor for delayed colorectal postpolypectomy hemorrhage. The interval between polypectomy and hemorrhage can be as long as 14 days in the presence of hypertension...
  31. ncbi Endoscopic management of biliocutaneous fistula after percutaneous radiofrequency ablation therapy for hepatocellular carcinoma
    Takeshi Tsujino
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Dig Endosc 22:53-5. 2010
    ..Biliocutaneous fistula is an extremely rare complication after percutaneous RFA, and the present case report suggests that endoscopic drainage is the first-line therapy for bile leaks after RFA...
  32. ncbi Treatment strategy for hepatocellular carcinoma: expanding the indications for radiofrequency ablation
    Ryosuke Tateishi
    Department of Gastroenterology, The University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 44:142-6. 2009
    ..This study investigated whether an apparent threshold exists in the diameter and number of nodules in terms of the prognosis of patients with HCC...
  33. ncbi The effect of body weight reduction on the incidence of colorectal adenoma
    Yutaka Yamaji
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Am J Gastroenterol 103:2061-7. 2008
    ..Obesity is thought to be associated with colorectal cancer and adenoma. We aimed to investigate the effect of body weight on the risk of colorectal adenoma both in cross-sectional and longitudinal analyses...
  34. ncbi Efficacy and safety of metallic stents in patients with unresectable pancreatic cancer receiving gemcitabine
    Yousuke Nakai
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Pancreas 37:405-10. 2008
    ..Expandable metallic stents (EMSs) are widely used to palliate unresectable malignant biliary obstructions. The efficacy and safety of EMS in patients receiving gemcitabine (GEM) for unresectable pancreatic cancer is evaluated...
  35. ncbi The malignant potential of freshly developed colorectal polyps according to age
    Yutaka Yamaji
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Cancer Epidemiol Biomarkers Prev 15:2418-21. 2006
    ..Newly developed adenomas found at the follow-up colonoscopies will reflect the exact relation between malignant potential and the age of development of colorectal polyps...
  36. ncbi Age-related comparison of the profiles of patients with hepatocellular carcinoma
    Tomonori Fujishima
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan
    Hepatogastroenterology 53:913-8. 2006
    ..Concerning hepatocarcinogenesis, male and HBsAg positive patients were at high risk in young. Of the HCV-related HCC patients, heavy drinking may accelerate the progression from chronic hepatitis to cirrhosis and HCC...
  37. ncbi Prediction of recurrence of hepatocellular carcinoma after curative ablation using three tumor markers
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 44:1518-27. 2006
    ..In conclusion, tumor markers pre- and post-ablation were significant predictors for HCC recurrence and can complement imaging modalities in the evaluation of treatment efficacy...
  38. ncbi Neither hepatitis C virus genotype nor virus load affects survival of patients with hepatocellular carcinoma
    Masatoshi Akamatsu
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Eur J Gastroenterol Hepatol 16:459-66. 2004
    ..958) were significant predictors for survival (P = 0.814 and 0.958, respectively) and recurrence (P = 0.505 and 0.736, respectively). CONCLUSIONS: Neither genotype nor virus load of HCV affected prognosis of HCC patients...
  39. ncbi Interferon therapy after tumor ablation improves prognosis in patients with hepatocellular carcinoma associated with hepatitis C virus
    Yasushi Shiratori
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113, Japan
    Ann Intern Med 138:299-306. 2003
    ..Even after the surgical or medical treatment of hepatocellular carcinoma, tumors frequently develop at new foci, leading to a poor prognosis...
  40. ncbi Endoscopic papillary balloon dilation for bile duct stone removal in patients 60 years old or younger
    Takeshi Tsujino
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Gastroenterol 45:1072-9. 2010
    ..The aim of this study was to evaluate short- and long-term outcomes in relatively young patients (≤ 60 years old) who underwent endoscopic papillary balloon dilation (EPBD) for bile duct stone removal...
  41. ncbi Preservation of papillary relaxation after endoscopic papillary balloon dilation
    Shintaro Kondo
    Department of Gastroenterology University of Tokyo, Bunkyo ku, Tokyo, 113 8655, Japan
    Hepatogastroenterology 55:855-8. 2008
    ..Several manometric studies have suggested that endoscopic papillary balloon dilation can be expected to preserve papillary function. However, the aspect of the preservation of postprandial relaxation has not been addressed...
  42. ncbi Outcomes after clearance of pancreatic stones with or without pancreatic stenting
    Naoki Sasahira
    Department of Gastroenterology, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 42:63-9. 2007
    ..Treatment for stricture of the main pancreatic duct (MPD) with a pancreatic stent after clearance of pancreatic stones may reduce the recurrence of pancreatic symptoms and stones...
  43. ncbi Functional variability of cagA gene in Japanese isolates of Helicobacter pylori
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Gene 343:165-72. 2004
    ..pylori induces distinct diseases on host...
  44. ncbi Right-side shift of metachronous colorectal adenomas after polypectomy
    Yutaka Yamaji
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Scand J Gastroenterol 42:1466-72. 2007
    ..The aim of the present study was to investigate the location of metachronous colorectal adenomas after endoscopic polypectomy...
  45. ncbi Risk assessment of hepatocellular carcinoma in chronic hepatitis C patients by transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    J Clin Gastroenterol 42:839-43. 2008
    ..In this cross-sectional study, we investigated the relationship between liver stiffness and HCC presence...
  46. ncbi Prospective risk assessment for hepatocellular carcinoma development in patients with chronic hepatitis C by transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatology 49:1954-61. 2009
    ..The utility of LSM is not limited to a surrogate for liver biopsy but can be applied as an indicator of the wide range of the risk of HCC development...
  47. ncbi Extrahepatic metastasis of hepatocellular carcinoma: incidence and risk factors
    Miho Kanda
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Liver Int 28:1256-63. 2008
    ..Extrahepatic metastasis of hepatocellular carcinoma (HCC) is of growing importance as the survival of patients has been improved owing to advances in treatments to intrahepatic lesions...
  48. ncbi Risk factors for acute suppurative cholangitis caused by bile duct stones
    Takeshi Tsujino
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Eur J Gastroenterol Hepatol 19:585-8. 2007
    ..The major cause of acute suppurative cholangitis is bile duct stones, but it is not known which patients with bile duct stones are likely to develop acute suppurative cholangitis...
  49. ncbi Autotaxin as a novel serum marker of liver fibrosis
    Hayato Nakagawa
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Clin Chim Acta 412:1201-6. 2011
    ..Serum ATX enzymatic activity reportedly increases in parallel with liver fibrosis and exhibits a gender difference...
  50. ncbi NF-kappaB and ERK-signaling pathways contribute to the gene expression induced by cag PAI-positive-Helicobacter pylori infection
    Wataru Shibata
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Gastroenterol 11:6134-43. 2005
    ....
  51. ncbi Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients
    Toru Arano
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655
    Int J Cancer 129:2226-35. 2011
    ..In conclusion, Patients who had CHC with high serum adiponectin levels had a higher risk of liver cancer development. Adiponectin may thus be tumorigenic or indicate a liver disease state independently of other clinical parameters...
  52. ncbi Withdrawal times affects polyp and diverticulum detection on the right-side colon
    Haruka Kajiwara
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 59:108-11. 2012
    ..We aimed to investigate the association between colorectal polyp detection rates and withdrawal times, and also to investigate diverticulum detection rates as a counterpart lesion...
  53. ncbi Altered composition of fatty acids exacerbates hepatotumorigenesis during activation of the phosphatidylinositol 3-kinase pathway
    Yotaro Kudo
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Hepatol 55:1400-8. 2011
    ....
  54. ncbi Increased liver elasticity in patients with biliary obstruction
    Yoko Yashima
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    J Gastroenterol 46:86-91. 2011
    ..Because little is known about liver elasticity in patients with obstructive jaundice, we evaluated this feature in these patients...
  55. ncbi Efficacy and safety of faropenem in eradication therapy of Helicobacter pylori
    Keiji Ogura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Helicobacter 12:618-22. 2007
    ..To seek a better regimen for eradication therapy, we assessed the sensitivity of clinical strains seen in Japan to faropenem and then evaluated the efficacy and safety of eradication therapy containing this antibiotic...
  56. ncbi Clinical relevance of Helicobacter pylori sabA genotype in Japanese clinical isolates
    Ayako Yanai
    Division of Gastroenterology, The Institute for Adult Diseases, Asahi Life Foundation, Chiyoda ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:2228-32. 2007
    ..The aim of this study was to assess the relationship between the status of H. pylori sialic acid-binding adhesin (sabA) and the severity of gastric inflammation and diseases...
  57. ncbi [Cost-effectiveness of antiviral therapy for chronic hepatitis C patients in prevention of hepatocellular cancer ]
    Haruhiko Yoshida
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine
    Nippon Rinsho 62:511-4. 2004
  58. ncbi Comparison of liver biopsy and transient elastography based on clinical relevance
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Can J Gastroenterol 22:753-7. 2008
    ..Liver stiffness measurement (LSM) by transient elastography has recently been validated for the evaluation of liver fibrosis in chronic liver diseases. The present study focused on cases in which liver biopsy and LSM were discordant...
  59. ncbi Factors affecting the prognosis of patients with hepatocellular carcinoma invading the portal vein--a retrospective analysis using 952 consecutive HCC patients
    Yukihiro Koike
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Hepatogastroenterology 50:2035-9. 2003
    ..Hepatocellular carcinoma with portal venous invasion has a very poor prognosis. The aim of this study is to clarify the factors contributing to the survival of hepatocellular carcinoma patients with portal venous invasion...
  60. ncbi Hemorrhagic complications of percutaneous radiofrequency ablation for liver tumors
    Eriko Goto
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    J Clin Gastroenterol 44:374-80. 2010
    ..1% to 0.5% mortality. This study analyzed the risk factors and management of hemorrhagic complications, such as hemoperitoneum, hemothorax, and hemobilia...
  61. ncbi Obesity did not diminish the efficacy of percutaneous ablation for hepatocellular carcinoma
    Takamasa Ohki
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Liver Int 27:360-7. 2007
    ..In addition, overweight may affect the treatment efficacy of ultrasound-guided percutaneous ablation. We evaluated the impact of overweight on the safety and efficacy of percutaneous ablation to hepatocellular carcinoma (HCC)...
  62. ncbi Twenty-four weeks of interferon alpha-2b in combination with ribavirin for Japanese hepatitis C patients: sufficient treatment period for patients with genotype 2 but not for patients with genotype 1
    Keiichi Fujiwara
    Department of Medicine and Clinical Oncology, Graduate School of Medicine, Chiba University, Chiba, Japan
    Liver Int 26:520-8. 2006
    ..CONCLUSION: Our current study showed that a 24-week course of IFN plus ribavirin combination therapy was effective with respect to virologic response in Japanese hepatitis C patients, particularly in patients with HCV genotype 2...
  63. ncbi Prognostic significance of genetic alterations detected by high-density single nucleotide polymorphism array in gastric cancer
    Motohisa Tada
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Cancer Sci 101:1261-9. 2010
    ..Using high-density SNP arrays, we identified several novel and minute genomic alterations. LOH of four genes could be useful for prediction of lymph node metastasis and prognosis in early stage gastric cancers...
  64. ncbi Ulinastatin for pancreatitis after endoscopic retrograde cholangiopancreatography: a randomized, controlled trial
    Takeshi Tsujino
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Gastroenterol Hepatol 3:376-83. 2005
    ..Because ulinastatin, a protease inhibitor, has proved effective in the treatment of acute pancreatitis, the aim of this study was to assess the efficacy of ulinastatin for the prevention of post-ERCP pancreatitis and hyperenzymemia...
  65. ncbi Utility of contrast-enhanced ultrasonography with Sonazoid in radiofrequency ablation for hepatocellular carcinoma
    Ryota Masuzaki
    Graduate School of Medicine, Department of Gastroenterology, The University of Tokyo, Tokyo, Japan
    J Gastroenterol Hepatol 26:759-64. 2011
    ..The utility of Sonazoid in radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) was investigated in this study...
  66. ncbi Surveillance of small intestinal abnormalities in patients with hepatocellular carcinoma: a prospective capsule endoscopy study
    Atsuo Yamada
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Dig Endosc 23:124-9. 2011
    ..The objective of this study is to estimate the prevalence of small intestinal mucosal abnormalities in HCC patients using capsule endoscopy (CE)...
  67. ncbi Pancreatic cancer in patients with pancreatic cystic lesions: a prospective study in 197 patients
    Minoru Tada
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 4:1265-70. 2006
    ..Those cystic lesions are often found by chance with modern radiologic imaging modalities. In this study, we prospectively examined the prognosis of patients with pancreatic cystic lesions, focusing on pancreatic cancer development...
  68. ncbi Neoplastic seeding after radiofrequency ablation for hepatocellular carcinoma
    Jun Imamura
    Department of Gastroenterology, The University of Tokyo Hospital, Tokyo, Japan
    Am J Gastroenterol 103:3057-62. 2008
    ..The aim of this study is to assess the incidence, risk factors, and prognosis of neoplastic seeding after RFA among a large number of patients with a long-term follow-up...
  69. ncbi MyD88 and TNF receptor-associated factor 6 are critical signal transducers in Helicobacter pylori-infected human epithelial cells
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Immunol 176:3796-803. 2006
    ..These results suggest that the cag pathogenicity island of H. pylori is a cell type-specific NF-kappaB activator. TAK1, TRAF6, and MyD88 are important signal transducers in H. pylori-infected human epithelial cells...
  70. ncbi Ablation therapy in containing extension of hepatocellular carcinoma: a simulative analysis of dropout from the waiting list for liver transplantation
    Noriyo Yamashiki
    Department of Gastroenterology, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Liver Transpl 11:508-14. 2005
    ..In conclusion, local ablation therapy for HCC was effective in containing the tumor progression within the Milan criteria in selected patients...
  71. ncbi Thrombocytopenia is more severe in patients with advanced chronic hepatitis C than B with the same grade of liver stiffness and splenomegaly
    Kazuaki Tejima
    Department of Clinical Laboratory Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Gastroenterol 45:876-84. 2010
    ..We have examined the potential difference in thrombocytopenia between patients with CLD-B and those with CLD-C in terms of liver fibrosis adjustment and splenomegaly...
  72. ncbi Flat-type early colorectal cancer preferentially develops in right-sided colon in older patients
    Makoto Okamoto
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Dis Colon Rectum 48:101-7. 2005
    ..This suggests that flat-type early cancer may be a precursor of advanced cancer in the right colon, especially in older people...
  73. ncbi Relationship between nuclear factor-kappaB activation and virulence factors of Helicobacter pylori in Japanese clinical isolates
    Shin Maeda
    Department of Gastroenterology, University of Tokyo, Japan
    J Gastroenterol Hepatol 17:556-62. 2002
    ..The aim of the present study was to evaluate these candidates in nuclear factor (NF)-kappaBeta activation, which is a critical regulator of genes involved in inflammatory reactions...
  74. ncbi [Multicenter study on the inhibition of hepatocarcinogenesis by interferon therapy (IHIT)]
    Haruhiko Yoshida
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine
    Nippon Rinsho 62:463-6. 2004
  75. ncbi [Effectiveness of long-acting interferon (peginterferon)]
    Yuji Kondo
    Department of Gastroenterology, University of Tokyo
    Nippon Rinsho 62:515-8. 2004
  76. ncbi Interferon reduces the risk of hepatocellular carcinoma in hepatitis C virus-related chronic hepatitis/liver cirrhosis
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Oncology 78:17-23. 2010
    ..The prevention of the recurrence of HCC, or tertiary prevention, is currently one of the most challenging tasks in hepatology...
  77. ncbi Serum IL-6 levels and the risk for hepatocarcinogenesis in chronic hepatitis C patients: an analysis based on gender differences
    Hayato Nakagawa
    Department of Gastroenterology, University of Tokyo, Tokyo 113 8655, Japan
    Int J Cancer 125:2264-9. 2009
    ..Measurement of serum IL-6 levels may provide useful information for predicting future HCC development in female chronic hepatitis C patients...
  78. ncbi [Fibrosis progression in hepatitis C]
    Ryosuke Tateishi
    Department of Gastroenterology, University of Tokyo
    Nippon Rinsho 62:585-9. 2004
  79. ncbi Nucleotide change of codon 38 in the X gene of hepatitis B virus genotype C is associated with an increased risk of hepatocellular carcinoma
    Ryosuke Muroyama
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Hepatol 45:805-12. 2006
    ..In this study, we investigated whether nucleotide changes in the X gene of genotype C are associated with the development of HCC...
  80. ncbi Plasma concentration of bioactive lipid mediator sphingosine 1-phosphate is reduced in patients with chronic hepatitis C
    Hitoshi Ikeda
    Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Chim Acta 411:765-70. 2010
    ..Because our previous evidence suggests that S1P is involved in liver pathophysiology, we examined plasma S1P concentration in chronic hepatitis C patients...
  81. ncbi A genetic polymorphism of CYP2C19 is associated with susceptibility to biliary tract cancer
    Yoshihiro Isomura
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Gastroenterol 45:1045-52. 2010
    ..Cell lines of various gastroenterological cancers were screened in the first phase. A clinical investigation was then conducted to confirm the association with the candidate cancer in the second phase...
  82. ncbi A novel display of reconstruction computed tomography for the detection of small hepatocellular carcinoma
    Takuma Teratani
    University of Tokyo Graduate School of Medicine, Gastroenterology, Tokyo, Japan
    Liver Int 24:619-24. 2004
    ..To evaluate the usefulness of the alternate display of arterial and equilibrium phase images (ADAEI) of 2 mm-pitch reconstruction computed tomography (CT) in the detection of hepatocellular carcinoma (HCC)...
  83. ncbi Assessing liver tumor stiffness by transient elastography
    Ryota Masuzaki
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
    Hepatol Int 1:394-7. 2007
    ..Transient elastography is a novel noninvasive method to assess liver fibrosis by measuring liver stiffness. This study is a first step toward the provision of a noninvasive measurement of hepatic tumor stiffness by transient elastography...
  84. ncbi Safety and efficacy of lamivudine after radiofrequency ablation in patients with hepatitis B virus-related hepatocellular carcinoma
    Hideo Yoshida
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, Japan, 113 8655
    Hepatol Int 2:89-94. 2008
    ..Antiviral treatments for hepatitis B virus (HBV) are not established in patients with HBV-related hepatocellular carcinoma (HCC)...
  85. ncbi Prevention and treatment of hepatocellular carcinoma
    Masao Omata
    Department of Gastroenterology, University of Tokyo, Japan
    Liver Transpl 10:S111-4. 2004
    ..An effective treatment of HCC should include measures to control de novo carcinogenesis...
  86. ncbi Treatment of hepatocellular carcinoma by percutaneous tumor ablation methods: Ethanol injection therapy and radiofrequency ablation
    Masao Omata
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 127:S159-66. 2004
    ..We initiated a prospective controlled study to evaluate treatment with PTA and interferon. Results suggest that if the virus is eradicated, a 5-year survival rate as high as 80% can be expected...
  87. ncbi Progression from chronic hepatitis to hepatocellular carcinoma: natural course and treatments
    Masao Omata
    Department of Medicine II, Tokyo University Hospital, Tokyo, Japan
    J Gastroenterol Hepatol 17:S434-6. 2002
  88. ncbi Helicobacter pylori CagA protein activates serum response element-driven transcription independently of tyrosine phosphorylation
    Yoshihiro Hirata
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 123:1962-71. 2002
    ..Here we identify a new role for CagA protein as an activator of host cell signaling...
  89. ncbi Hepatocellular carcinoma in elderly patients: beneficial therapeutic efficacy using percutaneous ethanol injection therapy
    Takuma Teratani
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Japan
    Cancer 95:816-23. 2002
    ..The age of patients with hepatocellular carcinoma (HCC) has been increasing worldwide. The objective of this study was to assess the efficacy and safety of percutaneous ethanol injection therapy (PEIT) in elderly patients with HCC...
  90. ncbi Rectosigmoid findings are not associated with proximal colon cancer: analysis of 6 196 consecutive cases undergoing total colonoscopy
    Makoto Okamoto
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    World J Gastroenterol 11:2249-54. 2005
    ..To review the risk of proximal colon cancer in patients undergoing colonoscopy...
  91. ncbi Analysis of factors influencing hepatocellular carcinoma detection: efficient use of computed tomography during arterial portography and during hepatic arteriography
    Tomonori Fujishima
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan
    J Gastroenterol 40:266-73. 2005
    ....
  92. ncbi Prevention of hepatocellular carcinoma and its recurrence in chronic hepatitis C patients by interferon therapy
    Masao Omata
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Clin Gastroenterol Hepatol 3:S141-3. 2005
    ..Further improvement in prognosis may be expected in the future because the current combination therapy of pegylated interferon and ribavirin shows higher efficiency than interferon alone...
  93. ncbi Helicobacter pylori activates the proto-oncogene c-fos through SRE transactivation
    Yuzo Mitsuno
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 291:868-74. 2002
    ..pylori possessing intact cag PAI. SRE is required for the activation of c-fos by H. pylori. These results suggest a direct involvement of H. pylori infection in cellular proliferation, which may play a role in neoplastic transformation...
  94. ncbi Amebic colitis in asymptomatic subjects with positive fecal occult blood test results: clinical features different from symptomatic cases
    Makoto Okamoto
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Am J Trop Med Hyg 73:934-5. 2005
    ..Ulcerative lesions were observed only in the cecum and ascending colon; another portion of the colon and rectum appeared normal. We may encounter amebic colitis during colonoscopic examination even in subjects who are asymptomatic...
  95. ncbi Early liver cancer: concepts, diagnosis, and management
    Hideo Yoshida
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Clin Oncol 10:384-90. 2005
    ..Here, we give an overview of the present management of hepatocellular carcinoma. Further studies in diagnosis, treatment, and prevention are required to achieve the best clinical management of this disease...
  96. ncbi Cholecystitis after metallic stent placement in patients with malignant distal biliary obstruction
    Hiroyuki Isayama
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Clin Gastroenterol Hepatol 4:1148-53. 2006
    ..The aim of the present study was to identify risk factors for cholecystitis in patients treated with covered or uncovered MS...
  97. ncbi Endoscopic papillary balloon dilation for bile duct stone: immediate and long-term outcomes in 1000 patients
    Takeshi Tsujino
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Gastroenterol Hepatol 5:130-7. 2007
    ..The long-term outcomes of endoscopic papillary balloon dilation (EPBD) for bile duct stone removal are not well known...
  98. ncbi A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C
    Masao Omata
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine, Hongo 7 3 1, Bunkyo, Tokyo 113 8655, Japan
    Gut 56:1747-53. 2007
    ..We assessed oral ursodeoxycholic acid (UDCA) on serum biomarkers as a possible treatment for interferon non-responders...
  99. ncbi The evaluation of putative virulence factors of Helicobacter pylori for gastroduodenal disease by use of a short-term Mongolian gerbil infection model
    Masao Akanuma
    Department of Gastroenterology, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Infect Dis 185:341-7. 2002
    ..The Mongolian gerbil model was useful for the screening of virulence determinants in vivo, which confirmed the importance of cag PAI while questioning that of HP0499...
  100. ncbi [Management of asymptomatic HBV carriers]
    Haruhiko Yoshida
    Department of Gastroenterology, University of Tokyo Graduate School of Medicine
    Nippon Rinsho 62:238-41. 2004
  101. ncbi Right-side shift of colorectal adenomas with aging
    Yutaka Yamaji
    Department of Gastroenterology, University of Tokyo, Japan
    Gastrointest Endosc 63:453-8; quiz 464. 2006
    ..LIMITATIONS: Small lesions might have been missed even by 2 serial colonoscopies. CONCLUSIONS: Adenomas on the right-side colon increased with aging...