Yoshifumi Yokota

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. pmc Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse
    Susan Marino
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical School Stanford, CA 94305, USA
    BMC Cancer 4:91. 2004
  2. ncbi request reprint In vivo function of a differentiation inhibitor, Id2
    Y Yokota
    Department of Biochemistry, Fukui Medical University, Matsuoka, Japan
    IUBMB Life 51:207-14. 2001
  3. ncbi request reprint Role of Id family proteins in growth control
    Yoshifumi Yokota
    Department of Biochemistry, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    J Cell Physiol 190:21-8. 2002
  4. ncbi request reprint Id and development
    Y Yokota
    Department of Biochemistry, Fukui Medical University, Shimoaizuki 23 3, Matsuoka, Fukui 910 1193, Japan
    Oncogene 20:8290-8. 2001
  5. doi request reprint The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues
    Hisanori Kurooka
    Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Biochem Biophys Res Commun 433:579-85. 2013
  6. pmc Regulation of Id2 expression by CCAAT/enhancer binding protein beta
    Kazuhiro Karaya
    Department of Molecular Genetics, School of Medicine, University of Fukui 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Nucleic Acids Res 33:1924-34. 2005
  7. ncbi request reprint Expression of recombinant Streptolysin O and specific antibody production
    Hisashi Kimoto
    Department of Molecular Genetics, Fukui University, Matsuoka, Japan
    J Mol Microbiol Biotechnol 10:64-8. 2005
  8. doi request reprint BMP signaling is responsible for serum-induced Id2 expression
    Hisanori Kurooka
    Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Biochem Biophys Res Commun 420:281-7. 2012
  9. ncbi request reprint Forced expression of cyclin D1 does not compensate for Id2 deficiency in the mammary gland
    Seiichi Mori
    Department of Biochemistry, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, 910 1193 Fukui, Japan
    FEBS Lett 551:123-7. 2003
  10. ncbi request reprint Nucleo-cytoplasmic shuttling of Id2, a negative regulator of basic helix-loop-helix transcription factors
    Hisanori Kurooka
    Department of Molecular Genetics, School of Medicine, University of Fukui, 23 3, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    J Biol Chem 280:4313-20. 2005

Collaborators

Detail Information

Publications41

  1. pmc Wnt1 is epistatic to Id2 in inducing mammary hyperplasia, ductal side-branching, and tumors in the mouse
    Susan Marino
    Department of Developmental Biology, Howard Hughes Medical Institute, Beckman Center, Stanford University Medical School Stanford, CA 94305, USA
    BMC Cancer 4:91. 2004
    ..During pregnancy, the mammary glands from Id2 mutant animals are deficient in lobulo-alveolar development. This failure of development is believed to be due to a proliferation defect...
  2. ncbi request reprint In vivo function of a differentiation inhibitor, Id2
    Y Yokota
    Department of Biochemistry, Fukui Medical University, Matsuoka, Japan
    IUBMB Life 51:207-14. 2001
    ..Here, we present and discuss recent results obtained using Id2-deficient mice, which manifest intriguing phenotypes in various systems...
  3. ncbi request reprint Role of Id family proteins in growth control
    Yoshifumi Yokota
    Department of Biochemistry, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    J Cell Physiol 190:21-8. 2002
    ..Here, we summarize and discuss the biological activities of Id proteins from the standpoint of cell growth control...
  4. ncbi request reprint Id and development
    Y Yokota
    Department of Biochemistry, Fukui Medical University, Shimoaizuki 23 3, Matsuoka, Fukui 910 1193, Japan
    Oncogene 20:8290-8. 2001
    ..The topics discussed include neurogenesis, natural killer cell development, lymphoid organogenesis, mammary gland development and spermatogenesis...
  5. doi request reprint The metalloid arsenite induces nuclear export of Id3 possibly via binding to the N-terminal cysteine residues
    Hisanori Kurooka
    Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Biochem Biophys Res Commun 433:579-85. 2013
    ..Our results imply that Id3 may be involved in the biological action of arsenite...
  6. pmc Regulation of Id2 expression by CCAAT/enhancer binding protein beta
    Kazuhiro Karaya
    Department of Molecular Genetics, School of Medicine, University of Fukui 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Nucleic Acids Res 33:1924-34. 2005
    ..p.c.), compared with that in wild-type mammary glands. Thus, our data demonstrate that Id2 is a direct target of C/EBPbeta and provide insight into molecular mechanisms underlying mammary gland development during pregnancy...
  7. ncbi request reprint Expression of recombinant Streptolysin O and specific antibody production
    Hisashi Kimoto
    Department of Molecular Genetics, Fukui University, Matsuoka, Japan
    J Mol Microbiol Biotechnol 10:64-8. 2005
    ..Further, anti-SLO antibody with high specificity was obtained by immunizing with purified SLO protein...
  8. doi request reprint BMP signaling is responsible for serum-induced Id2 expression
    Hisanori Kurooka
    Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Biochem Biophys Res Commun 420:281-7. 2012
    ..Thus, we concluded that BMP signaling is primarily responsible for the serum-induced Id2 expression. Our results also suggest that some of the cellular effects caused by serum are mediated through BMP signaling...
  9. ncbi request reprint Forced expression of cyclin D1 does not compensate for Id2 deficiency in the mammary gland
    Seiichi Mori
    Department of Biochemistry, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, 910 1193 Fukui, Japan
    FEBS Lett 551:123-7. 2003
    ..These results suggest that Id2 acts downstream or independently of cyclin D1 in the control of mammary cell proliferation during pregnancy...
  10. ncbi request reprint Nucleo-cytoplasmic shuttling of Id2, a negative regulator of basic helix-loop-helix transcription factors
    Hisanori Kurooka
    Department of Molecular Genetics, School of Medicine, University of Fukui, 23 3, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    J Biol Chem 280:4313-20. 2005
    ..Based on all these findings, we propose that nucleo-cytoplasmic shuttling is a novel mechanism for the regulation of Id2 function...
  11. ncbi request reprint Id2 haploinsufficiency in mice leads to congenital hydronephrosis resembling that in humans
    Yoshitaka Aoki
    Department of Molecular Genetics, School of Medicine, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Genes Cells 9:1287-96. 2004
    ..Our results thus raise the possibility that Id2 is a gene responsible for the pathogenesis of hydronephrosis in man...
  12. doi request reprint Identification of BMP-responsive elements in the mouse Id2 gene
    Takeshi Nakahiro
    Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, School of Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Biochem Biophys Res Commun 399:416-21. 2010
    ..Therefore, we have identified the BMP-responsive elements in mouse Id2 and also shown that the CGCC sequence contributes to target recognition by Smad proteins...
  13. ncbi request reprint Identification of the nuclear export signal in the helix-loop-helix inhibitor Id1
    Jun Makita
    Department of Molecular Genetics, School of Medicine, University of Fukui, 23 3, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    FEBS Lett 580:1812-6. 2006
    ..Thus, our results indicate that the intracellular localization of Id1 is regulated differently from that of Id2...
  14. ncbi request reprint Synergistic effect of hypoxia and TNF-alpha on production of PAI-1 in human proximal renal tubular cells
    Xuan Li
    Division of Nephrology, Department of General Medicine, School of Medicine, Faculty of Medical Sciences, Fukui University, Fukui, Japan
    Kidney Int 68:569-83. 2005
    ..We also closely examined the effects of hypoxia and tumor necrosis factor-alpha (TNF-alpha) on PAI-1 expression in cultured human proximal renal tubular cells (HPTECs)...
  15. pmc Impairment of intestinal intraepithelial lymphocytes in Id2 deficient mice
    J K Kim
    Department of Molecular Genetics, School of Medicine, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Gut 53:480-6. 2004
    ..Id2, an inhibitor of basic helix-loop-helix transcription factors, regulates cell differentiation. Id2-/- mice exhibit a variety of phenotypes in the immune system...
  16. ncbi request reprint Taxon-specific zeta -crystallin in Japanese tree frog (Hyla japonica) lens
    Y Fujii
    Department of Chemistry, Faculty of Medicine, Fukui Medical University, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, USA
    J Biol Chem 276:28134-9. 2001
    ..The crystallin gene was expressed specifically in the lens. These results show that taxon-specific crystallins such as zeta- and rho-crystallins may be available for the biochemical discrimination of Hyla- and Rana groups among frogs...
  17. ncbi request reprint Dual role for Id2 in chemical carcinogen-induced skin tumorigenesis
    Atsushi Tokuriki
    Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Carcinogenesis 30:1645-50. 2009
    ....
  18. ncbi request reprint Genetic and biochemical properties of streptococcal NAD-glycohydrolase inhibitor
    Hisashi Kimoto
    Department of Molecular Genetics, Faculty of Medicine, Fukui University, 23 3 Shimoaizuki, Matsuoka, Fukui, Japan
    J Biol Chem 281:9181-9. 2006
    ..Unlike other bacterial NADase inhibitors, SNI was thermostable. This protein, coexpressed and complexed with NADase, may protect the producer cocci from exhaustion of NAD...
  19. ncbi request reprint Molecular characterization of NADase-streptolysin O operon of hemolytic streptococci
    Hisashi Kimoto
    Department of Molecular Genetics, Faculty of Medicine, Fukui University, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Biochim Biophys Acta 1681:134-49. 2005
    ..Additional results suggest that NADase, synthesized as precursor with feeble activity, is activated by removing the carboxyl terminal region during or after secretion into culture medium...
  20. ncbi request reprint Localization of Id2 mRNA in the adult mouse brain
    Kazuhito Kitajima
    Department of Molecular Genetics, School of Medicine, University of Fukui, 23 3 Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Brain Res 1073:93-102. 2006
    ..Id4 mRNA was detected in the regions such as the caudate putamen and the lateral amygdaloid nucleus. Thus, the expression pattern of Id2 is distinct from those of other Id gene family members...
  21. ncbi request reprint Glutathione S-transferase M1 inhibits dexamethasone-induced apoptosis in association with the suppression of Bim through dual mechanisms in a lymphoblastic leukemia cell line
    Naoko Hosono
    First Department of Internal Medicine, University of Fukui, Matsuoka, Eiheiji, Fukui, Japan
    Cancer Sci 101:767-73. 2010
    ..Thus, we propose that GSTM1, a novel regulator of dexamethasone-induced apoptosis, causes dexamethasone resistance by suppression of Bim through dual mechanisms of both downregulation of p38-MAPK and upregulation of NF-kappaB p50...
  22. pmc Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice
    Anna Lasorella
    Institute for Cancer Genetics, Columbia University, 1150 St Nicholas Avenue, New York, NY 10032, USA
    Mol Cell Biol 25:3563-74. 2005
    ..In human neuroblastoma, the N-Myc-driven expression of Id2 is sufficient and necessary for expression of VEGF. These results establish that aberrant Id2 activity directs initiation and progression of embryonal cancer...
  23. ncbi request reprint Initiation of NALT organogenesis is independent of the IL-7R, LTbetaR, and NIK signaling pathways but requires the Id2 gene and CD3(-)CD4(+)CD45(+) cells
    Satoshi Fukuyama
    Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, Suita, Japan
    Immunity 17:31-40. 2002
    ....
  24. ncbi request reprint Transcriptional profiling identifies Id2 function in dendritic cell development
    Christine Hacker
    Max Delbruck Center for Molecular Medicine, MDC, Robert Rossle Str 10, 13092 Berlin, Germany
    Nat Immunol 4:380-6. 2003
    ..We also show that Id2 represses B cell genes in DCs. These findings reveal a TGF-beta-Id2 signaling pathway in DCs and suggest a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors...
  25. pmc The balance between Pax5 and Id2 activities is the key to AID gene expression
    Hiroyuki Gonda
    Center for Molecular Biology and Genetics, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    J Exp Med 198:1427-37. 2003
    ..Finally, enforced expression of Pax5 induces AID transcription in pro-B cell lines. Our results provide evidence that the balance between Pax5 and Id2 activities has a key role in AID gene expression...
  26. ncbi request reprint TH2 dominance and defective development of a CD8+ dendritic cell subset in Id2-deficient mice
    Takashi Kusunoki
    Department of Pediatrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Allergy Clin Immunol 111:136-42. 2003
    ..Although the TH1/TH2 balance is important in many clinical situations, the regulatory mechanisms in vivo have not been well elucidated...
  27. ncbi request reprint Role of Id proteins in B lymphocyte activation: new insights from knockout mouse studies
    Manabu Sugai
    Center for Molecular Biology and Genetics, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, 606 8507 Kyoto, Japan
    J Mol Med (Berl) 82:592-9. 2004
    ..This review presents several new insights into B cell differentiation and activation programs and the physiological role of Id proteins in B cell activation...
  28. ncbi request reprint Impaired IgG production in mice deficient for heat shock transcription factor 1
    Sachiye Inouye
    Departments of Biochemistry and Molecular Biology and Microbiology, Yamaguchi University School of Medicine, Minami Kogushi 1 1 1, Ube 755 8505, Japan
    J Biol Chem 279:38701-9. 2004
    ..Furthermore, we demonstrated that the IL-6 gene is a direct target gene of HSF1. These results revealed a novel molecular link between HSF1 and a gene related to immune response and inflammation...
  29. ncbi request reprint Id2 is dispensable for myc-induced lymphomagenesis
    Jonas A Nilsson
    Department of Biochemistry and the Animal Resource Center, St Jude Children s Research Hospital, Memphis, Tennessee, USA
    Cancer Res 64:7296-301. 2004
    ..Collectively these findings argue that targeting Id2 functions may be ineffective in preventing Myc-associated malignancies...
  30. ncbi request reprint Essential role of Id2 in negative regulation of IgE class switching
    Manabu Sugai
    Center for Molecular Biology and Genetics, Kyoto University, Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Nat Immunol 4:25-30. 2003
    ..Id2 might act as molecular safeguard to suppress IgE CSR to prevent serious complications such as allergic hypersensitivity during the normal course of immune responses...
  31. ncbi request reprint CpG inhibits IgE class switch recombination through suppression of NF kappa B activity, but not through Id2 or Bcl6
    Takashi Kusunoki
    Department of Pediatrics, Kyoto University Graduate School of Medicine, Sakyo ku, Kyoto 606 8507, Japan
    Biochem Biophys Res Commun 328:499-506. 2005
    ..These data indicate the critical role of NF kappa B and Irf4 in the regulation of IgE CSR through actions downstream of CpG signaling...
  32. ncbi request reprint Id2 is critical for cellular proliferation and is the oncogenic effector of N-myc in human neuroblastoma
    Anna Lasorella
    Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 62:301-6. 2002
    ..We suggest that Id2 overexpression may be a better prognostic indicator than N-myc gene amplification in neuroblastoma. Thus, disrupting Id2 function may lead to new and useful therapeutic strategies for cancer patients...
  33. doi request reprint The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
    Yu Hikosaka
    Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
    Immunity 29:438-50. 2008
    ..These results indicate that RANKL produced by positively selected thymocytes is responsible for fostering thymic medulla formation, thereby establishing central tolerance...
  34. ncbi request reprint Forced expression of Id2 in fetal thymic T cell progenitors allows some of their progeny to adopt NK cell fate
    Shinji Fujimoto
    Department of Immunology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogoin Kawahara cho, Sakyo ku, Kyoto 606 8507, Japan
    Int Immunol 19:1175-82. 2007
    ..Our data strongly suggest that forced expression of Id2 allows some progeny of p-T to adopt an NK cell fate, and that p-T retain a program for NK lineage development that can be implemented by inhibiting the function of E proteins...
  35. ncbi request reprint Id sustains Hes1 expression to inhibit precocious neurogenesis by releasing negative autoregulation of Hes1
    Ge Bai
    Laboratory of Molecular Cell Biology, Key Laboratory of Stem Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Dev Cell 13:283-97. 2007
    ..These results indicate that Id proteins participate in NSC maintenance through sustaining Hes1 expression in early embryos...
  36. ncbi request reprint RFX1 mediates the serum-induced immediate early response of Id2 gene expression
    Kui Rong Wang
    Division of Molecular Genetics, Department of Biochemistry and Bioinformative Sciences, University of Fukui, Fukui, Japan
    J Biol Chem 282:26167-77. 2007
    ..Our results unveil a novel transcriptional control of immediate early gene expression...
  37. ncbi request reprint A molecular pathway including Id2, Tbx5, and Nkx2-5 required for cardiac conduction system development
    Ivan P G Moskowitz
    Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
    Cell 129:1365-76. 2007
    ..We conclude that a molecular pathway including Tbx5, Nkx2-5, and Id2 coordinates specification of ventricular myocytes into the ventricular conduction system lineage...
  38. pmc Interaction of mature CD3+CD4+ T cells with dendritic cells triggers the development of tertiary lymphoid structures in the thyroid
    Tatjana Marinkovic
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029 6574, USA
    J Clin Invest 116:2622-32. 2006
    ..These findings indicate that the formation of tertiary lymphoid structures does not require Id2-dependent conventional LTis but depends on a program initiated by mature CD3+CD4+ T cells...
  39. pmc Receptor activator of NF-kappaB ligand regulates the proliferation of mammary epithelial cells via Id2
    Nam Shik Kim
    Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang 790 783, Kyungbuk, South Korea
    Mol Cell Biol 26:1002-13. 2006
    ..Our results indicate that the inhibitor of helix-loop-helix protein, Id2, is critical to control the proliferation of mammary epithelial cells in response to RANKL stimulation...
  40. pmc Id helix-loop-helix proteins negatively regulate TRANCE-mediated osteoclast differentiation
    Junwon Lee
    Medical Research Center for Gene Regulation, Chonnam National University Medical School, Hak Dong 5, Dong Ku, Gwangju 501 746, Korea
    Blood 107:2686-93. 2006
    ..Taken together, our results reveal both a new facet of negative regulation, mediated by Id proteins, as well as the mechanism whereby TRANCE signaling overcomes it, allowing osteoclastogenesis to proceed...
  41. pmc Mature natural killer cell and lymphoid tissue-inducing cell development requires Id2-mediated suppression of E protein activity
    Markus D Boos
    Committee on Immunology, University of Chicago, Chicago, IL 60657, USA
    J Exp Med 204:1119-30. 2007
    ..Our findings redefine the essential functions of Id2 in lymphoid development and provide insight into the dynamic regulation of E and Id proteins during this process...