Affiliation: University of Tokyo
Yokomizo T, Kato K, Hagiya H, Izumi T, Shimizu T. Hydroxyeicosanoids bind to and activate the low affinity leukotriene B4 receptor, BLT2. J Biol Chem. 2001;276:12454-9 pubmed
..These findings suggest that BLT2 functions as a low affinity receptor, with broader ligand specificity for various eicosanoids, and mediates distinct biological and pathophysiological roles from BLT1. ..
Liu M, Yokomizo T. The role of leukotrienes in allergic diseases. Allergol Int. 2015;64:17-26 pubmed publisher
..This review will provide an update on the synthesis, biological function, and relevance of LTs to the pathobiology of allergic diseases, and examine the current and future therapeutic prospects of LT modifiers. ..
Asahara M, Ito N, Yokomizo T, Nakamura M, Shimizu T, Yamada Y. The absence of the leukotriene B4 receptor BLT1 attenuates peripheral inflammation and spinal nociceptive processing following intraplantar formalin injury. Mol Pain. 2015;11:11 pubmed publisher
..Thus, LTB4-BLT1 signaling is a potential target for therapeutic intervention of acute and persistent pain induced by tissue injury. ..
Lee H, Yokomizo T. Applications of mass spectrometry-based targeted and non-targeted lipidomics. Biochem Biophys Res Commun. 2018;504:576-581 pubmed publisher
..Current limitations and challenges in lipidomics and possible solutions are also discussed. ..
Luo L, Tanaka R, Kanazawa S, Lu F, Hayashi A, Yokomizo T, et al
. A synthetic leukotriene B4 receptor type 2 agonist accelerates the cutaneous wound healing process in diabetic rats by indirect stimulation of fibroblasts and direct stimulation of keratinocytes. J Diabetes Complications. 2017;31:13-20 pubmed publisher
..CAY is a promising pharmaceutical agent for diabetic wounds. ..
Ikeda K, Koga T, Sasaki F, Ueno A, Saeki K, Okuno T, et al
. Generation and characterization of a human-mouse chimeric high-affinity antibody that detects the DYKDDDDK FLAG peptide. Biochem Biophys Res Commun. 2017;486:1077-1082 pubmed publisher
..This human-mouse chimeric high-affinity anti-FLAG Ab will prove useful for future immunohistochemical analysis of mouse tissues. ..
Yokomizo T. Two distinct leukotriene B4 receptors, BLT1 and BLT2. J Biochem. 2015;157:65-71 pubmed publisher
..BLT1 and BLT2 are therefore potential targets for the development of novel drugs. ..
Iwamoto S, Koga T, Ohba M, Okuno T, Koike M, Murakami A, et al
. Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B4 receptor 2. Sci Rep. 2017;7:13267 pubmed publisher
..Thus, our results reveal that NSAIDs delay corneal wound healing by inhibiting 12-HHT production, and suggest that stimulation of the 12-HHT/BLT2 axis represents a novel therapeutic approach to corneal wound healing. ..
Saeki K, Yokomizo T. Identification, signaling, and functions of LTB4 receptors. Semin Immunol. 2017;33:30-36 pubmed publisher
..BLT2 signaling also enhances cell-cell junctions, protectes against transepidermal water loss, and preventes entry of environmental substances into the body. ..