Kosei Yasumoto

Summary

Affiliation: University of Occupational and Environmental Health
Country: Japan

Publications

  1. ncbi request reprint Phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel in patients with completely resected non-small cell lung cancer
    Masakazu Sugaya
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 30:3039-44. 2010
  2. ncbi request reprint Identification of tumor associated antigens recognized by IgG from tumor-infiltrating B cells of lung cancer: correlation between Ab titer of the patient's sera and the clinical course
    Makiko Mizukami
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Cancer Sci 96:882-8. 2005
  3. ncbi request reprint Effect of IgG produced by tumor-infiltrating B lymphocytes on lung tumor growth
    Makiko Mizukami
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 26:1827-31. 2006
  4. ncbi request reprint Simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer
    Yoshinobu Ichiki
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Immunol 172:4844-50. 2004
  5. ncbi request reprint The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance
    Shoji Nakata
    Second Department of Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    Cancer 106:2190-9. 2006
  6. ncbi request reprint Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung
    Masakazu Sugaya
    The Second Department of Surgery, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Int J Cancer 120:1055-62. 2007
  7. ncbi request reprint Antigens recognized by IgG derived from tumor-infiltrating B lymphocytes in human lung cancer
    Manabu Yasuda
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Anticancer Res 26:3607-11. 2006
  8. ncbi request reprint Expression of deltaNp63 in squamous cell carcinoma of the esophagus
    Masaru Morita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Anticancer Res 25:3533-9. 2005
  9. ncbi request reprint Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma
    Takashi Fukuyama
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Res 66:4922-8. 2006
  10. doi request reprint Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Oncol 5:1136-42. 2010

Detail Information

Publications97

  1. ncbi request reprint Phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel in patients with completely resected non-small cell lung cancer
    Masakazu Sugaya
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 30:3039-44. 2010
    ..Adjuvant chemotherapy improves the prognosis of patients with non-small cell lung cancer (NSCLC) after a complete resection despite unacceptable toxicity and low compliance...
  2. ncbi request reprint Identification of tumor associated antigens recognized by IgG from tumor-infiltrating B cells of lung cancer: correlation between Ab titer of the patient's sera and the clinical course
    Makiko Mizukami
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Cancer Sci 96:882-8. 2005
    ..Our results suggest that TIB recognized tumor antigens and the antibody titers against these antigens were changed along with the patient's clinical course. Therefore, these antibodies could be used as tumor markers for the patient...
  3. ncbi request reprint Effect of IgG produced by tumor-infiltrating B lymphocytes on lung tumor growth
    Makiko Mizukami
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 26:1827-31. 2006
    ..Tumor-infiltrating B lymphocytes (TIB) are often observed in lung cancer. The role of TIB in tumor growth has not been well investigated...
  4. ncbi request reprint Simultaneous cellular and humoral immune response against mutated p53 in a patient with lung cancer
    Yoshinobu Ichiki
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Immunol 172:4844-50. 2004
    ..This approach may allow us to better understand the mechanisms of T and B cell immunity against the same tumor Ag in cancer patients...
  5. ncbi request reprint The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance
    Shoji Nakata
    Second Department of Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    Cancer 106:2190-9. 2006
    ....
  6. ncbi request reprint Identification of HLA-A24 restricted shared antigen recognized by autologous cytotoxic T lymphocytes from a patient with large cell carcinoma of the lung
    Masakazu Sugaya
    The Second Department of Surgery, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Int J Cancer 120:1055-62. 2007
    ..This peptide is therefore considered to be potentially useful for performing specific immunotherapy in a significant proportion of lung cancer patients bearing HLA-A24...
  7. ncbi request reprint Antigens recognized by IgG derived from tumor-infiltrating B lymphocytes in human lung cancer
    Manabu Yasuda
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Anticancer Res 26:3607-11. 2006
    ..Lung cancer tissues are often infiltrated by B lymphocytes, but it is not clear whether these infiltrations represent tumor-specific immune response or a nonspecific reaction...
  8. ncbi request reprint Expression of deltaNp63 in squamous cell carcinoma of the esophagus
    Masaru Morita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Anticancer Res 25:3533-9. 2005
    ..The p63 gene is present as two isoforms, namely TAp63 and deltaNp63. The biological role of deltaNp63 in the progression of esophageal cancer is still controversial...
  9. ncbi request reprint Identification of a new cancer/germline gene, KK-LC-1, encoding an antigen recognized by autologous CTL induced on human lung adenocarcinoma
    Takashi Fukuyama
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Res 66:4922-8. 2006
    ..The new cancer/germline gene was located in Xq22, which is apparently different from the locations of previously reported cancer/germline genes...
  10. doi request reprint Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Oncol 5:1136-42. 2010
    ..Why such certain patients are susceptible to the development of EGFR-mutant tumors is currently unknown...
  11. ncbi request reprint Results of surgical treatment for lung cancer in young adults
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan
    Int Surg 93:50-4. 2008
    ..There were no significant differences in survival rates between younger group and elderly groups. This study suggests that surgical resection is also recommended as the first-line treatment for younger patients with lung cancer...
  12. ncbi request reprint Antitumor effect of antibody against a SEREX-defined antigen (UOEH-LC-1) on lung cancer xenotransplanted into severe combined immunodeficiency mice
    Makiko Mizukami
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Res 67:8351-7. 2007
    ..Complement-dependent cytotoxicity was one of the mechanisms to suppress the tumor growth. These results suggest that the antibody against UOEH-LC-1 therefore seems to have a promising therapeutic potential as a treatment for lung cancer...
  13. ncbi request reprint A lack of prognostic significance regarding DeltaNp63 immunoreactivity in lung cancer
    Teruo Iwata
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Lung Cancer 50:67-73. 2005
    ..The prognostic effects of DeltaNp63 expression do not appear to act as an important prognostic indicator in lung cancer. Our findings do not support that immunocytochemical markers demonstrate a relevant prognostic role in lung cancer...
  14. ncbi request reprint A different pattern of cytotoxic T lymphocyte recognition against primary and metastatic tumor cells in a patient with nonsmall cell lung carcinoma
    Tetsuya So
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer 103:200-8. 2005
    ..Lung carcinoma represents the most frequent cause of cancer death worldwide because of tumor metastases. The objective of the current study was to analyze the immunologic response during the progress of lung carcinoma metastasis...
  15. ncbi request reprint A point mutation in the NFYC gene generates an antigenic peptide recognized by autologous cytolytic T lymphocytes on a human squamous cell lung carcinoma
    Mitsuhiro Takenoyama
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Int J Cancer 118:1992-7. 2006
    ..These results strengthened the notion that unique tumor-specific antigens are highly represented not only in melanoma but also in other types of tumors, like nonsmall cell lung cancer...
  16. ncbi request reprint Identification of the HLA-Cw*0702-restricted tumor-associated antigen recognized by a CTL clone from a lung cancer patient
    Yoshika Nagata
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu City, Fukuoka, Japan
    Clin Cancer Res 11:5265-72. 2005
    ..A large number of tumor-associated antigens have been used in vaccination trials for mainly melanomas. Our purpose of this study is to identify a novel tumor antigen useful for immunotherapy of lung cancer patients...
  17. doi request reprint Results of surgical resection for patients with large cell carcinoma of the lung
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807, Japan
    Int J Surg 8:391-4. 2010
    ..The clinical features of large cell carcinoma (LCC) of the lung have remained unclear due to the low incidence of the disease. This study investigated the clinicopathological features and the surgical outcome in patients with LCC...
  18. doi request reprint Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations
    Kenji Sugio
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Lung Cancer 64:314-8. 2009
    ..This study prospectively assessed the efficacy of gefitinib and the survival benefit for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations...
  19. doi request reprint Significance of Smoking as a Postoperative Prognostic Factor in Patients with Non-small Cell Lung Cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807, Japan
    J Thorac Oncol 3:1127-32. 2008
    ..In this study, we investigated the influence of smoking on the postoperative prognosis in patients with non-small cell lung cancer...
  20. ncbi request reprint Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis
    Tsunehiro Oyama
    Department of Environmental Health, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Front Biosci 12:4497-503. 2007
    ..5%) than those without (12.2%) mutation. Since in patients with early NSCLC, CYP positivity showed a close correlation with a poor survival (p less than 0.01), expression of CYP in bronchial epithelium has a prognostic potential...
  21. doi request reprint Malignant mesothelioma-associated antigens recognized by tumor-infiltrating B cells and the clinical significance of the antibody titers
    Yoshiki Shigematsu
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 100:1326-34. 2009
    ..The titers of the antibodies against Gene-X and THBS-2 could be used as tumor markers for the diagnosis and follow up of patients with MPM...
  22. doi request reprint Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status
    Takamitsu Onitsuka
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Lung Cancer 68:198-203. 2010
    ..However, most of the patients with this type of sensitive mutations in their tumor show acquired resistance during the TKI treatment...
  23. ncbi request reprint Lack and restoration of sensitivity of lung cancer cells to cellular attack with special reference to expression of human leukocyte antigen class I and/or major histocompatibility complex class I chain related molecules A/B
    Tetsuro Baba
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Cancer Sci 98:1795-802. 2007
    ..Reconstruction of HLA-class I and MHC class I chain related molecules A expression could abrogate evasion from cellular attack by CTL and NK cells, and it may lead to a breakthrough in the development of cancer immunotherapy...
  24. ncbi request reprint Haplotype loss of HLA class I antigen as an escape mechanism from immune attack in lung cancer
    Tetsuya So
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    Cancer Res 65:5945-52. 2005
    ....
  25. doi request reprint Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung
    Naohiro Nose
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Clin Oncol 27:411-7. 2009
    ....
  26. doi request reprint Clinical significance of HLA class I alleles on postoperative prognosis of lung cancer patients in Japan
    Yoshika Nagata
    Second Department of Surgery, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu City, Fukuoka 807 8555, Japan
    Lung Cancer 65:91-7. 2009
    ..We previously reported the correlation between HLA alleles and the postoperative prognosis of 204 patients with non-small cell lung cancer (NSCLC). The present study was based on 695 patients with NSCLC to confirm these correlations...
  27. ncbi request reprint Molecular genetic tumor markers in non-small cell lung cancer
    Tsunehiro Oyama
    Department of Surgery II and Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan
    Anticancer Res 25:1193-6. 2005
    ..This paper reviews MGTMs characteristic of lung cancer and clarifies the clinical usefulness and applications of MGTM for cancer treatment...
  28. doi request reprint Sleeve lobectomy for patients with non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu 807, Japan
    Int J Surg 8:39-43. 2010
    ..We investigated the clinico-pathological features and treatment responses of lung cancer patients who underwent sleeve lobectomy in our department...
  29. ncbi request reprint Identification of a tumour associated antigen in lung cancer patients with asbestos exposure
    Manabu Yasuda
    Second Department of Surgery, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555 Japan
    Anticancer Res 30:2631-9. 2010
    ..This study analysed the humoral immune response in asbestos exposed lung cancer patients to identify new surrogate markers of the carcinogenic risk in populations exposed to asbestos...
  30. ncbi request reprint Survival and prognostic factors of surgically resected T4 non-small cell lung cancer
    Toshihiro Osaki
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Ann Thorac Surg 75:1745-51; discussion 1751. 2003
    ..We retrospectively analyzed the survival of patients with surgically resected T4 NSCLC to evaluate the evidence for prognostic implications according to the subgroups of T4 category, nodal status, and resection completeness...
  31. doi request reprint Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer
    Yoshiki Shigematsu
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Lung Cancer 68:105-10. 2010
    ..0037). Expression of MAGE-A3, NY-ESO-1 or KK-LC-1 did not affect survival of patients with NSCLC significantly, however, expression of at least one of such CT antigens negatively affect survival of patients with NSCLC (p=0.045)...
  32. doi request reprint Identification of a lung cancer antigen evading CTL attack due to loss of human leukocyte antigen (HLA) class I expression
    Tetsuro Baba
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 101:2115-20. 2010
    ..Furthermore, such an antigen may help in achieving a better understanding of the immunological escape mechanisms and it may also provide a favorable immune response in cancer immunotherapy...
  33. doi request reprint Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma
    Koji Kuroda
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 101:46-53. 2010
    ..These results may indicate that RPL19 is a novel overexpressed antigen which may therefore be a useful candidate as a target for specific immunotherapy...
  34. doi request reprint Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status
    Takamitsu Onitsuka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Thorac Oncol 5:591-6. 2010
    ..The purpose of this study was to clarify the role of the epidermal growth factor receptor (EGFR), K-ras, MET, and hepatocyte growth factor (HGF) status in lung adenocarcinoma...
  35. doi request reprint Association between lymphangiogenesis-/micrometastasis- and adhesion-related molecules in resected stage I NSCLC
    Toshihiro Yamashita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Japan
    Lung Cancer 70:320-8. 2010
    ..The purpose of this study was to clarify the role and clinical significance of lymphangiogenesis/micrometastases and adhesion molecules in resected stage I non-small cell lung cancer (NSCLC)...
  36. ncbi request reprint Gender difference as a prognostic factor in patients undergoing resection of non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, 807 8555, Japan
    Surg Today 37:546-51. 2007
    ..We studied the effects of gender difference on the incidence of lung cancer and its mortality rate, which is a subject of much discussion...
  37. ncbi request reprint Postoperative prognosis in patients with non-small cell lung cancer according to the method of initial detection
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Oncol 2:907-11. 2007
    ..In this study, we investigated the difference in the surgical results of non-small cell lung cancer according to the method of initial detection...
  38. ncbi request reprint Cytochrome P450 expression (CYP) in non-small cell lung cancer
    Tsunehiro Oyama
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 12:2299-308. 2007
    ..Therefore, the spectrum of CYP proteins in lung cancer could be useful for changing the present "order-made" therapy to the "tailor-made" therapy...
  39. ncbi request reprint Tumor-infiltrating B lymphocytes as a potential source of identifying tumor antigen in human lung cancer
    Manabu Yasuda
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan
    Cancer Res 62:1751-6. 2002
    ..Our approach using TIB may allow the identification of key antigens in the humoral cancer-related immune system...
  40. ncbi request reprint A new mechanism for primary resistance to gefitinib in lung adenocarcinoma: the role of a novel G796A mutation in exon 20 of EGFR
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 27:2297-303. 2007
    ..This study suggests that screening tumour samples for a range of EGFR mutations may improve our ability to identify the patients most likely to benefit from EFGR TKIs...
  41. ncbi request reprint Tumor specific expression of survivin-2B in lung cancer as a novel target of immunotherapy
    Yoshinobu Ichiki
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Lung Cancer 48:281-9. 2005
    ..Furthermore, survivin-2B includes the epitope peptide (survivin-2B(80-88)) which is capable of binding to HLA-A24. In this study, we evaluated whether survivin-2B could be a novel vaccine target against lung cancer...
  42. ncbi request reprint Cytokine production of lung cancer cell lines: Correlation between their production and the inflammatory/immunological responses both in vivo and in vitro
    Takashi Fukuyama
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Cancer Sci 98:1048-54. 2007
    ..The present results suggest that the production of various cytokines from tumor cells might exert various paracrine effects both in vivo and in vitro...
  43. ncbi request reprint Primary pulmonary collision cancer consisting of large cell carcinoma and adenocarcinoma
    Shoji Nakata
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Ann Thorac Surg 80:340-2. 2005
    ..This case is the first report of a primary pulmonary collision tumor consisting of large cell carcinoma and adenocarcinoma...
  44. doi request reprint Preoperative CYFRA 21-1 and CEA as prognostic factors in patients with stage I non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807, Japan
    Lung Cancer 74:112-7. 2011
    ..This study investigated the preoperative serum levels of CYFRA 21-1 and CEA as prognostic factors in patients with stage I non-small cell lung cancer...
  45. ncbi request reprint Resistance to gefitinib
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Int J Clin Oncol 11:487-91. 2006
    ..Such observations should also help us in the search for more effective therapies against a specific subset of NSCLC...
  46. ncbi request reprint Pleural lavage cytology immediately after thoracotomy in patients with completely resected non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807, Japan
    Int Surg 96:171-5. 2011
    ..The positive finding in PLC showed a tendency of an unfavorable prognosis for NSCLC patents following complete resection. Further clinical studies will be necessary to evaluate the efficacy of adjuvant therapy for PLC-positive patients...
  47. ncbi request reprint Carinal resection after induction bronchial arterial infusion for locally advanced non-small cell lung cancer
    Tetsuya So
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Jpn J Thorac Cardiovasc Surg 52:143-7. 2004
    ..There was neither BAI-related intraoperative nor postoperative complications. BAI with CDDP was thus found to be a useful and effective therapeutic modality for locally advanced NSCLC invading the carina...
  48. doi request reprint Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins
    Kenji Ono
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer 115:3489-500. 2009
    ....
  49. ncbi request reprint Y-box-binding protein-1 expression is not correlated with p53 expression but with proliferating cell nuclear antigen expression in non-small cell lung cancer
    Takashi Yoshimatsu
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 25:3437-43. 2005
    ..These results suggest that YB-1 expression is correlated with PCNA expression in NSCLC. In addition, the DNA repair pathway and tumor proliferation mediated by YB-1 linking to PCNA may be responsible for controlling the growth of NSCLC...
  50. ncbi request reprint Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer
    Masaru Morita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Front Biosci 10:2319-24. 2005
    ..To our knowledge, this is the first study demonstrating the induction of ALDH2 in the esophagus by ethanol consumption...
  51. doi request reprint Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence
    Hidehiko Shimokawa
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Cardiovasc Surg 141:895-8. 2011
    ..The purpose of this study was to clarify the role and clinical significance of metastasis associated in colon cancer 1 in resected stage I non-small cell lung cancers...
  52. ncbi request reprint Expression of deltaNp73 predicts poor prognosis in lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Cancer Res 10:6905-11. 2004
    ..The aim of this study was to detect DeltaNp73 expression in lung cancer and to evaluate the relationship between the DeltaNp73 expression level and the prognosis of patients with resected lung cancer...
  53. doi request reprint Time trends of surgical outcome in patients with non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan
    J Thorac Oncol 5:825-9. 2010
    ..A surgical resection is a potentially curative treatment for non-small cell lung cancer (NSCLC). This study investigated the time trends of the surgical outcome in patients with NSCLC...
  54. doi request reprint Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR-TKI for adenocarcinoma of the lung
    Naohiro Nose
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Lung Cancer 71:350-5. 2011
    ..The aim of this study is to elucidate the correlation between expression of ER beta and the therapeutic effect of EGFR-TKI in adenocarcinoma of the lung...
  55. doi request reprint Surgical treatment for chest wall invasion due to the local recurrence of breast cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu 807 8555, Japan
    Breast Cancer 15:298-302. 2008
    ..In this study, we investigated the surgical results for chest wall invasion of local recurrence of breast cancer...
  56. ncbi request reprint Expression of the p53 family in lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 26:1785-90. 2006
    ..The aim of this study was to detect p53, deltaNp73 and deltaNp63 expressions in lung cancer and to evaluate the relationship between the expression levels of the proteins and the prognosis of patients with resectable lung cancer...
  57. ncbi request reprint Expression of cytochrome P450 in non-small cell lung cancer
    Tsunehiro Oyama
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 13:5787-93. 2008
    ..The understanding of the local expression of CYP enzymes in tumor tissues is important in the development of better treatment for lung cancer and a standardized treatment, tailor-made, for individual patients...
  58. ncbi request reprint Detection of EGFR and K-ras mutations for diagnosis of multiple lung adenocarcinomas
    Teruo Iwata
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Front Biosci (Landmark Ed) 16:2961-9. 2011
    ..04). These findings suggest that the combination method including gene mutation and morphological analysis can guide treatment decisions and that there is a need for systemic chemotherapy, and surveillance monitoring...
  59. doi request reprint Results of surgical treatment for patients with small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Oncol 4:964-8. 2009
    ..This study investigated the clinical features and the postoperative prognosis in patients with small cell lung cancer (SCLC)...
  60. ncbi request reprint A randomized phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel versus carboplatin plus gemcitabine in patients with completely resected non-small cell lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Anticancer Res 30:4695-9. 2010
    ..However, treatment-related deaths sometimes occur. Therefore, the development of a safer regimen is necessary...
  61. ncbi request reprint A case-case study comparing the usefulness of serum trace elements (Cu, Zn and Se) and tumor markers (CEA, SCC and SLX) in non-small cell lung cancer patients
    Tsunehiro Oyama
    Departments of Environmental Health and Surgery II, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Anticancer Res 23:605-12. 2003
    ..Cu and Zn in serum are storable and the determination of Cu/Zn level is so simple and inexpensive that it can be helpful in determining clinical stages and predicting the prognoses of NSCLC patients...
  62. doi request reprint Differences in sensitivity to tumor-specific CTLs between primary and metastatic esophageal cancer cell lines derived from the same patient
    Yoshinobu Ichiki
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Surg Today 42:272-9. 2012
    ..We examined the expression patterns of these molecules in both primary and metastatic esophageal carcinoma cells from the same patient and evaluated the cellular immune responses against these cells...
  63. ncbi request reprint Evidence-based prevention (EBP): approach to lung cancer prevention based on cytochrome 1A1 and cytochrome 2E1 polymorphism
    Tsunehiro Oyama
    Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 23:1731-7. 2003
    ....
  64. ncbi request reprint Smoking cessation program and CYP2A6 polymorphism
    Shinichi Ozaki
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 11:2590-7. 2006
    ..Although treatment of nicotine patch is efficacious to smoking cessation, cases with CYP2A619934/19934 might be more sensitive to nicotine adverse effects and more difficult to quit smoking once they have smoking habit...
  65. ncbi request reprint [Tumor marker in primary lung cancer]
    Kenji Sugio
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 26:473-9. 2004
    ..This review summarizes the clinical usefulness of tumor markers in primary lung cancer...
  66. ncbi request reprint Epidermal growth factor receptor mutations are associated with gefitinib sensitivity in non-small cell lung cancer in Japanese
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Lung Cancer 51:71-7. 2006
    ..033). These data show that adenocarcinomas from patients who had never smoked comprise a specific subset of patients with NSCLC sensitive to gefitinib treatment...
  67. ncbi request reprint Establishment of an immortalized T-cell line from lung cancer tissue: phenotypic and functional analyses
    Satoru Imahayashi
    Second Department of Surgery, Faculty of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyusyu 807 8555, Japan
    Int J Clin Oncol 7:38-44. 2002
    ..In this study, we analyzed the phenotypic and functional characteristics of TIL, using an immortalized cell line prepared by cotransfection of human c-myc and c-Ha-ras...
  68. ncbi request reprint p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression
    Hidetaka Uramoto
    Department of Molecular Biology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 277:31694-702. 2002
    ..Our data suggest that p73 stimulates the transcription of the YB-1 promoter by enhancing recruitment of the c-Myc-Max complex to the E-box...
  69. pmc Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression
    Hidetaka Uramoto
    Department of Molecular Biology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem J 371:301-10. 2003
    ..These results provide novel information on the functional interplay between CTF2 and p53/p73 as important determinants of their function in cell proliferation, apoptosis, DNA repair and cisplatin resistance...
  70. pmc Detection of micrometastatic tumor cells in pN0 lymph nodes of patients with completely resected nonsmall cell lung cancer: impact on recurrence and Survival
    Chun Dong Gu
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Ann Surg 235:133-9. 2002
    ....
  71. ncbi request reprint Activating transcription factor 4 increases the cisplatin resistance of human cancer cell lines
    Mizuho Tanabe
    Departments of Molecular Biology and Surgery II, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Fukuoka, Japan
    Cancer Res 63:8592-5. 2003
    ..Both were less sensitive to cisplatin than the parental cells but equally sensitive to vincristine. Our findings suggest that levels of ATF4 expression could help to predict cisplatin sensitivity...
  72. ncbi request reprint Prognostic value of cytokeratin-positive cells in the bone marrow and lymph nodes of patients with resected nonsmall cell lung cancer: a multicenter prospective study
    Kosei Yasumoto
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Ann Thorac Surg 76:194-201; discussion 202. 2003
    ....
  73. doi request reprint Congenital tracheoesophageal fistula in an elderly patient with thoracic empyema
    Manabu Yasuda
    Second Department of Surgery, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi ku, Kitakyushu, Japan
    Gen Thorac Cardiovasc Surg 57:622-4. 2009
    ..Following tube drainage of the left thoracic empyema, transection of the fistula was performed. The postoperative course was uneventful, and she is doing well at 1 year after surgery without recurrence of the symptoms...
  74. ncbi request reprint Hypertrophic osteoarthropathy associated with esophageal cancer
    Masaru Morita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan
    Ann Thorac Surg 76:1744-6. 2003
    ..Furthermore, the patient has demonstrated a disease-free survival of more than 3 years...
  75. ncbi request reprint Clinicopathologic significance of an immunohistochemical expression of p27 in scirrhous carcinoma of the breast
    Tadahiro Nozoe
    Second Department of Surgery, University of Environmental and Occupational Health, Iseigaoka, Kitakyushu, Japan
    Breast Cancer 14:277-80. 2007
    ..The aim of the current study was to clarify clinicopathologic significance of scirrhous carcinoma of the breast with special reference to p27 expression...
  76. ncbi request reprint The immunomodulatory effect of cryopreservation in rat tracheal allotransplantation
    Ryoichi Nakanishi
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Heart Lung Transplant 21:890-8. 2002
    ..Cryopreservation is one solution to the problem of donor organ deficit. To investigate the effect of cryopreservation on tracheal allografts, we performed 2 experiments in rats...
  77. ncbi request reprint [Future prospects for specific immunotherapy]
    Masakazu Sugaya
    Second Department of Surgery, University of Occupational and Environmental Health, Japan
    Nihon Rinsho 60:609-13. 2002
  78. ncbi request reprint Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer
    Toshihiro Osaki
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Clin Oncol 20:2930-6. 2002
    ....
  79. ncbi request reprint Tissue-distribution of aldehyde dehydrogenase 2 and effects of the ALDH2 gene-disruption on the expression of enzymes involved in alcohol metabolism
    Tsunehiro Oyama
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 10:951-60. 2005
    ..This observation suggests that a metabolite(s) of Aldh2 might down-regulate the expression of Cyp2e1 gene...
  80. doi request reprint Lung cancer-associated tumor antigens and the present status of immunotherapy against non-small-cell lung cancer
    Kosei Yasumoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    Gen Thorac Cardiovasc Surg 57:449-57. 2009
    ..We review recent studies regarding the identification of tumor antigens in lung cancer, tumor immune escape mechanisms, and clinical vaccine trials in lung cancer...
  81. ncbi request reprint Significance of immunohistochemical expression of p27 and involucrin as the marker of cellular differentiation of squamous cell carcinoma of the esophagus
    Tadahiro Nozoe
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Oncology 71:402-10. 2006
    ..Involucrin has been known as a marker of differentiation of squamous cell carcinoma (SCC). The aim of this study was to evaluate the clinicopathologic significance of the expression of p27 and involucrin in esophageal SCC...
  82. ncbi request reprint Significance of immunohistochemical expression of estrogen receptors alpha and beta in squamous cell carcinoma of the esophagus
    Tadahiro Nozoe
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Cancer Res 13:4046-50. 2007
    ..The aim of the current study was to clarify the clinicopathologic significance of an immunohistochemical expression of estrogen receptors alpha and beta (ER alpha and ER beta) in ESCC...
  83. ncbi request reprint Expression of aromatase CYP19 and its relationship with parameters in NSCLC
    Tsunehiro Oyama
    Second Department of Surgery and Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci (Landmark Ed) 14:2285-92. 2009
    ..The results suggest that the aromatase inhibitors might be useful for the management of non-small cell lung cancer in postmenopausal women...
  84. ncbi request reprint Immunohistochemical evaluation of cytochrome P450 (CYP) and p53 in breast cancer
    Tsunehiro Oyama
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 10:1156-61. 2005
    ..Since CYP3A is involved in the conversion of tamoxifen to its metabolites, the variation of the CYP3A expression in breast cancer tissues among ethnic groups might cause differences in the efficacy of tamoxifen...
  85. doi request reprint Clinicopathological characteristics of invasive lobular carcinoma of the breast
    Takeshi Hanagiri
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Asian J Surg 32:76-80. 2009
    ..The clinical features of invasive lobular carcinoma (ILC) of the breast have remained unclear due to the rarity of such cases. This study investigated the clinical and pathological features of ILC...
  86. ncbi request reprint Efficacy of Multiglycosidorum tripterygii for rat tracheal allografts
    Ryoichi Nakanishi
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Heart Lung Transplant 24:289-95. 2005
    ..We evaluated the efficacy of Multiglycosidorum tripterygii as a new immunosuppressant using a heterotopic rat tracheal allotransplantation model...
  87. ncbi request reprint Visceral pleural involvement in nonsmall cell lung cancer: prognostic significance
    Toshihiro Osaki
    Department of Chest Surgery, Kitakyushu Municipal Medical Center, Kitakyushu, Japan
    Ann Thorac Surg 77:1769-73; discussion 1773. 2004
    ..It is unclear whether the T2 category includes the p2 status alone or incorporates the extent of the p1 status...
  88. ncbi request reprint [Prediction of effectiveness of EGFR tyrosine kinase inhibitors for the patients with by EGFR mutations]
    Hidetaka Uramoto
    Second Dept of Surgery of Environmental Health School of Medicine, University of Occupational and Environmental Health
    Gan To Kagaku Ryoho 34:538-43. 2007
    ..These patients with EGFR mutations were not only favorable responders but also had a longer survival than without. In this article, we discuss the EGFR-TKI predictive factors by EGFR mutations...
  89. ncbi request reprint Expression of FHIT in esophageal epithelium and carcinoma: reference to drinking, smoking and multicentric carcinogenesis
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 26:2243-8. 2006
    ..The purpose of this study was to clarify whether the fragile histidine triad (FHIT) is their target gene in esophageal carcinogenesis as well as in multicentric carcinogenesis...
  90. ncbi request reprint Lack of tumor recognition by cytolytic T lymphocyte clones recognizing peptide 195-203 encoded by gene MAGE-A3 and presented by HLA-A24 molecules
    Tomoko So
    Christian de Duve Institute of Cellular Pathology, Universite Catholique de Louvain, Avenue Hippocrate 74, UCL 7459, 1200 Brussels, Belgium
    Cancer Immunol Immunother 56:259-69. 2007
    ..A24 CTL clones. These results suggest that peptide MAGE-A3(195-203) is poorly processed and is not an appropriate target for cancer immunotherapy...
  91. ncbi request reprint Establishment of 15 cancer cell lines from patients with lung cancer and the potential tools for immunotherapy
    Masakazu Sugaya
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Chest 122:282-8. 2002
    ..In order to resolve these difficulties, we tried to establish and characterize lung cancer cell lines as useful tools for the analysis of tumor-specific immune responses in patients with lung cancer...
  92. ncbi request reprint P53R2, p53 inducible ribonucleotide reductase gene, correlated with tumor progression of non-small cell lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 26:983-8. 2006
    ..Though our findings do not support that the p53R2 immunocytochemical marker alone plays an important prognostic role in NSCLC, the DNA repair pathway mediated by p53R2 may be responsible for controlling the growth of lung cancer...
  93. ncbi request reprint Survival and characteristics of lymph node involvement in patients with N1 non-small cell lung cancer
    Toshihiro Osaki
    Department of Chest Surgery, Kitakyushu Municipal Medical Center, 2 1 1 Bashaku, Kokurakita ku, Kitakyushu 802 0077, Japan
    Lung Cancer 43:151-7. 2004
    ..In patients with pathologic N1 disease, microscopic N1 and single-node N1 diseases may be an early stage, whereas multiple-node N1 disease behaves like an advanced stage...
  94. ncbi request reprint Multiglycosidorum tripterygii versus Tacrolimus for rat tracheal allografts
    Ryoichi Nakanishi
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Eur J Cardiothorac Surg 28:588-93. 2005
    ..We tried to elucidate the treatment effect of Multiglycosidorum tripterygii on tracheal allografts in comparison to that of Tacrolimus...
  95. ncbi request reprint Risk factors for multicentric occurrence of carcinoma in the upper aerodigestive tract-analysis with a serial histologic evaluation of the whole resected-esophagus including carcinoma
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    J Surg Oncol 83:216-21. 2003
    ..The aim of this study was to elucidate the relationship between the number of carcinomas and risk factors...
  96. ncbi request reprint Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Lung Cancer 49:55-62. 2005
    ..The ER stress pathway mediated by Grp78 may therefore be responsible for controlling the growth of lung cancer cells...
  97. ncbi request reprint Iris metastasis of esophageal cancer
    Yoshinobu Ichiki
    Second Department of Surgery, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Ann Thorac Surg 79:1782-4. 2005
    ..We herein report a case of esophageal cancer in which the ocular metastasis was controlled by systemic chemotherapy...