Mikio Yanase

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Functional diversity between Rho-kinase- and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line
    Mikio Yanase
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033, Tokyo, Japan
    Biochem Biophys Res Commun 305:223-8. 2003
  2. ncbi request reprint Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells
    Hitoshi Ikeda
    Dept of Gastroenterology, Univ of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G880-6. 2003
  3. ncbi request reprint Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 320:754-9. 2004
  4. ncbi request reprint Treatment with leucine stimulates the production of hepatocyte growth factor in vivo
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 322:772-7. 2004
  5. ncbi request reprint Ischemic preconditioning in liver pathophysiology
    Masahiro Arai
    Department of Gastroenterology, Toshiba General Hospital, Shinagawa ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:S65-7. 2007
  6. ncbi request reprint Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity
    Naoko Watanabe
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Life Sci 81:1009-15. 2007
  7. ncbi request reprint Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells
    Kazuaki Tejima
    Department of Gastroenterology, University of Tokyo, and Toshiba General Hospital, 6 3 22 Higashiooi, Shinagawa ku, Tokyo 140 8522, Japan
    World J Gastroenterol 13:5071-8. 2007
  8. ncbi request reprint Effect of rapamycin on hepatocyte function and proliferation induced by growth factors
    Tomoaki Tomiya
    Department of Gastroenterology, Fuculty of Medicine, University of Tokyo, Tokyo, Japan
    Chemotherapy 53:59-69. 2007
  9. ncbi request reprint The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Japan
    Life Sci 78:2226-33. 2006
  10. ncbi request reprint Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats
    Kazuaki Tejima
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 127:1488-96. 2004

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Functional diversity between Rho-kinase- and MLCK-mediated cytoskeletal actions in a myofibroblast-like hepatic stellate cell line
    Mikio Yanase
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 0033, Tokyo, Japan
    Biochem Biophys Res Commun 305:223-8. 2003
    ..These findings suggest that the actomyosin-based cytoskeletal actions can be functionally diverse depending on the Rho-kinase-mediated pathway and the MLCK-mediated pathway...
  2. ncbi request reprint Involvement of Rho/Rho kinase pathway in regulation of apoptosis in rat hepatic stellate cells
    Hitoshi Ikeda
    Dept of Gastroenterology, Univ of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Physiol Gastrointest Liver Physiol 285:G880-6. 2003
    ..Inhibition of the Rho/Rho kinase pathway did not affect p53, Bcl-2, or Bax levels in HSCs. Thus we concluded that the Rho/Rho kinase pathway may play a role in the regulation of HSC survival...
  3. ncbi request reprint Sphingosine 1-phosphate enhances portal pressure in isolated perfused liver via S1P2 with Rho activation
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Biochem Biophys Res Commun 320:754-9. 2004
    ..2 microM, S1P might readily regulate portal vascular tone in physiological and pathological status. The antagonist for S1P2 merits consideration for treatment of portal hypertension...
  4. ncbi request reprint Treatment with leucine stimulates the production of hepatocyte growth factor in vivo
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 322:772-7. 2004
    ..Taken together with our previous report showing that leucine stimulates HGF production by hepatic stellate cells in culture, leucine, among BCAAs, may induce an increase in HGF production by the liver in vivo...
  5. ncbi request reprint Ischemic preconditioning in liver pathophysiology
    Masahiro Arai
    Department of Gastroenterology, Toshiba General Hospital, Shinagawa ku, Tokyo, Japan
    J Gastroenterol Hepatol 22:S65-7. 2007
    ....
  6. ncbi request reprint Plasma lysophosphatidic acid level and serum autotaxin activity are increased in liver injury in rats in relation to its severity
    Naoko Watanabe
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
    Life Sci 81:1009-15. 2007
    ..Whether increased ATX and LPA in the blood in liver injury is simply a result or also a cause of the injury should be further clarified...
  7. ncbi request reprint Induction of ischemic tolerance in rat liver via reduced nicotinamide adenine dinucleotide phosphate oxidase in Kupffer cells
    Kazuaki Tejima
    Department of Gastroenterology, University of Tokyo, and Toshiba General Hospital, 6 3 22 Higashiooi, Shinagawa ku, Tokyo 140 8522, Japan
    World J Gastroenterol 13:5071-8. 2007
    ..To elucidate the mechanisms of hepatocyte preconditioning by H2O2 to better understand the pathophysiology of ischemic preconditioning...
  8. ncbi request reprint Effect of rapamycin on hepatocyte function and proliferation induced by growth factors
    Tomoaki Tomiya
    Department of Gastroenterology, Fuculty of Medicine, University of Tokyo, Tokyo, Japan
    Chemotherapy 53:59-69. 2007
    ..Conclusion: HGF and TGFalpha stimulate proliferation and function of hepatocytes depending upon the conditions, and rapamycin inhibited these stimulatory effects, possibly by inhibiting the mTOR-dependent signaling pathway...
  9. ncbi request reprint The herbal medicine inchin-ko-to (TJ-135) induces apoptosis in cultured rat hepatic stellate cells
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, Bunkyo ku, Japan
    Life Sci 78:2226-33. 2006
    ..Thus, the induction of HSC apoptosis could be the mechanism how TJ-135 works on the resolution of hepatic fibrosis. Our current data may shed light on the novel effect of the herbal remedy...
  10. ncbi request reprint Ischemic preconditioning protects hepatocytes via reactive oxygen species derived from Kupffer cells in rats
    Kazuaki Tejima
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Gastroenterology 127:1488-96. 2004
    ..We aimed to determine whether ischemic preconditioning directly protects hepatocytes and to elucidate its mechanisms...
  11. ncbi request reprint Antiproliferative property of sphingosine 1-phosphate in rat hepatocytes involves activation of Rho via Edg-5
    Hitoshi Ikeda
    Department of Gastroenterology, University of Tokyo, Japan
    Gastroenterology 124:459-69. 2003
    ..Because the major part of injected S1P was distributed into the liver in mice, we wondered whether the liver would be one of its targets. The effects of S1P on hepatocytes, the major constituent cells in the liver, were examined...
  12. ncbi request reprint Leucine stimulates the secretion of hepatocyte growth factor by hepatic stellate cells
    Tomoaki Tomiya
    Department of Gastroenterology, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 297:1108-11. 2002
    ..These results demonstrate that, among BCAAs, leucine stimulates the secretion of HGF by cultured hepatic stellate cells...
  13. ncbi request reprint p53 May positively regulate hepatocyte proliferation in rats
    Yukiko Inoue
    Department of Gastroenterology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hepatology 36:336-44. 2002
    ..Considering previous findings indicating the importance of endogenous TGF-alpha for the proliferation of hepatocytes stimulated by HGF, TGF-alpha might play a role in HGF-p53 mediated hepatocyte proliferation...
  14. ncbi request reprint Stabilization of RNA strands in protein synthesis by type I procollagen C-proteinase enhancer protein, a potential RNA-binding protein, in hepatic stellate cells
    Atsushi Matsui
    Department of Gastroentelorogy, University of Tokyo, Tokyo, Japan
    Biochem Biophys Res Commun 290:898-902. 2002
    ..PCPE may be involved in stabilization of RNA strands in noncollagenous protein synthesis as well as collagen synthesis...
  15. ncbi request reprint Both plasma lysophosphatidic acid and serum autotaxin levels are increased in chronic hepatitis C
    Naoko Watanabe
    Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Clin Gastroenterol 41:616-23. 2007
    ..Autotaxin (ATX), originally purified as an autocrine motility factor for melanoma cells, was revealed to be a key enzyme in LPA synthesis. We determined LPA and ATX levels in the blood of patients with liver disease...