Research Topics
Species | H YamasueSummaryAffiliation: University of Tokyo Country: Japan Publications
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Publications
Function and structure in social brain regions can link oxytocin-receptor genes with autistic social behaviorHidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Brain Dev 35:111-8. 2013..For further development of this research area, this mini-review integrates recent accumulating evidence about human behavioral and neural correlates of OXTR...
Integrative approaches utilizing oxytocin to enhance prosocial behavior: from animal and human social behavior to autistic social dysfunctionHidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
J Neurosci 32:14109-17. 2012....
[Investigating endophenotype of endogeneous psychotic disorders]Hidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655 Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 27:85-90. 2007..Then, we discussed the possibility of endophenotyping of bipolar disorder and introduced our preliminary study. Finally, methodological considerations and future directions of endophenotyping of endogeneous psychosis were suggested...
Neuroanatomy in monozygotic twins with Asperger disorder discordant for comorbid depressionH Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Neurology 65:491-2. 2005
Association between mitochondrial DNA 10398A>G polymorphism and the volume of amygdalaH Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Genes Brain Behav 7:698-704. 2008..These provocative findings might provide a clue to the complex relationship between mtDNA, brain structure and mental disorders...
Gender-common and -specific neuroanatomical basis of human anxiety-related personality traitsHidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Cereb Cortex 18:46-52. 2008..The results may have implications for why susceptibility to stress-related disorders such as anxiety disorders and depression shows gender and/or individual differences...
Localized volume reduction in prefrontal, temporolimbic, and paralimbic regions in schizophrenia: an MRI parcellation studyHidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo 113 8655, Japan
Psychiatry Res 131:195-207. 2004..These findings indicate the importance of ACG abnormalities in the pathophysiology of schizophrenia...
Human brain structural change related to acute single exposure to sarinHidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Ann Neurol 61:37-46. 2007....
Abnormal association between reduced magnetic mismatch field to speech sounds and smaller left planum temporale volume in schizophreniaHidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo 113 8655, Japan
Neuroimage 22:720-7. 2004..These results suggest that structural abnormalities of the planum temporale may underlie the functional abnormalities of fundamental language-related processing in schizophrenia...
Drug-induced parkinsonism in relation to choline-containing compounds measured by 1H-MR spectroscopy in putamen of chronically medicated patients with schizophreniaHidenori Yamasue
Department of Neuropsychiatry, University of Tokyo, Tokyo, Japan
Int J Neuropsychopharmacol 6:353-60. 2003..These results suggest a potential of 1H-MRS as a non-invasive monitoring method of neurobiological correlates of EPS associated with neuroleptic treatments in patients with schizophrenia...
Oxytocin, sexually dimorphic features of the social brain, and autismHidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Psychiatry Clin Neurosci 63:129-40. 2009....
Voxel-based analysis of MRI reveals anterior cingulate gray-matter volume reduction in posttraumatic stress disorder due to terrorismH Yamasue
Department of Neuropsychiatry and Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Proc Natl Acad Sci U S A 100:9039-43. 2003....
1H-MR spectroscopy and gray matter volume of the anterior cingulate cortex in schizophreniaH Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neuroreport 13:2133-7. 2002..These results provide further support to the idea that the measures of H-MRS indicate not only neuronal loss but also neuronal dysfunction in schizophrenia...
Functional (GT)n polymorphisms in promoter region of N-methyl-d-aspartate receptor 2A subunit (GRIN2A) gene affect hippocampal and amygdala volumesH Inoue
Department of Neuropsychiatry, University of Tokyo, Bunkyo ku, Japan
Genes Brain Behav 9:269-75. 2010....
Age-related change in brain metabolite abnormalities in autism: a meta-analysis of proton magnetic resonance spectroscopy studiesY Aoki
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo, Japan
Transl Psychiatry 2:e69. 2012....
Decreased prefrontal activation during letter fluency task in adults with pervasive developmental disorders: a near-infrared spectroscopy studyHitoshi Kuwabara
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Behav Brain Res 172:272-7. 2006..The present results may be also potentially useful for applying NIRS to clinical settings of child psychiatry...
Absence of age-related prefrontal NAA change in adults with autism spectrum disordersY Aoki
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Transl Psychiatry 2:e178. 2012..The current (1)H-MRS study provided new evidence that atypical age-related change of neurochemical aspects of brain maturation in ASD individuals expands beyond childhood and persists during adulthood...
Evidence for acquired pregenual anterior cingulate gray matter loss from a twin study of combat-related posttraumatic stress disorderKiyoto Kasai
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Biol Psychiatry 63:550-6. 2008..We employed a case-control design in monozygotic twin pairs discordant for combat exposure to address the preexisting versus acquired origin of brain morphometric abnormalities in PTSD...
Disrupted integrity of the fornix is associated with impaired memory organization in schizophreniaKunio Takei
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Schizophr Res 103:52-61. 2008..We investigated an association between DTI abnormalities of the fornix and impairment of memory organization in schizophrenia...
Hypoactivation of the prefrontal cortex during verbal fluency test in PTSD: a near-infrared spectroscopy studyKoji Matsuo
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Psychiatry Res 124:1-10. 2003..The 'frontal dysfunction' observed in subjects with PTSD may be a secondary phenomenon to reduced attentional capacity...
Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophreniaYoichiro Takayanagi
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
Schizophr Res 121:55-65. 2010..In addition, it remains elusive whether the OFC morphology in first-episode patients is related to their clinical features...
Post-traumatic stress disorder symptoms in victims of Tokyo subway attack: a 5-year follow-up studyToshiyuki Ohtani
Department of Psychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Psychiatry Clin Neurosci 58:624-9. 2004..A significant correlation between the total score of Impact of Event Scale-Revised (IES-R) and CAPS was found, indicating that IES-R is a useful tool for evaluating PTSD...
Activation of the prefrontal cortex to trauma-related stimuli measured by near-infrared spectroscopy in posttraumatic stress disorder due to terrorismKoji Matsuo
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Psychophysiology 40:492-500. 2003..Significantly enhanced SCR was also observed in the victims with PTSD during trauma-related stimuli. The findings suggest that measurement of cerebral hemodynamic response by NIRS is useful for psychophysiological assessment of PTSD...
No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese populationMamoru Tochigi
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo, 113 8655 Japan
Schizophr Res 88:260-4. 2006..Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population...
Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variablesYoichiro Takayanagi
Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
Prog Neuropsychopharmacol Biol Psychiatry 34:10-7. 2010..Brain morphometric measures from magnetic resonance imaging (MRI) have not been used to discriminate between first-episode patients with schizophrenia and healthy subjects...
Increased positive thought disorder with illness duration in patients with schizophreniaKeiko Maeda
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
Psychiatry Clin Neurosci 61:687-90. 2007..TDI scores were not associated with verbal memory or executive functioning. These results indicate an ongoing worsening of positive thought disorder through the course of illness in schizophrenia...
Perospirone in the treatment of schizophrenia: effect on verbal memory organizationTsuyoshi Araki
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
Prog Neuropsychopharmacol Biol Psychiatry 30:204-8. 2006..Negative symptoms and extrapyramidal side effects were also ameliorated after switching to perospirone. The distinct cognitive enhancement profile of perospirone may be attributable to its partial 5-HT1A agonist action...
Tract-specific analysis of the superior occipitofrontal fasciculus in schizophreniaNatsuko Kunimatsu
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Tokyo, Japan
Psychiatry Res 164:198-205. 2008..726 (x10(-3) mm(2)/s) (S.D. 0.027)]. Our results suggest that the so-called SOFF may be a structural component connecting the prefrontal area to the thalamus and that it is deteriorated in schizophrenia...
Structural and diffusional brain abnormality related to relatively low level alcohol consumptionHiroki Sasaki
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neuroimage 46:505-10. 2009..The current results suggest female brain vulnerability to alcohol, and a relation between subtle abnormality in the right amygdala and alcohol misuse...
Aging effects on cerebral asymmetry: a voxel-based morphometry and diffusion tensor imaging studyHidemasa Takao
Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Magn Reson Imaging 28:65-9. 2010..Our results showed no significant effects of aging on either gray matter volume asymmetry or white matter fractional anisotropy asymmetry...
Voxel-based analyses of gray/white matter volume and diffusion tensor data in major depressionOsamu Abe
Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Psychiatry Res 181:64-70. 2010..These results suggest that the frontolimbic neural circuit might play an important role in the neuropathology of patients with major depressive disorder...
Cerebral asymmetry in patients with schizophrenia: a voxel-based morphometry (VBM) and diffusion tensor imaging (DTI) studyHidemasa Takao
Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Magn Reson Imaging 31:221-6. 2010..To evaluate the differences in gray- and white-matter asymmetry between schizophrenia patients and normal subjects...
Age-related changes in regional brain volume evaluated by atlas-based methodWataru Gonoi
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
Neuroradiology 52:865-73. 2010..We introduce an atlas-based method as a methodological alternative that calculates absolute volume as a non-biased and semi-automatic whole-brain technique...
Sex dimorphism in gray/white matter volume and diffusion tensor during normal agingOsamu Abe
Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
NMR Biomed 23:446-58. 2010..Our results provide strong evidence of sex dimorphism in global and focal diffusion characteristics during normal aging...
Effect of tryptophan hydroxylase-2 gene variants on amygdalar and hippocampal volumesHideyuki Inoue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Brain Res 1331:51-7. 2010..These results suggest that amygdalar and hippocampal volumes assessed using MRI may be a useful intermediate phenotype that will uncover the biological pathway linking 5-HT synthesis and emotional behaviors and affective disorders...
Voxel-based analysis of the diffusion tensorOsamu Abe
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 8655, Japan
Neuroradiology 52:699-710. 2010....
Structural disruption of the dorsal cingulum bundle is associated with impaired Stroop performance in patients with schizophreniaKunio Takei
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Schizophr Res 114:119-27. 2009....
Neuroanatomy and neurophysiology in schizophreniaKiyoto Kasai
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
Neurosci Res 43:93-110. 2002..Finally, we addressed the issue of the heterogeneity of schizophrenia from the neurobiological perspective, in relation to the neuroanatomical and neurophysiological measures...
Delayed automatic detection of change in speech sounds in adults with autism: a magnetoencephalographic studyKiyoto Kasai
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655 Tokyo, Japan
Clin Neurophysiol 116:1655-64. 2005..e. automatic change detection of speech and non-speech sounds, using magnetoencephalographic recording of mismatch response elicited by change in vowels and tones...
[Neuroimaging in posttraumatic stress disorder]Kiyoto Kasai
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8655, Japan
No To Shinkei 57:285-90. 2005
Parahippocampal activation evoked by masked traumatic images in posttraumatic stress disorder: a functional MRI studyHideshi Sakamoto
Department of Neuropsychiatry, University of Tokyo, Tokyo, Japan
Neuroimage 26:813-21. 2005....
Confirmation of a relationship between reduced auditory P300 amplitude and thought disorder in schizophreniaKenji Kirihara
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyoku, Tokyo 113 8655, Japan
Schizophr Res 80:197-201. 2005..These results further suggest that electrophysiological abnormalities of information processing may underlie positive thought disorder in schizophrenia...
Amyotrophic lateral sclerosis: diffusion tensor tractography and voxel-based analysisOsamu Abe
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, 113 8655, Japan
NMR Biomed 17:411-6. 2004..These results suggested that the combination of voxel-based diffusion tensor analysis and diffusion tensor tractography might help determine the location of the affected neuronal tissues among ALS patients in a non-invasive manner...
Auditory P300 latency prolongation with age in schizophrenia: gender and subcomponent effectsTsuyoshi Araki
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Schizophr Res 88:217-21. 2006..Our findings may provide evidence for progressive change in the brain function in schizophrenia, and this change may be slower in female than male patients. P3b may serve as a more sensitive index for cognitive decline than P3a...
Aging in the CNS: comparison of gray/white matter volume and diffusion tensor dataOsamu Abe
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neurobiol Aging 29:102-16. 2008..These results indicate that diffusion properties and brain volume are complementary markers to the effects of aging...
Multiple-time replicability of near-infrared spectroscopy recording during prefrontal activation task in healthy menToshiaki Kono
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Neurosci Res 57:504-12. 2007..Further studies using different conditions or assessing sensitivity to longitudinal changes following interventions are necessary...
Reduced planum temporale volume and delusional behaviour in patients with schizophreniaSyudo Yamasaki
Department of Rehabilitation, Graduate School of Medicine, The University of Tokyo, Tokyo, 113 8655, Japan
Eur Arch Psychiatry Clin Neurosci 257:318-24. 2007....
Electrophysiological abnormalities of spatial attention in adults with autism during the gap overlap taskYuki Kawakubo
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo, Japan
Clin Neurophysiol 118:1464-71. 2007..We evaluated event-related potentials (ERPs) elicited by attentional disengagement in individuals with autism...
Topography of the human corpus callosum using diffusion tensor tractographyOsamu Abe
Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Comput Assist Tomogr 28:533-9. 2004..To evaluate the crossing fiber trajectory through the corpus callosum using distortion-corrected diffusion tensor tractography in the human brain...
Reduced frontopolar activation during verbal fluency task in schizophrenia: a multi-channel near-infrared spectroscopy studyRyu Takizawa
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Schizophr Res 99:250-62. 2008....
Voxel-based diffusion tensor analysis reveals aberrant anterior cingulum integrity in posttraumatic stress disorder due to terrorismOsamu Abe
Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Psychiatry Res 146:231-42. 2006..The present study demonstrated further evidence of abnormalities of both the ACC, a structure that is pivotally involved in attention, emotional regulation, and fear conditioning, and of subjacent white matter in the pathology of PTSD...
Association between lower P300 amplitude and smaller anterior cingulate cortex volume in patients with posttraumatic stress disorder: a study of victims of Tokyo subway sarin attackTsuyoshi Araki
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
Neuroimage 25:43-50. 2005..These results provide the first evidence that electrophysiological deficits of controlled attention observed in patients with PTSD may be linked to underlying brain morphological abnormalities...
No evidence for an association between the BDNF Val66Met polymorphism and schizophrenia or personality traitsMamoru Tochigi
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo, Tokyo113 8655, Japan
Schizophr Res 87:45-7. 2006..Thus, the present study did not provide evidence for an association between the BDNF gene and schizophrenia or personality traits in the Japanese population...
[Neuroanatomy and neurophysiology in schizophrenia]Kiyoto Kasai
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo
Seishin Shinkeigaku Zasshi 106:851-66. 2004..Finally, we described important issues, in terms of the infrastructure and system, which need to be improved in clinical psychiatry research in Japan...
Sex-linked neuroanatomical basis of human altruistic cooperativenessHidenori Yamasue
Department of Neuropsychiatry, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Cereb Cortex 18:2331-40. 2008..The present findings may also have an implication for the pathophysiology of autism; characterized by severe dysfunction in social reciprocity, abnormalities in social-brain, and disproportionately low probability in females...
Support for relationship between serum cholinesterase and post-traumatic stress disorder; 5-year follow-ups of victims of the Tokyo subway sarin poisoningMamoru Tochigi
Neurosci Res 52:129-31. 2005
Anterior cingulate cortex volume reduction in patients with panic disorderTakeshi Asami
Department of Psychiatry, Yokohama City University School of Medicine, Yokohama, Japan
Psychiatry Clin Neurosci 62:322-30. 2008....
Prefrontal cortex and amygdala volume in first minor or major depressive episode after cancer diagnosisEisho Yoshikawa
Psycho-Oncology Division, National Cancer Center Research Institute East, Kashiwa, Chiba, Japan
Biol Psychiatry 59:707-12. 2006..CONCLUSIONS: It might be suggested that amygdala volume was associated with a first minor and/or major depressive episode after cancer diagnosis...
Comparison between mismatch negativity amplitude and magnetic mismatch field strength in normal adultsNoriko Kudo
Department of Cognitive and Information Sciences, Graduate School of Humanities, Chiba University, Chiba, Japan
Biol Psychol 71:54-62. 2006..To further clarify the differential significance of recording MMN/MMF may be important to establish MMN/MMF as clinical indices of individual ability of preattentive stage of auditory processing...
