Affiliation: University of Tokyo
Kiyama Y, Kikkawa Y, Kinoshita M, Matsumoto Y, Kondo K, Fujimoto C, et al
. The adhesion molecule cadherin 11 is essential for acquisition of normal hearing ability through middle ear development in the mouse. Lab Invest. 2018;98:1364-1374 pubmed publisher
..This mutant mouse may be a promising animal model for elucidating the causes of conductive hearing loss and otitis media. ..
Yamasoba T, Pourbakht A, Sakamoto T, Suzuki M. Ebselen prevents noise-induced excitotoxicity and temporary threshold shift. Neurosci Lett. 2005;380:234-8 pubmed
..These findings suggest that scavenging peroxynitrite can attenuate noise-induced excitotoxicity and, thereby, TTS. ..
Yamasoba T, Kondo K. Supporting cell proliferation after hair cell injury in mature guinea pig cochlea in vivo. Cell Tissue Res. 2006;325:23-31 pubmed
..These findings indicate that Deiters cells in the mature mammalian cochlea maintain a limited competence to re-enter the cell cycle and proliferate after hair cell injury, and that they can survive at least for 1 month. ..
Yamasoba T, Lin F, Someya S, Kashio A, Sakamoto T, Kondo K. Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hear Res. 2013;303:30-8 pubmed publisher
..These may explain the large variations of the onset and extent of AHL among elderly subjects. This article is part of a Special Issue entitled "Annual Reviews 2013". ..
Tuerdi A, Kinoshita M, Kamogashira T, Fujimoto C, Iwasaki S, Shimizu T, et al
. Manganese superoxide dismutase influences the extent of noise-induced hearing loss in mice. Neurosci Lett. 2017;642:123-128 pubmed publisher
..Outer hair cell damage was significantly greater in all cochlear turns in HET mice compared with WT mice. Collectively, these findings suggest that Mn-SOD plays an important role in protecting the cochlea from noise-induced damage. ..
Yamasoba T, Kikuchi S, Higo R. Deafness associated with vertebrobasilar insufficiency. J Neurol Sci. 2001;187:69-75 pubmed
..These findings indicate that hearing loss occurs in approximately one-fifth of VBI patients, much less frequently than vestibular disturbances, and that deafness associated with VBI mainly involves the cochlea...
Yamasoba T, Someya S, Yamada C, Weindruch R, Prolla T, Tanokura M. Role of mitochondrial dysfunction and mitochondrial DNA mutations in age-related hearing loss. Hear Res. 2007;226:185-93 pubmed
..Together these findings indicate that decreased energy metabolism due to accumulation of mtDNA mutations/deletions and decline of respiratory chain function play an important role in the manifestation of AHL. ..
Mizushima Y, Fujimoto C, Kashio A, Kondo K, Yamasoba T. Macrophage recruitment, but not interleukin 1 beta activation, enhances noise-induced hearing damage. Biochem Biophys Res Commun. 2017;493:894-900 pubmed publisher
..Therefore, macrophages may be a promising therapeutic target in human sensorineural hearing losses such as NIHL. ..