Tadashi Yamashita

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis
    Tadashi Yamashita
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Genesis 43:175-80. 2005
  2. pmc Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions
    Tadashi Yamashita
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:2725-30. 2005
  3. ncbi request reprint The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis
    Mari Kono
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:29367-73. 2004
  4. pmc Essential role for sphingosine kinases in neural and vascular development
    Kiyomi Mizugishi
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1821, USA
    Mol Cell Biol 25:11113-21. 2005
  5. pmc Enhanced insulin sensitivity in mice lacking ganglioside GM3
    Tadashi Yamashita
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, 10 Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:3445-9. 2003
  6. pmc Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage
    Hiroki Mizukami
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 109:1215-21. 2002
  7. ncbi request reprint Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis
    Tadashi Yamashita
    Genetics of Development and Disease Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1821, USA
    Biochim Biophys Acta 1573:236-40. 2002
  8. ncbi request reprint G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation
    Maria L Allende
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:3665-7. 2003
  9. ncbi request reprint Novel class of glycosphingolipids involved in male fertility
    Roger Sandhoff
    Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    J Biol Chem 280:27310-8. 2005
  10. ncbi request reprint In vivo modulation of epidermal growth factor receptor phosphorylation in mice expressing different gangliosides
    Jose L Daniotti
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    J Cell Biochem 99:1442-51. 2006

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Conditional LoxP-flanked glucosylceramide synthase allele controlling glycosphingolipid synthesis
    Tadashi Yamashita
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    Genesis 43:175-80. 2005
    ..The floxed Ugcg allele will facilitate analysis of the function of glycosphingolipids in development, physiology, and in diseases such as diabetes and cancer...
  2. pmc Interruption of ganglioside synthesis produces central nervous system degeneration and altered axon-glial interactions
    Tadashi Yamashita
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 102:2725-30. 2005
    ..These results indicate that ganglioside synthesis is essential for the development of a stable CNS, possibly by means of the promotion of interactions between axon and glia...
  3. ncbi request reprint The sphingosine-1-phosphate receptors S1P1, S1P2, and S1P3 function coordinately during embryonic angiogenesis
    Mari Kono
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 279:29367-73. 2004
    ..Our results indicate that the S1P(1), S1P(2) and S1P(3) receptors have redundant or cooperative functions for the development of a stable and mature vascular system during embryonic development...
  4. pmc Essential role for sphingosine kinases in neural and vascular development
    Kiyomi Mizugishi
    Genetics of Development and Disease Branch, NIDDK, National Institutes of Health, Bethesda, MD 20892 1821, USA
    Mol Cell Biol 25:11113-21. 2005
    ..Our findings also suggest that exploitation of this potent neuronal survival pathway could lead to the development of novel therapeutic approaches for neurological diseases...
  5. pmc Enhanced insulin sensitivity in mice lacking ganglioside GM3
    Tadashi Yamashita
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Building 10, 10 Center Drive, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 100:3445-9. 2003
    ..Importantly, the mutant mice were protected from high-fat diet-induced insulin resistance. Our results show that GM3 ganglioside is a negative regulator of insulin signaling, making it a potential therapeutic target in type 2 diabetes...
  6. pmc Systemic inflammation in glucocerebrosidase-deficient mice with minimal glucosylceramide storage
    Hiroki Mizukami
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Clin Invest 109:1215-21. 2002
    ..However, the mutant mice do not accumulate large amounts of glucosylceramide or exhibit classic Gaucher cells in tissues...
  7. ncbi request reprint Early developmental expression of the gene encoding glucosylceramide synthase, the enzyme controlling the first committed step of glycosphingolipid synthesis
    Tadashi Yamashita
    Genetics of Development and Disease Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892 1821, USA
    Biochim Biophys Acta 1573:236-40. 2002
    ..These mice allowed the visualization of glucosylceramide synthase expression during early embryonic development...
  8. ncbi request reprint G-protein-coupled receptor S1P1 acts within endothelial cells to regulate vascular maturation
    Maria L Allende
    Genetics of Development and Disease Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Blood 102:3665-7. 2003
    ..The phenotype of the conditional mutant embryos mimicked the one obtained in the embryos globally deficient in S1P1. Thus, vessel coverage by VSMCs is directed by the activity of the S1P1 receptor in ECs...
  9. ncbi request reprint Novel class of glycosphingolipids involved in male fertility
    Roger Sandhoff
    Department of Cellular and Molecular Pathology, German Cancer Research Center, Heidelberg, Germany
    J Biol Chem 280:27310-8. 2005
    ..More importantly, the neutral subset of this new GSL class strictly correlates with male fertility. These data implicate polyunsaturated, fucosylated GSLs as essential for spermatogenesis and male mouse fertility...
  10. ncbi request reprint In vivo modulation of epidermal growth factor receptor phosphorylation in mice expressing different gangliosides
    Jose L Daniotti
    Departamento de Quimica Biologica, Facultad de Ciencias Quimicas, Centro de Investigaciones en Quimica Biologica de Cordoba, CIQUIBIC UNC CONICET, Universidad Nacional de Cordoba, Ciudad Universitaria, 5000 Cordoba, Argentina
    J Cell Biochem 99:1442-51. 2006
    ..These studies provide, for the first time, an approach for studying the molecular mechanisms involved in the in vivo regulation of EGFr function by gangliosides...
  11. ncbi request reprint Lysosomal glycosphingolipid recognition by NKT cells
    Dapeng Zhou
    University of Chicago, Department of Pathology, Chicago, IL 60637, USA
    Science 306:1786-9. 2004
    ..We suggest that expression of iGb3 in peripheral tissues may be involved in controlling NKT cell responses to infections and malignancy and in autoimmunity...