Hiroshi Yamamoto

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice
    Hiroshi Yamamoto
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan 113 8655
    J Appl Physiol 102:2361-8. 2007
  2. ncbi request reprint Calcitonin gene-related peptide mediates acid-induced lung injury in mice
    Tomoko Aoki-Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Respirology 12:807-13. 2007
  3. ncbi request reprint A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice
    Takahide Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 284:L720-6. 2003
  4. doi request reprint Acute exogenous lipoid pneumonia caused by accidental kerosene ingestion in an elderly patient with dementia: a case report
    Hiroshi Gotanda
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Geriatr Gerontol Int 13:222-5. 2013
  5. doi request reprint The high frequency of periodic limb movements in patients with Lewy body dementia
    Shinichiro Hibi
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Psychiatr Res 46:1590-4. 2012
  6. ncbi request reprint Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice
    Tomoko Aoki-Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 283:L963-70. 2002
  7. ncbi request reprint Airspace enlargement with airway cell apoptosis in klotho mice: a model of aging lung
    Masaki Ishii
    Department of Geriatric Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Gerontol A Biol Sci Med Sci 63:1289-98. 2008
  8. ncbi request reprint Effect of nasal continuous positive airway pressure treatment on plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome: roles of nocturnal hypoxia and oxidant stress
    Hiroshi Yamamoto
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hypertens Res 30:1065-76. 2007
  9. ncbi request reprint Long-term oxygen administration reduces plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome
    Hiroshi Yamamoto
    Department of Geriatric Medicine, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Sleep Med 9:80-7. 2007
  10. ncbi request reprint [Reproducible efficacy of tricyclic antidepressant on chronic pain in an elderly patient with osteoporosis]
    Shinichiro Hibi
    Department of Geriatric Medicine, Division of Aging Science, Graduate School of Medicine, The Tokyo University
    Nihon Ronen Igakkai Zasshi 44:256-61. 2007

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Adrenomedullin insufficiency increases allergen-induced airway hyperresponsiveness in mice
    Hiroshi Yamamoto
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan 113 8655
    J Appl Physiol 102:2361-8. 2007
    ..ADM mutant mice might provide novel insights to study the pathophysiological role of ADM in vivo...
  2. ncbi request reprint Calcitonin gene-related peptide mediates acid-induced lung injury in mice
    Tomoko Aoki-Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Respirology 12:807-13. 2007
    ..Calcitonin gene-related peptide (CGRP) is a neuropeptide that has various biological actions. The current study investigated whether CGRP might have pathophysiological roles in acid-induced lung injury...
  3. ncbi request reprint A potent inhibitor of cytosolic phospholipase A2, arachidonyl trifluoromethyl ketone, attenuates LPS-induced lung injury in mice
    Takahide Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 284:L720-6. 2003
    ..The current observations suggest that pharmacological intervention of cPLA(2) could be a novel therapeutic approach to acute lung injury caused by sepsis syndrome...
  4. doi request reprint Acute exogenous lipoid pneumonia caused by accidental kerosene ingestion in an elderly patient with dementia: a case report
    Hiroshi Gotanda
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Geriatr Gerontol Int 13:222-5. 2013
    ..Acute exogenous lipoid pneumonia should be considered in the differential diagnosis for acute respiratory disorders in the rapidly aging population...
  5. doi request reprint The high frequency of periodic limb movements in patients with Lewy body dementia
    Shinichiro Hibi
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Psychiatr Res 46:1590-4. 2012
    ....
  6. ncbi request reprint Attenuation of antigen-induced airway hyperresponsiveness in CGRP-deficient mice
    Tomoko Aoki-Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Am J Physiol Lung Cell Mol Physiol 283:L963-70. 2002
    ..The CGRP-mutant mice may provide appropriate models to study molecular mechanisms underlying CGRP-related diseases...
  7. ncbi request reprint Airspace enlargement with airway cell apoptosis in klotho mice: a model of aging lung
    Masaki Ishii
    Department of Geriatric Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Gerontol A Biol Sci Med Sci 63:1289-98. 2008
    ..These data suggest that significantly increased apoptosis of airway cells via inhibition of the EGF-dependent pathway may be involved in the development of the aging lungs in KL(-/-) mice...
  8. ncbi request reprint Effect of nasal continuous positive airway pressure treatment on plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome: roles of nocturnal hypoxia and oxidant stress
    Hiroshi Yamamoto
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Hypertens Res 30:1065-76. 2007
    ..These observations suggest that nCPAP therapy could reduce OSAS-induced nocturnal hypoxemia, generation of ROS, and ADM in patients with OSAS...
  9. ncbi request reprint Long-term oxygen administration reduces plasma adrenomedullin levels in patients with obstructive sleep apnea syndrome
    Hiroshi Yamamoto
    Department of Geriatric Medicine, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Sleep Med 9:80-7. 2007
    ..We further hypothesized that oxygen administration treatment may decrease OSAS-induced hypoxic stress and ADM levels...
  10. ncbi request reprint [Reproducible efficacy of tricyclic antidepressant on chronic pain in an elderly patient with osteoporosis]
    Shinichiro Hibi
    Department of Geriatric Medicine, Division of Aging Science, Graduate School of Medicine, The Tokyo University
    Nihon Ronen Igakkai Zasshi 44:256-61. 2007
    ..Because chronic pain due to osteoporosis is often difficult to treat in elderly patients, the classic antidepressant, amitriptyline, may help pain control by narcotics and anti-inflammatory agents in some elderly patients...
  11. ncbi request reprint [A 94-year-old woman with nontuberculous mycobacterium who developed small intestinal intussusception associated with a percutaneous endoscopic jejunostomy tube]
    Masaki Ishii
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo
    Nihon Ronen Igakkai Zasshi 44:648-52. 2007
    ..Although the PEJ can be a good parenteral nutrition route for frail elderly with dysphagia, we need to consider possible complications including intussusception...
  12. ncbi request reprint [A case of limbic encephalitis with small cell lung carcinoma in which the cognitive function improved and redeteriorated during tumor therapy]
    So Fujimoto
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo
    Nihon Ronen Igakkai Zasshi 47:79-85. 2010
    ..In our case, we also observed a reworsening of the cognitive function in association with the acquired chemoresistence...
  13. ncbi request reprint [An elderly case with nontuberculous mycobacteria acompanied by unilateral massive pleural effusion following the video-assisted thoracic surgery (VATS) for lung cancer]
    Michiko Matsukawa
    Department of Geriatric Medicine, Division of Aging Science, Graduate School of Medicine, The University of Tokyo
    Nihon Ronen Igakkai Zasshi 43:643-7. 2006
    ..The pathogenesis and diagnosis of HTM in elderly cases was discussed...
  14. ncbi request reprint Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1
    Eijiro Ohga
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Japan
    J Appl Physiol 94:179-84. 2003
    ..Treatment of OSAS using nCPAP can be, therefore, a potential approach to decrease risk of the progression of OSAS-associated disorders...
  15. ncbi request reprint Beta-defensin overexpression induces progressive muscle degeneration in mice
    Yasuhiro Yamaguchi
    Dept of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Am J Physiol Cell Physiol 292:C2141-9. 2007
    ..The present findings may unravel a concealed linkage between the innate immune system and the pathophysiology of degenerative diseases...
  16. ncbi request reprint Analgesic effects of ketamine ointment in patients with complex regional pain syndrome type 1
    Takahiro Ushida
    Departments of Orthopedic Surgery, Kochi Medical School, Nankoku, Kochi, Japan
    Reg Anesth Pain Med 27:524-8. 2002
    ....
  17. ncbi request reprint Effects of oxygen administration on the circulating vascular endothelial growth factor (VEGF) levels in patients with obstructive sleep apnea syndrome
    Shinji Teramoto
    Department of Geriatric Medicine, The University of Tokyo Hospital, Tokyo
    Intern Med 42:681-5. 2003
    ..We hypothesized that circulating vascular endothelial growth factor (VEGF) levels are affected by nocturnal hypoxemia in patients with OSAS...
  18. ncbi request reprint A pivotal role of cytosolic phospholipase A(2) in bleomycin-induced pulmonary fibrosis
    Takahide Nagase
    Department of Geriatric Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Nat Med 8:480-4. 2002
    ..The inhibition of cPLA(2)-initiated pathways might provide a novel therapeutic approach to pulmonary fibrosis, for which no pharmaceutical agents are currently available...
  19. ncbi request reprint The role of the receptor for advanced glycation end-products in lung fibrosis
    Mei He
    Department of Geriatric and Respiratory Medicine, Tohoku University School of Medicine, Sendai, Japan
    Am J Physiol Lung Cell Mol Physiol 293:L1427-36. 2007
    ..Our results suggested that RAGE contributes to bleomycin-induced lung fibrosis through EMT and profibrotic cytokine production. Thus, RAGE may be a new therapeutic target for pulmonary fibrosis...
  20. pmc Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice
    Kazutake Tsujikawa
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Proc Natl Acad Sci U S A 104:16702-7. 2007
    ..These results indicate that CGRP signaling through CLR/RAMP1 receptors plays a crucial role in the regulation of both blood pressure by vascular relaxation and proinflammatory cytokine production from dendritic cells...
  21. ncbi request reprint Endotoxin apheresis for sepsis
    Tomoharu Shimizu
    Department of Surgery, Shiga University of Medical Science, Shiga, Japan
    Transfus Apher Sci 35:271-82. 2006
    ..Lixelle and CTR which have recently been shown to remove circulating bacterial components are also included in this review...
  22. ncbi request reprint Circulating concentrations of adiponectin, an endogenous lipopolysaccharide neutralizing protein, decrease in rats with polymicrobial sepsis
    Hiroshi Tsuchihashi
    Department of Surgery, Shiga University of Medical Science, Shiga, Japan
    J Surg Res 134:348-53. 2006
    ..A direct interaction between adiponectin and lipopolysaccharide (LPS) is not fully understood. To elucidate the effects of adiponectin on LPS, we first investigated interactions between recombinant adiponectin and LPS...
  23. pmc Identification of mouse orthologue of endogenous secretory receptor for advanced glycation end-products: structure, function and expression
    Ai Harashima
    Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa 920 8640, Japan
    Biochem J 396:109-15. 2006
    ..The esRAGE expression was increased in the kidney of diabetic wild-type mice. The present study has thus provided an animal orthologue of esRAGE for clarification of its roles in health and disease...
  24. ncbi request reprint Response of cochlear blood flow to prostaglandin E1 applied topically to the round window
    Mitsuo Tominaga
    Department of Otorhinolaryngology, Nagoya University School of Medicine, Nagoya, Japan
    Acta Otolaryngol 126:232-6. 2006
    ..The increase in cochlear blood flow (CBF) after administration of prostaglandin E1 (PGE1) to the round window depends on increased blood flow through the anterior inferior cerebellar artery (AICA)...
  25. ncbi request reprint Discovery, structure-activity relationship study, and oral analgesic efficacy of cyproheptadine derivatives possessing N-type calcium channel inhibitory activity
    Takashi Yamamoto
    Pharmaceutical Research Laboratory, Ajinomoto Company Inc, 1 1, Suzuki cho, Kawasaki ku, Kawasaki shi, Japan
    Bioorg Med Chem 14:5333-9. 2006
    ..13 showed an oral analgesic activity in rat formalin-induced pain model...
  26. ncbi request reprint Receptor for advanced glycation end products is involved in impaired angiogenic response in diabetes
    Takuhito Shoji
    Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1 4 3 Asahi machi, Osaka 545 8585, Japan
    Diabetes 55:2245-55. 2006
    ..Thus, RAGE appears to be involved in impairment of angiogenesis in diabetes, and blockade of RAGE might be a potential therapeutic target...
  27. ncbi request reprint Distribution of pendrin in the organ of Corti of mice observed by electron immunomicroscopy
    Takahiko Yoshino
    Department of Otorhinolaryngology, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 4668550, Japan
    Eur Arch Otorhinolaryngol 263:699-704. 2006
    ..Our study revealed that pendrin occurs in the organ of Corti. The role of pendrin in the organ of Corti and its association with the Cl- or pH regulation of neurotransmission require further study...
  28. ncbi request reprint The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury
    Ke Xiang Liu
    Department of Cardiovascular Surgery, The Second Clinical Hospital, Jilin University, Changchun, China
    Ann Thorac Cardiovasc Surg 13:301-7. 2007
    ..Thomas' Hospital cardioplegic solution (STS) to clarify the mechanism by which intracellular Na+ is accumulated after cardioplegic arrest...
  29. ncbi request reprint Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products
    Yuichi Kaji
    Department of Ophthalmology, University of Tsukuba, Institute of Clinical Medicine, Ibaraki, Japan
    Invest Ophthalmol Vis Sci 48:858-65. 2007
    ..In the present study, the role of an AGE receptor, RAGE, was investigated in the development of diabetic retinopathy in vivo...
  30. ncbi request reprint CD90-positive cells, an additional cell population, produce laminin alpha2 upon transplantation to dy(3k)/dy(3k) mice
    So ichiro Fukada
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamada oka, Suita, Osaka 565 0871, Japan
    Exp Cell Res 314:193-203. 2008
    ..Thus, CD90(+) cells are a newly identified additional cell fraction that increased during skeletal muscle regeneration in vivo and could be another cell source for therapy for lama2-deficient muscular dystrophy...
  31. ncbi request reprint Direct hemoperfusion using a polymyxin B immobilized column improves acute respiratory distress syndrome
    Kenji Tsushima
    First Department of Internal Medicine, Shinshu University School of Medicine, Asahi, Matsumoto, Japan
    J Clin Apher 17:97-102. 2002
    ..In ARDS patients, PMX-DHP improved circulatory disturbance and oxygenation despite the underlying diseases. The mortality improved compared with that before induction of PMX-DHP...
  32. ncbi request reprint Autologous transplantation of SM/C-2.6(+) satellite cells transduced with micro-dystrophin CS1 cDNA by lentiviral vector into mdx mice
    Madoka Ikemoto
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan
    Mol Ther 15:2178-85. 2007
    ..These results suggest that there is potential for lentiviral vector-mediated ex vivo gene therapy for DMD...
  33. ncbi request reprint Adult Langerhans cell histiocytosis with independently relapsing lung and liver lesions that was successfully treated with etoposide
    Satoshi Konno
    First Department of Medicine, Hokkaido University School of Medicine, Sapporo
    Intern Med 46:1231-5. 2007
    ..Intravenous etoposide was started, and the liver nodules decreased markedly. The difference in the clinical course between the lung and liver lesions might have been the result of differences in the clonality of these two organs...
  34. ncbi request reprint Molecular signature of quiescent satellite cells in adult skeletal muscle
    So ichiro Fukada
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira, Tokyo 187 8502, Japan
    Stem Cells 25:2448-59. 2007
    ..Our data provide roles of CTR in quiescent satellite cells and a solid scaffold to further dissect molecular regulation of satellite cells. Disclosure of potential conflicts of interest is found at the end of this article...
  35. ncbi request reprint Inflammatory lesions of the lung, submandibular gland, bile duct and prostate in a patient with IgG4-associated multifocal systemic fibrosclerosis
    Ghullam Hamed
    First Department of Internal Medicine, Shinsu University School of Medicine, Asahi Matsumoto, Japan
    Respirology 12:455-7. 2007
    ..It is now necessary for MSF to be considered in patients with pulmonary lesions mimicking lung cancer...
  36. ncbi request reprint Expression of mdr1 is required for efficient long term regeneration of dystrophic muscle
    David Israeli
    Genethon, CNRS UMR 8115, Evry, France
    Exp Cell Res 313:2438-50. 2007
    ..Moreover, our results suggest a hitherto unappreciated role of mdr1 in precursor cells of regenerating tissue; they therefore provide an important clue to the physiological significance of mdr1 expression in stem cells...
  37. ncbi request reprint gammadelta T cells: firefighters or fire boosters in the front lines of inflammatory responses
    Masanobu Nanno
    Yakult Central Institute for Microbiological Research, Kunitachi, Tokyo, Japan
    Immunol Rev 215:103-13. 2007
    ..Taken together, in addition to the homeostatic regulation of epithelial tissues, gammadelta T cells appear to play a pivotal role in the modification of inflammatory responses induced in many organs containing epithelia...
  38. pmc The secreted form of the p40 subunit of interleukin (IL)-12 inhibits IL-23 functions and abrogates IL-23-mediated antitumour effects
    Osamu Shimozato
    Division of Pathology, Chiba Cancer Center Research Institute, Nitona, Chiba, Japan
    Immunology 117:22-8. 2006
    ..p40 can thereby antagonize IL-23 and is a possible therapeutic agent for suppression of IL-23 functions...
  39. ncbi request reprint Disruption of orofacial movement topographies in congenic mutants with dopamine D5 but not D4 receptor or DARPP-32 transduction 'knockout'
    Katsunori Tomiyama
    Nihon University Advanced Research Institute for the Sciences and Humanities, Tokyo 102, Japan
    Eur Neuropsychopharmacol 16:437-45. 2006
    ..In assuming that the well-recognised role of the D(1)-like family in regulating orofacial movements involves primarily D(1) receptors, a role for their D(5) counterparts may have been overlooked...
  40. pmc Identification of histidine kinases that act as sensors in the perception of salt stress in Synechocystis sp. PCC 6803
    Kay Marin
    Universitat Rostock, FB Biowisenschaften, Pflanzenphysiologie, Albert Einsteinstrasse 3a, 18051 Rostock, Germany
    Proc Natl Acad Sci U S A 100:9061-6. 2003
    ..We also used DNA microarrays to investigate the effect of various salts on gene expression. Our results indicate that Hik33 responds to sodium salts and not to KCl, whereas the Hik16/Hik41 system responds only to NaCl...
  41. pmc Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice
    Hiroaki Masuzaki
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 112:83-90. 2003
    ..The potential role of adipose 11beta-HSD1 in mediating critical features of the metabolic syndrome extends beyond obesity and metabolic complications to include the most central cardiovascular feature of this disorder...
  42. ncbi request reprint Clinical efficacy and toxicity of gefitinib in patients with lung cancer
    Shinji Teramoto
    Lancet 361:1992-3. 2003
  43. ncbi request reprint Dietary cadmium inhibits spontaneous hepatocarcinogenesis in C3H/HeN mice and hepatitis in A/J mice, but not in C57BL/6 mice
    Shoji Nishiyama
    Department of Environmental Health, Kochi Medical School, Nankoku, Kochi 783 8506, Japan
    Toxicol Appl Pharmacol 186:1-6. 2003
    ..Our results suggest that low doses of cadmium in the diet or environment may play a beneficial role in the prevention of hepatic disease in humans and animals...
  44. ncbi request reprint In vivo response of neutrophils and epithelial cells to lipopolysaccharide injected into the monkey ileum
    Hirotsugu Imaeda
    Department of Anatomy, Shiga University of Medical Science, Otsu, Shiga, 520 2192, Japan
    Histochem Cell Biol 118:381-8. 2002
    ..Expression of TLR4 and IRAK-1 in the epithelial cells suggests that epithelial cells may react to LPS and produce chemoattractant mediator to induce the neutrophil chemotaxis...
  45. pmc Salt stress inhibits the repair of photodamaged photosystem II by suppressing the transcription and translation of psbA genes in synechocystis
    Suleyman I Allakhverdiev
    Department of Regulation Biology, National Institute for Basic Biology, Myodaiji, Okazaki 444 8585, Japan
    Plant Physiol 130:1443-53. 2002
    ..Thus, our results suggest that salt stress inhibits the repair of PSII via suppression of the activities of the transcriptional and translational machinery...
  46. pmc A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis
    Katsushi Yamaguchi
    Department of Regulation Biology, National Institute for Basic Biology, Okazaki 444 8585, Japan
    Plant Cell 14:2901-13. 2002
    ..At low concentrations of Mn(2+) ions, ManS does not generate a signal, with resulting inactivation of ManR and subsequent expression of the mntCAB operon...
  47. ncbi request reprint [An adult patient with varicella-zoster pneumonia while under inhaled steroid treatment]
    Masanori Yasuo
    Department of Respiratory Medicine, Komoro Kousei General Hospital, 2 31 Yora cho, Komoro, Nagano 384 8588, Japan
    Nihon Kokyuki Gakkai Zasshi 40:77-80. 2002
    ..The demonstration of varicella-zoster virus DNA in a bronchoalveolar lavage specimen by the polymerase chain reaction technique was useful in the formulation of a definitive diagnosis...
  48. ncbi request reprint Muscle regeneration by reconstitution with bone marrow or fetal liver cells from green fluorescent protein-gene transgenic mice
    So ichiro Fukada
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    J Cell Sci 115:1285-93. 2002
    ..The results suggest that both bone marrow and fetal liver cells may have the potential to differentiate into muscle satellite cells and participate in muscle regeneration after muscle damage as well as in physiological muscle generation...
  49. ncbi request reprint Homeostatic regulation of intestinal villous epithelia by B lymphocytes
    Yasuhiro Nishiyama
    Department of Microbiology, Keio University School of Medicine, Nippon Medical School, Tokyo, Japan
    J Immunol 168:2626-33. 2002
    ....
  50. ncbi request reprint Interleukin 6 induces overexpression of the sarcolemmal utrophin in neonatal mdx skeletal muscle
    Keita Fujimori
    Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Hum Gene Ther 13:509-18. 2002
    ..Taken together, these results suggest that IL-6 can induce overexpression of utrophin on the extrasynaptic sarcolemma but requires preexisting factors in neonatal mdx muscle to fully regulate utrophin expression...
  51. ncbi request reprint Lung tissue distribution after intravenous administration of grepafloxacin: comparative study with levofloxacin
    Hiroshi Yamamoto
    First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan
    Jpn J Pharmacol 88:63-8. 2002
    ..These observations suggest that the pharmacokinetic characteristics of GPFX in the lung may provide a new insight into the strategy for clinical treatment of various pulmonary infections, especially cytotropic bacterial infections...
  52. ncbi request reprint Effects of resuscitation with hydroxyethyl starch (HES) on pulmonary hemodynamics and lung lymph balance in hemorrhagic sheep; comparative study of low and high molecular HES
    Toshimichi Kaneki
    First Department of Internal Medicine, Shinshu University School of Medicine, 3 1 1 Asahi Matsumoto, Shinshu, 390 8621, Japan
    Resuscitation 52:101-8. 2002
    ..These data suggest that low molecular HES is as useful a plasma substitute as high molecular HES, but has a possibility to increase lung lymph filtration during the early phase of resuscitation...
  53. ncbi request reprint Simultaneous live video presentation during knee arthroscopy
    Masanobu Tanaka
    Department of Orthopaedic Surgery, Kochi Medical School, Oko cho, Nankoku, 783 8505, Japan
    J Orthop Sci 8:518-21. 2003
    ..Live video-presented outpatient arthroscopic knee surgery could be considered a method for improving patient understanding of knee pathology...
  54. ncbi request reprint Effects of a selective nitric oxide synthase inhibitor on endotoxin-induced alteration in hypoxic pulmonary vasoconstriction in sheep
    Hitoshi Ogasawara
    First Department of Medicine, Shinshu University School of Medicine, Masumoto, Japan
    J Cardiovasc Pharmacol 42:521-6. 2003
    ..1+/-3.6% in Exp 2, 5 hours, 25.3+/-2.5% in Exp 1 versus 7.7+/-2.2% in Exp 2, 24 hours). It is suggested that inducible nitric oxide is related to pulmonary vascular hyporesponsiveness to hypoxia during endotoxemia in sheep...
  55. ncbi request reprint Role of gamma delta T cells in the inflammatory response of experimental colitis mice
    Takahiro Tsuchiya
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    J Immunol 171:5507-13. 2003
    ....
  56. ncbi request reprint Leukemia inhibitory factor induces endothelial differentiation in cardiac stem cells
    Tomomi Mohri
    Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, Suita City, Osaka, Japan
    J Biol Chem 281:6442-7. 2006
    ..Collectively, it is proposed that LIF regulates the commitment of cardiac stem cells into the endothelial cell lineage, contributing to neovascularization in the process of tissue remodeling and/or regeneration...
  57. ncbi request reprint Upregulation of HSP by geranylgeranylacetone protects the cochlear lateral wall from endotoxin-induced inflammation
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Hear Res 204:140-6. 2005
    ..The results of the present study suggest that GGA can protect the cochlea against other injuries including those induced by noise, ototoxic drugs, and ischemia by upregulating HSP70...
  58. pmc The N-terminal domain of thrombomodulin sequesters high-mobility group-B1 protein, a novel antiinflammatory mechanism
    Kazuhiro Abeyama
    Department of Laboratory and Molecular Medicine, Shin Nippon Biomedical Laboratories Inc SNBL, Kagoshima University, Japan
    J Clin Invest 115:1267-74. 2005
    ....
  59. ncbi request reprint Obstructive sleep apnea causes systemic inflammation and metabolic syndrome
    Shinji Teramoto
    Chest 127:1074-5. 2005
  60. ncbi request reprint Roles of the receptor for advanced glycation endproducts in diabetes-induced vascular injury
    Hideto Yonekura
    Department of Biochemistry and Molecular Vascular Biology, Kanazawa University Graduate School of Medical Science, Kanazawa
    J Pharmacol Sci 97:305-11. 2005
    ..The AGE-RAGE system should be, therefore, a candidate molecular target for overcoming diabetic vascular complications...
  61. ncbi request reprint Increased neutrophils in bronchoalveolar lavage fluids from a patient with pulmonary edema associated with pheochromocytoma
    Noriaki Sukoh
    Department of Pulmonary Disease, Hokkaido Cancer Center, Sapporo
    Intern Med 43:1194-7. 2004
    ..Bronchoalveolar lavage fluids (BALF) showed a marked accumulation of neutrophils, suggesting involvement of neutrophil-mediated lung injury in noncardiogenic pulmonary edema associated with a pheochromocytoma...
  62. ncbi request reprint Topographical effects of D1-like dopamine receptor agonists on orofacial movements in mice and their differential regulation via oppositional versus synergistic D1-like: D2-like interactions: cautionary observations on SK&F 82958 as an anomalous agent
    Yasuyuki Makihara
    Department of Pharmacology, Nihon University School of Dentistry, Tokyo, Japan
    J Psychopharmacol 18:484-95. 2004
    ..Additionally, results obtained using SK&F 82958 as a probe for D1-like mechanisms should be treated with considerable caution until they are confirmed using other D1-like agonists...
  63. ncbi request reprint Aminopeptidase N/CD13 regulates the fetal liver microenvironment of hematopoiesis
    Naoki Sakane
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, Japan
    Biol Pharm Bull 27:2014-20. 2004
    ..We propose that aminopeptidase N/CD13 is a critical molecule that regulates the survival of c-kit+ cells in the FL microenvironment...
  64. ncbi request reprint Correlation between semaphorin3A-induced facilitation of axonal transport and local activation of a translation initiation factor eukaryotic translation initiation factor 4E
    Chanxia Li
    Department of Molecular Pharmacology and Neurobiology, Yokohama City University Graduate School of Medicine, Yokohama 236 0004, Japan
    J Neurosci 24:6161-70. 2004
    ..These results provide evidence for a mutual regulatory mechanism between local protein synthesis and axonal transport...
  65. ncbi request reprint Benzamides and benzamidines as specific inhibitors of epidermal growth factor receptor and v-Src protein tyrosine kinases
    Toru Asano
    Department of Chemistry, Graduate School of Science, Tohoku University, Sendai 980 8588, Japan
    Bioorg Med Chem 12:3529-42. 2004
    ..61, whereas that of the benzamide 1c was 5.05. In a similar manner, the LigScore2 value of the cyclic benzamidine 3a was calculated as 5.10...
  66. ncbi request reprint Up-regulation of IL-4 production by the activated cAMP/cAMP-dependent protein kinase (protein kinase A) pathway in CD3/CD28-stimulated naive T cells
    Koji Tokoyoda
    Department of Immunology, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Int Immunol 16:643-53. 2004
    ..These findings indicate that the cAMP/PKA pathway transduces the critical activation signal to T(h)2 polarization by a CD3/CD28 co-stimulation signal and a PKA activating reagent...
  67. ncbi request reprint Advanced glycation end products increase collagen-specific chaperone protein in mouse diabetic nephropathy
    Seiji Ohashi
    Department of Clinical Biology and Medicine, Course of Biological Medicine, School of Medicine, The University of Tokushima, 3 18 15 Kuramoto cho, Tokushima 770 8503, Japan
    J Biol Chem 279:19816-23. 2004
    ..In conclusion, AGEs increase the expression of HSP47 in association with collagens, both in vivo and in vitro. The processes may be mediated by TGF-beta...
  68. ncbi request reprint A comparative study of intratympanic steroid and NO synthase inhibitor for treatment of cochlear lateral wall damage due to acute otitis media
    Michihiko Sone
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa, Nagoya 466 8550, Japan
    Eur J Pharmacol 482:313-8. 2003
    ..Our results show the effectiveness of intratympanic dexamethasone or NOS-inhibitor in treating cochlear lateral wall damage caused by otitis media...
  69. ncbi request reprint Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine
    Hiromasa Hamada
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Immunol 168:57-64. 2002
    ..These findings indicate that ILF, PP, and CP constitute three distinct organized gut-associated lymphoid tissues that reside in the lamina propria of the mouse small intestine...