Shizuo Yamada

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi request reprint In vivo demonstration of M3 muscarinic receptor subtype selectivity of darifenacin in mice
    Shizuo Yamada
    Department of Pharmacokinetics and Pharmacodynamics, University of Shizuoka, Shizuoka 422 8526, Japan
    Life Sci 80:127-32. 2006
  2. doi request reprint Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice
    Yoshihiko Ito
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Eur J Pharmacol 615:201-6. 2009
  3. doi request reprint Novel solid self-emulsifying drug delivery system of coenzyme Q₁₀ with improved photochemical and pharmacokinetic behaviors
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 46:492-9. 2012
  4. doi request reprint Physicochemical and pharmacological characterization of alpha-tocopherol-loaded nano-emulsion system
    Junya Hatanaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Int J Pharm 396:188-93. 2010
  5. doi request reprint Comparative studies on physicochemical stability of cyclosporine A-loaded amorphous solid dispersions
    Hideyuki Sato
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 426:302-6. 2012
  6. doi request reprint Novel dry powder inhaler formulation of glucagon with addition of citric acid for enhanced pulmonary delivery
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 382:144-50. 2009
  7. doi request reprint Stable dry powder inhaler formulation of tranilast attenuated antigen-evoked airway inflammation in rats
    Yohei Kawabata
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, University of Shizuoka, Shizuoka, Japan
    Eur J Pharm Biopharm 77:178-81. 2011
  8. doi request reprint Inhalable sustained-release formulation of long-acting vasoactive intestinal peptide derivative alleviates acute airway inflammation
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Peptides 35:182-9. 2012
  9. doi request reprint Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria
    Chika Taniguchi
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 434:148-54. 2012
  10. doi request reprint Liposomal formulations of glucagon-like peptide-1: improved bioavailability and anti-diabetic effect
    Junko Hanato
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 382:111-6. 2009

Collaborators

Detail Information

Publications127 found, 100 shown here

  1. ncbi request reprint In vivo demonstration of M3 muscarinic receptor subtype selectivity of darifenacin in mice
    Shizuo Yamada
    Department of Pharmacokinetics and Pharmacodynamics, University of Shizuoka, Shizuoka 422 8526, Japan
    Life Sci 80:127-32. 2006
    ..In conclusion, the present study has shown that oral darifenacin may exert a pronounced and long-lasting binding of muscarinic receptors in tissues expressing the M(3) subtype...
  2. doi request reprint Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice
    Yoshihiko Ito
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Eur J Pharmacol 615:201-6. 2009
    ..Oral solifenacin may be advantageous for the treatment of overactive bladder, in terms of high affinity for M(3) receptors in the bladder...
  3. doi request reprint Novel solid self-emulsifying drug delivery system of coenzyme Q₁₀ with improved photochemical and pharmacokinetic behaviors
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 46:492-9. 2012
    ..From the improved physicochemical and pharmacokinetic data, the s-SEDDS approach upon spray-drying might be a suitable dosage option for enhancing nutraceutical and pharmaceutical values of CoQ(10)...
  4. doi request reprint Physicochemical and pharmacological characterization of alpha-tocopherol-loaded nano-emulsion system
    Junya Hatanaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Int J Pharm 396:188-93. 2010
    ..With these findings, the NE approach might be efficacious to improve the oral bioavailability and anti-oxidative activities of alpha-TC...
  5. doi request reprint Comparative studies on physicochemical stability of cyclosporine A-loaded amorphous solid dispersions
    Hideyuki Sato
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 426:302-6. 2012
    ..From these findings, stability on CsA-loaded SD might be variable depending on the preparation methodology, and the wet-milling approach could be a viable option for preparing efficacious SD formulations with improved stability...
  6. doi request reprint Novel dry powder inhaler formulation of glucagon with addition of citric acid for enhanced pulmonary delivery
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 382:144-50. 2009
    ..Based on these physicochemical and pharmacological characterization, the dry powder inhaler of glucagon with addition of citric acid would be of use as an alternative to injection form...
  7. doi request reprint Stable dry powder inhaler formulation of tranilast attenuated antigen-evoked airway inflammation in rats
    Yohei Kawabata
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, University of Shizuoka, Shizuoka, Japan
    Eur J Pharm Biopharm 77:178-81. 2011
    ..Given these findings, inhalable TL formulation might be an interesting alternative to oral therapy for the treatment of asthma and other airway inflammatory diseases with sufficient dispersing stability...
  8. doi request reprint Inhalable sustained-release formulation of long-acting vasoactive intestinal peptide derivative alleviates acute airway inflammation
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Peptides 35:182-9. 2012
    ..From these findings, newly prepared IK312532/NS-RP might be of clinical importance in improving duration of action and medication compliance for treatment of airway inflammatory diseases...
  9. doi request reprint Novel formulations of dipyridamole with microenvironmental pH-modifiers for improved dissolution and bioavailability under hypochlorhydria
    Chika Taniguchi
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 434:148-54. 2012
    ..From these findings, the addition of TS as a microenvironmental pH-modifier in DP formulation might be beneficial in expanding the therapeutic potential of DP in hypochlorhydric patients...
  10. doi request reprint Liposomal formulations of glucagon-like peptide-1: improved bioavailability and anti-diabetic effect
    Junko Hanato
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 382:111-6. 2009
    ..Upon these findings, anionic liposomal formulation of GLP-1 would provide the improved pharmacokinetics and insulinotropic action, possibly leading to efficacious anti-diabetic medication...
  11. doi request reprint Inhalable dry-emulsion formulation of cyclosporine A with improved anti-inflammatory effects in experimental asthma/COPD-model rats
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, University of Shizuoka, Shizuoka, Japan
    Eur J Pharm Biopharm 80:54-60. 2012
    ..From these findings, use of inhalable DE formulation of CsA might be a promising approach for the treatment of airway inflammatory diseases with improved pharmacodynamics and lower systemic exposure...
  12. ncbi request reprint Pharmacologically relevant receptor binding characteristics and 5alpha-reductase inhibitory activity of free Fatty acids contained in saw palmetto extract
    Masayuki Abe
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 32:646-50. 2009
    ..6 microg/ml. In conclusion, lauric acid, oleic acid, myristic acid, and linoleic acid, major constituents of SPE, exerted binding activities of alpha(1)-adrenergic, muscarinic and 1,4-DHP receptors and inhibited 5alpha-reductase activity...
  13. doi request reprint Chemical synthesis and formulation design of a PEGylated vasoactive intestinal peptide derivative with improved metabolic stability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 49:382-9. 2013
    ..From these findings, PEGylation of a VIP derivative, as well as its strategic application to the RP formulation, may be a viable approach to improve its therapeutic potential for the treatment of airway inflammatory diseases...
  14. doi request reprint Fesoterodine, its active metabolite, and tolterodine bind selectively to muscarinic receptors in human bladder mucosa and detrusor muscle
    Akira Yoshida
    Department of Pharmacokinetics and Pharmacodynamics, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Urology 81:920.e1-5. 2013
    ..To comparatively characterize the binding activity of fesoterodine, its active metabolite (5-hydroxymethyl tolterodine [5-HMT]), and tolterodine in the human bladder mucosa, detrusor muscle, and parotid gland...
  15. doi request reprint In vitro and in vivo characterization of new formulations of St. John's Wort extract with improved pharmacokinetics and anti-nociceptive effect
    Junya Hatanaka
    Department of Pharmacokinetics and Pharmacodynamics School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Drug Metab Pharmacokinet 26:551-8. 2011
    ..From these findings, the NE approach might be efficacious in improving the oral bioavailability and anti-nociceptive effect of SJW extract...
  16. ncbi request reprint Enhancement by grapefruit juice of morphine antinociception
    Takashi Okura
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence and Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 31:2338-41. 2008
    ..These results suggest that oral administration of grapefruit juice enhances the morphine antinociception by increasing the intestinal absorption of this agent...
  17. pmc Combined use of in vitro phototoxic assessments and cassette dosing pharmacokinetic study for phototoxicity characterization of fluoroquinolones
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Japan
    AAPS J 13:482-92. 2011
    ..Combined use of in vitro photobiochemical and cassette dosing PK data will be useful for predicting in vivo phototoxic potentials of drug candidates with high productivity and reliability...
  18. doi request reprint Development of novel solid dispersion of tranilast using amphiphilic block copolymer for improved oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 452:220-6. 2013
    ..From these findings, pMB-based SD formulation approach might be an efficacious approach for enhancing the therapeutic potential of TL...
  19. ncbi request reprint Physicochemical and pharmacokinetic characterization of amorphous solid dispersion of tranilast with enhanced solubility in gastric fluid and improved oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Drug Metab Pharmacokinet 27:379-87. 2012
    ..With these data, the ASD approach could be a viable formulation strategy for enhancing the wettability and oral bioavailability of TL, resulting in improved therapeutic potential of TL for the treatment of inflammatory diseases...
  20. doi request reprint Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 426:61-6. 2012
    ..Given the improved systemic exposure early after oral administration in hypochlorhydric rats, the DPG/FA might provide better clinical outcomes in hypochlorhydric patients...
  21. doi request reprint Inhalable powder formulation of a stabilized vasoactive intestinal peptide (VIP) derivative: anti-inflammatory effect in experimental asthmatic rats
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Peptides 31:72-8. 2010
    ..Thus, inhalable powder formulation of IK312532 exerts its anti-inflammatory activity by suppressing granulocyte recruitment to the lung and epithelial hyperplasia, followed by the reduction of cytotoxic peroxidases...
  22. doi request reprint Development of inhalable nanocrystalline solid dispersion of tranilast for airway inflammatory diseases
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    J Pharm Sci 100:622-33. 2011
    ....
  23. ncbi request reprint Effects of continuous administration of paroxetine on ligand binding site and expression of serotonin transporter protein in mouse brain
    Kazufumi Hirano
    Department of Biopharmaceutical Sciences and Center of Excellence COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res 1053:154-61. 2005
    ..Such down-regulation of SERT may partly underlie the therapeutic effect of long-term treatment with SSRIs in human...
  24. pmc Quantitative analysis of the loss of muscarinic receptors in various peripheral tissues in M1-M5 receptor single knockout mice
    Yoshihiko Ito
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, Japan
    Br J Pharmacol 156:1147-53. 2009
    ..To compare loss in binding to muscarinic receptor (mAChR) subtypes with their known functions, the total density of muscarinic receptors was measured in peripheral tissues from wild type (WT) and mAChR knockout (KO) mice...
  25. doi request reprint Development of cyclosporine A-loaded dry-emulsion formulation using highly purified glycerol monooleate for safe inhalation therapy
    Hideyuki Sato
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 448:282-9. 2013
    ..Thus, the strategic use of hpGMO would improve oxidative stability and local toxicity compared with a GMO-based DE formulation, and its application to RP formulation could be a promising approach for effective inhalation therapy...
  26. doi request reprint In vitro photochemical and phototoxicological characterization of major constituents in St. John's Wort (Hypericum perforatum) extracts
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Phytochemistry 72:1814-20. 2011
    ..In conclusion, our results suggested that hypericin, pseudohypericin, and hyperforin might be responsible for the in vitro phototoxic effects of SJW extract...
  27. doi request reprint Self-assembled micellar formulation of chafuroside A with improved anti-inflammatory effects in experimental asthma/COPD-model rats
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 45:184-9. 2012
    ..From these observations, the SAM formulation might be an efficacious approach for enhancing the therapeutic potential of CFA for treatment of inflammatory diseases...
  28. ncbi request reprint In vivo characterization of muscarinic receptors in peripheral tissues: evaluation of bladder selectivity of anticholinergic agents to treat overactive bladder
    Shuji Maruyama
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:463-71. 2008
    ....
  29. doi request reprint Development of high-energy amorphous solid dispersion of nanosized nobiletin, a citrus polymethoxylated flavone, with improved oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Pharm Sci 100:3793-801. 2011
    ..These findings suggest that an amorphous, nanosized SD could be a viable option for enhancing the bioavailability and CNS delivery of NOB...
  30. doi request reprint Noninvasive evaluation of brain muscarinic receptor occupancy of oxybutynin, darifenacin and imidafenacin in rats by positron emission tomography
    Akira Yoshida
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Life Sci 87:175-80. 2010
    ..The current study was conducted to evaluate, by the noninvasive positron emission tomography (PET), the binding of antimuscarinic agents used to treat overactive bladder (OAB) to muscarinic receptors in rat brain...
  31. ncbi request reprint Characterization of muscarinic receptor binding and inhibition of salivation after oral administration of tolterodine in mice
    Tomomi Oki
    Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Science, University of Shizuoka, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharmacol 529:157-63. 2006
    ....
  32. doi request reprint Formulation design and in vivo evaluation of dry powder inhalation system of new vasoactive intestinal peptide derivative ([R(15, 20, 21), L(17), A(24,25), des-N(28)]-VIP-GRR) in experimental asthma/COPD model rats
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 410:54-60. 2011
    ..Thus, respirable powder formulation of IK312548 might be a promising medication for asthma, COPD, and other airway inflammatory diseases...
  33. ncbi request reprint Antinociceptive effects of St. John's wort, Harpagophytum procumbens extract and Grape seed proanthocyanidins extract in mice
    Shinya Uchida
    Department of Pharmacokinetics and Pharmacodynamics and Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Biol Pharm Bull 31:240-5. 2008
    ..In addition, opioidergic system seems to be involved in the antinociceptive effect of HPE but not SJW and GSPE. Furthermore, SJW potentiates morphine-induced antinociception possibly by pharmacodynamic interaction...
  34. doi request reprint Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: basic approaches and practical applications
    Yohei Kawabata
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 420:1-10. 2011
    ..A better understanding of the physicochemical and biopharmaceutical properties of drug substances and the limitations of each delivery option should lead to efficient formulation development for poorly water-soluble drugs...
  35. doi request reprint In vitro and in vivo characterization on amorphous solid dispersion of cyclosporine A for inhalation therapy
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Control Release 138:16-23. 2009
    ..Upon these findings, WM/CsA-RP would be efficacious dosage form for clinical treatment of airway inflammations with minimal systemic side effects...
  36. doi request reprint Effects of quinidine on antinociception and pharmacokinetics of morphine in rats
    Takashi Okura
    Department of Pharmacokinetics, Pharmacodynamics, Global Center of Excellence COE and Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Pharm Pharmacol 61:593-7. 2009
    ..The aim of this study was to investigate the effect of quinidine, a P-glycoprotein inhibitor, on the pharmacokinetics and pharmacodynamics of morphine in rats...
  37. doi request reprint Characterization of muscarinic receptors in the human bladder mucosa: direct quantification of subtypes using 4-DAMP mustard
    Akira Yoshida
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Urology 78:721.e7-721.e12. 2011
    ..To characterize pharmacologically relevant muscarinic receptors in the human bladder mucosa and detrusor muscle using radioligand binding assays with [N-methyl-3H]scopolamine methyl chloride ([3H]NMS) and 4-DAMP mustard...
  38. ncbi request reprint Comparative evaluation of central muscarinic receptor binding activity by oxybutynin, tolterodine and darifenacin used to treat overactive bladder
    Tomomi Oki
    Department of Pharmacokinetics and Pharmacodynamics, University of Shizuoka, Suruga ku, Shizuoka, Japan
    J Urol 177:766-70. 2007
    ..We characterized muscarinic receptor binding in the mouse cerebral cortex after oral administration of anticholinergic agents used to treat overactive bladder...
  39. ncbi request reprint Onset of clinical effects and plasma concentration of fluvoxamine in Japanese patients
    Yasuhiro Katoh
    Department of Pharmacy Practice and Science, University of Shizuoka, Japan
    Biol Pharm Bull 33:1999-2002. 2010
    ..Our results suggest that HAMD score after the first week of treatment with fluvoxamine and the upper threshold of plasma drug concentration could predict whether a patient is a non-responder...
  40. pmc Relationship between brain serotonin transporter binding, plasma concentration and behavioural effect of selective serotonin reuptake inhibitors
    Kazufumi Hirano
    Department of Biopharmaceutical Sciences and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Br J Pharmacol 144:695-702. 2005
    ....
  41. doi request reprint Improved dissolution and pharmacokinetic behavior of cyclosporine A using high-energy amorphous solid dispersion approach
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Int J Pharm 399:94-101. 2010
    ..From the improved dissolution and pharmacokinetic data, the amorphous SD approach using wet-milling technology should lead to consistent and enhanced bioavailability, leading to an improved therapeutic potential of CsA...
  42. ncbi request reprint Comparative evaluation of exocrine muscarinic receptor binding characteristics and inhibition of salivation of solifenacin in mice
    Tomomi Oki
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 29:1397-400. 2006
    ....
  43. doi request reprint High-throughput screening system for identifying phototoxic potential of drug candidates based on derivatives of reactive oxygen metabolites
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Pharm Res 27:1610-9. 2010
    ..The present study aimed to develop a high-throughput screening strategy for predicting the phototoxic potential of pharmaceutical substances, using a derivatives-of-reactive-oxygen-metabolites (D-ROM) assay...
  44. doi request reprint Up-regulation of nicotinic and muscarinic receptor mRNA in rat bladder by repeated administration of nicotine in relation to the pharmacokinetics
    Noriyuki Yamamoto
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Life Sci 89:343-8. 2011
    ..The current study aimed to investigate the effects of repeated treatment with nicotine on nicotinic and muscarinic receptors in the rat bladder...
  45. ncbi request reprint The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: bladder selectivity based on in vivo drug-receptor binding characteristics of antimuscarinic agents for treatment of overactive bladder
    Akira Yoshida
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Pharmacol Sci 112:142-50. 2010
    ..Similar findings were also observed with positron emission tomography in conscious rhesus monkeys. The newer generation of antimuscarinic agents may be advantageous in the bladder selectivity after systemic administration...
  46. doi request reprint Pharmacological effects of saw palmetto extract in the lower urinary tract
    Mayumi Suzuki
    Department of Pharmacokinetics and Pharmacodynamics, Pharmacognosy and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Acta Pharmacol Sin 30:227-81. 2009
    ..This review should contribute to the understanding of the pharmacological effects of SPE in the treatment of patients with BPH and associated lower urinary tract symptoms (LUTS)...
  47. doi request reprint Inhalable powder formulation of vasoactive intestinal peptide derivative, [R15,20,21, L17]-VIP-GRR, attenuated neutrophilic airway inflammation in cigarette smoke-exposed rats
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 41:508-14. 2010
    ..The present findings suggest that an inhalable formulation of IK312532 might be efficacious as a therapy for COPD or other airway inflammatory diseases because of its potent immunomodulating activities...
  48. doi request reprint Evaluation of the pharmacokinetic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence COE, Practical Pharmacy and Clinical Pharmaceutics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Pharm Pharmacol 63:58-64. 2011
    ....
  49. doi request reprint In vitro photobiochemical characterization of sulfobutylether-β-cyclodextrin formulation of bufexamac
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Pharm Biomed Anal 55:591-6. 2011
    ..The phototoxic risk of bufexamac might be attenuated by SBECD complexation, and cyclodextrin inclusion complexes might be a useful approach for modulating the phototoxicity of drugs...
  50. ncbi request reprint Muscarinic receptor binding of the novel radioligand, [(3)h]imidafenacin in the human bladder and parotid gland
    Akira Yoshida
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Pharmacol Sci 124:40-6. 2014
    ..3)H]Imidafenacin may also be a useful radioligand for labeling the M3 subtype of muscarinic receptors with higher selectivity than other radioligands. ..
  51. doi request reprint Effects of Ginkgo biloba extract on the pharmacokinetics and pharmacodynamics of tolbutamide in protein-restricted rats
    Yuko Taki
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Pharm Pharmacol 63:1238-43. 2011
    ..Effects of repeated administration of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide were examined in rats fed a low-protein diet...
  52. ncbi request reprint Urodynamics and bladder muscarinic receptors in rats with cerebral infarction and bladder outlet obstruction
    Shuji Maruyama
    Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Neurosci Lett 414:80-4. 2007
    ....
  53. doi request reprint Novel vasoactive intestinal peptide derivatives with improved stability protect rat alveolar L2 cells from cigarette smoke-induced cytotoxicity and apoptosis
    Shingen Misaka
    Department of Pharmacokinetics, University of Shizuoka, Suruga ku, Shizuoka 422 8526, Japan
    Peptides 32:401-7. 2011
    ..Thus, the present study is the first to demonstrate that novel stabilized VIP derivatives exert anti-apoptotic and cytoprotective effects on CSE-induced cytotoxicity...
  54. ncbi request reprint Different effects of morphine and morphine-6beta-glucuronide on formalin-evoked spinal glutamate release in conscious and freely moving rats
    Takashi Okura
    Department of Pharmacokinetics and Pharmacodynamics and Center of Excellence COE Research Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurosci Lett 415:169-73. 2007
    ..These results suggest a significant difference between morphine and M6G in the participation of spinal glutamate for the antinociceptive effect...
  55. doi request reprint Physicochemical and pharmacokinetic characterization of water-soluble Coenzyme Q(10) formulations
    Junya Hatanaka
    Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Int J Pharm 363:112-7. 2008
    ..Although similar kinetic values were seen with T(max) of 1.5 and 1.7h, respectively, for NE and crystalline CoQ(10), NE exhibited ca 1.7-fold higher AUC and C(max) than the crystalline CoQ(10)...
  56. doi request reprint Formulation design and photochemical studies on nanocrystal solid dispersion of curcumin with improved oral bioavailability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Pharm Sci 99:1871-81. 2010
    ..On the basis of these observations, taken together with dissolution and pharmacokinetic behaviors, CSD strategy would be efficacious to enhance bioavailability of curcumin with high photochemical stability...
  57. doi request reprint The N-oxide metabolite contributes to bladder selectivity resulting from oral propiverine: muscarinic receptor binding and pharmacokinetics
    Shizuo Yamada
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Drug Metab Dispos 38:1314-21. 2010
    ..Thus, M-2 may contribute greatly to the relatively selective and long-lasting occupation of bladder muscarinic receptors after oral administration of propiverine...
  58. ncbi request reprint Effects of green tea catechins on cytochrome P450 2B6, 2C8, 2C19, 2D6 and 3A activities in human liver and intestinal microsomes
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Drug Metab Pharmacokinet 28:244-9. 2013
    ..1 µM, respectively. EGCG moderately inhibited CYP3A activity in a noncompetitive manner. These results suggest that green tea catechins cause clinically relevant interactions with substrates for CYP2B6 and CYP2C8 in addition to CYP3A...
  59. ncbi request reprint Development of dry powder inhalation system of novel vasoactive intestinal peptide (VIP) analogue for pulmonary administration
    Yuki Ohmori
    Department of Pharmacokinetics and Pharmacodynamics and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Life Sci 79:138-43. 2006
    ..This effect by IK312532-DPI compared with VIP-DPI lasted for a longer period. Thus, IK312532-DPI may be a pharmacologically useful drug delivery system for the VIP therapy of pulmonary diseases such as asthma...
  60. ncbi request reprint Binding activities by propiverine and its N-oxide metabolites of L-type calcium channel antagonist receptors in the rat bladder and brain
    Shinya Uchida
    Department of Pharmacokinetics and Pharmacodynamics and Center of Excellence Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka Taiho Pharmaceutical Co LTD, Japan
    Life Sci 80:2454-60. 2007
    ....
  61. doi request reprint Novel dry powder formulation of ovalbumin for development of COPD-like animal model: Physicochemical characterization and biomarker profiling in rats
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Eur J Pharm Sci 37:469-76. 2009
    ..Upon these findings, OVA-DPI can be useful and reproducible research tool for the development of experimental asthma/COPD model...
  62. doi request reprint Pharmacokinetics and pharmacodynamics of low doses of midazolam administered intravenously and orally to healthy volunteers
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Clin Exp Pharmacol Physiol 37:290-5. 2010
    ..In addition, PSV, PSA and VAS may be useful for the simultaneous evaluation of the pharmacokinetics and pharmacodynamics of midazolam at subtherapeutic doses...
  63. doi request reprint Novel crystalline solid dispersion of tranilast with high photostability and improved oral bioavailability
    Yohei Kawabata
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 39:256-62. 2010
    ..According to these observations, taken together with dissolution and pharmacokinetic behaviors, crystalline solid dispersion strategy would be efficacious to enhance bioavailability of TL with high photochemical stability...
  64. ncbi request reprint In vivo demonstration of muscarinic receptor binding activity of N-desethyl-oxybutynin, active metabolite of oxybutynin
    Tomomi Oki
    Department of Biopharmaceutical Sciences and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Life Sci 76:2445-56. 2005
    ....
  65. doi request reprint Effect of 2 weeks' consumption of pomegranate juice on the pharmacokinetics of a single dose of midazolam: an open-label, randomized, single-center, 2-period crossover study in healthy Japanese volunteers
    Shingen Misaka
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Clin Ther 33:246-52. 2011
    ..It has been reported that pomegranate juice significantly increased the AUC of orally administered carbamazepine in rats, which suggests that pomegranate may inhibit the cytochrome P450 3A (CYP3A)-mediated carbamazepine metabolism...
  66. ncbi request reprint Muscarinic and alpha 1-adrenergic receptor binding characteristics of saw palmetto extract in rat lower urinary tract
    Mayumi Suzuki
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Urology 69:1216-20. 2007
    ..To elucidate the in vitro and ex vivo effects of saw palmetto extract (SPE) on autonomic receptors in the rat lower urinary tract...
  67. doi request reprint Development of (-)-epigallocatechin-3-gallate (EGCG)-loaded enteric microparticles with intestinal mucoadhesive property
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Pharm 410:111-3. 2011
    ..From these findings, newly prepared EGCG/MS might be of clinical importance in both stabilizing and delivering EGCG for treatment of intestinal diseases...
  68. ncbi request reprint Drug-induced phototoxicity; an early in vitro identification of phototoxic potential of new drug entities in drug discovery and development
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Curr Drug Saf 4:123-36. 2009
    ....
  69. ncbi request reprint Comparative characterization of lung muscarinic receptor binding after intratracheal administration of tiotropium, ipratropium, and glycopyrrolate
    Masaki Ogoda
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Pharmacol Sci 115:374-82. 2011
    ....
  70. ncbi request reprint Pharmacological effects of Hachi-mi-jio-gan extract (Harncare) on the contractile response and on pharmacologically relevant receptors in the rat bladder
    Yoshihiko Ito
    Department of Pharmacokinetics and Pharmacodynamics and Global COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Yakugaku Zasshi 129:957-64. 2009
    ..HE seemed to exhibit little pharmacokinetic interaction with drugs...
  71. ncbi request reprint Effects of Ginkgo biloba extract on pharmacokinetics and pharmacodynamics of tolbutamide and midazolam in healthy volunteers
    Shinya Uchida
    Department of Pharmacokinetics, Center of Excellence Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    J Clin Pharmacol 46:1290-8. 2006
    ..Thus, it is suggested that the combination of GBE and drugs should be cautious in terms of the potential interactions, especially in elderly patients or patients treated with drugs exerting relatively narrow therapeutic windows...
  72. doi request reprint High-throughput screening strategy for photogenotoxic potential of pharmaceutical substances using fluorescent intercalating dye
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Pharm Biomed Anal 52:781-6. 2010
    ..These findings suggest that the IBP assay could be a fast and reliable tool for predicting the photogenotoxic potential of a large number of drug candidates at early stages of drug discovery...
  73. ncbi request reprint Advantages for transdermal over oral oxybutynin to treat overactive bladder: Muscarinic receptor binding, plasma drug concentration, and salivary secretion
    Tomomi Oki
    Department of Pharmacokinetics and Pharmacodynamics and Center of Excellence Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Pharmacol Exp Ther 316:1137-45. 2006
    ..Thus, the present study provides further pharmacological basis for advantage of transdermal over oral oxybutynin in the therapy of overactive bladder...
  74. doi request reprint Development of PACAP38 analogue with improved stability: physicochemical and in vitro/in vivo pharmacological characterization
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Mol Neurosci 43:85-93. 2011
    ....
  75. doi request reprint In vitro/in vivo phototoxic risk assessments of griseofulvin based on photobiochemical and pharmacokinetic behaviors
    Yoshiki Seto
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Eur J Pharm Sci 38:104-11. 2009
    ..The combination use of photobiochemical and pharmacokinetic data would be valuable to provide reliable prediction on phototoxic risk and possible toxic pathways of new drug entities in the early stage of drug discovery...
  76. doi request reprint New treatments for chronic obstructive pulmonary disease and viable formulation/device options for inhalation therapy
    Satomi Onoue
    University of Shizuoka, School of Pharmaceutical Sciences, Department of Pharmacokinetics and Pharmacodynamics, Global Center of Excellence COE Program, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Expert Opin Drug Deliv 6:793-811. 2009
    ..This article aims to review recent developments in COPD drugs and the delivery systems for inhalation therapy, with particular emphasis on device options and formulations of DPI systems...
  77. pmc Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice
    Tomomi Oki
    Department of Biopharmaceutical Sciences, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Br J Pharmacol 145:219-27. 2005
    ..It is concluded that oral solifenacin persistently binds to muscarinic receptors in tissues expressing the M(3) subtype, such as the bladder...
  78. ncbi request reprint Isolation and pharmacological characterization of fatty acids from saw palmetto extract
    Masayuki Abe
    Department of Pharmacokinetics and Pharmacodynamics, and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Suruga, Shizuoka 422 8526, Japan
    Anal Sci 25:553-7. 2009
    ..In addition, oleic and lauric acids inhibited 5alpha-reductase, possibly leading to therapeutic effects against benign prostatic hyperplasia and related lower urinary-tract symptoms...
  79. ncbi request reprint Effects of saw palmetto extract on micturition reflex of rats and its autonomic receptor binding activity
    Tomomi Oki
    Department of Biopharmacy and Center of Excellence Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Urol 173:1395-9. 2005
    ..We examined the effects of saw palmetto extract (SPE) on the rat micturition reflex and on autonomic receptors in the lower urinary tract...
  80. ncbi request reprint In vivo receptor binding of benidipine and amlodipine in mesenteric arteries and other tissues of spontaneously hypertensive rats
    Shizuo Yamada
    Department of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Life Sci 70:1999-2011. 2002
    ....
  81. doi request reprint Inhalable sustained-release formulation of glucagon: in vitro amyloidogenic and inhalation properties, and in vivo absorption and bioactivity
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Pharm Res 28:1157-66. 2011
    ..The present study aimed to develop novel glucagon-loaded PLGA nanospheres without cytotoxic fibril formation for chronic glucagon replacement therapy...
  82. doi request reprint Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis
    Akira Yoshida
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, University of Shizuoka School of Pharmaceutical Sciences, Shizuoka, Japan
    Urology 76:1017.e7-12. 2010
    ....
  83. ncbi request reprint The decrease in level of serum thyroxine by 2,2',4,5,5'-pentachlorobiphenyl in rats and mice: no correlation with formation of methylsulfonyl metabolites
    Yoshihisa Kato
    School of Pharmaceutical Sciences, University of Shizuoka, hizuoka, Japan
    Drug Metab Dispos 33:1661-5. 2005
    ....
  84. pmc Different distribution of morphine and morphine-6 beta-glucuronide after intracerebroventricular injection in rats
    Takashi Okura
    Department of Biopharmacy, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Br J Pharmacol 140:211-7. 2003
    ..c.v. injection...
  85. ncbi request reprint A possible mechanism for decrease in serum thyroxine level by polychlorinated biphenyls in Wistar and Gunn rats
    Yoshihisa Kato
    School of Pharmaceutical Sciences, COE Program in the 21st Century, University of Shizuoka, 52 1, Yada, Shizuoka 422 8526, Japan
    Toxicol Sci 81:309-15. 2004
    ..Furthermore, even in Wistar rats, the PCB-mediated decrease in serum T(4) level might occur not only through the increase in hepatic T(4)-UDP-GT but also via formation of hydroxylated PCB metabolites...
  86. ncbi request reprint Quantitative analysis of binding parameters of [3H]N-methylscopolamine in central nervous system of muscarinic acetylcholine receptor knockout mice
    Tomomi Oki
    Department of Biopharmaceutical Sciences and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res Mol Brain Res 133:6-11. 2005
    ....
  87. doi request reprint Selective binding of bladder muscarinic receptors in relation to the pharmacokinetics of a novel antimuscarinic agent, imidafenacin, to treat overactive bladder
    Shizuo Yamada
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Pharmacol Exp Ther 336:365-71. 2011
    ..Furthermore, the imidafenacin excreted in urine may play an important role in pharmacokinetic and pharmacological selectivity...
  88. ncbi request reprint Decrease in serum thyroxine level by phenobarbital in rats is not necessarily dependent on increase in hepatic UDP-glucuronosyltransferase
    Yoshihisa Kato
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Drug Metab Dispos 33:1608-12. 2005
    ....
  89. doi request reprint Structure-activity relationship of vasoactive intestinal peptide (VIP): potent agonists and potential clinical applications
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Naunyn Schmiedebergs Arch Pharmacol 377:579-90. 2008
    ....
  90. doi request reprint Novel methodology for predicting photogenotoxic risk of pharmaceutical substances based on reactive oxygen species (ROS) and DNA-binding assay
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    J Pharm Sci 98:3647-58. 2009
    ..The combination use of ROS assay and DNA-binding assay could be fast and reliable prediction for the photogenotoxic potential of a large number of drug candidates at the drug-discovery stage...
  91. doi request reprint Pituitary adenylate cyclase-activating polypeptide attenuates streptozotocin-induced apoptotic death of RIN-m5F cells through regulation of Bcl-2 family protein mRNA expression
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence Program, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    FEBS J 275:5542-51. 2008
    ..The data obtained suggest the anti-apoptotic role of PACAP in streptozotocin-treated RIN-m5F cells through the regulation of pro-apoptotic and pro-survival factors...
  92. doi request reprint Reactive oxygen species assay-based risk assessment of drug-induced phototoxicity: classification criteria and application to drug candidates
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Pharm Biomed Anal 47:967-72. 2008
    ..These results verify the usefulness of the ROS assay for understanding the phototoxicity risk of pharmaceutical substances, and the ROS assay can be used for screening purposes in the drug discovery stage...
  93. doi request reprint Bladder angiotensin-II receptors: characterization and alteration in bladder outlet obstruction
    Shizuo Yamada
    Department of Pharmacokinetics and Pharmacodynamics, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Eur Urol 55:482-9. 2009
    ..It is assumed that angiotensin II (AngII) is significantly implicated in the pathogenesis of urinary dysfunction because of bladder outlet obstruction (BOO)...
  94. doi request reprint Physicochemical and pharmacological characterization of novel vasoactive intestinal peptide derivatives with improved stability
    Satomi Onoue
    Department of Pharmacokinetics and Pharmacodynamics, University of Shizuoka, Shizuoka, Japan
    Eur J Pharm Biopharm 73:95-101. 2009
    ....
  95. ncbi request reprint Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6beta-glucuronide in rats
    Takashi Okura
    Department of Pharmacokinetics and Pharmacodynamics and Center of Excellence Research Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Life Sci 80:1319-26. 2007
    ..Simultaneous measurement of spinal CSF concentration and antinociception by using microdialysis should be useful for elucidating the relationship between pharmacokinetics and pharmacodynamics of various opioids...
  96. ncbi request reprint Effects of cigarette smoking and cytochrome P450 2D6 genotype on fluvoxamine concentration in plasma of Japanese patients
    Yasuhiro Katoh
    Department of Pharmacy Practice and Science, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Biol Pharm Bull 33:285-8. 2010
    ..Our findings suggest that cigarette smoking has a significant impact on the steady-state plasma concentration of fluvoxamine in Japanese patients...
  97. doi request reprint In vitro phototoxic potential and photochemical properties of imidazopyridine derivative: a novel 5-HT4 partial agonist
    Satomi Onoue
    Worldwide Pharmaceutical Sciences, Pfizer Global Research and Development PGRD, Nagoya Laboratories, Pfizer Japan, Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Pharm Sci 97:4307-18. 2008
    ..These results suggest the phototoxic risk of newly synthesized imidazopyridine derivative and also verify the usefulness of ROS assay for phototoxicity prediction...
  98. ncbi request reprint High-throughput reactive oxygen species (ROS) assay: an enabling technology for screening the phototoxic potential of pharmaceutical substances
    Satomi Onoue
    Analytical Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Pharm Biomed Anal 46:187-93. 2008
    ..The developed assay system will be an effective tool for predicting the phototoxic potential of pharmaceutical candidates in early stage of pharmaceutical development...
  99. ncbi request reprint In vivo identification and characterization of binding sites for selective serotonin reuptake inhibitors in mouse brain
    Kazufumi Hirano
    Department of Biopharmaceutical Sciences and Center of Excellence COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Life Sci 75:2933-45. 2004
    ..Thus, the present study has revealed that [3H]paroxetine may be a suitable radioligand for in vivo characterization of brain binding sites and pharmacological effects of SSRIs...
  100. pmc In vitro and ex vivo effects of a selective nociceptin/orphanin FQ (N/OFQ) peptide receptor antagonist, CompB, on specific binding of [3H]N/OFQ and [35S]GTPgammaS in rat brain and spinal cord
    Shizuo Yamada
    Department of Biopharmacy, School of Pharmaceutical Sciences and COE21, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Br J Pharmacol 139:1462-8. 2003
    ..The present study has shown that CompB may exhibit pharmacological effects through a predominant blockade of N/OFQ peptide receptors in the spinal cord under in vivo conditions...
  101. doi request reprint Alteration of muscarinic and purinergic receptors in urinary bladder of rats with cyclophosphamide-induced interstitial cystitis
    Aiko Kageyama
    Department of Pharmacokinetics and Pharmacodynamics and Global Center of Excellence COE Program, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurosci Lett 436:81-4. 2008
    ..Thus, the present study offers further pharmacological evidence that both muscarinic and purinergic mechanisms contribute significantly to the urinary dysfunction due to IC...