Kazuya Yamada

Summary

Affiliation: University of Fukui
Country: Japan

Publications

  1. ncbi request reprint Identification of proteins that interact with NF-YA
    K Yamada
    Department of Biochemistry, Fukui Medical University, Japan
    FEBS Lett 460:41-5. 1999
  2. ncbi request reprint Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli
    Kazuya Yamada
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Japan
    Front Biosci 10:3151-71. 2005
  3. ncbi request reprint Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Biol Reprod 70:76-82. 2004
  4. ncbi request reprint Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Japan
    J Biol Chem 278:30719-24. 2003
  5. ncbi request reprint SHARP-2/Stra13/DEC1 as a potential repressor of phosphoenolpyruvate carboxykinase gene expression
    Kazuya Yamada
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    FEBS Lett 579:1509-14. 2005
  6. pmc Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, and Japan and CREST, Japan Science and Technology, Fukui 910 1193, Japan
    Biochem J 373:167-78. 2003
  7. ncbi request reprint Cloning and functional expression of an E box-binding protein from rat granulosa cells
    K Yamada
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193 and CREST, JST Japan Science and Technology, Japan
    Biol Reprod 64:1315-9. 2001
  8. ncbi request reprint Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1)
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Japan
    Biochem Biophys Res Commun 297:368-74. 2002
  9. ncbi request reprint Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer
    Satoko Hirano
    Department of Pediatrics, Fukui Medical University, Fukui 910 1193, Japan
    Gene 290:107-14. 2002
  10. ncbi request reprint Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells
    Takashi Kajitani
    Department of Biochemistry, Fukui Medical University, Matsuoka, Fukui, 910 1193, Japan
    Endocrinology 145:2307-18. 2004

Collaborators

Detail Information

Publications32

  1. ncbi request reprint Identification of proteins that interact with NF-YA
    K Yamada
    Department of Biochemistry, Fukui Medical University, Japan
    FEBS Lett 460:41-5. 1999
    ..Two different domains of NF-YA, a glutamine-rich region and a serine/threonine-rich region, are necessary for the interactions with ZHX1 and SRF, respectively...
  2. ncbi request reprint Basic helix-loop-helix transcription factors, BHLHB2 and BHLHB3; their gene expressions are regulated by multiple extracellular stimuli
    Kazuya Yamada
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Japan
    Front Biosci 10:3151-71. 2005
    ..The structural features, functions, and biological roles of the novel bHLH transcription factors, BHLHB2 and BHLHB3, are discussed along with the mechanisms in which the genes encoding these factors are regulated...
  3. ncbi request reprint Gene expression of basic helix-loop-helix transcription factor, SHARP-2, is regulated by gonadotropins in the rat ovary and MA-10 cells
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Biol Reprod 70:76-82. 2004
    ..We conclude that the level of SHARP-2 mRNA is regulated by gonadotropins and that SHARP-2 functions as a transcriptional repressor localized in the nucleus...
  4. ncbi request reprint Insulin induces the expression of the SHARP-2/Stra13/DEC1 gene via a phosphoinositide 3-kinase pathway
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Japan
    J Biol Chem 278:30719-24. 2003
    ..In addition, nuclear run-on assay revealed that transcription of the rat SHARP-2 gene was induced by insulin. Thus, we conclude that insulin induces the transcription of the rat SHARP-2 gene via a phosphoinositide 3-kinase pathway...
  5. ncbi request reprint SHARP-2/Stra13/DEC1 as a potential repressor of phosphoenolpyruvate carboxykinase gene expression
    Kazuya Yamada
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    FEBS Lett 579:1509-14. 2005
    ..Based on these findings, we conclude that SHARP-2 is a potential repressor of PEPCK gene expression...
  6. pmc Analysis of zinc-fingers and homeoboxes (ZHX)-1-interacting proteins: molecular cloning and characterization of a member of the ZHX family, ZHX3
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, and Japan and CREST, Japan Science and Technology, Fukui 910 1193, Japan
    Biochem J 373:167-78. 2003
    ....
  7. ncbi request reprint Cloning and functional expression of an E box-binding protein from rat granulosa cells
    K Yamada
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193 and CREST, JST Japan Science and Technology, Japan
    Biol Reprod 64:1315-9. 2001
    ..Thus, we report molecular cloning, expression, and functional characterization of full-length rat USF2 cDNA...
  8. ncbi request reprint Functional analysis and the molecular dissection of zinc-fingers and homeoboxes 1 (ZHX1)
    Kazuya Yamada
    Department of Biochemistry, Fukui Medical University, Japan
    Biochem Biophys Res Commun 297:368-74. 2002
    ..The acidic region corresponding to the amino acid sequence between 831 and 873 was a repressor domain and dimerization was prerequisited for full repressor activity...
  9. ncbi request reprint Rat zinc-fingers and homeoboxes 1 (ZHX1), a nuclear factor-YA-interacting nuclear protein, forms a homodimer
    Satoko Hirano
    Department of Pediatrics, Fukui Medical University, Fukui 910 1193, Japan
    Gene 290:107-14. 2002
    ..Thus, we report on the molecular cloning, expression and characterization of full-length rat ZHX1 cDNA...
  10. ncbi request reprint Cloning and characterization of granulosa cell high-mobility group (HMG)-box protein-1, a novel HMG-box transcriptional regulator strongly expressed in rat ovarian granulosa cells
    Takashi Kajitani
    Department of Biochemistry, Fukui Medical University, Matsuoka, Fukui, 910 1193, Japan
    Endocrinology 145:2307-18. 2004
    ....
  11. ncbi request reprint The mouse zinc-fingers and homeoboxes (ZHX) family; ZHX2 forms a heterodimer with ZHX3
    Hiroko Kawata
    CREST, JST Japan Science and Technology, 910 1193, Fukui, Japan
    Gene 323:133-40. 2003
    ..5-, 6.5- and 4.4-kb, are ubiquitously expressed, although their levels vary. Lastly, in vitro and in vivo protein-protein interaction assays revealed that ZHX2 is able to form a heterodimer with ZHX3 via a region containing each HD1...
  12. ncbi request reprint Genomic structure and analysis of transcriptional regulation of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene
    Zhangfei Shou
    Department of Biochemistry, Fukui Medical University, 910 1193, Fukui, Japan
    Gene 302:83-94. 2003
    ..Thus, we conclude that PEA3 and YY1 synergistically stimulate the transcription of the ZHX1 gene...
  13. ncbi request reprint Transcriptional regulation of the epiregulin gene in the rat ovary
    Toshio Sekiguchi
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Endocrinology 143:4718-29. 2002
    ..The restricted and hormonally regulated expression of epiregulin in the rat ovarian granulosa cells may correspond to the physiological relevance of this peptide growth factor to the FSH-induced ovarian follicular growth and maturation...
  14. ncbi request reprint Early growth response gene-1 regulates the expression of the rat luteinizing hormone receptor gene
    Miki Yoshino
    Department of Biochemistry, Fukui Medical University, Shimoaizuki, Matsuoka, Fukui 910, Japan
    Biol Reprod 66:1813-9. 2002
    ..The present study provides further support to the hypothesis that Egr-1 plays important roles in the pituitary-gonadal axis...
  15. pmc Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor
    Hiroko Kawata
    Core Research for Evolutional Science and Technology CREST, Japan Science and Technology JST, Fukui 910 1193, Japan
    Biochem J 373:747-57. 2003
    ..Thus the ZHX family of proteins may participate in the expression of a number of NF-Y-regulated genes via a more organized transcription network...
  16. ncbi request reprint The rat enhancer of split- and hairy-related protein-2 gene: hepatic expression, genomic structure, and promoter analysis
    Satoko Hirano
    Department of Pediatrics, Fukui Medical University, 910 1193 Fukui, Japan
    Arch Biochem Biophys 422:81-90. 2004
    ..Therefore, other E box-binding transcription factors differing from USF proteins or USF-associated proteins are necessary for transcriptional stimulation of the rat SHARP-2 gene...
  17. ncbi request reprint Differentiation of adult stem cells derived from bone marrow stroma into Leydig or adrenocortical cells
    Takashi Yazawa
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, Fukui 910 1193, Japan
    Endocrinology 147:4104-11. 2006
    ..These results indicate that MSCs represent a useful source of stem cells for producing steroidogenic cells that may provide basis for their use in cell and gene therapy...
  18. ncbi request reprint Involvement of cyclic adenosine 5'-monophosphate response element-binding protein, steroidogenic factor 1, and Dax-1 in the regulation of gonadotropin-inducible ovarian transcription factor 1 gene expression by follicle-stimulating hormone in ovarian gran
    Takashi Yazawa
    Department of Biochemistry, Fukui Medical University, Fukui 910 1193, Japan
    Endocrinology 144:1920-30. 2003
    ..These results suggest that the synergistic action of CRE binding protein and SF-1 and the rapid down-regulation of Dax-1 are responsible for the acute induction of GIOT1 gene by gonadotropin...
  19. ncbi request reprint BS69, a corepressor interacting with ZHX1, is a bifunctional transcription factor
    Hiroko Ogata-Kawata
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Front Biosci 12:1911-26. 2007
    ..Therefore, our results suggest that BS69 may function either as a transcriptional repressor or as a transcriptional activator depending on its regulatory partner...
  20. pmc Co-activator p120 is increased by gonadotropins in the rat ovary and enhances progesterone receptor activity
    Miki Yoshino
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Shimoaizuki, Matsuoka, Fukui 910 1193, Japan
    Reprod Biol Endocrinol 4:50. 2006
    ..In this study we identify rat homologue of p120, a nuclear transcription co-activator, as one of the FSH inducible genes in the rat granulosa cells...
  21. doi request reprint Regulation of NGFI-B/Nur77 gene expression in the rat ovary and in leydig tumor cells MA-10
    Yoshihiko Inaoka
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    Mol Reprod Dev 75:931-9. 2008
    ..The rapid induction of NGFI-B/Nur77 gene expression by LH/hCG in MA-10 cells appears to be mediated by both CREB and Jun family proteins through the cAMP-protein kinase A (PKA) pathway...
  22. ncbi request reprint ZHX2 and ZHX3 repress cancer markers in normal hepatocytes
    Kazuya Yamada
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Fukui 910 1193, Japan
    Front Biosci (Landmark Ed) 14:3724-32. 2009
    ....
  23. ncbi request reprint A mechanism of induction of the mouse zinc-fingers and homeoboxes 1 (ZHX1) gene expression by interleukin-2
    Zhangfei Shou
    Department of Biochemistry, Faculty of Medical Sciences, University of Fukui, Matsuoka cho, 910 1193, Fukui, Japan
    Biochem Biophys Res Commun 314:885-90. 2004
    ....
  24. doi request reprint Glucose deprivation accelerates VLDL receptor-mediated TG-rich lipoprotein uptake by AMPK activation in skeletal muscle cells
    Yasuo Zenimaru
    Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Eiheiji cho, Fukui 910 1193, Japan
    Biochem Biophys Res Commun 368:716-22. 2008
    ..Our study suggests that the VLDL-R-mediated uptake of TG-rich lipoproteins might compensate for glucose shortfall through AMPK activation in skeletal muscle...
  25. ncbi request reprint Nuclear factor 1 family members interact with hepatocyte nuclear factor 1alpha to synergistically activate L-type pyruvate kinase gene transcription
    Shin ichi Satoh
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    J Biol Chem 280:39827-34. 2005
    ..Thus, we conclude that cooperative interaction between NF1 family members and HNF1alpha plays an important role in hepatic L-PK transcription...
  26. ncbi request reprint Identification and characterization of the hematopoietic cell-specific enhancer-like element of the mouse hex gene
    Ayuko Sato
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8601
    J Biochem 135:259-68. 2004
    ..Thus, we conclude that Hex expression in hematopoietic cells is mainly regulated by GATA-1, GATA-2, and c-Myb via this intronic enhancer-like element...
  27. ncbi request reprint Insulin stimulates expression of the pyruvate kinase M gene in 3T3-L1 adipocytes
    Yuuki Asai
    Department of Applied Molecular Biosciences, Nagoya University Graduate School of Bioagricultural Sciences, Chikusa ku, Nagoya 464 8601, Japan
    Biosci Biotechnol Biochem 67:1272-7. 2003
    ..Thus, we suggest that insulin increases the level of M2-PK mRNA in adipocytes by acting at transcriptional and post-transcriptional levels through signaling pathways involving both PI3K and MAPK kinase...
  28. ncbi request reprint Identification of cis-regulatory elements and trans-acting proteins of the rat carbohydrate response element binding protein gene
    Shin ichi Satoh
    Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa ku, Nagoya 464 8601, Japan
    Arch Biochem Biophys 461:113-22. 2007
    ..Thus, we conclude that functional synergisms between these transcription factors are critical for ChREBP gene transcription...
  29. ncbi request reprint Identification of the insulin-regulated interaction of phosphodiesterase 3B with 14-3-3 beta protein
    Hiroshi Onuma
    Department of Laboratory Medicine, Ehime University School of Medicine, Shigenobu, Ehime 791 0295, Japan
    Diabetes 51:3362-7. 2002
    ..Because insulin receptor substrate-1 also associates with 14-3-3, the dimeric 14-3-3 beta could function as a scaffolding protein in the activation of PDE3B by insulin...
  30. ncbi request reprint Sequence analysis of mouse muscle-type phosphofructokinase gene introns 10 and 11 with special reference to the exon skipping
    Tomoyuki Yamasaki
    Second Department of Internal Medicine, Osaka University Medical School, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Res Commun Mol Pathol Pharmacol 115:97-101. 2004
    ..Although further investigation would be required to understand the mechanisms and physiological significance of exon-skipping, the exon-skipping in PFK-M transcripts would be unlikely to have the physiological significance...
  31. ncbi request reprint Plasma resistin, associated with single nucleotide polymorphism -420, is correlated with insulin resistance, lower HDL cholesterol, and high-sensitivity C-reactive protein in the Japanese general population
    Haruhiko Osawa
    Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime, Japan
    Diabetes Care 30:1501-6. 2007
    ..We report here on the relation between plasma resistin and either SNP -420 genotype or factors related to insulin resistance...
  32. pmc The G/G genotype of a resistin single-nucleotide polymorphism at -420 increases type 2 diabetes mellitus susceptibility by inducing promoter activity through specific binding of Sp1/3
    Haruhiko Osawa
    Department of Laboratory Medicine, Ehime University School of Medicine, Ehime, Japan
    Am J Hum Genet 75:678-86. 2004
    ..Therefore, the specific recognition of -420G by Sp1/3 increases RETN promoter activity, leading to enhanced serum resistin levels, thereby inducing human T2DM...