Tetsuro Watabe

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis
    Yasuhiro Yoshimatsu
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Int J Inflam 2011:724080. 2011
  2. doi request reprint Roles of transcriptional network during the formation of lymphatic vessels
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biochem 152:213-20. 2012
  3. doi request reprint Roles of Dppa2 in the regulation of the present status and future of pluripotent stem cells
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    J Biochem 152:1-3. 2012
  4. doi request reprint Roles of TGF-beta family signaling in stem cell renewal and differentiation
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Res 19:103-15. 2009
  5. doi request reprint Roles of old players in the suppression of a new player: networks for the transcriptional control of angiogenesis
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Biochem 149:117-9. 2011
  6. doi request reprint Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis
    Kaori Harada
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Cell Sci 122:3923-30. 2009
  7. doi request reprint BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo
    Yuka Suzuki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Cell Sci 123:1684-92. 2010
  8. pmc Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression
    Yasuhiro Yoshimatsu
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 110:18940-5. 2013
  9. ncbi request reprint TGF-beta signaling in embryonic stem cell-derived endothelial cells
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Japan
    Methods Mol Biol 330:341-51. 2006
  10. doi request reprint Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis
    Masako Oka
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Blood 111:4571-9. 2008

Collaborators

Detail Information

Publications32

  1. pmc Roles of TGF-β Signals in Endothelial-Mesenchymal Transition during Cardiac Fibrosis
    Yasuhiro Yoshimatsu
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Int J Inflam 2011:724080. 2011
    ..Better understanding of the mechanisms of the formation of cardiac fibroblasts via EndMT may provide an opportunity to develop therapeutic strategies to cure heart diseases...
  2. doi request reprint Roles of transcriptional network during the formation of lymphatic vessels
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biochem 152:213-20. 2012
    ..This review highlights recent advances in our understanding of the transcriptional control of LEC fate determination and reflects on efforts to understand the roles of transcriptional networks during this discrete developmental process...
  3. doi request reprint Roles of Dppa2 in the regulation of the present status and future of pluripotent stem cells
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    J Biochem 152:1-3. 2012
    ..These results suggest that an epigenetic regulator of pluripotent stem cells plays important roles in normal development and tumorigenesis...
  4. doi request reprint Roles of TGF-beta family signaling in stem cell renewal and differentiation
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Res 19:103-15. 2009
    ..Here, we illustrate the roles of TGF-beta family members in the maintenance and differentiation of ES cells, somatic stem cells, and cancer stem cells...
  5. doi request reprint Roles of old players in the suppression of a new player: networks for the transcriptional control of angiogenesis
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Biochem 149:117-9. 2011
    ..These findings reveal a novel interplay between HLH transcription factors that regulate angiogenesis...
  6. doi request reprint Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesis
    Kaori Harada
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Cell Sci 122:3923-30. 2009
    ..These findings indicate that transcriptional networks of Prox1 and HoxD8 play important roles in the maturation and maintenance of lymphatic vessels...
  7. doi request reprint BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo
    Yuka Suzuki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Cell Sci 123:1684-92. 2010
    ..These findings suggest that BMP-9 signaling activates the endothelium tested in the present study via ALK-1...
  8. pmc Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression
    Yasuhiro Yoshimatsu
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 110:18940-5. 2013
    ..Our findings reveal a unique molecular basis for the physiological and pathological roles of BMP-9/ALK-1 signals in LV formation. ..
  9. ncbi request reprint TGF-beta signaling in embryonic stem cell-derived endothelial cells
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Japan
    Methods Mol Biol 330:341-51. 2006
    ..In this chapter, we present how to study the cellular and biochemical effects of TGF-beta signals on endothelial cells derived from mouse ESCs...
  10. doi request reprint Inhibition of endogenous TGF-beta signaling enhances lymphangiogenesis
    Masako Oka
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Blood 111:4571-9. 2008
    ..These findings suggest that TGF-beta transduces signals in LECs and plays an important role in the regulation of lymphangiogenesis in vivo...
  11. doi request reprint Snail is required for TGFbeta-induced endothelial-mesenchymal transition of embryonic stem cell-derived endothelial cells
    Takashi Kokudo
    Department of Molecular Pathology, Graduate School of Medicine and the Global Center of Excellence Program for Integrative Life Science Based on the Study of Biosignaling Mechanisms, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Cell Sci 121:3317-24. 2008
    ..These results indicate that Snail mediates the actions of endogenous TGFbeta signals that induce EndMT...
  12. doi request reprint VEGFR2-PLCgamma1 axis is essential for endothelial specification of VEGFR2+ vascular progenitor cells
    Hitoshi Sase
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo, Japan
    J Cell Sci 122:3303-11. 2009
    ..Taken together, these findings indicate that VEGFR2-PLCgamma1 signal relay gives rise to the unique function of VEGFR2, thus enabling endothelial differentiation from vascular progenitors...
  13. pmc Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski
    Masafumi Takeda
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Japan
    Mol Biol Cell 15:963-72. 2004
    ..We also found that c-Ski interacted with Smad3 or Smad4 without disrupting Smad3-Smad4 heteromer formation. c-Ski (ARPG) would be useful for selectively suppressing TGF-beta/activin signaling...
  14. ncbi request reprint BMPs promote proliferation and migration of endothelial cells via stimulation of VEGF-A/VEGFR2 and angiopoietin-1/Tie2 signalling
    Yuka Suzuki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Biochem 143:199-206. 2008
    ..BMP-4 also increased the expression and phosphorylation of VEGFR2 and Tie2. These findings suggest that BMP signalling activates endothelium via activation of VEGF/VEGFR2 and Angiopoietin/Tie2 signalling...
  15. doi request reprint Ets family members induce lymphangiogenesis through physical and functional interaction with Prox1
    Yasuhiro Yoshimatsu
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Cell Sci 124:2753-62. 2011
    ..Furthermore, we found that both Prox1 and Ets-2 bind to the VEGFR3 promoter in intact chromatin. These findings suggest that Ets family members function as transcriptional cofactors that enhance Prox1-induced lymphangiogenesis...
  16. pmc Prox1 induces lymphatic endothelial differentiation via integrin alpha9 and other signaling cascades
    Koichi Mishima
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Mol Biol Cell 18:1421-9. 2007
    ....
  17. doi request reprint Thyroid transcription factor-1 inhibits transforming growth factor-beta-mediated epithelial-to-mesenchymal transition in lung adenocarcinoma cells
    Roy Akira Saito
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cancer Res 69:2783-91. 2009
    ....
  18. doi request reprint PROX1 suppresses vitamin K-induced transcriptional activity of Steroid and Xenobiotic Receptor
    Kotaro Azuma
    Department of Geriatric Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Genes Cells 16:1063-70. 2011
    ..These results suggest that PROX1 could negatively regulate SXR signals in some tumor cells, such as HCC cells, where both SXR and PROX1 are expressed...
  19. pmc Ras signaling directs endothelial specification of VEGFR2+ vascular progenitor cells
    Kyoko Kawasaki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Bunkyo, Tokyo 113 0033, Japan
    J Cell Biol 181:131-41. 2008
    ..VEGF-A thus activates temporally distinct Ras-Erk signaling to direct endothelial specification of VEGFR2(+) vascular progenitor cells...
  20. ncbi request reprint VEGF-A and FGF-2 synergistically promote neoangiogenesis through enhancement of endogenous PDGF-B-PDGFRbeta signaling
    Mitsunobu R Kano
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    J Cell Sci 118:3759-68. 2005
    ..The findings provide insights into the mechanisms underlying the effects of co-stimulation by growth factors, which could lead to rational design of therapeutic angiogenic strategies...
  21. ncbi request reprint BMP signals inhibit proliferation and in vivo tumor growth of androgen-insensitive prostate carcinoma cells
    Hideyo Miyazaki
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Oncogene 23:9326-35. 2004
    ..Furthermore, this is the first report of a role for BMP signaling in reducing growth kinetics of androgen-insensitive prostate tumors...
  22. ncbi request reprint Roles of vascular endothelial growth factor receptor 3 signaling in differentiation of mouse embryonic stem cell-derived vascular progenitor cells into endothelial cells
    Hiroyuki Suzuki
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Blood 105:2372-9. 2005
    ..Thus, VEGFR2 signaling is required for the endothelial differentiation of mouse ES cells induced by VEGF-C, and VEGFR3 signaling may confer lymphatic endothelial-like phenotypes to ECs...
  23. doi request reprint COUP-TFII regulates the functions of Prox1 in lymphatic endothelial cells through direct interaction
    Tomoko Yamazaki
    Department of Molecular Pathology, Graduate School of Medicine, Global Center of Excellence Program for Integrative Life Science Based on the Study of Biosignaling Mechanisms, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Cells 14:425-34. 2009
    ..These results suggest that COUP-TFII physically and functionally interact during differentiation and maintenance of lymphatic vessels...
  24. doi request reprint Development of stabilin2+ endothelial cells from mouse embryonic stem cells by inhibition of TGFbeta/activin signaling
    Hidenori Nonaka
    Laboratory of Cell Growth and Differentiation, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 0032, Japan Japan Health Sciences Foundation, Chuo Ku, Tokyo, Japan
    Biochem Biophys Res Commun 375:256-60. 2008
    ..Our results reveal that TGFbeta/activin signaling negatively regulates the early events of HSEC differentiation...
  25. pmc TGF-beta receptor kinase inhibitor enhances growth and integrity of embryonic stem cell-derived endothelial cells
    Tetsuro Watabe
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, Hongo, Bunkyo ku, Tokyo, Japan
    J Cell Biol 163:1303-11. 2003
    ..These results suggest that endogenous TGF-beta/activin signals play important roles in regulating vascular growth and permeability...
  26. doi request reprint TGF-β-induced mesenchymal transition of MS-1 endothelial cells requires Smad-dependent cooperative activation of Rho signals and MRTF-A
    Hajime Mihira
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Biochem 151:145-56. 2012
    ..These results indicate that activation of Smad signals by TGF-β2 have dual effects on the activation of Rho signals and MRTF-A leading to the mesenchymal transition of MS-1 endothelial cells...
  27. doi request reprint TGF-β-induced epithelial-mesenchymal transition of A549 lung adenocarcinoma cells is enhanced by pro-inflammatory cytokines derived from RAW 264.7 macrophage cells
    Mikiko Kawata
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    J Biochem 151:205-16. 2012
    ..These findings provide direct evidence of the effects of RAW 264.7-derived TNF-α on TGF-β-induced EMT in A549 cells, which is transduced in part by NFκB signalling...
  28. ncbi request reprint Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro
    Kimiko Yamamoto
    Dept of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Heart Circ Physiol 288:H1915-24. 2005
    ....
  29. doi request reprint The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII
    Tomoko Yamazaki
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem J 452:345-57. 2013
    ..The results of the present study suggest that COUP-TFII-V2 negatively regulates the function of COUP-TFII by inhibiting its binding to DNA to decrease Cyp7a1 expression...
  30. pmc Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension
    Ayako Nishihara
    Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, Japan
    Mol Biol Cell 13:3055-63. 2002
    ..The differences in biological activities among the BMPR-II mutants observed thus suggest that additional genetic and/or environmental factors may play critical roles in the pathogenesis of PPH...
  31. pmc Widespread inference of weighted microRNA-mediated gene regulation in cancer transcriptome analysis
    Hiroshi I Suzuki
    Department of Molecular Pathology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    Nucleic Acids Res 41:e62. 2013
    ..This approach proposes a next-generation strategy for the interpretation of miRNA function and identification of target miRNAs as biomarkers and therapeutic targets...
  32. pmc Noncanonical Wnt signaling mediates androgen-dependent tumor growth in a mouse model of prostate cancer
    Sayuri Takahashi
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Bunkyo ku, Tokyo 113 0032, Japan
    Proc Natl Acad Sci U S A 108:4938-43. 2011
    ..These findings suggest that a noncanonical Wnt signal stimulates development of prostatic tumors with AR hyperfunction...