Research Topics
| Tsutomu WarashinaSummaryAffiliation: University of Shizuoka Country: Japan Publications
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Detail Information
Publications
New cardenolide and acylated lignan glycosides from the aerial parts of Asclepias curassavicaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
Chem Pharm Bull (Tokyo) 56:1159-63. 2008..Asclepiadaceae). The structure of each compound was determined based on interpretations of NMR and MS measurements and chemical evidence...
Melanin synthesis inhibitors from Lespedeza cyrtobotryaMaya Mori-Hongo
School of Pharmaceutical Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
J Nat Prod 72:63-71. 2009..Lipophilic flavonoids 2, 3, 7, 9, 11, 28, 30, and 39 exhibited strong inhibitory activities on melanin synthesis in normal human epidermal melanocytes...- Acylated-oxypregnane glycosides from the roots of Asclepias syriacaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka Suruga ku, Japan
Chem Pharm Bull (Tokyo) 57:177-84. 2009..Asclepiadaceae). These glycosides were confirmed to contain ikemagenin, 12-O-nicotinoyllineolon, 5alpha,6-dihydroikemagenin, and 12-O-tigloylisolineolon, as their aglycones, using both spectroscopic and chemical methods... - 8,14-Secopregnane glycosides from the aerial parts of Asclepias tuberosaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Phytochemistry 70:1294-304. 2009..Their structures were established using NMR spectroscopic analysis and chemical methodologies... - Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cellsKaoru Umehara
School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
J Nat Prod 72:2163-8. 2009..Bowdichione (20), an isoflavone with a quinone structure in its B-ring, showed activity against only one cell line associated with MCF-7 in these assays... - Acylated-oxypregnane glycosides from the roots of Araujia sericiferaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, Japan
Chem Pharm Bull (Tokyo) 51:1036-45. 2003.... - Glycosides of 14,15-seco and 13,14:14,15-disecopregnanes from the roots of Cynanchum sublanceolatumTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
Chem Pharm Bull (Tokyo) 54:1551-60. 2006.... - Constituents from the bark of Tabebuia impetiginosaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Phytochemistry 65:2003-11. 2004..Additionally, the sugar chains of these isocoumarin glycosides and phenolic glycosides were concluded to be beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside as well as those of osmanthuside H and above phenylethanoid glycosides... - Further constituents from the bark of Tabebuia impetiginosaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, Yada 52 1, Shizuoka 422 8526, Japan
Phytochemistry 66:589-97. 2005..The structures of these compounds were determined based on the interpretation of their NMR and MS measurements and by chemical evidence... - Constituents from the bark of Tabebuia impetiginosaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, Yada, Japan
Chem Pharm Bull (Tokyo) 54:14-20. 2006..ex DC) Standley (Bignoniaceae). The structures of these compounds were determined based on NMR, mass spectral and chemical evidence. Most of them have a glycosyl unit esterified by a benzoic acid derivative... - Hyaluronidase inhibitors from "Cimicifugae Rhizoma" (a mixture of the rhizomes of Cimicifuga dahurica and C. heracleifolia)Atsufumi Iwanaga
School of Pharmaceutical Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
J Nat Prod 73:573-8. 2010..Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid... - Echinocystic acid 3,16-O-bisglycosides from Albizia proceraToshio Miyase
School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
Phytochemistry 71:1375-80. 2010..The results showed the importance of the free hydroxyl group at the aglycone C-16 for exhibiting cytotoxic properties... - Constituents from the roots of Taraxacum platycarpum and their effect on proliferation of human skin fibroblastsTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, Japan
Chem Pharm Bull (Tokyo) 60:205-12. 2012..The structure of each new compound was established using NMR spectroscopy. Some triterpenes had a significant effect on the proliferation of normal human skin fibroblasts... - 8,12;8,20-Diepoxy-8,14-secopregnane glycosides from the aerial parts of Asclepias tuberosaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Chem Pharm Bull (Tokyo) 58:172-9. 2010..The structure of each of these compounds was elucidated based on the interpretation of NMR and MS measurements and from chemical evidence... - Sesquiterpenes from the roots of Cichorium endiviaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
Chem Pharm Bull (Tokyo) 56:1445-51. 2008..The compounds were identified as guaianolide, germacrenolide and elemanolide, based on spectroscopic methods and chemical evidence... - Steroidal glycosides from the roots of Asclepias curassavicaTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Chem Pharm Bull (Tokyo) 56:315-22. 2008.... - Triterpene saponins with hyaluronidase inhibitory activity from the seeds of Camellia sinensisMichiko Myose
School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
Chem Pharm Bull (Tokyo) 60:612-23. 2012..KUNTZE gave twelve new saponins (1-12) along with ten known saponins (13-22). These saponins (1-22) showed stronger hyaluronidase inhibitory activity than the positive control, rosmarinic acid... - Antiplasmodial triterpenoids from Ekebergia capensisToshihiro Murata
School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka 422 8526, Japan
J Nat Prod 71:167-74. 2008..Compound 27 at a dose of 500 mg/kg showed moderate parasitemia suppression of 52.9% against P. berghei NK 65 in a mouse model... - Cytotoxic triterpenoid saponins acylated with monoterpenic acids from fruits of Gleditsia caspica DesfToshio Miyase
School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
Phytochemistry 71:1908-16. 2010..5 and 5.4 μM, respectively, and IC₅₀ values > 10 μM against the other two cell lines. The number of monoterpene units seems to play a main role in determining the activity... - Caffeic acid oligomers with hyaluronidase inhibitory activity from Clinopodium gracileHiroaki Aoshima
School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, Japan
Chem Pharm Bull (Tokyo) 60:499-507. 2012..Clinopodic acid M (4) showed the strongest hyaluronidase inhibitory activity, IC(50) (19 µM) among the 22 compounds isolated from this plant... - Hydrocotylosides I-VII, new oleanane saponins from hydrocotylesibthorpioidesAki Matsushita
School of Pharmaceutical Sciences, University of Shizuoka, 52-1, Yada, Shizuoka 422-8526, Japan
J Nat Prod 67:384-8. 2004..The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence... - Phenolic constituents of the aerial parts of Cimicifuga simplex and Cimicifuga japonicaAtsufumi Iwanaga
School of Pharmaceutical Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
J Nat Prod 73:609-12. 2010..Cimicifugic acids K-N showed more potent hyaluronidase inhibitory activities than rosmarinic acid... - Studies on the constituents from the aerial part of Baccharis dracunculifolia DC. IIYoshimi Nagatani
Institute for Environmental Sciences, University of Shizuoka, Japan
Chem Pharm Bull (Tokyo) 50:583-9. 2002..These new compounds consisted of beta-D-glucopyranose or beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranose, and most possessed an (E)-caffeoyl group the same as dracunculifosides A-J... - Estrogenic constituents of the heartwood of Dalbergia parvifloraKaoru Umehara
School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Phytochemistry 69:546-52. 2008..Furthermore, these compounds were tested in the estrogen-responsive transient luciferase reporter assay... - Phytoestrogens from Aspalathus linearisNaomi Shimamura
School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
Biol Pharm Bull 29:1271-4. 2006..The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity... - 8,12;8,20-diepoxy-8,14-secopregnane glycosides from roots of Asclepias tuberosa and their effect on proliferation of human skin fibroblastsTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
Phytochemistry 72:1865-75. 2011..Some of these compounds also caused proliferation of skin fibroblasts... - Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. VillWataru Kobayashi
School of Pharmaceutical Sciences, University of Shizuoka, Japan
Biol Pharm Bull 25:1049-52. 2002..This is the first example of non-phenolic constituents showing significant competitive inhibitory activity being isolated from natural medicines... - Flavonoid Glycosides from Botrychium ternatumTsutomu Warashina
Institute for Environmental Sciences, University of Shizuoka
Chem Pharm Bull (Tokyo) 60:1561-73. 2012..The structures of new compounds were established using NMR spectroscopic analysis and chemical evidence... - Triterpene saponins from the pericarps of Akebia trifoliataSyuji Iwanaga
School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
Chem Pharm Bull (Tokyo) 60:1264-74. 2012..Eleven new triterpene saponin components (1-11) were isolated from the MeOH extract of pericarp of Akebia trifoliata (THUNB.) KOIDZ. Each of their structures was determined using NMR techniques and mass spectrometry... - Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell linesOrawan Monthakantirat
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
J Nat Prod 68:361-4. 2005..Along with 4, 5, 7, and 9, 3 was shown to stimulate not only MCF-7 but also T-47D human breast cancer cell proliferation...