Tsutomu Warashina

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi Studies on the constituents from the aerial part of Baccharis dracunculifolia DC. II
    Yoshimi Nagatani
    Institute for Environmental Sciences, University of Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 50:583-9. 2002
  2. doi Melanin synthesis inhibitors from Lespedeza cyrtobotrya
    Maya Mori-Hongo
    School of Pharmaceutical Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
    J Nat Prod 72:63-71. 2009
  3. ncbi Acylated-oxypregnane glycosides from the roots of Asclepias syriaca
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka Suruga ku, Japan
    Chem Pharm Bull (Tokyo) 57:177-84. 2009
  4. doi 8,14-Secopregnane glycosides from the aerial parts of Asclepias tuberosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Phytochemistry 70:1294-304. 2009
  5. doi Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells
    Kaoru Umehara
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Nat Prod 72:2163-8. 2009
  6. ncbi Constituents from the bark of Tabebuia impetiginosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Yada, Japan
    Chem Pharm Bull (Tokyo) 54:14-20. 2006
  7. ncbi New cardenolide and acylated lignan glycosides from the aerial parts of Asclepias curassavica
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 56:1159-63. 2008
  8. ncbi Acylated-oxypregnane glycosides from the roots of Araujia sericifera
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 51:1036-45. 2003
  9. ncbi Constituents from the bark of Tabebuia impetiginosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Phytochemistry 65:2003-11. 2004
  10. ncbi Further constituents from the bark of Tabebuia impetiginosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Yada 52 1, Shizuoka 422 8526, Japan
    Phytochemistry 66:589-97. 2005

Collaborators

Detail Information

Publications30

  1. ncbi Studies on the constituents from the aerial part of Baccharis dracunculifolia DC. II
    Yoshimi Nagatani
    Institute for Environmental Sciences, University of Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 50:583-9. 2002
    ..These new compounds consisted of beta-D-glucopyranose or beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranose, and most possessed an (E)-caffeoyl group the same as dracunculifosides A-J...
  2. doi Melanin synthesis inhibitors from Lespedeza cyrtobotrya
    Maya Mori-Hongo
    School of Pharmaceutical Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
    J Nat Prod 72:63-71. 2009
    ..Lipophilic flavonoids 2, 3, 7, 9, 11, 28, 30, and 39 exhibited strong inhibitory activities on melanin synthesis in normal human epidermal melanocytes...
  3. ncbi Acylated-oxypregnane glycosides from the roots of Asclepias syriaca
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka Suruga ku, Japan
    Chem Pharm Bull (Tokyo) 57:177-84. 2009
    ..Asclepiadaceae). These glycosides were confirmed to contain ikemagenin, 12-O-nicotinoyllineolon, 5alpha,6-dihydroikemagenin, and 12-O-tigloylisolineolon, as their aglycones, using both spectroscopic and chemical methods...
  4. doi 8,14-Secopregnane glycosides from the aerial parts of Asclepias tuberosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Phytochemistry 70:1294-304. 2009
    ..Their structures were established using NMR spectroscopic analysis and chemical methodologies...
  5. doi Flavonoids from the heartwood of the Thai medicinal plant Dalbergia parviflora and their effects on estrogenic-responsive human breast cancer cells
    Kaoru Umehara
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Nat Prod 72:2163-8. 2009
    ..Bowdichione (20), an isoflavone with a quinone structure in its B-ring, showed activity against only one cell line associated with MCF-7 in these assays...
  6. ncbi Constituents from the bark of Tabebuia impetiginosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Yada, Japan
    Chem Pharm Bull (Tokyo) 54:14-20. 2006
    ..ex DC) Standley (Bignoniaceae). The structures of these compounds were determined based on NMR, mass spectral and chemical evidence. Most of them have a glycosyl unit esterified by a benzoic acid derivative...
  7. ncbi New cardenolide and acylated lignan glycosides from the aerial parts of Asclepias curassavica
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 56:1159-63. 2008
    ..Asclepiadaceae). The structure of each compound was determined based on interpretations of NMR and MS measurements and chemical evidence...
  8. ncbi Acylated-oxypregnane glycosides from the roots of Araujia sericifera
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 51:1036-45. 2003
    ....
  9. ncbi Constituents from the bark of Tabebuia impetiginosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Phytochemistry 65:2003-11. 2004
    ..Additionally, the sugar chains of these isocoumarin glycosides and phenolic glycosides were concluded to be beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside as well as those of osmanthuside H and above phenylethanoid glycosides...
  10. ncbi Further constituents from the bark of Tabebuia impetiginosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Yada 52 1, Shizuoka 422 8526, Japan
    Phytochemistry 66:589-97. 2005
    ..The structures of these compounds were determined based on the interpretation of their NMR and MS measurements and by chemical evidence...
  11. ncbi Glycosides of 14,15-seco and 13,14:14,15-disecopregnanes from the roots of Cynanchum sublanceolatum
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 54:1551-60. 2006
    ....
  12. doi 8,12;8,20-diepoxy-8,14-secopregnane glycosides from roots of Asclepias tuberosa and their effect on proliferation of human skin fibroblasts
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Phytochemistry 72:1865-75. 2011
    ..Some of these compounds also caused proliferation of skin fibroblasts...
  13. doi Echinocystic acid 3,16-O-bisglycosides from Albizia procera
    Toshio Miyase
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Phytochemistry 71:1375-80. 2010
    ..The results showed the importance of the free hydroxyl group at the aglycone C-16 for exhibiting cytotoxic properties...
  14. doi Hyaluronidase inhibitors from "Cimicifugae Rhizoma" (a mixture of the rhizomes of Cimicifuga dahurica and C. heracleifolia)
    Atsufumi Iwanaga
    School of Pharmaceutical Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
    J Nat Prod 73:573-8. 2010
    ..Fukinolic acid (9) and cimicifugic acids A-J (10-16, 5-7) showed stronger hyaluronidase inhibitory activities than the positive control, rosmarinic acid...
  15. ncbi Constituents from the roots of Taraxacum platycarpum and their effect on proliferation of human skin fibroblasts
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 60:205-12. 2012
    ..The structure of each new compound was established using NMR spectroscopy. Some triterpenes had a significant effect on the proliferation of normal human skin fibroblasts...
  16. ncbi 8,12;8,20-Diepoxy-8,14-secopregnane glycosides from the aerial parts of Asclepias tuberosa
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Chem Pharm Bull (Tokyo) 58:172-9. 2010
    ..The structure of each of these compounds was elucidated based on the interpretation of NMR and MS measurements and from chemical evidence...
  17. ncbi Sesquiterpenes from the roots of Cichorium endivia
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 56:1445-51. 2008
    ..The compounds were identified as guaianolide, germacrenolide and elemanolide, based on spectroscopic methods and chemical evidence...
  18. ncbi Flavonoid glycosides from Botrychium ternatum
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Chem Pharm Bull (Tokyo) 60:1561-73. 2012
    ..The structures of new compounds were established using NMR spectroscopic analysis and chemical evidence...
  19. ncbi Steroidal glycosides from the roots of Asclepias curassavica
    Tsutomu Warashina
    Institute for Environmental Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Chem Pharm Bull (Tokyo) 56:315-22. 2008
    ....
  20. ncbi Triterpene saponins with hyaluronidase inhibitory activity from the seeds of Camellia sinensis
    Michiko Myose
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Chem Pharm Bull (Tokyo) 60:612-23. 2012
    ..KUNTZE gave twelve new saponins (1-12) along with ten known saponins (13-22). These saponins (1-22) showed stronger hyaluronidase inhibitory activity than the positive control, rosmarinic acid...
  21. doi Antiplasmodial triterpenoids from Ekebergia capensis
    Toshihiro Murata
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Nat Prod 71:167-74. 2008
    ..Compound 27 at a dose of 500 mg/kg showed moderate parasitemia suppression of 52.9% against P. berghei NK 65 in a mouse model...
  22. doi Cytotoxic triterpenoid saponins acylated with monoterpenic acids from fruits of Gleditsia caspica Desf
    Toshio Miyase
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Phytochemistry 71:1908-16. 2010
    ..5 and 5.4 μM, respectively, and IC₅₀ values > 10 μM against the other two cell lines. The number of monoterpene units seems to play a main role in determining the activity...
  23. ncbi Caffeic acid oligomers with hyaluronidase inhibitory activity from Clinopodium gracile
    Hiroaki Aoshima
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, Japan
    Chem Pharm Bull (Tokyo) 60:499-507. 2012
    ..Clinopodic acid M (4) showed the strongest hyaluronidase inhibitory activity, IC(50) (19 µM) among the 22 compounds isolated from this plant...
  24. ncbi Hydrocotylosides I-VII, new oleanane saponins from hydrocotylesibthorpioides
    Aki Matsushita
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1, Yada, Shizuoka 422 8526, Japan
    J Nat Prod 67:384-8. 2004
    ..The structures of the new compounds were elucidated on the basis of chemical and spectroscopic evidence...
  25. ncbi Triterpene saponins from the pericarps of Akebia trifoliata
    Syuji Iwanaga
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Chem Pharm Bull (Tokyo) 60:1264-74. 2012
    ..Eleven new triterpene saponin components (1-11) were isolated from the MeOH extract of pericarp of Akebia trifoliata (THUNB.) KOIDZ. Each of their structures was determined using NMR techniques and mass spectrometry...
  26. doi Phenolic constituents of the aerial parts of Cimicifuga simplex and Cimicifuga japonica
    Atsufumi Iwanaga
    School of Pharmaceutical Sciences, University of Shizuoka, Yada 52 1, Suruga ku, Shizuoka 422 8526, Japan
    J Nat Prod 73:609-12. 2010
    ..Cimicifugic acids K-N showed more potent hyaluronidase inhibitory activities than rosmarinic acid...
  27. ncbi Estrogenic constituents of the heartwood of Dalbergia parviflora
    Kaoru Umehara
    School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Phytochemistry 69:546-52. 2008
    ..Furthermore, these compounds were tested in the estrogen-responsive transient luciferase reporter assay...
  28. ncbi Phytoestrogens from Aspalathus linearis
    Naomi Shimamura
    School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Biol Pharm Bull 29:1271-4. 2006
    ..The absolute configuration of aspalalinin was presented on the basis of X-ray analysis. Each isolate was assessed for its estrogenic activity by an estrogen ELISA assay. Compounds 12, 15, and 24 showed the estrogenic activity...
  29. ncbi Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill
    Wataru Kobayashi
    School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Biol Pharm Bull 25:1049-52. 2002
    ..This is the first example of non-phenolic constituents showing significant competitive inhibitory activity being isolated from natural medicines...
  30. ncbi Phenolic constituents of the rhizomes of the Thai medicinal plant Belamcanda chinensis with proliferative activity for two breast cancer cell lines
    Orawan Monthakantirat
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok 10330, Thailand
    J Nat Prod 68:361-4. 2005
    ..Along with 4, 5, 7, and 9, 3 was shown to stimulate not only MCF-7 but also T-47D human breast cancer cell proliferation...