Hidetaka Uramoto

Summary

Affiliation: University of Occupational and Environmental Health
Country: Japan

Publications

  1. ncbi request reprint Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Lung Cancer 49:55-62. 2005
  2. doi request reprint Intrapleural chemotherapy improves the survival of non-small cell lung cancer patients with positive pleural lavage cytology
    Tetsuro Baba
    Second Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Surg Today 43:648-53. 2013
  3. ncbi request reprint Phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel in patients with completely resected non-small cell lung cancer
    Masakazu Sugaya
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 30:3039-44. 2010
  4. ncbi request reprint Clinical significance of expression of cancer/testis antigen and down-regulation of HLA class-I in patients with stage I non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 33:2123-8. 2013
  5. pmc The tumour shape of lung adenocarcinoma is related to the postoperative prognosis
    Tetsuro Baba
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Interact Cardiovasc Thorac Surg 15:73-6. 2012
  6. ncbi request reprint Results of surgical treatment for lung cancer in young adults
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan
    Int Surg 93:50-4. 2008
  7. ncbi request reprint Expression of deltaNp63 in squamous cell carcinoma of the esophagus
    Masaru Morita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Anticancer Res 25:3533-9. 2005
  8. pmc Survival impact of node zone classification in resected pathological N2 non-small cell lung cancer
    Tetsuro Baba
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Interact Cardiovasc Thorac Surg 14:760-4. 2012
  9. ncbi request reprint Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Oncol 5:1136-42. 2010
  10. doi request reprint Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations
    Kenji Sugio
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Lung Cancer 64:314-8. 2009

Detail Information

Publications124 found, 100 shown here

  1. ncbi request reprint Expression of endoplasmic reticulum molecular chaperone Grp78 in human lung cancer and its clinical significance
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Lung Cancer 49:55-62. 2005
    ..The ER stress pathway mediated by Grp78 may therefore be responsible for controlling the growth of lung cancer cells...
  2. doi request reprint Intrapleural chemotherapy improves the survival of non-small cell lung cancer patients with positive pleural lavage cytology
    Tetsuro Baba
    Second Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Surg Today 43:648-53. 2013
    ..Information regarding the treatment of pleural lavage cytology (PLC)-positive patients is still limited. This study evaluated the efficacy of intrapleural chemotherapy (IPC) in PLC-positive patients...
  3. ncbi request reprint Phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel in patients with completely resected non-small cell lung cancer
    Masakazu Sugaya
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 30:3039-44. 2010
    ..The patients received chemotherapy with carboplatin (CBDCA) area under the curve of 3 and paclitaxel (PTX) 90 mg/m(2) every 2 weeks for six cycles after surgery...
  4. ncbi request reprint Clinical significance of expression of cancer/testis antigen and down-regulation of HLA class-I in patients with stage I non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 33:2123-8. 2013
    ....
  5. pmc The tumour shape of lung adenocarcinoma is related to the postoperative prognosis
    Tetsuro Baba
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Interact Cardiovasc Thorac Surg 15:73-6. 2012
    ..04 and P < 0.01, respectively). In adenocarcinoma patients, the shape of the tumour is related to the postoperative survival...
  6. ncbi request reprint Results of surgical treatment for lung cancer in young adults
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan
    Int Surg 93:50-4. 2008
    ..There were no significant differences in survival rates between younger group and elderly groups. This study suggests that surgical resection is also recommended as the first-line treatment for younger patients with lung cancer...
  7. ncbi request reprint Expression of deltaNp63 in squamous cell carcinoma of the esophagus
    Masaru Morita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Anticancer Res 25:3533-9. 2005
    ..The p63 gene is present as two isoforms, namely TAp63 and deltaNp63. The biological role of deltaNp63 in the progression of esophageal cancer is still controversial...
  8. pmc Survival impact of node zone classification in resected pathological N2 non-small cell lung cancer
    Tetsuro Baba
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Interact Cardiovasc Thorac Surg 14:760-4. 2012
    ..86; P < 0.01) were independent and significant factors in predicting a poor prognosis. In pN2 NSCLC patients, the involved mediastinal zone according to the primary tumour site was important in prediction of survival...
  9. ncbi request reprint Correlation between HLA alleles and EGFR mutation in Japanese patients with adenocarcinoma of the lung
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Oncol 5:1136-42. 2010
    ..Why such certain patients are susceptible to the development of EGFR-mutant tumors is currently unknown...
  10. doi request reprint Prospective phase II study of gefitinib in non-small cell lung cancer with epidermal growth factor receptor gene mutations
    Kenji Sugio
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Lung Cancer 64:314-8. 2009
    ..This study prospectively assessed the efficacy of gefitinib and the survival benefit for non-small cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutations...
  11. pmc Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807, Japan
    J Cardiothorac Surg 6:144. 2011
    ..This study investigated whether the number of involved lymph nodes is associated with the prognosis in patients that underwent surgery for pathological stage (p-stage) III/N2 NSCLC...
  12. doi request reprint Sleeve lobectomy for patients with non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu 807, Japan
    Int J Surg 8:39-43. 2010
    ..We investigated the clinico-pathological features and treatment responses of lung cancer patients who underwent sleeve lobectomy in our department...
  13. doi request reprint Clinical significance of epithelial-mesenchymal transition-associated markers in malignant pleural mesothelioma
    Takashi Iwanami
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Oncology 86:109-16. 2014
    ..Although the individual proteins might not significantly affect the progression of MPM, the combination of γ-catenin and Twist staining can predict the prognosis of patients with MPM...
  14. pmc Temporal trends in the surgical outcomes of patients with breast cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807, Japan
    World J Surg Oncol 10:108. 2012
    ..This study investigated the temporal trends of the surgical outcomes in patients with breast cancer...
  15. doi request reprint Effects of hyaluronic acid and CD44 interaction on the proliferation and invasiveness of malignant pleural mesothelioma
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu 807, Japan
    Tumour Biol 33:2135-41. 2012
    ..HA-CD44 binding is important for the migration and proliferation of mesothelioma cells. Therefore, the HA-CD44 interaction is a potentially useful therapeutic target in MPM...
  16. ncbi request reprint Increased cytochrome P450 and aryl hydrocarbon receptor in bronchial epithelium of heavy smokers with non-small cell lung carcinoma carries a poor prognosis
    Tsunehiro Oyama
    Department of Environmental Health, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Front Biosci 12:4497-503. 2007
    ..5%) than those without (12.2%) mutation. Since in patients with early NSCLC, CYP positivity showed a close correlation with a poor survival (p less than 0.01), expression of CYP in bronchial epithelium has a prognostic potential...
  17. ncbi request reprint Results of surgical treatment for patients with small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Oncol 4:964-8. 2009
    ..This study investigated the clinical features and the postoperative prognosis in patients with small cell lung cancer (SCLC)...
  18. doi request reprint Acquired resistance to gefitinib: the contribution of mechanisms other than the T790M, MET, and HGF status
    Takamitsu Onitsuka
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Lung Cancer 68:198-203. 2010
    ..However, most of the patients with this type of sensitive mutations in their tumor show acquired resistance during the TKI treatment...
  19. doi request reprint Comprehensive molecular analyses of lung adenocarcinoma with regard to the epidermal growth factor receptor, K-ras, MET, and hepatocyte growth factor status
    Takamitsu Onitsuka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Thorac Oncol 5:591-6. 2010
    ..The purpose of this study was to clarify the role of the epidermal growth factor receptor (EGFR), K-ras, MET, and hepatocyte growth factor (HGF) status in lung adenocarcinoma...
  20. ncbi request reprint Results of surgical resection for patients with large cell carcinoma of the lung
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807, Japan
    Int J Surg 8:391-4. 2010
    ..The clinical features of large cell carcinoma (LCC) of the lung have remained unclear due to the low incidence of the disease. This study investigated the clinicopathological features and the surgical outcome in patients with LCC...
  21. doi request reprint Identification of a lung cancer antigen evading CTL attack due to loss of human leukocyte antigen (HLA) class I expression
    Tetsuro Baba
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 101:2115-20. 2010
    ..Furthermore, such an antigen may help in achieving a better understanding of the immunological escape mechanisms and it may also provide a favorable immune response in cancer immunotherapy...
  22. ncbi request reprint The methylation status and protein expression of CDH1, p16(INK4A), and fragile histidine triad in nonsmall cell lung carcinoma: epigenetic silencing, clinical features, and prognostic significance
    Shoji Nakata
    Second Department of Surgery, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    Cancer 106:2190-9. 2006
    ....
  23. ncbi request reprint A lack of prognostic significance regarding DeltaNp63 immunoreactivity in lung cancer
    Teruo Iwata
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Lung Cancer 50:67-73. 2005
    ..The prognostic effects of DeltaNp63 expression do not appear to act as an important prognostic indicator in lung cancer. Our findings do not support that immunocytochemical markers demonstrate a relevant prognostic role in lung cancer...
  24. doi request reprint Association between lymphangiogenesis-/micrometastasis- and adhesion-related molecules in resected stage I NSCLC
    Toshihiro Yamashita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Japan
    Lung Cancer 70:320-8. 2010
    ..The purpose of this study was to clarify the role and clinical significance of lymphangiogenesis/micrometastases and adhesion molecules in resected stage I non-small cell lung cancer (NSCLC)...
  25. doi request reprint Results of a surgical resection for patients with stage IV non--small-cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Lung Cancer 13:220-4. 2012
    ..This study retrospectively investigated the clinical significance of surgical treatment for stage IV non-small-cell lung cancer (NSCLC)...
  26. doi request reprint Clinical significance of IGF1R expression in non-small-cell lung cancer
    Makoto Nakagawa
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Lung Cancer 13:136-42. 2012
    ..The purpose of the current study was to clarify the clinical role of insulin-like growth factor receptor-1 (IGF1R) in NSCLC...
  27. doi request reprint Preoperative CYFRA 21-1 and CEA as prognostic factors in patients with stage I non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807, Japan
    Lung Cancer 74:112-7. 2011
    ..This study investigated the preoperative serum levels of CYFRA 21-1 and CEA as prognostic factors in patients with stage I non-small cell lung cancer...
  28. doi request reprint Association between estrogen receptor-beta expression and epidermal growth factor receptor mutation in the postoperative prognosis of adenocarcinoma of the lung
    Naohiro Nose
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Clin Oncol 27:411-7. 2009
    ....
  29. ncbi request reprint Epithelial-mesenchymal transition in EGFR-TKI acquired resistant lung adenocarcinoma
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 30:2513-7. 2010
    ..However to date, no study has investigated the association between the EMT status and acquired resistance using cancer specimens...
  30. doi request reprint Overexpression of MACC1 mRNA in lung adenocarcinoma is associated with postoperative recurrence
    Hidehiko Shimokawa
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Thorac Cardiovasc Surg 141:895-8. 2011
    ..The purpose of this study was to clarify the role and clinical significance of metastasis associated in colon cancer 1 in resected stage I non-small cell lung cancers...
  31. ncbi request reprint Gender difference as a prognostic factor in patients undergoing resection of non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, 807 8555, Japan
    Surg Today 37:546-51. 2007
    ..We studied the effects of gender difference on the incidence of lung cancer and its mortality rate, which is a subject of much discussion...
  32. ncbi request reprint Clinical significance of the frequency of regulatory T cells in regional lymph node lymphocytes as a prognostic factor for non-small-cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Lung Cancer 81:475-9. 2013
    ....
  33. doi request reprint Cancer/testis antigen expression as a predictor for epidermal growth factor receptor mutation and prognosis in lung adenocarcinoma
    Tetsuro Baba
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Eur J Cardiothorac Surg 43:759-64. 2013
    ..The aim of this study was to elucidate the correlation between the expression of CT antigens and clinicopathological factors, including the EGFR mutation, and to analyse the prognosis in lung adenocarcinoma...
  34. doi request reprint Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Surg Res 181:e57-63. 2013
    ..The purpose of the present study was to clarify the prognostic significance of human leukocyte antigen (HLA) class I expression in patients with non-small-cell lung cancer who underwent complete surgical resection...
  35. ncbi request reprint Pleural lavage cytology immediately after thoracotomy in patients with completely resected non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807, Japan
    Int Surg 96:171-5. 2011
    ..The positive finding in PLC showed a tendency of an unfavorable prognosis for NSCLC patents following complete resection. Further clinical studies will be necessary to evaluate the efficacy of adjuvant therapy for PLC-positive patients...
  36. ncbi request reprint Discrimination of multiple primary lung cancers from intrapulmonary metastasis based on the expression of four cancer-related proteins
    Kenji Ono
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer 115:3489-500. 2009
    ....
  37. ncbi request reprint Expression of the p53 family in lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 26:1785-90. 2006
    ..The aim of this study was to detect p53, deltaNp73 and deltaNp63 expressions in lung cancer and to evaluate the relationship between the expression levels of the proteins and the prognosis of patients with resectable lung cancer...
  38. doi request reprint Serum level of osteopontin as a prognostic factor in patients who underwent surgical resection for non-small-cell lung cancer
    Masaru Takenaka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Lung Cancer 14:288-94. 2013
    ..This study focused on the clinical significance of preoperative serum level of OPN in NSCLC patients who underwent a complete resection...
  39. doi request reprint An endobronchial lipoma successfully resected by high-frequency electric snare: a report of 2 cases
    Shinji Shinohara
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Bronchology Interv Pulmonol 19:68-71. 2012
    ..The tumor was bronchoscopically resected using a high-frequency electric snare and an neodymium-yttrium-aluminum-garnet laser. In both cases, the pathologic diagnosis was endobronchial lipoma...
  40. doi request reprint Results of surgical resection for patients with thymoma according to World Health Organization histology and Masaoka staging
    Shinji Shinohara
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Asian J Surg 35:144-8. 2012
    ..Thymomas are relatively rare tumors. In this study, we investigated the clinical features of patients who underwent surgical resection for thymoma...
  41. ncbi request reprint Esophageal bypass using a gastric tube for a malignant tracheoesophageal/bronchoesophageal fistula: a report of 4 cases
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Int Surg 96:189-93. 2011
    ..This bypass procedure is therefore considered to be a feasible treatment choice for patients with tracheoesophageal/bronchoesophageal fistulas...
  42. doi request reprint Expression of estrogen receptor beta predicts a clinical response and longer progression-free survival after treatment with EGFR-TKI for adenocarcinoma of the lung
    Naohiro Nose
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Lung Cancer 71:350-5. 2011
    ..The aim of this study is to elucidate the correlation between expression of ER beta and the therapeutic effect of EGFR-TKI in adenocarcinoma of the lung...
  43. ncbi request reprint [Experience in treating patients with malignant pleural mesothelioma]
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 32:257-64. 2010
    ..We should therefore consider selecting a multimodality treatment for such patients because the administration of either systemic chemotherapy or radiotherapy was found to be associated with a favorable prognosis...
  44. ncbi request reprint Time trends of surgical outcome in patients with non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu, Japan
    J Thorac Oncol 5:825-9. 2010
    ..A surgical resection is a potentially curative treatment for non-small cell lung cancer (NSCLC). This study investigated the time trends of the surgical outcome in patients with NSCLC...
  45. ncbi request reprint Expression of cytochrome P450 in non-small cell lung cancer
    Tsunehiro Oyama
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 13:5787-93. 2008
    ..The understanding of the local expression of CYP enzymes in tumor tissues is important in the development of better treatment for lung cancer and a standardized treatment, tailor-made, for individual patients...
  46. ncbi request reprint Identification of a tumour associated antigen in lung cancer patients with asbestos exposure
    Manabu Yasuda
    Second Department of Surgery, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555 Japan
    Anticancer Res 30:2631-9. 2010
    ..This study analysed the humoral immune response in asbestos exposed lung cancer patients to identify new surrogate markers of the carcinogenic risk in populations exposed to asbestos. Methods and..
  47. ncbi request reprint Detection of EGFR and K-ras mutations for diagnosis of multiple lung adenocarcinomas
    Teruo Iwata
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Front Biosci (Landmark Ed) 16:2961-9. 2011
    ..04). These findings suggest that the combination method including gene mutation and morphological analysis can guide treatment decisions and that there is a need for systemic chemotherapy, and surveillance monitoring...
  48. ncbi request reprint [Management of patients with bronchial foreign bodies]
    Masaru Takenaka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    J UOEH 33:157-61. 2011
    ..However, an early diagnosis is very important, because inflammatory granulation due to long-term impaction of foreign bodies makes its removal difficult...
  49. ncbi request reprint Cytochrome P450 expression (CYP) in non-small cell lung cancer
    Tsunehiro Oyama
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 12:2299-308. 2007
    ..Therefore, the spectrum of CYP proteins in lung cancer could be useful for changing the present "order-made" therapy to the "tailor-made" therapy...
  50. ncbi request reprint A new mechanism for primary resistance to gefitinib in lung adenocarcinoma: the role of a novel G796A mutation in exon 20 of EGFR
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 27:2297-303. 2007
    ..This study suggests that screening tumour samples for a range of EGFR mutations may improve our ability to identify the patients most likely to benefit from EFGR TKIs...
  51. doi request reprint Discriminative features of thin-slice computed tomography for peripheral intrapulmonary lymph nodes
    Masaru Takenaka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Asian J Surg 36:69-73. 2013
    ..However, few descriptions of the CT findings of IPLNs, with regard to their potential for the differential diagnosis of lung cancer, have been published...
  52. doi request reprint Prognostic factors before and after recurrence of resected non-small cell lung cancer
    Tetsuro Baba
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Iseigaoka 1 1, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Respir Investig 50:151-6. 2012
    ..Data on factors that affect the interval between surgery and recurrence or predict survival after recurrence in NSCLC patients are still limited...
  53. ncbi request reprint The expression of Ki-67, but not proliferating cell nuclear antigen, predicts poor disease free survival in patients with adenocarcinoma of the lung
    Soichi Oka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 31:4277-82. 2011
    ..However, no useful data are presently available regarding the biological significance of both molecules in lung cancer...
  54. ncbi request reprint The prognostic significance of HER2 overexpression in non-small cell lung cancer
    Masaru Takenaka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi, Kitakyushu 807, Japan
    Anticancer Res 31:4631-6. 2011
    ..The present study focused on the clinical significance of the expression of HER2 in non-small cell lung cancer (NSCLC)...
  55. ncbi request reprint The EMT status in the primary tumor does not predict postoperative recurrence or disease-free survival in lung adenocarcinoma
    Yasuhiro Chikaishi
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 31:4451-6. 2011
    ..However, whether or not the expression of EMT-related molecules can be used as a biomarker for the prognosis of lung cancer has yet to be fully determined...
  56. doi request reprint TS expression predicts postoperative recurrence in adenocarcinoma of the lung
    Hidehiko Shimokawa
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Lung Cancer 72:360-4. 2011
    ..Not all patients with lung cancer require postoperative adjuvant chemotherapy after a complete resection. However, no useful markers for either selecting appropriate candidates or for predicting clinical recurrence exist...
  57. ncbi request reprint Molecular genetic tumor markers in non-small cell lung cancer
    Tsunehiro Oyama
    Department of Surgery II and Environmental Health, University of Occupational and Environmental Health, Kitakyushu, Japan
    Anticancer Res 25:1193-6. 2005
    ..This paper reviews MGTMs characteristic of lung cancer and clarifies the clinical usefulness and applications of MGTM for cancer treatment...
  58. ncbi request reprint Evaluation of topoisomerase I/topoisomerase IIalpha status in esophageal cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 33:205-16. 2011
    ....
  59. doi request reprint Limited pulmonary resection for peripheral small-sized adenocarcinoma of the lung
    Yoshinobu Ichiki
    Second Department of Surgery, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Int J Surg 9:155-9. 2011
    ..It was recently reported that a limited pulmonary resection (segmentectomy or wedge resection) was not inferior to a lobectomy in the management of peripheral small-sized adenocarcinoma (tumor ≦ 20 mm) of the lung...
  60. ncbi request reprint A randomized phase II trial of adjuvant chemotherapy with bi-weekly carboplatin plus paclitaxel versus carboplatin plus gemcitabine in patients with completely resected non-small cell lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Anticancer Res 30:4695-9. 2010
    ..However, treatment-related deaths sometimes occur. Therefore, the development of a safer regimen is necessary...
  61. ncbi request reprint Expression of dysadherin and cytokeratin as prognostic indicators of disease-free survival in patients with stage I NSCLC
    Kenji Ono
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 30:3273-8. 2010
    ..Adjuvant chemotherapy is required following the resection of aggressive NSCLC. It is therefore necessary to identify factors that accurately predict prognosis...
  62. ncbi request reprint Epidermal growth factor receptor mutations are associated with gefitinib sensitivity in non-small cell lung cancer in Japanese
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Lung Cancer 51:71-7. 2006
    ..033). These data show that adenocarcinomas from patients who had never smoked comprise a specific subset of patients with NSCLC sensitive to gefitinib treatment...
  63. ncbi request reprint Resistance to gefitinib
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Int J Clin Oncol 11:487-91. 2006
    ..Such observations should also help us in the search for more effective therapies against a specific subset of NSCLC...
  64. pmc Basaloid carcinoma of the lung associated with central cavitation: a unique surgical case focusing on cytological and immunohistochemical findings
    Sohsuke Yamada
    Departments of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Diagn Pathol 7:175. 2012
    ..We should be aware that, owing to its characteristic features, cytopathologists might be able to raise basaloid carcinoma of the lung as one of differential diagnoses, based on careful cytological examination...
  65. ncbi request reprint Prognostic value of acquired resistance-related molecules in Japanese patients with NSCLC treated with an EGFR-TKI
    Hidetaka Uramoto
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Anticancer Res 32:3785-90. 2012
    ..It is therefore critical to determine the mechanisms of resistance against agents and the prognostic value of acquired resistance-related molecules to EGFR-TKI...
  66. ncbi request reprint Apocrine carcinoma of the breast
    Masaharu Yamazaki
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan Yahatanishi ku, Kitakyushu 807 8555, Japan
    J UOEH 33:293-301. 2011
    ..Thus, the pathological diagnosis was apocrine carcinoma. There were no metastases in the axillary lymph nodes. The patient has had no recurrence in 8 years after surgery...
  67. doi request reprint Surgical resection for patients with mucinous bronchioloalveolar carcinoma
    Souichi Oka
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Asian J Surg 33:89-93. 2010
    ..This study investigated the clinicopathological features and the surgical outcome in patients with mucinous BAC...
  68. ncbi request reprint Expression of aromatase CYP19 and its relationship with parameters in NSCLC
    Tsunehiro Oyama
    Second Department of Surgery and Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci (Landmark Ed) 14:2285-92. 2009
    ..The results suggest that the aromatase inhibitors might be useful for the management of non-small cell lung cancer in postmenopausal women...
  69. ncbi request reprint [Results of surgical resection for patients with pulmonary cryptococcosis]
    Masaru Takenaka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 32:237-43. 2010
    ..All of the patients in the current series showed a good outcome without any relapse including cryptococcal meningitis after a surgical resection...
  70. ncbi request reprint Clinicopathologic characteristics of mucinous carcinoma of the breast
    Takeshi Hanagiri
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Int Surg 95:126-9. 2010
    ..Mucinous carcinoma showed a lower incidence of lymph node metastasis than other types of invasive breast cancer. Mucinous carcinoma tended to have a better prognosis in comparison with other types of invasive breast carcinoma...
  71. ncbi request reprint [Clinical analysis of esophageal cancer associated with other primary cancers]
    Kenji Ono
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Kyobu Geka 64:93-6; discussion 97-8. 2011
    ..Post-operative follow up is considered to be necessary for early detection of multiple occurrences of carcinoma, especially in the upper aerodigestive tract...
  72. doi request reprint Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma
    Koji Kuroda
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cancer Sci 101:46-53. 2010
    ..These results may indicate that RPL19 is a novel overexpressed antigen which may therefore be a useful candidate as a target for specific immunotherapy...
  73. ncbi request reprint P53R2, p53 inducible ribonucleotide reductase gene, correlated with tumor progression of non-small cell lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Anticancer Res 26:983-8. 2006
    ..Though our findings do not support that the p53R2 immunocytochemical marker alone plays an important prognostic role in NSCLC, the DNA repair pathway mediated by p53R2 may be responsible for controlling the growth of lung cancer...
  74. ncbi request reprint [Clinical characteristics of pulmonary hamartoma resected surgically as undiagnosed pulmonary nodule]
    Shinji Sminohara
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 34:41-6. 2012
    ....
  75. doi request reprint Expression of selected gene for acquired drug resistance to EGFR-TKI in lung adenocarcinoma
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishiku, Kitakyushu, Japan
    Lung Cancer 73:361-5. 2011
    ..However, patients often experience a relapse after treatment with EGFR-TKIs, even when the tumors are initially highly sensitive. However, the "whole picture" regarding acquired resistance remains unclear...
  76. ncbi request reprint Two cases with a long-term survival following multidisciplinary treatment for recurrent breast cancer after surgery
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Anticancer Res 31:277-9. 2011
    ....
  77. ncbi request reprint Expression of aldehyde dehydrogenase 2 in the normal esophageal epithelium and alcohol consumption in patients with esophageal cancer
    Masaru Morita
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Front Biosci 10:2319-24. 2005
    ..To our knowledge, this is the first study demonstrating the induction of ALDH2 in the esophagus by ethanol consumption...
  78. ncbi request reprint Clinicopathologic significance of an immunohistochemical expression of p27 in scirrhous carcinoma of the breast
    Tadahiro Nozoe
    Second Department of Surgery, University of Environmental and Occupational Health, Iseigaoka, Kitakyushu, Japan
    Breast Cancer 14:277-80. 2007
    ..The aim of the current study was to clarify clinicopathologic significance of scirrhous carcinoma of the breast with special reference to p27 expression...
  79. ncbi request reprint [Surgical treatment for patients with pulmonary sclerosing hemangioma]
    Soichi Oka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    J UOEH 33:41-5. 2011
    ..The postoperative clinical courses of all cases were uneventful, and no findings of recurrence distant metastasis, lymph node metastasis and local recurrence after surgery were observed in any of the patients...
  80. ncbi request reprint TS, DHFR and GARFT expression in non-squamous cell carcinoma of NSCLC and malignant pleural mesothelioma patients treated with pemetrexed
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Anticancer Res 30:4309-15. 2010
    ..However, no useful markers for selecting appropriate candidates exist at present...
  81. ncbi request reprint [Risk assessment for outpatients for cancer chemotherapy]
    Hidetaka Uramoto
    Cancer Chemotherapy Center, University of Occupational and Environmental Health, School of Medicine
    Gan To Kagaku Ryoho 34:2259-62. 2007
    ..Therefore, a system assuring safe management is critically required for the establishment of a system for outpatient cancer chemotherapy treatment...
  82. ncbi request reprint Expression of deltaNp73 predicts poor prognosis in lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Clin Cancer Res 10:6905-11. 2004
    ..The aim of this study was to detect DeltaNp73 expression in lung cancer and to evaluate the relationship between the DeltaNp73 expression level and the prognosis of patients with resected lung cancer...
  83. ncbi request reprint Smoking cessation program and CYP2A6 polymorphism
    Shinichi Ozaki
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 11:2590-7. 2006
    ..Although treatment of nicotine patch is efficacious to smoking cessation, cases with CYP2A619934/19934 might be more sensitive to nicotine adverse effects and more difficult to quit smoking once they have smoking habit...
  84. ncbi request reprint [Chemotherapy for lung cancer patients]
    Hidetaka Uramoto
    Cancer Chemotherapy Center, University Hospital, University of Occupational and Environmental Health, Japan, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J UOEH 28:75-84. 2006
    ..New anti-cancer agents, including gefitinib, erlotinib, bevacizumab, pemetrexed and amrubicin, are being developed currently...
  85. ncbi request reprint [Bronchial artery-pulmonary vein fistula undergoing right upper lobectomy; report of a case]
    Souichi Oka
    Department of Surgery II, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Kyobu Geka 63:836-9. 2010
    ..When the surrounding lung reveals a congestive and organized changes due to the arteriovenous fistula, resection of the affected lung is considered necessary...
  86. ncbi request reprint Hazardous environmental factors enhance impairment of liver function in HBV and HCV hepatitis
    Yasunori Yashima
    Department of Environmental Health, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci (Landmark Ed) 14:4071-8. 2009
    ..Therefore, hazardous working conditions have to be carefully considered in the progress of chronic liver disease in workers infected with HBV and HCV...
  87. ncbi request reprint Immunohistochemical staining with deltaNp63 is useful for distinguishing the squamous cell component of adenosquamous cell carcinoma of the lung
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 30:4717-20. 2010
    ..The aim of this study was to detect the deltaNp63 expression in the squamous carcinoma component of adenosquamous carcinoma and evaluate its usefulness as a specific squamous carcinoma marker...
  88. ncbi request reprint p73 Interacts with c-Myc to regulate Y-box-binding protein-1 expression
    Hidetaka Uramoto
    Department of Molecular Biology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 277:31694-702. 2002
    ..Our data suggest that p73 stimulates the transcription of the YB-1 promoter by enhancing recruitment of the c-Myc-Max complex to the E-box...
  89. ncbi request reprint Enhanced expression of the human vacuolar H+-ATPase c subunit gene (ATP6L) in response to anticancer agents
    Takayuki Torigoe
    Department of Molecular Biology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 277:36534-43. 2002
    ..Our data suggest that the induction of V-ATPase expression is an anti-apoptotic defense, and V-ATPase inhibitors in combination with low-dose anticancer agents may provide a new therapeutic approach...
  90. pmc Physical interaction of tumour suppressor p53/p73 with CCAAT-binding transcription factor 2 (CTF2) and differential regulation of human high-mobility group 1 (HMG1) gene expression
    Hidetaka Uramoto
    Department of Molecular Biology, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem J 371:301-10. 2003
    ..These results provide novel information on the functional interplay between CTF2 and p53/p73 as important determinants of their function in cell proliferation, apoptosis, DNA repair and cisplatin resistance...
  91. ncbi request reprint Prediction of emergency hospitalization of outpatients receiving cancer chemotherapy
    Hidetaka Uramoto
    Cancer Chemotherapy Center, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 27:1133-6. 2007
    ..By combining selected clinical information for outpatients receiving cancer chemotherapy, the need for emergency hospitalization could be predicted...
  92. ncbi request reprint Evaluation of the quality of life between inpatients and outpatients receiving cancer chemotherapy in Japan
    Hidetaka Uramoto
    Cancer Chemotherapy Center, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 27:1127-32. 2007
    ..These data suggest that the present QOL study has a sufficient feasibility for the outpatients evaluated in our study, and QOL of outpatients after discharge is equal to that of inpatients receiving cancer chemotherapy...
  93. ncbi request reprint Human mitochondrial transcription factor A binds preferentially to oxidatively damaged DNA
    Yoichiro Yoshida
    Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka, Japan
    Biochem Biophys Res Commun 295:945-51. 2002
    ..The affinity for oxidatively damaged DNA of mtTFA is higher for A/8-oxo-dG and C/8-oxo-dG than for G/8-oxo-dG and T/8-oxo-dG. Our findings suggest that mtTFA plays an important role in the recognition of oxidative DNA damage...
  94. ncbi request reprint EGFR-activating mutations are not present in breast tumors of Japanese patients
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Anticancer Res 30:4219-22. 2010
    ..However, no investigations of the frequency of EGFR mutation and the potential role of EGFR tyrosine kinase inhibitor (TKI) in Japanese patients with breast cancer...
  95. doi request reprint Simple prophylactic fixation for lung torsion
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Ann Thorac Surg 90:2028-30. 2010
    ..We describe a new prophylactic method to repair the residual lobe by using an absorptive sheet and fibrin glue...
  96. ncbi request reprint Video-assisted thoracoscopic pericardiectomy for malignant pericardial effusion
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 30:4691-4. 2010
    ..However, no standard treatment has yet been established. The purpose of this study was to clarify the utility of performing video-assisted thoracoscopic (VATS) pericardiectomy in patients presenting malignant pericardial effusion...
  97. ncbi request reprint A positive relationship between filamin and VEGF in patients with lung cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Anticancer Res 30:3939-44. 2010
    ..Although our findings do not suggest that the expression of FLNA alone plays an independent prognostic role, the angiogenesis pathway mediated by FLNA appears to be responsible for controlling the growth of lung tumors...
  98. ncbi request reprint The development of bronchopleural fistula in lung cancer patients after major surgery: 31 years of experience with 19 cases
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 31:619-24. 2011
    ..We herein describe our experiences with BPF after major lung resection and describe the results of our management of the cases seen during the past 31 years...
  99. pmc Clinicopathological characteristics of resected adenosquamous cell carcinoma of the lung: risk of coexistent double cancer
    Hidetaka Uramoto
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Cardiothorac Surg 5:92. 2010
    ..adenosquamous carcinoma (ADSQ) of non-small cell lung cancer (NSCLC) is a rare disease and the biological behavior and clinicopathological characteristics have not yet been thoroughly described...
  100. ncbi request reprint Lack of direct association between EGFR mutations and ER beta expression in lung cancer
    Takamitsu Onitsuka
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Anticancer Res 31:855-60. 2011
    ..The molecular mechanism underlying the apparent link between EGFR mutations and ER beta expression in lung cancer cell lines was investigated...
  101. ncbi request reprint Immunohistochemical evaluation of cytochrome P450 (CYP) and p53 in breast cancer
    Tsunehiro Oyama
    Second Department of Surgery, University of Occupational and Environmental Health, Kitakyushu, 807 8555, Japan
    Front Biosci 10:1156-61. 2005
    ..Since CYP3A is involved in the conversion of tamoxifen to its metabolites, the variation of the CYP3A expression in breast cancer tissues among ethnic groups might cause differences in the efficacy of tamoxifen...