Keiko Unno

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi Ingestion of theanine, an amino acid in tea, suppresses psychosocial stress in mice
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Exp Physiol 98:290-303. 2013
  2. ncbi Stress response caused by chronic alcohol intake in aged rat brain
    Keiko Unno
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Alcohol Clin Exp Res 26:1017-23. 2002
  3. ncbi Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Free Radic Res 45:966-74. 2011
  4. ncbi Beta-cryptoxanthin, plentiful in Japanese mandarin orange, prevents age-related cognitive dysfunction and oxidative damage in senescence-accelerated mouse brain
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Biol Pharm Bull 34:311-7. 2011
  5. ncbi Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Biofactors 34:263-71. 2008
  6. ncbi Protection of brain and pancreas from high-fat diet: effects of catechin and caffeine
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Physiol Behav 96:262-9. 2009
  7. ncbi Daily consumption of green tea catechin delays memory regression in aged mice
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Biogerontology 8:89-95. 2007
  8. ncbi Deuterium-resistant algal cell line for D labeling of heterotrophs expresses enhanced level of Hsp60 in D2O medium
    Keiko Unno
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Appl Environ Microbiol 71:2256-9. 2005
  9. ncbi Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10)
    Keiko Unno
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Japan
    Exp Gerontol 39:1027-34. 2004
  10. ncbi Increased expression of Hsp70 for resistance to deuterium oxide in a yeast mutant cell line
    Keiko Unno
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biol Pharm Bull 26:799-802. 2003

Collaborators

  • N Oku
  • Toru Sasaki
  • Minoru Sugiura
  • Yumiko Nakano
  • Kazutoshi Sayama
  • K Shimoi
  • Hiroyuki Yamamoto
  • Minoru Hoshino
  • Kazuaki Iguchi
  • Kosuke Shimizu
  • Takahiro Kishido
  • Tomoya Miyashita
  • Satoshi Ohno
  • Kazuya Nishikawa
  • Rina Okada
  • Takashi Yokogawa
  • Atsushi Takeda
  • Tomohiro Asai
  • Wakako Hakamata
  • Naomi Kinouchi Shimizu
  • Rie Fukutomi
  • Daisuke Choba
  • Shunsuke Asahina
  • Hirotoshi Yoshida
  • Tokio Yamaguchi
  • Keiko Motoyama

Detail Information

Publications14

  1. ncbi Ingestion of theanine, an amino acid in tea, suppresses psychosocial stress in mice
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Exp Physiol 98:290-303. 2013
    ..The present study demonstrated that theanine prevents and relieves psychosocial stress through the modulation of hypothalamic-pituitary-adrenal axis activity...
  2. ncbi Stress response caused by chronic alcohol intake in aged rat brain
    Keiko Unno
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Alcohol Clin Exp Res 26:1017-23. 2002
    ..Among many heat shock proteins and molecular chaperones, Hsc70 might be important not only for the normal protein folding pathway but also for refolding of denatured proteins produced by mild and chronic stress...
  3. ncbi Theanine intake improves the shortened lifespan, cognitive dysfunction and behavioural depression that are induced by chronic psychosocial stress in mice
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Free Radic Res 45:966-74. 2011
    ..The intake of theanine might be a potential candidate for suppression of disadvantage under psychosocial stress...
  4. ncbi Beta-cryptoxanthin, plentiful in Japanese mandarin orange, prevents age-related cognitive dysfunction and oxidative damage in senescence-accelerated mouse brain
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Biol Pharm Bull 34:311-7. 2011
    ..3%) exhibited a higher survival when 12 month-old, the presenile age of SAMP10, than control mice. These results suggest that β-CRX is incorporated into the brain and has an important antioxidative role and anti-aging effect...
  5. ncbi Daily ingestion of green tea catechins from adulthood suppressed brain dysfunction in aged mice
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Biofactors 34:263-71. 2008
    ..The ages of 6 and 9 months are thought to be adult and middle ages, respectively in SAMP10 mice. This result suggested that GT-catechin was helpful in suppressing brain dysfunction with aging even when ingestion started at the adult age...
  6. ncbi Protection of brain and pancreas from high-fat diet: effects of catechin and caffeine
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Physiol Behav 96:262-9. 2009
    ..The results indicate the protective effect of green tea catechin and caffeine on the functions of brain and pancreas in mice fed a high-fat diet...
  7. ncbi Daily consumption of green tea catechin delays memory regression in aged mice
    Keiko Unno
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Biogerontology 8:89-95. 2007
    ..GT-catechin did not prolong the lifetime of SAMP10 mice, but it did delay brain senescence. These findings suggest that continued intake of GT-catechin might promote healthy ageing of the brain in older persons...
  8. ncbi Deuterium-resistant algal cell line for D labeling of heterotrophs expresses enhanced level of Hsp60 in D2O medium
    Keiko Unno
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Appl Environ Microbiol 71:2256-9. 2005
    ..Unno, T. Kishido, M. Morioka, S. Okada, and N. Oku, Biol. Pharm. Bull. 26:799-802, 2003). This suggests that the overexpression of heat shock proteins is required to compensate for the deuterium isotope effect...
  9. ncbi Suppressive effect of green tea catechins on morphologic and functional regression of the brain in aged mice with accelerated senescence (SAMP10)
    Keiko Unno
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Japan
    Exp Gerontol 39:1027-34. 2004
    ..These results suggest that GT-catechin intake partially improves the morphologic and functional alterations that occur naturally in the brains of aged SAMP10 mice...
  10. ncbi Increased expression of Hsp70 for resistance to deuterium oxide in a yeast mutant cell line
    Keiko Unno
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biol Pharm Bull 26:799-802. 2003
    ..The expression of Hsp70 was enhanced in the mutant. The increased expression also endowed the yeast with cold-resistance. The mutant might be useful for biosynthesis of D-labeled biomolecules...
  11. ncbi Decline in glutathione peroxidase activity is a reason for brain senescence: consumption of green tea catechin prevents the decline in its activity and protein oxidative damage in ageing mouse brain
    Takahiro Kishido
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Biogerontology 8:423-30. 2007
    ..Furthermore, the intake of GT-catechin protected the decline in GPx activity and age-related oxidative damage in the brain...
  12. ncbi Preventive effect of green tea catechins on experimental tumor metastasis in senescence-accelerated mice
    Kosuke Shimizu
    Department of Medical Biochemistry and Global COE Program, University of Shizuoka, Shizuoka, Japan
    Biol Pharm Bull 33:117-21. 2010
    ..The results suggest that GT-catechin intake prevented the experimental tumor metastasis in aged SAMP10 mice via its inhibition of a reduction in immune surveillance potential with age...
  13. ncbi Involvement of plasmin-mediated extracellular activation of progalanin in angiogenesis
    Hiroyuki Yamamoto
    Laboratory of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Biochem Biophys Res Commun 430:999-1004. 2013
    ..These results suggest that the activation of progalanin by plasmin in the extracellular compartment was involved in MMP-9 and MMP-2 activation and in angiogenesis in tumor tissue...
  14. ncbi Social stress increases biopyrrins, oxidative metabolites of bilirubin, in mouse urine
    Tomoya Miyashita
    Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka 422-8526, Japan
    Biochem Biophys Res Commun 349:775-80. 2006
    ..These results suggested that social stress causes oxidative stress and that biopyrrins could be useful biomarkers of psychosocial stress...