Yoichi Ueta


Affiliation: University of Occupational and Environmental Health
Country: Japan


  1. Ueno H, Serino R, Sanada K, Akiyama Y, Tanaka K, Nishimura H, et al. Effects of acute kidney dysfunction on hypothalamic arginine vasopressin synthesis in transgenic rats. J Physiol Sci. 2019;69:531-541 pubmed publisher
    ..Further studies are needed to identify the neural and/or humoral factors that activate AVP synthesis and regulate neuronal circuits during acute kidney dysfunction. ..
  2. Nishimura K, Yoshino K, Sanada K, Beppu H, Akiyama Y, Nishimura H, et al. Effect of oestrogen-dependent vasopressin on HPA axis in the median eminence of female rats. Sci Rep. 2019;9:5153 pubmed publisher
    ..These results suggest that stress-induced activation of the hypothalamic-pituitary-adrenal axis may be caused by oestrogen-dependent upregulation of AVP in the eME of female rats. ..
  3. Saito R, Tanaka K, Nishimura H, Nishimura K, Sonoda S, Ueno H, et al. Centrally administered kisspeptin suppresses feeding via nesfatin-1 and oxytocin in male rats. Peptides. 2019;112:114-124 pubmed publisher
    ..These results indicate that central administration of KP-10 activates nesfatin-1- and OXT neurons, and may play an important role in the suppression of feeding in male rats. ..
  4. Yoshimura M, Ueta Y. Advanced genetic and viral methods for labelling and manipulation of oxytocin and vasopressin neurones in rats. Cell Tissue Res. 2019;375:311-327 pubmed publisher
    ..These transgenic rat lines enable the interrogation of neuronal function and physiology in a way that was not possible in the past, providing novel insights into neuronal mechanisms both in vivo and ex vivo. ..
  5. Sonoda S, Yoshimura M, Abe C, Morita H, Ueno H, Motojima Y, et al. Effects of hypergravity on the gene expression of the hypothalamic feeding-related neuropeptides in mice via vestibular inputs. Peptides. 2018;105:14-20 pubmed publisher
    ..These results suggest that the hypothalamic feeding-related neuropeptides may be affected during the exposed duration of hypergravity via vestibular inputs. ..
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    Ueta Y, Serino R, Shibuya I, Kitamura K, Kangawa K, Russell J, et al. A physiological role for adrenomedullin in rats; a potent hypotensive peptide in the hypothalamo-neurohypophysial system. Exp Physiol. 2000;85 Spec No:163S-169S pubmed
  7. Ohkubo J, Ohbuchi T, Yoshimura M, Maruyama T, Hashimoto H, Matsuura T, et al. Differences in acid-induced currents between oxytocin-mRFP1 and vasopressin-eGFP neurons isolated from the supraoptic and paraventricular nuclei of transgenic rats. Neurosci Lett. 2014;583:1-5 pubmed publisher
    ..These currents were almost completely inhibited by amiloride. The difference of acid-sensitivity between OXT and AVP neurons might contribute to maintaining systematic order in hypothalamic function. ..
  8. Motojima Y, Nishimura H, Ueno H, Sonoda S, Nishimura K, Tanaka K, et al. Role of Trpv1 and Trpv4 in surgical incision-induced tissue swelling and Fos-like immunoreactivity in the central nervous system of mice. Neurosci Lett. 2018;678:76-82 pubmed publisher
    ..Our results indicate that surgical incision activates the PVN and that Trpv1 and Trpv4 might be involved in neuronal activity in the dorsal horn laminae III-IV after surgical incision. ..
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    Ueta Y, Fujihara H, Serino R, Dayanithi G, Ozawa H, Matsuda K, et al. Transgenic expression of enhanced green fluorescent protein enables direct visualization for physiological studies of vasopressin neurons and isolated nerve terminals of the rat. Endocrinology. 2005;146:406-13 pubmed

More Information


  1. Yoshimura M, Matsuura T, Ohkubo J, Maruyama T, Ishikura T, Hashimoto H, et al. A role of nesfatin-1/NucB2 in dehydration-induced anorexia. Am J Physiol Regul Integr Comp Physiol. 2014;307:R225-36 pubmed publisher
    ..These results suggested that nesfatin-1/NucB2 is a crucial peptide in dehydration-induced anorexia. ..
  2. Yoshimura M, Ohkubo J, Hashimoto H, Matsuura T, Maruyama T, Onaka T, et al. Effects of a subconvulsive dose of kainic acid on the gene expressions of the arginine vasopressin, oxytocin and neuronal nitric oxide synthase in the rat hypothalamus. Neurosci Res. 2015;99:62-8 pubmed publisher
    ..c. administration of KA. These results suggest that up-regulation of the gene expressions of the AVP, OXT and nNOS in the rat hypothalamus may be differentially affected by peripheral administration of a subconvulsive dose of KA. ..
  3. Ishikura T, Suzuki H, Shoguchi K, Koreeda Y, Aritomi T, Matsuura T, et al. Possible involvement of TRPV1 and TRPV4 in nociceptive stimulation- induced nocifensive behavior and neuroendocrine response in mice. Brain Res Bull. 2015;118:7-16 pubmed publisher
    ..Only TRPV1 might regulate the formalin behavioral response in peripheral neuron. ..
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    Ueta Y, Levy A, Powell M, Lightman S, Kinoshita Y, Yokota A, et al. Neuronal nitric oxide synthase gene expression in human pituitary tumours: a possible association with somatotroph adenomas and growth hormone-releasing hormone gene expression. Clin Endocrinol (Oxf). 1998;49:29-38 pubmed
    ..The relevance of these findings from a functional or pathologenic viewpoint remains unclear, but the data again emphasize that it is not just GH secretion that distinguishes somatotroph adenomas from other pituitary tumours. ..
  5. Ishii M, Hashimoto H, Ohkubo J, Ohbuchi T, Saito T, Maruyama T, et al. Transgenic approach to express the channelrhodopsin 2 gene in arginine vasopressin neurons of rats. Neurosci Lett. 2016;630:194-198 pubmed publisher
    ..Our work provides for the first time an optogenetic approach to selectively activate AVP neurons in the rat. ..
  6. So M, Hashimoto H, Saito R, Yamamoto Y, Motojima Y, Ueno H, et al. Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist. J Physiol Sci. 2018;68:129-136 pubmed publisher
    ..These results suggest that centrally administered ghrelin may activate the orexinergic and non-orexinergic pathways responsible for the regulation of feeding. ..
  7. Motojima Y, Matsuura T, Yoshimura M, Hashimoto H, Saito R, Ueno H, et al. Comparison of the induction of c-fos-eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection. Neuroscience. 2017;356:64-77 pubmed publisher
    ..5-4.5h, but more sensitive than endogenous Fos, suggesting that the c-fos-eGFP rat line can be useful for the study of nociceptive pathways and processing. ..
  8. Arase K, Hashimoto H, Sonoda S, Ueno H, Saito R, Motojima Y, et al. Possible involvement of central oxytocin in cisplatin-induced anorexia in rats. J Physiol Sci. 2018;68:471-482 pubmed publisher
    ..In the OXT-LI cells, cisplatin-induced Fos expression in the SON and the PVN was also suppressed by OXTR-A pretreatment. These results suggested that central OXT may be involved in cisplatin-induced anorexia in rats. ..
  9. Motojima Y, Kawasaki M, Matsuura T, Saito R, Yoshimura M, Hashimoto H, et al. Effects of peripherally administered cholecystokinin-8 and secretin on feeding/drinking and oxytocin-mRFP1 fluorescence in transgenic rats. Neurosci Res. 2016;109:63-9 pubmed publisher
    ..These results provide us the evidence that, at least in part, i.p. administration of CCK-8 or secretin might be involved in the regulation of feeding/drinking via a OXTergic pathway from the dpPVN to the NTS. ..
  10. Ohno S, Hashimoto H, Fujihara H, Fujiki N, Yoshimura M, Maruyama T, et al. Increased oxytocin-monomeric red fluorescent protein 1 fluorescent intensity with urocortin-like immunoreactivity in the hypothalamo-neurohypophysial system of aged transgenic rats. Neurosci Res. 2018;128:40-49 pubmed publisher
    ..The physiological role of the co-existence of oxytocin and urocortin in the SON and PVN of aged rats remains unclear. ..
  11. Yoshimura M, Nishimura K, Nishimura H, Sonoda S, Ueno H, Motojima Y, et al. Activation of endogenous arginine vasopressin neurons inhibit food intake: by using a novel transgenic rat line with DREADDs system. Sci Rep. 2017;7:15728 pubmed publisher
    ..This novel transgenic rat line may provide a revolutionary insight into the neuronal mechanism regarding central AVP system responsible for various kind of behaviours. ..
  12. Saito R, Sonoda S, Ueno H, Motojima Y, Yoshimura M, Maruyama T, et al. Involvement of central nesfatin-1 neurons on oxytocin-induced feeding suppression in rats. Neurosci Lett. 2017;655:54-60 pubmed publisher
    ..These results suggested that nesfatin-1-expressing neurons in the hypothalamus and brainstem may play a role in sensing the peripheral level of OXT and its suppression of feeding in rats. ..
  13. Akiyama Y, Yoshimura M, Nishimura K, Nishimura H, Sonoda S, Ueno H, et al. Activation of central nesfatin-1/NucB2 after intraperitoneally administered cisplatin in rats. Biochem Biophys Res Commun. 2017;490:794-799 pubmed publisher
    ..These results suggest that i.p. administration of cisplatin activated, at least in part, nesfatin-1/NucB2 neuron in the CNS and may exert anorexigenic effects in rats. ..
  14. Matsuura T, Kawasaki M, Hashimoto H, Yoshimura M, Motojima Y, Saito R, et al. Effects of central administration of oxytocin-saporin cytotoxin on chronic inflammation and feeding/drinking behaviors in adjuvant arthritic rats. Neurosci Lett. 2016;621:104-110 pubmed publisher
    ..These results suggest that central OXT-ergic pathways may be involved in anti-inflammation at the spinal level and suppression of feeding behavior at the forebrain-brainstem level in AA rats. ..
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    Ueta Y, Kannan H, Higuchi T, Negoro H, Yamaguchi K, Yamashita H. Activation of gastric afferents increases noradrenaline release in the paraventricular nucleus and plasma oxytocin level. J Auton Nerv Syst. 2000;78:69-76 pubmed
    ..v. administration of CCK-8. These results suggest that gastric vagal afferents activate the central noradrenergic system from the brainstem to the PVN and secretion of OXT...