Masaki Ueno

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Layer V cortical neurons require microglial support for survival during postnatal development
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Neurosci 16:543-51. 2013
  2. ncbi request reprint Cell cycle progression is required for nuclear migration of neural progenitor cells
    Masaki Ueno
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Brain Res 1088:57-67. 2006
  3. ncbi request reprint Cell cycle and cell death regulation of neural progenitor cells in the 5-azacytidine (5AzC)-treated developing fetal brain
    Masaki Ueno
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Neurol 198:154-66. 2006
  4. ncbi request reprint Repair process of fetal brain after 5-azacytidine-induced damage
    Masaki Ueno
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Eur J Neurosci 24:2758-68. 2006
  5. ncbi request reprint Essential role of p53 in trophoblastic apoptosis induced in the developing rodent placenta by treatment with a DNA-damaging agent
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Apoptosis 12:1743-54. 2007
  6. ncbi request reprint Evidence of apoptosis in the subventricular zone and rostral migratory stream in the MPTP mouse model of Parkinson disease
    Xi Jun He
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Neuropathol Exp Neurol 65:873-82. 2006
  7. ncbi request reprint Mitochondrial dysfunction is related to necrosis-like programmed cell death induced by A23187 in CEM cells
    Keigo Hamahata
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Pharmacol 516:187-96. 2005
  8. ncbi request reprint Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced rat fetal brain lesions
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, 113 8657 Tokyo, Japan
    Neurotoxicol Teratol 26:579-86. 2004
  9. doi request reprint Etoposide induces TRP53-dependent apoptosis and TRP53-independent cell cycle arrest in trophoblasts of the developing mouse placenta
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biol Reprod 80:813-22. 2009
  10. ncbi request reprint Microarray analysis of genes in fetal central nervous system after ethylnitrosourea administration
    Kei Ichi Katayama
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Birth Defects Res B Dev Reprod Toxicol 74:255-60. 2005

Collaborators

Detail Information

Publications50

  1. doi request reprint Layer V cortical neurons require microglial support for survival during postnatal development
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    Nat Neurosci 16:543-51. 2013
    ..Our results highlight a neuron-glia interaction that is indispensable for network formation during a specific period in the developing brain...
  2. ncbi request reprint Cell cycle progression is required for nuclear migration of neural progenitor cells
    Masaki Ueno
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Brain Res 1088:57-67. 2006
    ..Our results suggest that cell cycle regulators might control the machinery of migration through a common regulatory mechanism...
  3. ncbi request reprint Cell cycle and cell death regulation of neural progenitor cells in the 5-azacytidine (5AzC)-treated developing fetal brain
    Masaki Ueno
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Neurol 198:154-66. 2006
    ..Furthermore, some cells may have died due to mitotic catastrophe. Throughout brain development, various cell cycle and cell death regulation mechanisms provide neural progenitor cells with options for defense from DNA damage...
  4. ncbi request reprint Repair process of fetal brain after 5-azacytidine-induced damage
    Masaki Ueno
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Eur J Neurosci 24:2758-68. 2006
    ..We show here that the developing brain has the capacity to respond to the damage induced by extrinsic chemical stresses, including changing the expression of numerous genes and the induction of microglia to aid the repair process...
  5. ncbi request reprint Essential role of p53 in trophoblastic apoptosis induced in the developing rodent placenta by treatment with a DNA-damaging agent
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 8657, Japan
    Apoptosis 12:1743-54. 2007
    ..These results indicate that p53 is essential for DNA damage-induced trophoblastic apoptosis and suggest that the mechanisms that regulate the damage-induced apoptosis differ from those that regulate physiological apoptosis...
  6. ncbi request reprint Evidence of apoptosis in the subventricular zone and rostral migratory stream in the MPTP mouse model of Parkinson disease
    Xi Jun He
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    J Neuropathol Exp Neurol 65:873-82. 2006
    ..The present findings provide new insight into the extensive neurotoxicity of MPTP and may be valuable in reevaluating the MPTP mouse model of Parkinson disease...
  7. ncbi request reprint Mitochondrial dysfunction is related to necrosis-like programmed cell death induced by A23187 in CEM cells
    Keigo Hamahata
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Eur J Pharmacol 516:187-96. 2005
    ..Differences in the responses to A23187 between these two cell lines might derive from differences in the susceptibility of the mitochondrial membrane to rapid increases in intra-cellular calcium...
  8. ncbi request reprint Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced rat fetal brain lesions
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo, 113 8657 Tokyo, Japan
    Neurotoxicol Teratol 26:579-86. 2004
    ..In conclusion, prenatal treatment of Ara-C is thought to induce apoptosis and inhibition of cell proliferation mediated by p53 and its target genes in the fetal brain...
  9. doi request reprint Etoposide induces TRP53-dependent apoptosis and TRP53-independent cell cycle arrest in trophoblasts of the developing mouse placenta
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Biol Reprod 80:813-22. 2009
    ..Our study demonstrated that etoposide injection induced TRP53-dependent apoptosis and TRP53-independent cell cycle arrest in labyrinthine trophoblasts, providing insights into the molecular pathway of placental disorders...
  10. ncbi request reprint Microarray analysis of genes in fetal central nervous system after ethylnitrosourea administration
    Kei Ichi Katayama
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Birth Defects Res B Dev Reprod Toxicol 74:255-60. 2005
    ..These effects occur immediately after the administration of ENU to pregnant animals resulting in fetal brain anomalies and long-term effects include brain tumors in the offspring...
  11. ncbi request reprint Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced trophoblastic cell apoptosis and impaired proliferation in rat placenta
    Hirofumi Yamauchi
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo 113 8657, Japan
    Biol Reprod 70:1762-7. 2004
    ....
  12. ncbi request reprint Ethylnitrosourea induces neural progenitor cell apoptosis after S-phase accumulation in a p53-dependent manner
    Kei Ichi Katayama
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Neurobiol Dis 18:218-25. 2005
    ..Furthermore, these data also demonstrate that both ENU-induced apoptosis and cell cycle perturbation in the S phase require p53...
  13. doi request reprint Intraspinal rewiring of the corticospinal tract requires target-derived brain-derived neurotrophic factor and compensates lost function after brain injury
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Brain 135:1253-67. 2012
    ..Our findings establish the anatomical, functional and molecular basis for the intrinsic capacity of neurons to form compensatory neural network following injury...
  14. ncbi request reprint Ethylnitrosourea-induced apoptosis in primordial germ cells of the rat fetus
    Kei Ichi Katayama
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan
    Exp Toxicol Pathol 54:193-6. 2002
    ..Moreover, a possible involvement of p53 is suggested in the ENU-induced apoptosis in PGCs...
  15. ncbi request reprint 5-Azacytidine (5AzC)-induced histopathological changes in the central nervous system of rat fetuses
    Masaki Ueno
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Japan
    Exp Toxicol Pathol 54:91-6. 2002
    ..In addition, it is suggested that 5AzC-induced apoptosis might occur mainly in the post mitotic phase of cell cycle...
  16. pmc Mechanisms of 5-azacytidine (5AzC)-induced toxicity in the rat foetal brain
    Masaki Ueno
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo, Japan
    Int J Exp Pathol 83:139-50. 2002
    ..The present results indicate that 5AzC induced apoptosis and cell cycle arrest probably at G1 phase in the rat foetal brain and they might be mediated by p53 in response to DNA damage...
  17. doi request reprint c-Jun N-terminal kinase induces axonal degeneration and limits motor recovery after spinal cord injury in mice
    Kazuhiro Yoshimura
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita Shi, Osaka, Japan
    Neurosci Res 71:266-77. 2011
    ..These results indicate that both JNK1 and JNK3 induce axonal degeneration and limit motor recovery after SCI. Thus, a JNK inhibitor may be a suitable therapeutic agent for SCI...
  18. doi request reprint Corticospinal tract fibers cross the ephrin-B3-negative part of the midline of the spinal cord after brain injury
    Shusaku Omoto
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Neurosci Res 69:187-95. 2011
    ..Our results suggest that ephrin-B3 is not expressed along the entire midline of the spinal cord, and sprouting axons can cross the midline at ephrin-B3-negative areas...
  19. doi request reprint Genetic deletion of paired immunoglobulin-like receptor B does not promote axonal plasticity or functional recovery after traumatic brain injury
    Shusaku Omoto
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita Shi, Osaka 565 0871, Japan
    J Neurosci 30:13045-52. 2010
    ..Our results suggest that blocking the function of PirB is not sufficient to promote axonal reorganization or functional recovery after cortical injury...
  20. pmc Paired immunoglobulin-like receptor B knockout does not enhance axonal regeneration or locomotor recovery after spinal cord injury
    Yuka Nakamura
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Biol Chem 286:1876-83. 2011
    ..These results indicate that PIR-B knock-out is not sufficient to induce extensive axonal regeneration after spinal cord injury...
  21. doi request reprint Kinematic analyses reveal impaired locomotion following injury of the motor cortex in mice
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Exp Neurol 230:280-90. 2011
    ..Our findings provide practical parameters to assess motor deficits and recovery following cortical injury in mice...
  22. ncbi request reprint Gene expression profiles of drug-metabolizing enzymes (DMEs) in rat liver during pregnancy and lactation
    Xi Jun He
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Mol Pathol 83:428-34. 2007
    ....
  23. ncbi request reprint Effects of prenatal hydroxyurea-treatment on mouse offspring
    Gye Hyeong Woo
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo ku, Tokyo 113 8657, Japan
    Exp Toxicol Pathol 56:1-7. 2004
    ..Based on the above-mentioned previous and present studies of ours, we suggest that HU-induced apoptosis in fetal tissues may play an important role in the development of anomalies in the corresponding tissues of offspring...
  24. pmc Engulfment of axon debris by microglia requires p38 MAPK activity
    Tatsuhide Tanaka
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Suita, Osaka 565 0871, Japan
    J Biol Chem 284:21626-36. 2009
    ..We observed regrowth of the severed neurites after axon debris was removed. This finding suggests that axon debris, in addition to myelin debris, is an inhibitory factor for axon regeneration...
  25. ncbi request reprint Ethylnitrosourea induces apoptosis and growth arrest in the trophoblastic cells of rat placenta
    Kei Ichi Katayama
    Department of Veterinary Pathology, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo 113 8657, Japan
    Biol Reprod 67:431-5. 2002
    ..Moreover, a possible involvement of p53 in the induction of apoptosis and growth arrest is suggested...
  26. pmc Activated microglia inhibit axonal growth through RGMa
    Mari Kitayama
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    PLoS ONE 6:e25234. 2011
    ..These results suggest that activated microglia play a major role in inhibiting axon regeneration via RGMa in the injured CNS...
  27. doi request reprint Expression of galectin-1 in immune cells and glial cells after spinal cord injury
    Dai Kurihara
    Department of Molecular Neuroscience, Osaka University, Graduate School of Medicine, Suita, Osaka, Japan
    Neurosci Res 66:265-70. 2010
    ..These results suggest that galectin-1 may be associated with the pathogenesis of spinal cord injury...
  28. doi request reprint Limited functional recovery in rats with complete spinal cord injury after transplantation of whole-layer olfactory mucosa: laboratory investigation
    Masanori Aoki
    Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan
    J Neurosurg Spine 12:122-30. 2010
    ..To investigate the potential of the OM to restore motor function, the authors developed a rat model of SCI and delayed transplantation of syngenic OM...
  29. ncbi request reprint Intrinsic regenerative mechanisms of central nervous system neurons
    Rieko Muramatsu
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan
    Biosci Trends 3:179-83. 2009
    ..Enhancing the intrinsic regenerative machinery of injured axons in the adult CNS is a potentially powerful strategy for treating patients with a CNS injury...
  30. pmc Soluble β-amyloid Precursor Protein Alpha binds to p75 neurotrophin receptor to promote neurite outgrowth
    Noriko Hasebe
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka, Japan Department of Anesthesiology and Critical Care Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan Core Research for Evolutional Science and Technology CREST, Japan Science and Technology Agency JST, Tokyo, Japan
    PLoS ONE 8:e82321. 2013
    ..In this study, we have investigated the mechanism of sAPPα-mediated neurotrophic effects. sAPPα and sAPPβ interact with p75 neurotrophin receptor (p75(NTR)), and sAPPα promotes neurite outgrowth...
  31. ncbi request reprint Cultured murine dermal fibroblast-like cells from senescence-accelerated mice as in vitro models for higher oxidative stress due to mitochondrial alterations
    Yoichi Chiba
    Department of Neurology, Graduate School of Medicine, Kyoto University, Japan
    J Gerontol A Biol Sci Med Sci 60:1087-98. 2005
    ..These results suggest that cells from SAMP11 mice are useful models for spontaneous higher oxidative stress in vitro due to dysfunctional mitochondria...
  32. ncbi request reprint A novel mechanism for imatinib mesylate-induced cell death of BCR-ABL-positive human leukemic cells: caspase-independent, necrosis-like programmed cell death mediated by serine protease activity
    Masayuki Okada
    Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Blood 103:2299-307. 2004
    ..Taken together, our results suggest that imatinib mesylate induces a caspase-independent, necrosis-like programmed cell death mediated by the serine protease activity of Omi/HtrA2...
  33. pmc Strategies for regenerating injured axons after spinal cord injury - insights from brain development
    Masaki Ueno
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, 2 2, Yamadaoka, Suita Shi, Osaka 565 0871, Japan
    Biologics 2:253-64. 2008
    ..Thus, understanding the developmental process will provide us with an important clue for designing therapeutic strategies for recovery from SCI...
  34. ncbi request reprint Regulation of axonal elongation and pathfinding from the entorhinal cortex to the dentate gyrus in the hippocampus by the chemokine stromal cell-derived factor 1 alpha
    Yoichi Ohshima
    Department of Molecular Neuroscience, Graduate School of Medicine, Osaka University, Osaka 565 0871, Japan
    J Neurosci 28:8344-53. 2008
    ..These results demonstrate that SDF-1alpha plays a critical role in promoting the growth of perforant fibers from the EC to the DG...
  35. ncbi request reprint MRP-1/CD9 gene transduction downregulates Wnt signal pathways
    Cheng Long Huang
    The Second Department of Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, 761 0793, Japan
    Oncogene 23:7475-83. 2004
    ..Therefore, MRP-1/CD9 could suppress cell transformation including epithelial to mesenchymal transition through downregulation of Wnt1, and might suppress tumor metastasis through downregulation of Wnt5a...
  36. pmc Defective brain development in mice lacking the Hif-1alpha gene in neural cells
    Shuhei Tomita
    Department of Immune System Development, RIKEN Research Center for Allergy and Immunology, Tokushima 770 8503, Japan
    Mol Cell Biol 23:6739-49. 2003
    ....
  37. ncbi request reprint Blood-brain barrier disruption in white matter lesions in a rat model of chronic cerebral hypoperfusion
    Masaki Ueno
    Second Department of Pathology, Kagawa Medical University, Kita gun, Kagawa, Japan
    J Cereb Blood Flow Metab 22:97-104. 2002
    ..An extravasation of macromolecules, such as proteases and immunoglobulins, may contribute to the pathogenesis of white matter lesions...
  38. ncbi request reprint Wnt1 overexpression associated with tumor proliferation and a poor prognosis in non-small cell lung cancer patients
    Takashi Nakashima
    Department of General Thoracic Surgery, Breast and Endocrinological Surgery, Faculty of Medicine, Kagawa University, Kagawa 761 0793, Japan
    Oncol Rep 19:203-9. 2008
    ..983; P=0.0061). Our results revealed that the Wnt1 overexpression affects the tumor proliferation in NSCLCs, partly via the upregulation of c-Myc...
  39. ncbi request reprint Prepro-orexin mRNA expression in the rat brain is increased during pregnancy
    Kenji Kanenishi
    Department of Perinatology and Gynecology, Faculty of Medicine, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Neurosci Lett 368:73-7. 2004
    ..These results suggest that increased prepro-orexin mRNA levels at early gestational age in the maternal rat has a role on energy metabolism during pregnancy...
  40. ncbi request reprint Hypoxia-inducible factor-2alpha is involved in enhanced apoptosis in the placenta from pregnancies with fetal growth restriction
    Shu Yan Dai
    Department of Perinatology and Gynecology, Kagawa University School of Medicine, Ikenobe, Miki, Kagawa, Japan
    Pathol Int 54:843-9. 2004
    ..05). The upregulation of HIF-2alpha protein expression in the placenta from pregnancies with FGR may, at least in part, be involved in the increased placental apoptosis...
  41. ncbi request reprint Regional distribution and age-dependent expression of N-acylphosphatidylethanolamine-hydrolyzing phospholipase D in rat brain
    Jun Morishita
    Department of Biochemistry, Kagawa University School of Medicine, Kagawa, Japan
    J Neurochem 94:753-62. 2005
    ..These results demonstrated wide distribution of NAPE-PLD in various brain regions and its age-dependent expression, suggesting the central role of this enzyme in the formation of anandamide and other N-acylethanolamines in the brain...
  42. ncbi request reprint Two pathways of apoptosis are simultaneously induced in the embryonal brains of neural cell-specific HIF-1alpha-deficient mice
    Masaki Ueno
    Department of Pathology and Host Defense, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, 761 0793, Japan
    Histochem Cell Biol 125:535-44. 2006
    ..These results suggest that two pathways of apoptosis are induced in neuronal and vascular cells of the cortex in the neural cell-specific HIF-1alpha-deficient mouse...
  43. ncbi request reprint Wnt5a expression is associated with the tumor proliferation and the stromal vascular endothelial growth factor--an expression in non-small-cell lung cancer
    Cheng Long Huang
    Department of Second Surgery, Faculty of Medicine, Kagawa University, 1750 1, Miki cho, Kita gun, Kagawa 761 0793, Japan
    J Clin Oncol 23:8765-73. 2005
    ..The Wnt gene family encodes the multifunctional signaling glycoproteins. We performed the present study to investigate the clinical significance of Wnt5a expression in non-small-cell lung cancer (NSCLC)...
  44. ncbi request reprint Survivin gene expression is negatively regulated by the p53 tumor suppressor gene in non-small cell lung cancer
    Jun Nakano
    Second Department of Surgery, Faculty of Medicine, Kagawa University, Kita gun, Kagawa 761 0793, Japan
    Int J Oncol 27:1215-21. 2005
    ..0047). This study indicated survivin gene expression to be negatively regulated by p53 in NSCLC, and that survivin expression could inhibit apoptosis and accelerate tumor cell proliferation to produce more aggressive carcinomas...
  45. ncbi request reprint Protective effects of the whisky congeners on ethanol-induced gastric mucosal damage
    Yukinobu Goso
    Department of Biochemistry, Kitasato University Graduate School of Medical Sciences, Sagamihara, Japan
    Alcohol Clin Exp Res 31:390-4. 2007
    ..The ingestion of both ethanol and whisky can induce acute gastrointestinal bleeding. The effects of the congeners, substances other than ethanol in whisky, on the ethanol-induced gastric mucosal damage were examined in the rat model...
  46. ncbi request reprint Accumulation of triosephosphate isomerase, with sequence homology to Beta amyloid peptides, in vessel walls of the newborn piglet hippocampus
    Takashi Kusaka
    Maternal and Perinatal Center, Faculty of Medicine, Kagawa University, Miki cho 1750 1, Kita gun, Kagawa, Japan
    Microsc Res Tech 70:648-55. 2007
    ..These findings indicate that TPI with sequence homology to Abeta peptides accumulates in perivascular cells of the microglia/macrophage lineage located around arterial vessels of the newborn piglet hippocampus...
  47. ncbi request reprint Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies
    Kazuhito Tsuboi
    Department of Biochemistry, Kagawa University School of Medicine, 1750 1 Ikenobe, Miki, Kagawa 761 0793, Japan
    Biochim Biophys Acta 1771:623-32. 2007
    ..In brain, intraventricular macrophages were positively stained with anti-NAAA antibody, while microglia appeared to be negative. These results strongly suggested the importance of macrophages as an expression site of NAAA in rat tissues...
  48. ncbi request reprint Beneficial effect of galectin 9 on rheumatoid arthritis by induction of apoptosis of synovial fibroblasts
    Masako Seki
    Department of Immunology and Immunopathology, Faculty of Medicine, Kagawa University, 1750 1 Ikenobe, Miki cho, Kita gun, Kagawa, Japan
    Arthritis Rheum 56:3968-76. 2007
    ..To compare the expression of galectin 9 (Gal-9) in synovial tissue (ST) from rheumatoid arthritis (RA) patients and osteoarthritis (OA) patients and to evaluate the effects of Gal-9 on fibroblast-like synoviocytes (FLS) in these patients...
  49. ncbi request reprint E2F1 overexpression correlates with thymidylate synthase and survivin gene expressions and tumor proliferation in non small-cell lung cancer
    Cheng Long Huang
    Department of Second Surgery, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Clin Cancer Res 13:6938-46. 2007
    ..We investigated the clinical significance of E2F1 gene expression in relation to its target genes, thymidylate synthase (TS) and Survivin, in case of non-small-cell lung cancer (NSCLC)...
  50. pmc Tissue distribution, biochemical properties, and transmission of mouse type A AApoAII amyloid fibrils
    Tatsumi Korenaga
    Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, Matsumoto, Japan
    Am J Pathol 164:1597-606. 2004
    ..Induction of amyloidosis by heterologous amyloid fibrils clearly showed interactions between amyloid protein monomers and fibrils having different primary structures...