Koichi Uemura

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Apoptotic and necrotic brain lesions in a fatal case of carbon monoxide poisoning
    K Uemura
    Department of Legal Medicine, Yamaguchi University School of Medicine, 755 8505, Ube, Japan
    Forensic Sci Int 116:213-9. 2001
  2. doi request reprint A death due to perirenal hematoma complicating extracorporeal shockwave lithotripsy
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo corrected Tokyo, Japan
    J Forensic Sci 53:469-71. 2008
  3. ncbi request reprint A fatal case of post-operative pulmonary thromboembolism with cosmetic liposuction
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Clin Forensic Med 13:41-3. 2006
  4. ncbi request reprint Carbon monoxide protects cardiomyogenic cells against ischemic death through L-type Ca2+ channel inhibition
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 334:661-8. 2005
  5. pmc Sudden death of a patient with primary hypereosinophilia, colon tumours, and pulmonary emboli
    K Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Clin Pathol 57:541-3. 2004
  6. ncbi request reprint Hypothermia attenuates delayed cortical cell death and ROS generation following CO inhalation
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Toxicol Lett 145:101-6. 2003
  7. ncbi request reprint Two fatal cases involving concurrent use of methamphetamine and morphine
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Forensic Sci 48:1179-81. 2003
  8. doi request reprint Rho-kinase inhibitor Y-27632 attenuates arsenic trioxide toxicity in H9c2 cardiomyoblastoma cells
    Marie Bessho
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Cardiovasc Toxicol 13:267-77. 2013
  9. ncbi request reprint Endothelial NO Synthase (eNOS) phosphorylation regulates coronary diameter during ischemia-reperfusion in association with oxidative stress
    Sumihisa Hoshino
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Free Radic Res 39:481-9. 2005
  10. doi request reprint Biochemical blood markers and sampling sites in forensic autopsy
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    J Forensic Leg Med 15:312-7. 2008

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Apoptotic and necrotic brain lesions in a fatal case of carbon monoxide poisoning
    K Uemura
    Department of Legal Medicine, Yamaguchi University School of Medicine, 755 8505, Ube, Japan
    Forensic Sci Int 116:213-9. 2001
    ..The two types of cell death occurred in the cortex, basal ganglia, hippocampus, thalamus, and cerebellum. Hypoxia caused by CO-hemoglobin formation alone cannot explain the phenomena...
  2. doi request reprint A death due to perirenal hematoma complicating extracorporeal shockwave lithotripsy
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo corrected Tokyo, Japan
    J Forensic Sci 53:469-71. 2008
    ..Perirenal hematoma can easily be diagnosed with abdominal sonography, if pain or symptoms of anemia develop. Doctors must be aware of the possibilities of severe renal hematomas after ESWL...
  3. ncbi request reprint A fatal case of post-operative pulmonary thromboembolism with cosmetic liposuction
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Clin Forensic Med 13:41-3. 2006
    ..A female patient was in the home toilet after two days of immobilization following day-surgery liposuction. Clinicians must be aware of appropriate methods for the prevention of post operative PTE with cosmetic surgery...
  4. ncbi request reprint Carbon monoxide protects cardiomyogenic cells against ischemic death through L-type Ca2+ channel inhibition
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 334:661-8. 2005
    ..A whole cell patch-clamp experiment supports that CO inhibits L-type Ca(2+) channel mediated influx of Ca(2+) and the ischemic death of H9c2 cells...
  5. pmc Sudden death of a patient with primary hypereosinophilia, colon tumours, and pulmonary emboli
    K Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Clin Pathol 57:541-3. 2004
    ..Necropsy disclosed two solid tumours primarily composed of eosinophils in the ascending and transverse colon. The cause of the sudden death was pulmonary artery emboli, derived from a thrombus in the left iliac vein...
  6. ncbi request reprint Hypothermia attenuates delayed cortical cell death and ROS generation following CO inhalation
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Toxicol Lett 145:101-6. 2003
    ..CO inhalation injures neuron by reactive oxygen species (ROS), independent of hypoxia, as can be concluded from the histological comparison of DCD with HNE immunoreactivity...
  7. ncbi request reprint Two fatal cases involving concurrent use of methamphetamine and morphine
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    J Forensic Sci 48:1179-81. 2003
    ..In Japan, MAP is the most predominant cause of drug intoxication. The presented cases suggest that MOR may exert synergistic effect on hyperthermia due to the MAP intoxication, together with experimental findings...
  8. doi request reprint Rho-kinase inhibitor Y-27632 attenuates arsenic trioxide toxicity in H9c2 cardiomyoblastoma cells
    Marie Bessho
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Cardiovasc Toxicol 13:267-77. 2013
    ....
  9. ncbi request reprint Endothelial NO Synthase (eNOS) phosphorylation regulates coronary diameter during ischemia-reperfusion in association with oxidative stress
    Sumihisa Hoshino
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, 113 0033, Japan
    Free Radic Res 39:481-9. 2005
    ..Thus, vascular patency is correlated with eNOS-Ser1177 phosphorylation in association with ROS, and PKC during reperfusion. Endothelin inhibits vasodilatation by reducing NO availability during reperfusion...
  10. doi request reprint Biochemical blood markers and sampling sites in forensic autopsy
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Tokyo 113 0033, Japan
    J Forensic Leg Med 15:312-7. 2008
    ..For clinical forensic diagnosis of biochemical blood markers, we must determine the "forensic abnormal value" after collecting more cases by known causes with more information about the population...
  11. ncbi request reprint Ischemic preconditioning protects cardiomyocytes against ischemic injury by inducing GRP78
    Kaori Shintani-Ishida
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Bunkyo ku, Japan
    Biochem Biophys Res Commun 345:1600-5. 2006
    ..This study showed for the first time that early IP up-regulates myocardial GRP78. It was suggested that GRP78 induced by early IP contributes to protect cardiomyocytes against ischemic injury...
  12. doi request reprint Reactive oxygen species-independent rapid initiation of mitochondrial apoptotic pathway by chelerythrine
    Takeshi Funakoshi
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Toxicol In Vitro 25:1581-7. 2011
    ..Hence, chelerythrine initiates the rapid mitochondrial apoptotic death of H9c2 cardiomyoblastoma cells in a manner that is likely independent of the generation of ROS from mitochondria...
  13. doi request reprint Brief exposure to carbon monoxide preconditions cardiomyogenic cells against apoptosis in ischemia-reperfusion
    Mihoko Kondo-Nakamura
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 393:449-54. 2010
    ..These results suggest that CO pretreatment induces mitochondrial generation of O2(-), which is then converted by SOD to H2O2, and subsequent Akt activation by H2O2 attenuates apoptosis in ischemia-reperfusion...
  14. ncbi request reprint Hemichannels in cardiomyocytes open transiently during ischemia and contribute to reperfusion injury following brief ischemia
    Kaori Shintani-Ishida
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Am J Physiol Heart Circ Physiol 293:H1714-20. 2007
    ....
  15. doi request reprint Bifurcate effects of glucose on caspase-independent cell death during hypoxia
    Toshihiko Aki
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem Biophys Res Commun 396:614-8. 2010
    ..In contrast, excessive glucose also induces hypoxic cell death that is not accompanied by these events, suggesting a change in the mode of cell death between hypoxic cells with and without glucose supplementation...
  16. ncbi request reprint Determination of amobarbital and phenobarbital in serum by gas chromatography-mass spectrometry with addition of formic acid to the solvent
    Kanju Saka
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 869:9-15. 2008
    ..The correlation coefficients of the calibration curves were 0.9995 or better, and the accuracy and precision of intraday and interday assays were in line with Food and Drug Administration (FDA) criteria...
  17. doi request reprint Death due to blood transfusion-induced anaphylactic shock: A case report
    Akina Nara
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Leg Med (Tokyo) 12:148-50. 2010
    ..5 ng/mL). When considered comprehensively with autopsy findings and blood typing, we concluded that this patient was suspected to have suffered from anaphylactic shock as a result of blood transfusion...
  18. ncbi request reprint Death due to duodenal obstruction in a patient with an eating disorder: a case report
    Hiroshi Ikegaya
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int J Eat Disord 39:350-2. 2006
    ..A 30-year-old woman with a 2-year history of bulimia nervosa and severe abdominal pain after excessive food consumption visited our emergency room. Her abdomen showed marked generalized distension...
  19. doi request reprint Inducer of heme oxygenase-1 cobalt protoporphyrin accelerates autophagy and suppresses oxidative damages during lipopolysaccharide treatment in rat liver
    Kana Unuma
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo Department of Anatomy and Embryology, Ehime University Graduate School of Medicine, Ehime Department of Forensic Medicine, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hepatol Res 43:91-6. 2013
    ..Conclusion:  HO-1 promotes autophagy and elimination of damaged mitochondria thereby repressing oxidative stress in LPS-treated rat liver, revealing a novel mechanism for protection by HO-1 against septic liver damage...
  20. ncbi request reprint Protein kinase C-epsilon protects PC12 cells against methamphetamine-induced death: possible involvement of suppression of glutamate receptor
    Koichi Uemura
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 113 0033, Tokyo, Japan
    Life Sci 72:1595-607. 2003
    ..A glutamate receptor antagonist MK801 abrogated the cell death, which is reversed by PKC inhibition. These data suggest that PKC-epsilon promotes PC12 cell survival through glutamate receptor suppression...
  21. ncbi request reprint Acetic acid improves the sensitivity of theophylline analysis by gas chromatography-mass spectrometry
    Kanju Saka
    Department of Forensic Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 846:240-4. 2007
    ..This simple and sensitive method without derivatization can be applied to the quantification of theophylline in serum samples in clinical and toxicological practice...
  22. ncbi request reprint Ischemia promotes calpain-mediated degradation of p120-catenin in SH-SY5Y cells
    Hiroshi Ohno
    Department of Forensic Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 353:547-52. 2007
    ..This is the first report of the calpain-mediated degradation of p120-catenin and an association between the level of dephosphorylated p120-catenin and cell aggregation in ischemic neuronal cells...
  23. doi request reprint Sudden death of an alcoholic elderly man with acute esophageal necrosis (black esophagus)
    Kana Unuma
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Forensic Sci Int 212:e15-7. 2011
    ..The cause of death was undetermined. We discuss the possible role of acute esophageal necrosis in the cause of sudden death...
  24. pmc Starch accumulation in the lungs of two infants following positive ventilation
    Kana Unuma
    Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Forensic Sci Med Pathol 9:554-7. 2013
    ..This artifact may easily occur in infants because of their immature lungs and short respiratory tract. Non-powdered gloves should be worn instead of powdered gloves during tracheal intubation, especially in infants. ..
  25. ncbi request reprint Usefulness of serum mast cell-specific chymase levels for postmortem diagnosis of anaphylaxis
    Hajime Nishio
    Department of Legal Medicine, Osaka Medical College, Takatsuki 569 8686, Japan
    Int J Legal Med 119:331-4. 2005
    ..826, p=0.011). Furthermore, chymase was shown to be quite stable in serum. These results showed that measurement of serum chymase levels might be an additional tool for postmortem diagnosis of anaphylaxis...
  26. ncbi request reprint A new method for ABO genotyping to avoid discrepancy between genetic and serological determinations
    Kaori Shintani-Ishida
    Department of Forensic Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo, 113 0033, Japan
    Int J Legal Med 122:7-9. 2008
    ..This method can be used for the genotyping of badly decomposed remains or old bloodstains...
  27. doi request reprint A case in which a bone fragment caused by a bullet made a second channel in addition to the bullet channel
    Marie Bessho
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Leg Med (Tokyo) 14:188-90. 2012
    ..We also discuss the characteristics of an ear lobe injury found on the victim and show how this injury and blood and skin on the revolver were used as clues to determine the posture at the time of the shot...
  28. doi request reprint Cytoplasmic vacuolization during exposure to drugs and other substances
    Toshihiko Aki
    Section of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45, Yushima, Bunkyo ku, Tokyo, 113 8519, Japan
    Cell Biol Toxicol 28:125-31. 2012
    ..In this mini-review, we provide an overview of the origin, mechanism, and possible outcomes of cellular vacuolization during exposure to substances with lysosomotropic as well as other properties...
  29. doi request reprint A fatal case of air-bag-mediated liver injury in an unrestrained driver
    Koichi Uemura
    Section of Forensic Medicine, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Leg Med (Tokyo) 11:S555-7. 2009
    ..Autopsy disclosed liver laceration with intra-abdominal hemorrhage (2,000 mL), resulting in hemorrhagic shock. This is the first autopsy report of liver laceration caused by the rapid expansion of an air-bag during an automobile crash...
  30. doi request reprint Subarachnoid hemorrhage caused by a traffic accident: de novo aneurysm ruptured 30 years after surgical neck clipping
    Atsushi Yamada
    Department of Forensic Medicine, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    J Forensic Leg Med 22:90-2. 2014
    ..We diagnosed the cause of death was traumatic aneurysmal rupture. In addition, we discussed the cause of a newly formed de novo aneurysm which may be affected by past surgical neck clipping. ..