Masato Tsutsui

Summary

Affiliation: University of Occupational and Environmental Health
Country: Japan

Publications

  1. ncbi request reprint Development of genetically engineered mice lacking all three nitric oxide synthases
    Masato Tsutsui
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan
    J Pharmacol Sci 102:147-54. 2006
  2. ncbi request reprint Neuronal nitric oxide synthase as a novel anti-atherogenic factor
    Masato Tsutsui
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Fukuoka 807 8555, Japan
    J Atheroscler Thromb 11:41-8. 2004
  3. doi request reprint Spontaneous myocardial infarction and nitric oxide synthase
    Masato Tsutsui
    Department of Pharmacology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Trends Cardiovasc Med 18:275-9. 2008
  4. ncbi request reprint [Development of genetically engineered mice lacking all three nitric oxide synthase isoforms]
    Masato Tsutsui
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    Yakugaku Zasshi 127:1347-55. 2007
  5. ncbi request reprint [Structure and function of nitric oxide synthases]
    Masato Tsutsui
    Tanpakushitsu Kakusan Koso 47:2024-31. 2002
  6. ncbi request reprint Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice
    Masato Tsutsui
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Circ J 73:986-93. 2009
  7. doi request reprint Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet
    Yasuko Yatera
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cardiovasc Res 87:675-82. 2010
  8. ncbi request reprint Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress
    Osamu Suda
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 24:1682-8. 2004
  9. ncbi request reprint Effects of resveratrol, a grape polyphenol, on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells
    Yuko Shinohara
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem Pharmacol 74:1608-18. 2007
  10. doi request reprint Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms
    Sei Nakata
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Circulation 117:2211-23. 2008

Detail Information

Publications74

  1. ncbi request reprint Development of genetically engineered mice lacking all three nitric oxide synthases
    Masato Tsutsui
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan
    J Pharmacol Sci 102:147-54. 2006
    ....
  2. ncbi request reprint Neuronal nitric oxide synthase as a novel anti-atherogenic factor
    Masato Tsutsui
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Fukuoka 807 8555, Japan
    J Atheroscler Thromb 11:41-8. 2004
    ..These results provide the first direct evidence that nNOS plays important roles in suppressing arteriosclerotic vascular lesion formation. Thus, nNOS could be regarded as a novel anti-atherogenic factor...
  3. doi request reprint Spontaneous myocardial infarction and nitric oxide synthase
    Masato Tsutsui
    Department of Pharmacology, University of Occupational and Environmental Health, Kitakyushu, Japan
    Trends Cardiovasc Med 18:275-9. 2008
    ..This is the first in vivo demonstration showing that the defective NOS system is involved in the pathogenesis of spontaneous MI. Based on the evidence, this review summarizes our current knowledge of spontaneous MI and NOS...
  4. ncbi request reprint [Development of genetically engineered mice lacking all three nitric oxide synthase isoforms]
    Masato Tsutsui
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Iseigaoka, Kitakyushu, Japan
    Yakugaku Zasshi 127:1347-55. 2007
    ....
  5. ncbi request reprint [Structure and function of nitric oxide synthases]
    Masato Tsutsui
    Tanpakushitsu Kakusan Koso 47:2024-31. 2002
  6. ncbi request reprint Nitric oxide synthases and cardiovascular diseases: insights from genetically modified mice
    Masato Tsutsui
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Circ J 73:986-93. 2009
    ..Based on studies with murine NOS genetic models, this review summarizes the latest knowledge of NOSs and cardiovascular diseases...
  7. doi request reprint Severe dyslipidaemia, atherosclerosis, and sudden cardiac death in mice lacking all NO synthases fed a high-fat diet
    Yasuko Yatera
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Cardiovasc Res 87:675-82. 2010
    ..The precise role of the nitric oxide synthase (NOS) system in lipid metabolism remains to be elucidated. We addressed this point in mice that we have recently developed and that lack all three NOS isoforms...
  8. ncbi request reprint Asymmetric dimethylarginine produces vascular lesions in endothelial nitric oxide synthase-deficient mice: involvement of renin-angiotensin system and oxidative stress
    Osamu Suda
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 24:1682-8. 2004
    ..However, in this study, we examined our hypothesis that the long-term vascular effects of ADMA are not mediated by inhibition of endothelial NO synthesis...
  9. ncbi request reprint Effects of resveratrol, a grape polyphenol, on catecholamine secretion and synthesis in cultured bovine adrenal medullary cells
    Yuko Shinohara
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem Pharmacol 74:1608-18. 2007
    ..The present findings suggest that resveratrol inhibits acetylcholine-induced catecholamine secretion and synthesis through suppressing ion influx in cultured bovine adrenal medullary cells...
  10. doi request reprint Spontaneous myocardial infarction in mice lacking all nitric oxide synthase isoforms
    Sei Nakata
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Circulation 117:2211-23. 2008
    ..In this study, we examined this point in mice deficient in all 3 NOS isoforms (triply n/i/eNOS(-/-) mice) that we have recently developed...
  11. doi request reprint Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol level
    Ke Yong Wang
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 31:800-7. 2011
    ..In the present study, we generated apolipoprotein E (apoE) and histamine synthesizing histidine decarboxylase double knockout (DKO) mice on a C57BL/6J (wild-type mice) background to clarify the roles of histamine in atherosclerosis...
  12. ncbi request reprint Stimulation of catecholamine synthesis via activation of p44/42 MAPK in cultured bovine adrenal medullary cells by milnacipran
    Koji Shinkai
    Department of Psychiatry, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, 807 8555, Japan
    Naunyn Schmiedebergs Arch Pharmacol 375:65-72. 2007
    ..The present findings suggest that milnacipran activates tyrosine hydroxylase and then stimulates catecholamine synthesis through a p44/42 MAPK-dependent pathway in cultured bovine adrenal medullary cells...
  13. ncbi request reprint Dual effects of nobiletin, a citrus polymethoxy flavone, on catecholamine secretion in cultured bovine adrenal medullary cells
    Han Zhang
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi ku, Kitakyushu, Japan
    J Neurochem 114:1030-8. 2010
    ....
  14. doi request reprint Crucial vasculoprotective role of the whole nitric oxide synthase system in vascular lesion formation in mice: Involvement of bone marrow-derived cells
    Yumi Furuno
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Nitric Oxide 25:350-9. 2011
    ..Our findings also suggest that the NOS system in bone marrow-derived cells may be involved in this vasculoprotective mechanism...
  15. ncbi request reprint Vascular neuronal NO synthase is selectively upregulated by platelet-derived growth factor: involvement of the MEK/ERK pathway
    Sei Nakata
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 25:2502-8. 2005
    ..In this study, we examined the molecular mechanism(s) for vascular neuronal NOS (nNOS) expression...
  16. ncbi request reprint The hypothalamo-pituitary axis responses to lipopolysaccharide-induced endotoxemia in mice lacking inducible nitric oxide synthase
    Soichiro Akasaka
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Brain Res 1089:1-9. 2006
    ..These results suggest that iNOS-derived NO may therefore play a stimulatory role in the activity of the hypothalamo-pituitary axis during endotoxemia...
  17. ncbi request reprint Statin treatment upregulates vascular neuronal nitric oxide synthase through Akt/NF-kappaB pathway
    Sei Nakata
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 27:92-8. 2007
    ..In this study, we examined whether statins also upregulate vascular expression of neuronal NOS (nNOS)...
  18. doi request reprint Simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine via blocking Na+ and Ca2+ influx in bovine adrenal medullary cells
    Taeko Matsuda
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Pharmacol Exp Ther 327:130-6. 2008
    ..These findings suggest that simvastatin inhibits catecholamine secretion and synthesis induced by acetylcholine through suppression of Na(+) and Ca(2+) influx in the adrenal medulla and probably in the sympathetic neurons...
  19. pmc Nephrogenic diabetes insipidus in mice lacking all nitric oxide synthase isoforms
    Tsuyoshi Morishita
    Second Department of Internal Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Proc Natl Acad Sci U S A 102:10616-21. 2005
    ..These results provide evidence that the NOS system plays a critical role in maintaining homeostasis, especially in the kidney...
  20. doi request reprint Genetic disruption of all NO synthase isoforms enhances BMD and bone turnover in mice in vivo: involvement of the renin-angiotensin system
    Ken Sabanai
    Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Bone Miner Res 23:633-43. 2008
    ..To address this point, we successfully generated mice in which all three NOS genes are completely disrupted. In this study, we examined whether bone metabolism is abnormal in those mice...
  21. ncbi request reprint Dual effects of daidzein, a soy isoflavone, on catecholamine synthesis and secretion in cultured bovine adrenal medullary cells
    Minhui Liu
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Kitakyushu, Japan
    Endocrinology 148:5348-54. 2007
    ..The latter effect of daidzein may be a beneficial action on the cardiovascular system...
  22. ncbi request reprint Vasculoprotective roles of neuronal nitric oxide synthase
    Tsuyoshi Morishita
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    FASEB J 16:1994-6. 2002
    ..These results provide the first direct evidence that nNOS plays important roles in suppressing arteriosclerotic vascular lesion formation in vivo...
  23. doi request reprint Opposite effects of milnacipran, a serotonin norepinephrine reuptake inhibitor, on the levels of nitric oxide and brain-derived neurotrophic factor in mouse brain cortex
    Atsuko Ikenouchi-Sugita
    Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, Japan
    Naunyn Schmiedebergs Arch Pharmacol 380:479-86. 2009
    ..These findings suggest that milnacipran has opposite effects on the levels of NO and BDNF in the brain cortex, namely, downregulation of NO and upregulation of BDNF...
  24. ncbi request reprint Stimulation of catecholamine synthesis by environmental estrogenic pollutants
    Nobuyuki Yanagihara
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu 807 8555, Japan
    Endocrinology 146:265-72. 2005
    ..These findings suggest that short-term and long-term treatment of cells with estrogenic pollutants at environmental concentrations stimulates catecholamine synthesis and MAPK through an estrogen receptor-independent pathway...
  25. doi request reprint Increasing dihydrobiopterin causes dysfunction of endothelial nitric oxide synthase in rats in vivo
    Katsuhiko Noguchi
    Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Am J Physiol Heart Circ Physiol 301:H721-9. 2011
    ..These results indicate, for the first time, that increasing BH(2) causes eNOS dysfunction in vivo even in the absence of BH(4) deficiency, demonstrating a novel insight into the regulation of endothelial function...
  26. ncbi request reprint Capsaicin inhibits catecholamine secretion and synthesis by blocking Na+ and Ca2+ influx through a vanilloid receptor-independent pathway in bovine adrenal medullary cells
    Kojiro Takahashi
    Department of Hospital Pharmacy, University of Occupational and Environmental Health, Kitakyushu, Japan
    Naunyn Schmiedebergs Arch Pharmacol 374:107-16. 2006
    ..4 and 39.0 microM, respectively). The present findings suggest that capsaicin inhibits catecholamine secretion and synthesis via suppression of Na(+) and Ca(2+) influx through a vanilloid receptor-independent pathway...
  27. ncbi request reprint Long-term treatment with N(omega)-nitro-L-arginine methyl ester causes arteriosclerotic coronary lesions in endothelial nitric oxide synthase-deficient mice
    Osamu Suda
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Circulation 106:1729-35. 2002
    ..We addressed this point in mice that are deficient in the endothelial NO synthase gene (eNOS-KO mice)...
  28. ncbi request reprint Histamine upregulates the expression of inducible nitric oxide synthase in human intimal smooth muscle cells via histamine H1 receptor and NF-kappaB signaling pathway
    Akihide Tanimoto
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi, Kitakyushu 807 8555, Japan
    Arterioscler Thromb Vasc Biol 27:1556-61. 2007
    ..To investigate the relation between histamine and NO production in intimal smooth muscle cells (SMCs), we studied the effect of histamine on inducible NO synthase (iNOS) expression in the SMCs...
  29. ncbi request reprint Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats
    Fumihiko Kamezaki
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku 807 8555, Kitakyushu, Japan
    Am J Respir Crit Care Med 177:219-26. 2008
    ..Objectives: In the present study, we examined whether intratracheal gene transfer of human extracellular superoxide dismutase (EC-SOD) could ameliorate monocrotaline (MCT)-induced PH in rats...
  30. ncbi request reprint Role of histamine produced by bone marrow-derived vascular cells in pathogenesis of atherosclerosis
    Yasuyuki Sasaguri
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental of Health, Kitakyushu, Japan
    Circ Res 96:974-81. 2005
    ..These results indicate that histamine produced from BM-derived progenitor cells, which could transdifferentiate into SMC- or macrophage-like cells, are important for the formation of neointima and atheromatous plaques...
  31. ncbi request reprint Hyperhomocysteinemia is associated with human coronary atherosclerosis through the reduction of the ratio of endothelium-bound to basal extracellular superoxide dismutase
    Shun ichi Nihei
    Second Department of Internal MedicineUniversity of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Circ J 68:822-8. 2004
    ....
  32. ncbi request reprint Long-term treatment with san'o-shashin-to, a kampo medicine, markedly ameliorates cardiac ischemia-reperfusion injury in ovariectomized rats via the redox-dependent mechanism
    Mayuko Sakanashi
    Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan
    Circ J 77:1827-37. 2013
    ..To explore alternative therapy, we examined whether san'o-shashin-to (TJ-113), a kampo medicine, ameliorates cardiac ischemia-reperfusion (IR) injury in a climacteric rat model...
  33. ncbi request reprint Long-term treatment with imidapril but not with nifedipine enhances plasma NOx concentration in patients with essential hypertension
    Osamu Suda
    Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Pharmacol Sci 101:159-65. 2006
    ..This effect does not seem to be due to the decrease in blood pressure. The increase in bradykinin concentration may be involved in the enhancing effect of the ACE inhibitor on NOx production in vivo...
  34. ncbi request reprint Monocyte chemoattractant protein-1 expression is enhanced by granulocyte-macrophage colony-stimulating factor via Jak2-Stat5 signaling and inhibited by atorvastatin in human monocytic U937 cells
    Akihide Tanimoto
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Biol Chem 283:4643-51. 2008
    ....
  35. doi request reprint Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells
    Noriaki Satoh
    Bio information Research Center, University of Occupational and Environmental Health, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    Naunyn Schmiedebergs Arch Pharmacol 385:921-31. 2012
    ..The present findings suggest that the ROCK inhibitor fasudil up-regulates NET function in a Ca(2+)-dependent and/or nocodazole-sensitive pathway in adrenal medullary cells...
  36. ncbi request reprint Angiotensin receptor blocker improves coronary flow velocity reserve in hypertensive patients: comparison with calcium channel blocker
    Fumihiko Kamezaki
    The Second Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Hypertens Res 30:699-706. 2007
    ..7 cm/s at 2 months, and to 48.1+/-20.2 cm/s at 6 months. We concluded that the ARB valsartan not only reduced high blood pressure but improved CFVR in hypertensive patients. However, these effects were not seen with the CCB nifedipine...
  37. doi request reprint Upregulation of norepinephrine transporter function by prolonged exposure to nicotine in cultured bovine adrenal medullary cells
    Hideaki Itoh
    Department of Rehabilitation Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Naunyn Schmiedebergs Arch Pharmacol 382:235-43. 2010
    ..The present findings suggest that long-term exposure to nicotine increases NET activity through a Ca(2+)-dependent post-transcriptional process in the adrenal medulla...
  38. ncbi request reprint Spontaneous development of left ventricular hypertrophy and diastolic dysfunction in mice lacking all nitric oxide synthases
    Kiyoko Shibata
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyusyu, Japan
    Circ J 74:2681-92. 2010
    ..The role of the nitric oxide synthase (NOS) system in cardiac architecture and function remains unknown. This point was addressed in mice that lack all 3 NOS genes...
  39. ncbi request reprint Effects of nitric oxide synthase isoform deletion on oxytocin and vasopressin messenger RNA in mouse hypothalamus
    Masayoshi Nomura
    Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Neuroreport 16:413-7. 2005
    ..These results suggest that neuronal nitric-oxide-synthase-derived nitric oxide may be involved in the regulation of oxytocin gene expression in the anterior commissural nucleus...
  40. ncbi request reprint Effect of prolonged exposure to milnacipran on norepinephrine transporter in cultured bovine adrenal medullary cells
    Koji Shinkai
    Department of Psychiatry, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem Pharmacol 70:1389-97. 2005
    ..The present findings suggest that prolonged exposure to milnacipran up-regulates the NET function, probably through a post-transcriptional process of NET or other proteins...
  41. ncbi request reprint Stimulation of catecholamine synthesis through unique estrogen receptors in the bovine adrenomedullary plasma membrane by 17beta-estradiol
    Nobuyuki Yanagihara
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem Biophys Res Commun 339:548-53. 2006
    ..These findings suggest that E(2) acutely stimulates catecholamine synthesis via activation of p44/42MAPK through unique estrogen receptors in the plasma membrane of bovine adrenal medulla...
  42. ncbi request reprint Upregulation of vascular extracellular superoxide dismutase in patients with acute coronary syndromes
    Masataka Horiuchi
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 24:106-11. 2004
    ..We examined the vascular expression levels of extracellular superoxide dismutase (EC-SOD), a major antioxidant enzyme in the cardiovascular system, in patients with acute coronary syndromes...
  43. ncbi request reprint Inhibition of the norepinephrine transporter function in cultured bovine adrenal medullary cells by bisphenol A
    Yumiko Toyohira
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishiku, Kitakyushu 807 8555, Japan
    Biochem Pharmacol 65:2049-54. 2003
    ..The present findings suggest that bisphenol A inhibits the function of the NE transporter by acting on a site different from that of 17beta-estradiol in the adrenal medulla and probably in the brain noradrenergic neurons...
  44. doi request reprint Stimulatory effects of the soy phytoestrogen genistein on noradrenaline transporter and serotonin transporter activity
    Yumiko Toyohira
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Yahatanishiku, Kitakyushu, Japan
    Mol Nutr Food Res 54:516-24. 2010
    ..These findings suggest that genistein up-regulates the activity of neuronal monoamine transporters probably through processes involving protein tyrosine phosphorylation...
  45. ncbi request reprint Stimulation of catecholamine synthesis by orexin-A in bovine adrenal medullary cells through orexin receptor 1
    Yasusada Kawada
    Department of Pediatrics, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Biochem Pharmacol 66:141-7. 2003
    ..These findings suggest that orexin-A activates tyrosine hydroxylase and then stimulates catecholamine synthesis, probably via activation of the OX(1)R-protein kinase C pathway in adrenal medullary cells...
  46. ncbi request reprint Complete disruption of all nitric oxide synthase genes causes markedly accelerated renal lesion formation following unilateral ureteral obstruction in mice in vivo
    Naoya Morisada
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    J Pharmacol Sci 114:379-89. 2010
    ....
  47. ncbi request reprint Pentazocine inhibits norepinephrine transporter function by reducing its surface expression in bovine adrenal medullary cells
    Go Obara
    Department of Anesthesiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Pharmacol Sci 121:138-47. 2013
    ..These findings suggest that PTZ inhibits the NET function by reducing the amount of NET in the cell surface membranes through an opioid and σ-receptor-independent pathway...
  48. ncbi request reprint Extracellular superoxide dismutase overexpression reduces cuff-induced arterial neointimal formation
    Kiyoshi Ozumi
    Second Department of Internal Medicine, University of Occupational and Environmental Health, Yahatanishiku, Kitakyushu, Japan
    Atherosclerosis 181:55-62. 2005
    ..These results suggest that ROS, especially superoxide anions at an adventitia, are responsible for neointimal formation in a cuff-injury model...
  49. ncbi request reprint Selective blockade of nicotinic acetylcholine receptors by pimobendan, a drug for the treatment of heart failure: reduction of catecholamine secretion and synthesis in adrenal medullary cells
    Yumiko Toyohira
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, 1 1, Iseigaoka, Yahatanishiku, Kitakyushu 807 8555, Japan
    Naunyn Schmiedebergs Arch Pharmacol 371:107-13. 2005
    ..8 and 4.3 microM). These findings suggest that pimobendan inhibits carbachol-induced catecholamines secretion and synthesis through suppression of nicotinic acetylcholine receptors...
  50. ncbi request reprint Heparin-released extracellular superoxide dismutase is reduced in patients with coronary artery atherosclerosis
    Hiromi Tasaki
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Atherosclerosis 187:131-8. 2006
    ..We studied whether the amount of heparin-released extracellular superoxide dismutase (EC-SOD), which is an antioxidative enzyme, is associated with coronary artery disease (CAD)...
  51. ncbi request reprint Nitric oxide synthases and heart failure - lessons from genetically manipulated mice
    Kiyoko Shibata
    Department of Second Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 35:147-58. 2013
    ..Our studies with triple n/i/eNOS(-/-) mice provide pivotal insights into an understanding of the pathophysiology of NOSs in human heart failure...
  52. ncbi request reprint Cross-over trial of intensive monotherapy with atorvastatin and combined therapy with atorvastatin and colestimide for Japanese familial hypercholesterolemia
    Hiromi Tasaki
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu 807 8555, Japan
    Circ J 70:14-20. 2006
    ..This study investigated the advantages of combined therapy with atorvastatin and colestimide vs intensive monotherapy with atorvastatin...
  53. ncbi request reprint Regulation of catecholamine synthesis by leptin
    Izumi Shibuya
    Departments of Pharmacology and Physiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu 807 8555, Japan
    Ann N Y Acad Sci 971:522-7. 2002
    ..These findings suggest that leptin phosphorylates and activates tyrosine hydroxylase and subsequently stimulates catecholamine synthesis through MAPK and probably Ca(2+) pathways in the adrenal medulla...
  54. doi request reprint Improvement of impaired endothelial function by tetrahydrobiopterin in stroke-prone spontaneously hypertensive rats
    Katsuhiko Noguchi
    Department of Pharmacology, School of Medicine, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Eur J Pharmacol 631:28-35. 2010
    ..These results demonstrate that the impaired endothelial function in SHRSP cannot be explained simply by the decrease in absolute amount of BH4...
  55. doi request reprint Pathophysiological relevance of NO signaling in the cardiovascular system: novel insight from mice lacking all NO synthases
    Masato Tsutsui
    Department of Pharmacology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Pharmacol Ther 128:499-508. 2010
    ..This review, based on the research outcomes obtained from the triply NOS(-/-) genetic model, summarizes the latest knowledge of the pathophysiological relevance of NO signaling in the cardiovascular system...
  56. ncbi request reprint [Expression and functions of inducible nitric oxide synthase]
    Masato Tsutsui
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine
    Nihon Rinsho 62:460-4. 2004
  57. ncbi request reprint Plasma level of homocysteine is inversely-associated with the development of collateral circulation in patients with single-vessel coronary artery disease
    Yoshitaka Nagai
    2nd Department of Internal Medicine, University of Occupational and Environmental Health School of Medicine, Kitakyushu, Japan
    Circ J 66:158-62. 2002
    ..Homocysteine might be a new undesirable aspect of ischemic heart disease through its inhibition of collateral development...
  58. ncbi request reprint New insights into the pharmacological potential of plant flavonoids in the catecholamine system
    Nobuyuki Yanagihara
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan
    J Pharmacol Sci 124:123-8. 2014
    ..The present review shows that plant flavonoids have various pharmacological potentials on the catecholamine system in adrenal medullary cells, and probably also in sympathetic neurons...
  59. ncbi request reprint Effects of selective estrogen receptor modulators on plasma membrane estrogen receptors and catecholamine synthesis and secretion in cultured bovine adrenal medullary cells
    Hirohide Inagaki
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, Japan
    J Pharmacol Sci 124:66-75. 2014
    ....
  60. doi request reprint Multicenter study verifying a method of noninvasive continuous cardiac output measurement using pulse wave transit time: a comparison with intermittent bolus thermodilution cardiac output
    Takashige Yamada
    Department of Anesthesiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
    Anesth Analg 115:82-7. 2012
    ..We evaluated the efficacy of noninvasive esCCO using pulse wave transit time in this multicenter study...
  61. pmc Matrix metalloproteinase 12 accelerates the initiation of atherosclerosis and stimulates the progression of fatty streaks to fibrous plaques in transgenic rabbits
    Sohsuke Yamada
    Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Pathol 172:1419-29. 2008
    ..Therefore, a specific MMP-12 inhibitor might prove useful for the treatment of progressive atherosclerosis...
  62. ncbi request reprint Direct inhibition of N-methyl-D-aspartate (NMDA)-receptor function by antiglaucomatous beta-antagonists
    Tatsuo Nagata
    Department of Ophthalmology, School of Medicine, University of Occupational and Environmental Health, Japan
    J Pharmacol Sci 106:423-34. 2008
    ..These results suggest that timolol and betaxolol may have an additional role that they directly inhibit NMDA-receptor function, possibly via N616 of the NR1a subunit...
  63. doi request reprint Inducible nitric oxide synthase downmodulates contact hypersensitivity by suppressing dendritic cell migration and survival
    Kazunari Sugita
    Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Invest Dermatol 130:464-71. 2010
    ..Finally, we showed that iNOS inhibitor enhanced LC survival in vitro. We concluded that NO suppresses migration and survival of cutaneous DCs, resulting in a downmodulation of CHS...
  64. ncbi request reprint Copper, zinc-superoxide dismutase enhances the mutagenicity in Salmonella typhimurium induced by 2-amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole
    Hiroaki Nii
    Department of Pharmacology, University of Occupational and Environmental Health, School of Medicine, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Mutat Res 653:14-22. 2008
    ..These findings suggest that the enhancing cytosol factor for the mutagenicity of Glu-P-1 is CuZn-SOD, which stimulates the mutagenicity of N-hydroxylated Glu-P-1 without changing its metabolism...
  65. ncbi request reprint Up-regulation of noradrenaline transporter in response to prolonged exposure to ketamine
    Koji Hara
    Department of Anaesthesiology, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, 807 8555, Japan
    Naunyn Schmiedebergs Arch Pharmacol 365:406-12. 2002
    ..This may imply that ketamine negatively modulates sympathetic nervous activity through an up-regulation of NAT during long anaesthesia...
  66. ncbi request reprint Association between plasma lipoprotein(a) and endothelial dysfunction in normocholesterolemic and non-diabetic patients with angiographically normal coronary arteries
    Tatsuya Ioka
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Circ J 66:267-71. 2002
    ..033). These findings suggest that elevated levels of plasma Lp(a) might be a strong predictor of endothelial dysfunction in normocholesterolemic and non-diabetic subjects...
  67. ncbi request reprint Granulocyte macrophage-colony stimulating factor increases the expression of histamine and histamine receptors in monocytes/macrophages in relation to arteriosclerosis
    Yoshitaka Murata
    Kyurin Omtest Laboratory, Kyurin Corporation, Yahatanishi ku, Kitakyushu, Japan
    Arterioscler Thromb Vasc Biol 25:430-5. 2005
    ..Furthermore, the molecular mechanisms of GM-CSF-induced HDC and HH1R expression in monocytic U937 cells were investigated...
  68. ncbi request reprint Vasospastic angina in a 16-year-old female
    Kengo Kobayashi
    Second Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Circ J 67:467-9. 2003
    ..This is the youngest healthy young female to be diagnosed with coronary vasospasm by provocation test. Because there are no risk factors, the vasospasm must be related to unknown hereditary factors...
  69. ncbi request reprint ApoE gene deficiency enhances the reduction of bone formation induced by a high-fat diet through the stimulation of p53-mediated apoptosis in osteoblastic cells
    Hideyuki Hirasawa
    Department of Orthopaedic Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Bone Miner Res 22:1020-30. 2007
    ..LDL or oxidized LDL increased apoptosis in the calvarial cells of apoE(-/-) mice. The increase in p53-mediated apoptosis is apparently related to a high-fat diet-induced osteopenia in apoE(-/-) mice...
  70. ncbi request reprint Sites of positive allosteric modulation by neurosteroids on ionotropic gamma-aminobutyric acid receptor subunits
    Susumu Ueno
    Department of Pharmacology, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishiku, Kitakyushu, Fukuoka 807 8555, Japan
    FEBS Lett 566:213-7. 2004
    ....
  71. ncbi request reprint Effects of phytoestrogens on catecholamine synthesis and secretion
    Nobuyuki Yanagihara
    Nihon Yakurigaku Zasshi 132:150-4. 2008
  72. pmc Crucial role of nitric oxide synthases system in endothelium-dependent hyperpolarization in mice
    Aya Takaki
    Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai 980 8575, Japan
    J Exp Med 205:2053-63. 2008
    ..These results provide the first evidence that EDHF-mediated responses are dependent on the NOSs system in mouse mesenteric arteries...
  73. ncbi request reprint Up-regulated neuronal nitric oxide synthase compensates coronary flow response to bradykinin in endothelial nitric oxide synthase-deficient mice
    M A Hassan Talukder
    Department of Cardiovascular Medicine, Kyushu University, Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    J Cardiovasc Pharmacol 44:437-45. 2004
    ..These results indicate that nNOS compensates coronary flow response to bradykinin in eNOS-/- mice, for which up-regulation of nNOS in VSMCs may be involved...
  74. ncbi request reprint Endothelial nitric oxide synthase-independent effects of an ACE inhibitor on coronary flow response to bradykinin in aged mice
    M A Hassan Talukder
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cardiovasc Pharmacol 44:557-63. 2004
    ..These results indicate that coronary flow response to bradykinin is preserved in aged mice even in the absence of eNOS, and an ACE inhibitor augments this response by both eNOS-dependent and -independent mechanisms...