Y Tsunemi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Multiple eruptive dermatofibromas with CD34+ cells in a patient with hypertriglyceridemia
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Dermatology 207:319-21. 2003
  2. ncbi request reprint The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Exp Dermatol 13:715-9. 2004
  3. ncbi request reprint Multiple dermatofibromas in a patient with systemic lupus erythematosus and Sjögren's syndrome
    Y Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    Clin Exp Dermatol 29:483-5. 2004
  4. ncbi request reprint Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    Acta Derm Venereol 84:187-90. 2004
  5. ncbi request reprint Square-shaped scleredema in the back: probably induced by mechanical stress
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Dermatol 44:769-70. 2005
  6. ncbi request reprint Lack of association between the promoter polymorphisms at positions -308 and -238 of the tumor necrosis factor alpha gene and psoriasis vulgaris in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Dermatology 207:371-4. 2003
  7. ncbi request reprint Dermal endothelial cells express eotaxin in hypereosinophilic syndrome
    Yuichiro Tsunemi
    Department of Dermatology, University of Tokyo, Hongo, Japan
    J Am Acad Dermatol 49:918-21. 2003
  8. ncbi request reprint CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Eur J Immunol 36:2116-27. 2006
  9. ncbi request reprint Post-transplantation chronic graft-versus-host disease with overlapping features similar to those of various collagen diseases
    Y Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Dermatol 42:292-4. 2003
  10. ncbi request reprint Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 30:100-7. 2002

Detail Information

Publications53

  1. ncbi request reprint Multiple eruptive dermatofibromas with CD34+ cells in a patient with hypertriglyceridemia
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Dermatology 207:319-21. 2003
    ..Our case and the review of previous reports suggest that hyperlipidemia, including hypertriglyceridemia, could induce MEDF and that highly cellular areas in DFs are sometimes positive for CD34...
  2. ncbi request reprint The -431C>T polymorphism of thymus and activation-regulated chemokine increases the promoter activity but is not associated with susceptibility to atopic dermatitis in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Exp Dermatol 13:715-9. 2004
    ..Thymus and activation-regulated chemokine (TARC) plays an important role in the pathogenesis of atopic dermatitis (AD). We recently detected the single nucleotide polymorphism (SNP) (-431C>T) in the 5'-flanking region of TARC gene...
  3. ncbi request reprint Multiple dermatofibromas in a patient with systemic lupus erythematosus and Sjögren's syndrome
    Y Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    Clin Exp Dermatol 29:483-5. 2004
    ..Therefore, if multiple DFs are present it is important that the status of the patient be evaluated from the standpoint of autoimmune diseases, particularly SLE, or immunosuppression...
  4. ncbi request reprint Lack of association of CCR4 single nucleotide polymorphism with atopic dermatitis in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    Acta Derm Venereol 84:187-90. 2004
    ..C1014T SNP of CCR4 does not appear to be associated with susceptibility to atopic dermatitis in Japanese patients...
  5. ncbi request reprint Square-shaped scleredema in the back: probably induced by mechanical stress
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Dermatol 44:769-70. 2005
  6. ncbi request reprint Lack of association between the promoter polymorphisms at positions -308 and -238 of the tumor necrosis factor alpha gene and psoriasis vulgaris in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Dermatology 207:371-4. 2003
    ....
  7. ncbi request reprint Dermal endothelial cells express eotaxin in hypereosinophilic syndrome
    Yuichiro Tsunemi
    Department of Dermatology, University of Tokyo, Hongo, Japan
    J Am Acad Dermatol 49:918-21. 2003
    ....
  8. ncbi request reprint CCL17 transgenic mice show an enhanced Th2-type response to both allergic and non-allergic stimuli
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Eur J Immunol 36:2116-27. 2006
    ..AD-like conditions such as increased number of mast cells and elevated levels of serum IgE were observed. Thus, CCL17 may participate in the pathogenesis of skin diseases such as AD by regulating both allergic and irritant inflammation...
  9. ncbi request reprint Post-transplantation chronic graft-versus-host disease with overlapping features similar to those of various collagen diseases
    Y Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Dermatol 42:292-4. 2003
  10. ncbi request reprint Interleukin-13 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 30:100-7. 2002
    ..This result suggests that 4257A allele is associated with susceptibility to AD and that it may function in the pathogenesis of AD itself, presumably by other mechanisms than inducing IgE production...
  11. ncbi request reprint Interleukin-12 p40 gene (IL12B) 3'-untranslated region polymorphism is associated with susceptibility to atopic dermatitis and psoriasis vulgaris
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 30:161-6. 2002
    ..9%, p = 0.031) and increased in PsV patients (60.1%, p = 0.035) compared with controls (50.5%). This suggests that IL12B SNP is associated with susceptibility to AD and PsV, presumably by affecting the Th1/Th2 balance...
  12. doi request reprint Extramammary Paget's disease with intracytoplasmic lumen formation
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol 36:649-53. 2009
    ..Signet ring cells and glandular formation support the traditional speculation that EMPD is derived from apocrine sweat gland and intracytoplasmic lumen formation may mimic the intrafollicular apocrine duct...
  13. pmc Interleukin-4 and interleukin-13 enhance CCL26 production in a human keratinocyte cell line, HaCaT cells
    S Kagami
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Exp Immunol 141:459-66. 2005
    ..These results suggest that keratinocytes are involved in the migration of CC chemokine receptor 3 positive cells such as eosinophils in a Th2-dominant situation like atopic dermatitis...
  14. ncbi request reprint Enhanced TARC production by dust-mite allergens and its modulation by immunosuppressive drugs in PBMCs from patients with atopic dermatitis
    Hirotoshi Furukawa
    Department of Dermatology, Fukushima Medical University, School of Medicine Hikarigaoka 1, Fukushima 960 1295, Japan
    J Dermatol Sci 35:35-42. 2004
    ..Thymus and activation regulated chemokine (TARC) is a CC chemokine that attracts CCR4+ T cells. We reported previously that TARC is an important chemokine that defines Th2 imbalance in the pathogenesis of atopic dermatitis (AD)...
  15. pmc Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis
    S Kagami
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Exp Immunol 134:309-13. 2003
    ....
  16. ncbi request reprint Eotaxin gene single nucleotide polymorphisms in the promoter and exon regions are not associated with susceptibility to atopic dermatitis, but two of them in the promoter region are associated with serum IgE levels in patients with atopic dermatitis
    Yuichiro Tsunemi
    Department of Dermatology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 29:222-8. 2002
    ..053) in -384A > G SNP in AD patients. Eotaxin gene SNPs in the promoter and exon regions are not associated with susceptibility to AD, but two of them in the promoter region are associated with phenotype of AD...
  17. ncbi request reprint Polymorphisms of vitamin D receptor gene in Japanese patients with psoriasis vulgaris
    Hidehisa Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 30:167-71. 2002
    ..05). We show that polymorphisms of VDR gene are associated with Japanese patients with PsV. Allelic variance in the VDR gene or other genes in linkage disequilibrium with this gene might predispose to the development of PsV...
  18. ncbi request reprint A keratin 9 Gene mutation (Asn160Ser) in a Japanese patient with epidermolytic palmoplantar keratoderma
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol 29:768-72. 2002
    ..This is the first case with an Asn160Ser mutation in a Japanese. The substitution of Ser for Asn at codon 160 of the keratin 9 gene is assumed to be fatal for keratin filament assembly regardless of race or ethnicity...
  19. ncbi request reprint Eccrine angiomatous hamartoma with massive mucin deposition
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Eur J Dermatol 15:291-2. 2005
    ..Our case and a similar reported one indicate that EAH includes a rare variant with a large amount of mucin as one of the hamartoma components...
  20. ncbi request reprint CCL28 production in HaCaT cells was mediated by different signal pathways from CCL27
    Shinji Kagami
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan
    Exp Dermatol 15:95-100. 2006
    ..Our study results suggest that CCL28 produced by keratinocytes is mediated by different signal pathways from CCL27 and that both CCL27 and CCL28 are involved in the pathogenesis of inflammatory skin diseases...
  21. doi request reprint Secondary cutaneous candidiasis with eosinophilia
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Dermatol 37:175-8. 2010
    ..This case and a similar reported case suggest that Candida can sometimes cause cutaneous inflammation predominantly composed of eosinophils...
  22. ncbi request reprint Macrophage-derived chemokine (MDC)/CCL22 produced by monocyte derived dendritic cells reflects the disease activity in patients with atopic dermatitis
    Shinichi Hashimoto
    Department of Dermatology, Fukushima Medical University, Hikarigaoka 1, Fukushima, Fukushima 960 1295, Japan
    J Dermatol Sci 44:93-9. 2006
    ..Dendritic cells (DCs) are antigen-presenting cells that are divided into two subgroups including monocyte derived DCs (MoDCs) and plasmacytoid DCs (pDCs)...
  23. doi request reprint CCL27-transgenic mice show enhanced contact hypersensitivity to Th2, but not Th1 stimuli
    Shinji Kagami
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Eur J Immunol 38:647-57. 2008
    ..These results indicated that CCL27 modified inflammation by attracting CCR10-positive and CCR4-positive cells into the lesional skin, and may participate in the pathogenesis of Th2-shifted skin diseases such as atopic dermatitis...
  24. ncbi request reprint Prevalence of atopic dermatitis in Japanese elementary schoolchildren
    H Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Br J Dermatol 152:110-4. 2005
    ....
  25. ncbi request reprint Ultraviolet A irradiation inhibits thymus and activation-regulated chemokine (TARC/CCL17) production by a human keratinocyte HaCaT cell line
    Xueyi Zheng
    Department of Dermatology, Fukushima Medical University School of Medicine, Hikarigaoka 1, Fukushima 960 1295, Japan
    Eur J Dermatol 13:348-53. 2003
    ..Our data provide the first evidence that UVA inhibits TARC mRNA expression and TARC protein production by keratinocytes in a dose-dependent manner. These results may suggest an explanation for the UV-induced therapeutic effect...
  26. doi request reprint CCR4 and CCR10 are expressed on epidermal keratinocytes and are involved in cutaneous immune reaction
    Seiki Fujimoto
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Cytokine 44:172-8. 2008
    ..Thus this study provided new insight into chemokine/chemokine receptors of KCs...
  27. ncbi request reprint Variations in the human Th2-specific chemokine TARC gene
    Takashi Sekiya
    Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Immunogenetics 54:742-5. 2003
    ..However, when the genotypes at the SNP site were determined for 158 healthy individuals, 105 patients with BA and 148 patients with AD, we observed no significant association of the SNP with susceptibility to BA or AD...
  28. ncbi request reprint Increased serum cutaneous T cell-attracting chemokine (CCL27) levels in patients with atopic dermatitis and psoriasis vulgaris
    Takashi Kakinuma
    Department of Dermatology, University of Tokyo, Tokyo, Japan
    J Allergy Clin Immunol 111:592-7. 2003
    ..It is selectively expressed in skin and attracts CC chemokine receptor 10-expressing skin-homing memory T cells. The epidermal keratinocyte is a main source of CTACK, suggesting the involvement of various inflammatory skin diseases...
  29. doi request reprint Hyperviscosity syndrome associated with systemic plasmacytosis
    S Noda
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Exp Dermatol 36:273-6. 2011
    ....
  30. ncbi request reprint A case of epidermolysis bullosa simplex with a newly found missense mutation and polymorphism in the highly conserved helix termination motif among type I keratins, which was previously reported as a pathogenic missense mutation
    N Hattori
    Department of Dermatology, Fraternity Memorial Hospital, Tokyo, Japan
    Br J Dermatol 155:1062-3. 2006
  31. ncbi request reprint Penicillium marneffei infection diagnosed by polymerase chain reaction from the skin specimen
    Yuichiro Tsunemi
    Department of Dermatology, International Medical Center of Japan, Tokyo, Japan
    J Am Acad Dermatol 49:344-6. 2003
    ..We identified P marneffei from the skin biopsy specimen by polymerase chain reaction using a set of primers specific for this pathogen...
  32. ncbi request reprint Gene mutation analysis in five cases of dermatofibrosarcoma protuberans using formalin-fixed, paraffin-embedded tissues
    Hidehisa Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    Acta Derm Venereol 85:221-4. 2005
    ....
  33. ncbi request reprint Community validation of the U.K. diagnostic criteria for atopic dermatitis in Japanese elementary schoolchildren
    Hidehisa Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 47:227-31. 2007
    ..K. working party. This list served well for both hospital patients with skin diseases and in general population within the U.K...
  34. ncbi request reprint Analysis of gene mutations in three cases of dermatofibrosarcoma protuberans (DFSP): ordinary DFSP, DFSP with fibrosarcomatous lesion (DFSP-FS) and lung metastasis of DFSP-FS
    Hidehisa Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol Sci 33:161-7. 2003
    ..Various exons of the COL1A1 gene have been shown to be involved in the fusion with exon 2 of the PDGFB gene...
  35. ncbi request reprint The lesional skin of linear IgA bullous dermatosis expresses growth-regulated peptide (GRO)-alpha
    Yuichiro Tsunemi
    Department of Dermatology, Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol 31:546-51. 2004
    ..This suggests that GRO-alpha plays a role in the infiltration of neutrophils into the lesional skin and in bulla formation in linear IgA bullous dermatosis...
  36. doi request reprint Prevalent LIPH founder mutations lead to loss of P2Y5 activation ability of PA-PLA1alpha in autosomal recessive hypotrichosis
    Satoru Shinkuma
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Hum Mutat 31:602-10. 2010
    ..These results suggest defective activation of P2Y5 due to reduced 2-acyl lysophosphatidic acid production by the mutant PA-PLA(1)alpha is involved in the pathogenesis of ARH...
  37. ncbi request reprint Novel mutation (Asp158Val) in H1 domain of keratin 5 gene in a Japanese patient with Köbner-type epidermolysis bullosa simplex
    Hidehisa Saeki
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 8655, Japan
    J Dermatol 33:692-5. 2006
    ..We identified a novel mutation (Asp158Val) in the H1 domain of the K5 gene in this Japanese patient with EBS-KB. This is the first gene mutation report of EBS-KB in the H1 domain of the K5 gene...
  38. ncbi request reprint Increased serum CCL28 levels in patients with atopic dermatitis, psoriasis vulgaris and bullous pemphigoid
    Shinji Kagami
    J Invest Dermatol 124:1088-90. 2005
  39. doi request reprint Serum thymic stromal lymphopoietin levels are not elevated in patients with atopic dermatitis
    Koichiro Nakamura
    J Dermatol 35:546-7. 2008
  40. ncbi request reprint Prevalence of atopic dermatitis determined by clinical examination in Japanese adults
    Hidehisa Saeki
    J Dermatol 33:817-9. 2006
  41. ncbi request reprint Cytotoxic T lymphocyte antigen-4 gene (CTLA4) polymorphisms in Japanese patients with psoriasis vulgaris
    Yuichiro Tsunemi
    J Dermatol Sci 32:163-5. 2003
  42. ncbi request reprint Lack of association of CCR3 single nucleotide polymorphism with atopic dermatitis in Japanese population
    Yuichiro Tsunemi
    J Dermatol Sci 33:130-3. 2003
  43. ncbi request reprint Mannose-binding lectin (MBL) single nucleotide polymorphism is not associated with atopic dermatitis in Japanese patients
    Shinichi Hashimoto
    J Dermatol 32:1038-40. 2005
  44. ncbi request reprint A case of lichen sclerosus et atrophicus with marked fibrosis in the dermis: analysis of fibrogenetic cytokines by reverse transcriptase-polymerase chain reaction
    Yuichiro Tsunemi
    J Dermatol 31:142-5. 2004
  45. ncbi request reprint Recurrent cutaneous eosinophilic vasculitis presenting as annular urticarial plaques
    Yuichiro Tsunemi
    Acta Derm Venereol 85:380-1. 2005
  46. ncbi request reprint Psoriasis guttata in association with hepatocellular carcinoma
    Yuichiro Tsunemi
    Acta Derm Venereol 83:70-1. 2003
  47. ncbi request reprint Diagnosis of epidermolytic palmoplantar keratoderma in a very early stage by gene analysis
    Kiyo Shimazu
    J Dermatol 32:859-61. 2005
  48. ncbi request reprint A novel keratin 9 gene mutation (Met156Arg) in a Japanese patient with epidermolytic palmoplantar keratoderma
    Kiyo Shimazu
    Int J Dermatol 45:1128-30. 2006
  49. ncbi request reprint Eosinophilic pustular folliculitis with a butterfly rash-like distribution
    Yuichiro Tsunemi
    Dermatology 208:229-30. 2004
  50. ncbi request reprint Necrobiotic xanthogranuloma with paraproteinemia successfully treated with melphalan, prednisolone and skin graft
    Hidehisa Saeki
    J Dermatol 34:795-7. 2007
  51. ncbi request reprint Psoriasis vulgaris associated with superior vena cava syndrome due to lung cancer metastasis
    Hidehisa Saeki
    J Dermatol 34:356-9. 2007
  52. ncbi request reprint Rosai-Dorfman disease presenting as large pigmented indurated plaques
    Yuichiro Tsunemi
    Acta Derm Venereol 83:57-8. 2003
  53. ncbi request reprint Nuchal fibroma clearly visualized by computed tomography: a case report
    Yuichiro Tsunemi
    Int J Dermatol 44:703-4. 2005