Research Topics
Genomes and Genes
| Naoyuki TsuchiyaSummaryAffiliation: University of Tokyo Country: Japan Publications
| Collaborators
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Detail Information
Publications
Fcgamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibilityChieko Kyogoku
University of Tokyo, Tokyo, Japan
Arthritis Rheum 46:1242-54. 2002....
TLR7 single-nucleotide polymorphisms in the 3' untranslated region and intron 2 independently contribute to systemic lupus erythematosus in Japanese women: a case-control association studyAya Kawasaki
Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
Arthritis Res Ther 13:R41. 2011..To test whether additional polymorphisms contribute to SLE in Japanese, we systematically analyzed the association of TLR7 with SLE in a Japanese female population...- New single nucleotide polymorphisms in the coding region of human TNFR2: association with systemic lupus erythematosusN Tsuchiya
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan 113 0033
Genes Immun 1:501-3. 2000..Two other cSNPs, nt543 (C-->T) (P181P) and nt694 (G-->A) (E232K), were not significantly associated with SLE. Thus, among the non-synonymous cSNPs, only nt587 (T-->G) (M196R) was found to be significantly associated with SLE in Japanese... - Genetic background of Japanese patients with antineutrophil cytoplasmic antibody-associated vasculitis: association of HLA-DRB1*0901 with microscopic polyangiitisNaoyuki Tsuchiya
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
J Rheumatol 30:1534-40. 2003..Little is known on the genetic background of AAV in Japanese patients mainly because of the difficulty in collecting a sufficient number of samples for the genetics study... - Association of HLA-DRB1*0901-DQB1*0303 haplotype with microscopic polyangiitis in JapaneseN Tsuchiya
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Hongo, Tokyo, Japan
Genes Immun 7:81-4. 2006.... - Association of a functional CD19 polymorphism with susceptibility to systemic sclerosisNaoyuki Tsuchiya
Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Arthritis Rheum 50:4002-7. 2004..In this study, we examined whether CD19 polymorphisms are associated with genetic susceptibility to SSc... - Role of Fc gamma receptor IIb polymorphism in the genetic background of systemic lupus erythematosus: insights from AsiaNaoyuki Tsuchiya
Graduate School of Medicine, The University of Tokyo, Department of Human Genetics, Tokyo 113 0033, Japan
Autoimmunity 38:347-52. 2005..These results indicate that FCGR2B is a susceptibility gene to SLE in the context of a genetic background, both in humans and mice... - Analysis of the association of HLA-DRB1, TNFalpha promoter and TNFR2 (TNFRSF1B) polymorphisms with SLE using transmission disequilibrium testN Tsuchiya
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Genes Immun 2:317-22. 2001..In addition, a possible disease-protective role for TNF haplotype coding for -1031C, -863A, -857C was suggested... 
Association of IRF5 polymorphisms with systemic lupus erythematosus in a Japanese population: support for a crucial role of intron 1 polymorphismsAya Kawasaki
University of Tsukuba, Tsukuba, Japan
Arthritis Rheum 58:826-34. 2008..To determine whether the IRF5 gene, which encodes interferon regulatory factor 5, is associated with systemic lupus erythematosus (SLE) in a Japanese population...- Role of STAT4 polymorphisms in systemic lupus erythematosus in a Japanese population: a case-control association study of the STAT1-STAT4 regionAya Kawasaki
Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba 305 8575, Japan
Arthritis Res Ther 10:R113. 2008..To accomplish these aims, we carried out a comprehensive association analysis of 52 tag single nucleotide polymorphisms (SNPs) encompassing the STAT1-STAT4 region... - Association of a functional polymorphism in the IRF5 region with systemic sclerosis in a Japanese populationIkue Ito
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
Arthritis Rheum 60:1845-50. 2009..We undertook the present study to determine whether IRF5 polymorphisms are also associated with a predisposition to SSc in Japanese... - Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese populationAya Kawasaki
Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
J Biomed Biotechnol 2010:207578. 2010..013). These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations... - Association of the FAM167A-BLK region with systemic sclerosisIkue Ito
University of Tsukuba, Tsukuba, Japan
Arthritis Rheum 62:890-5. 2010..We undertook the current study to examine whether the FAM167A-BLK region is also associated with susceptibility to systemic sclerosis (SSc)... - Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association studyAya Kawasaki
Molecular and Genetic Epidemiology Laboratory, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
Arthritis Res Ther 12:R174. 2010..In this study, we investigated whether the association of TNIP1 with SLE was replicated in a Japanese population. In addition, association of TNIP1 with RA was also examined... - Replication of the association between the C8orf13-BLK region and systemic lupus erythematosus in a Japanese populationIkue Ito
University of Tsukuba, Tsukuba, Japan
Arthritis Rheum 60:553-8. 2009..The purpose of this study was to evaluate the significance of this region in the genetic background of Japanese patients with SLE... - Association of IRF5, STAT4 and BLK with systemic lupus erythematosus and other rheumatic diseasesNaoyuki Tsuchiya
Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba
Nihon Rinsho Meneki Gakkai Kaishi 33:57-65. 2010..Thus, a substantial proportion of susceptibility genes are shared by multiple autoimmune rheumatic diseases... - Molecular genetic analyses of human NKG2C (KLRC2) gene deletionRisa Miyashita
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
Int Immunol 16:163-8. 2004..These results indicated that NKG2C deletion is commonly present in Japanese and Dutch, suggesting that NKG2C is not essential for survival and reproduction, and is not associated with rheumatic diseases... - FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signalingHajime Kono
Department of Allergy and Rheumatology, Faculty of Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Tokyo 113 8655, Japan
Hum Mol Genet 14:2881-92. 2005..Collectively, the present findings indicate that the Ile232Thr substitution affects the localization and function of FcgammaRIIB and that the molecular mechanism may link the polymorphism and susceptibility to SLE... - CD72 polymorphisms associated with alternative splicing modify susceptibility to human systemic lupus erythematosus through epistatic interaction with FCGR2BYuki Hitomi
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Japan
Hum Mol Genet 13:2907-17. 2004..These results indicated that the presence of CD72-*2 allele decreases risk for human SLE conferred by FCGR2B-232Thr, possibly by increasing the AS isoform of CD72... - Association of killer cell immunoglobulin-like receptor genotypes with microscopic polyangiitisRisa Miyashita
University of Tokyo, Hongo, Tokyo, Japan
Arthritis Rheum 54:992-7. 2006..In this study, we examined possible associations of the presence or absence of KIR loci with a genetic predisposition to MPA... - IFNGR1 polymorphisms in Thai malaria patientsIzumi Naka
Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
Infect Genet Evol 9:1406-9. 2009..These data also provide useful information for future genetic studies of IFNG polymorphisms in Thai patients... - Targeting Id1 and Id3 inhibits peritoneal metastasis of gastric cancerTakeshi Tsuchiya
Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, Bunkyo ku, Japan
Cancer Sci 96:784-90. 2005..Id should be considered an ideal target for the treatment and prevention of gastric cancer, and RNA interference is an attractive and promising strategy to achieve it... - Cumulative association of eight susceptibility genes with systemic lupus erythematosus in a Japanese female populationMinori Koga
Molecular and Genetic Epidemiology Laboratory, Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
J Hum Genet 56:503-7. 2011..30, CI 1.09-4.83, P=0.025). This study suggested that the cumulative number of risk alleles may efficiently distinguish groups with high and low genetic predisposition to SLE and its severe manifestation... - Role of B cell inhibitory receptor polymorphisms in systemic lupus erythematosus: a negative times a negative makes a positiveNaoyuki Tsuchiya
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo, 113 0033, Japan
J Hum Genet 51:741-50. 2006..These observations emphasize the need to understand human immune system diversity if we are to improve our understanding of the pathogenesis of autoimmune diseases... - Association of Fcgamma receptor IIA, but not IIB and IIIA, polymorphisms with systemic lupus erythematosus: A family-based association study in CaucasiansChieko Kyogoku
University of Tokyo, Tokyo, Japan
Arthritis Rheum 50:671-3. 2004 - Variations in immune response genes and their associations with multifactorial immune disordersNaoyuki Tsuchiya
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
Immunol Rev 190:169-81. 2002..At the same time, our observations may indicate that the 'classical' candidate gene approach will remain a strong alternative, even in the age of 'post genome-sequence'... - A replication study of the association between the IL12B promoter allele CTCTAA and susceptibility to cerebral malaria in Thai populationIzumi Naka
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
Malar J 8:290. 2009..An IL12B promoter allele, CTCTAA, at rs17860508 has been reported to be associated with susceptibility to cerebral malaria in African populations. However, this association has not so far been replicated in non-African populations... - Association of a functional polymorphism in the 3'-untranslated region of SPI1 with systemic lupus erythematosusKoki Hikami
University of Tsukuba, Tsukuba, Japan
Arthritis Rheum 63:755-63. 2011..In view of the significance of the type I interferon pathway in systemic lupus erythematosus (SLE), this study was undertaken to investigate a possible association between SPI1 polymorphisms and SLE... - Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malariaIzumi Naka
Doctoral Programme in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
Malar J 8:232. 2009.... - Association of IL-10 receptor 2 (IL10RB) SNP with systemic sclerosisKoki Hikami
Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
Biochem Biophys Res Commun 373:403-7. 2008..0019). Serum IL-10 level was significantly associated with the number of rs2834167A allele (P=0.007). These findings suggested that signaling through IL-10R2 may play a causative role in dcSSc... - Immunogenetic features in 120 Japanese patients with idiopathic inflammatory myopathyTakefumi Furuya
Institute of Rheumatology and Department of Neurology, Tokyo Women s Medical University, Tokyo, Japan
J Rheumatol 31:1768-74. 2004..To examine the role of HLA-DRB1 and tumor necrosis factor (TNF) promoter genotypes in the development and the autoantibody profiles of idiopathic inflammatory myopathy (IIM) in Japanese patients... - The human histocompatibility leukocyte antigen (HLA) haplotype is associated with the onset of postherpetic neuralgia after herpes zosterMasako Sato-Takeda
Department of Anesthesiology and Pain Relief Center, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
Pain 110:329-36. 2004..These results suggest that the HLA-A*3303-B*4403-DRB1*1302 haplotype plays an important role in the development of PHN after herpes zoster, but not in the onset of herpes zoster... - [Current studies on susceptibility genes in rheumatoid arthritis]Naoyuki Tsuchiya
Department of Human Genetics, Graduate School of Medicine, The University of Tokyo
Nippon Rinsho 63:111-6. 2005 - Comparative study of the haplotype structure and linkage disequilibrium of chromosome 1p36.2 region in the Korean and Japanese populationsTamao Akesaka
Department of Human Genetics, University of Tokyo, Tokyo, Japan
J Hum Genet 49:603-9. 2004..Significant difference in LD strength was present near the TNFR2 region between the Japanese and Korean populations... - Effects of down-regulating the Id genes in human colorectal cancer cells on early steps of haematogenous metastasisYurai Okaji
Department of Surgical Oncology, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
Eur J Cancer 42:668-73. 2006..The present results indicate important roles of Id genes in tumour cells during early steps of haematogenous metastasis and suggest dual effects from their therapeutic inhibition... - The impact of natural selection on an ABCC11 SNP determining earwax typeJun Ohashi
Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan
Mol Biol Evol 28:849-57. 2011..Our results provide a striking example of how local adaptation has played a significant role in the diversification of human traits... - Association of ADAMTS13 polymorphism with cerebral malariaSirima Kraisin
Doctoral Program in Biomedical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
Malar J 10:366. 2011.... - Diversity of human immune system multigene families and its implication in the genetic background of rheumatic diseasesNaoyuki Tsuchiya
Doctoral Program in Social and Environmental Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
Curr Med Chem 14:431-9. 2007..These results emphasize the role of multigene families in the diversity of human immune response and susceptibility to diseases... - A novel method for isolation of endothelial cells and macrophages from murine tumors based on Ac-LDL uptake and CD16 expressionYurai Okaji
Department of Surgical Oncology, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
J Immunol Methods 295:183-93. 2004..The present method is hoped to be useful for the evaluation of tumor angiogenesis and antitumor immunity... - The Q223R polymorphism in LEPR is associated with obesity in Pacific IslandersTakuro Furusawa
Asian Studies Network ASNET, Division for International Relations, The University of Tokyo, Tokyo, Japan
Hum Genet 127:287-94. 2010..The 223Q allele was widely found among the AN-speaking study subjects, thus suggesting that the LEPR Q223R polymorphism is one of the factors contributing to the high prevalence of obesity in the Pacific Island populations... - Crucial role of inhibitor of DNA binding/differentiation in the vascular endothelial growth factor-induced activation and angiogenic processes of human endothelial cellsDaisuke Sakurai
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
J Immunol 173:5801-9. 2004..Based on these findings, it was proposed that inhibition of expression and/or function of Id1 and Id3 may potentially be of therapeutic value for conditions associated with pathological angiogenesis... - Variations in the human Th2-specific chemokine TARC geneTakashi Sekiya
Department of Allergy and Rheumatology, University of Tokyo Graduate School of Medicine, Tokyo, Japan
Immunogenetics 54:742-5. 2003..However, when the genotypes at the SNP site were determined for 158 healthy individuals, 105 patients with BA and 148 patients with AD, we observed no significant association of the SNP with susceptibility to BA or AD... - Evaluation of microsatellite markers in association studies: a search for an immune-related susceptibility gene in sarcoidosisGoh Tanaka
Department of Respiratory Diseases, Research Institute, International Medical Center of Japan, Tokyo 162-8655, Japan
Immunogenetics 56:861-70. 2005.... - Extensive polymorphisms of LILRB1 (ILT2, LIR1) and their association with HLA-DRB1 shared epitope negative rheumatoid arthritisKimiko Kuroki
Division of Structural Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
Hum Mol Genet 14:2469-80. 2005..In addition, these observations suggested that the polymorphisms of LILR family members may be substantially involved in the diversity of human immune responses... - TNFR2 position 196 polymorphism in Japanese patients with rheumatoid arthritis: comment on the article by Dieudé et alChieko Kyogoku
Arthritis Rheum 48:273-4. 2003 - Association of CYP17 with HLA-B27-negative seronegative spondyloarthropathy in Japanese malesKanji Mori
Department of Orthopaedic Surgery, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga, Japan
Am J Med Genet A 130:169-71. 2004..Haplotype analysis did not demonstrate more significant association. The CYP17 SNP is associated with SNSA in HLA-B27-negative Japanese males... - BAFF/BLyS can potentiate B-cell selection with the B-cell coreceptor complexHidenori Hase
Division of Immunology, Institute for Medical Science, and Department of Pathology, Dokkyo University School of Medicine, Mibu, Tochigi 321 0293, Japan
Blood 103:2257-65. 2004.... - Role of the Fcgamma receptor IIA polymorphism in the antiphospholipid syndrome: an international meta-analysisFotini B Karassa
University of Ioannina School of Medicine, Ioannina, Greece
Arthritis Rheum 48:1930-8. 2003..To assess the impact of the FcgammaRIIA-R/H131 polymorphism on the risk for antiphospholipid syndrome (APS), both primary and secondary to systemic lupus erythematosus (SLE)...