Gouji Toyokawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cancer 10:65. 2011
  2. pmc Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo, Japan
    Neoplasia 13:887-98. 2011
  3. doi request reprint The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis
    Daechun Kang
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Genes Chromosomes Cancer 52:126-39. 2013
  4. doi request reprint The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Int J Cancer 131:E179-89. 2012
  5. pmc Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    Nat Commun 3:1072. 2012
  6. doi request reprint The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Prev Res (Phila) 4:2051-61. 2011
  7. pmc RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Neoplasia 14:476-86. 2012
  8. pmc Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1
    Hyun Soo Cho
    Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Neoplasia 13:676-84. 2011
  9. doi request reprint Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression
    Masashi Takawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, and National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Cancer Res 72:3217-27. 2012
  10. doi request reprint Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
    Masashi Takawa
    Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Cancer Sci 102:1298-305. 2011

Collaborators

Detail Information

Publications14

  1. pmc Minichromosome Maintenance Protein 7 is a potential therapeutic target in human cancer and a novel prognostic marker of non-small cell lung cancer
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cancer 10:65. 2011
    ..This can only be achieved if the drug used is against a specific target located in the tumor cells. In this study, we evaluated Minichromosome Maintenance Protein 7 (MCM7) as a novel therapeutic target in cancer...
  2. pmc Histone lysine methyltransferase Wolf-Hirschhorn syndrome candidate 1 is involved in human carcinogenesis through regulation of the Wnt pathway
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo, Japan
    Neoplasia 13:887-98. 2011
    ....
  3. doi request reprint The histone methyltransferase Wolf-Hirschhorn syndrome candidate 1-like 1 (WHSC1L1) is involved in human carcinogenesis
    Daechun Kang
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Genes Chromosomes Cancer 52:126-39. 2013
    ..As WHSC1L1 expression is significantly low in various normal tissues including vital organs, WHSC1L1 could be a good candidate molecule for development of novel treatment for various types of cancer...
  4. doi request reprint The JmjC domain-containing histone demethylase KDM3A is a positive regulator of the G1/S transition in cancer cells via transcriptional regulation of the HOXA1 gene
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, Japan
    Int J Cancer 131:E179-89. 2012
    ..Together, our results suggest that elevated expression of KDM3A plays a critical role in the growth of cancer cells, and further studies may reveal a cancer therapeutic potential in KDM3A inhibition...
  5. pmc Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo, Japan
    Nat Commun 3:1072. 2012
    ..We also find that methylated HSP70 has a growth-promoting effect in cancer cells. Our findings demonstrate a crucial role of HSP70 methylation in human carcinogenesis...
  6. doi request reprint The histone demethylase JMJD2B plays an essential role in human carcinogenesis through positive regulation of cyclin-dependent kinase 6
    Gouji Toyokawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Cancer Prev Res (Phila) 4:2051-61. 2011
    ..Deregulation of histone demethylation resulting in perturbation of the cell cycle, represents a novel mechanism for human carcinogenesis and JMJD2B is a feasible molecular target for anticancer therapy...
  7. pmc RB1 methylation by SMYD2 enhances cell cycle progression through an increase of RB1 phosphorylation
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Neoplasia 14:476-86. 2012
    ..Further study may explore SMYD2-dependent RB1 methylation as a potential therapeutic target in human cancer...
  8. pmc Enhanced expression of EHMT2 is involved in the proliferation of cancer cells through negative regulation of SIAH1
    Hyun Soo Cho
    Human Genome Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Neoplasia 13:676-84. 2011
    ....
  9. doi request reprint Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression
    Masashi Takawa
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, and National Cancer Center Hospital, Chuo Ku, Tokyo, Japan
    Cancer Res 72:3217-27. 2012
    ..Together, our findings reveal a function for lysine methylation on a nonhistone protein and suggest that aberrant lysine methylation of PCNA may play a role in human carcinogenesis...
  10. doi request reprint Validation of the histone methyltransferase EZH2 as a therapeutic target for various types of human cancer and as a prognostic marker
    Masashi Takawa
    Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Cancer Sci 102:1298-305. 2011
    ....
  11. doi request reprint Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G(1)/S transition
    Masaharu Kogure
    Laboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
    Cancer Lett 336:76-84. 2013
    ..As expression levels of JMJD2A are low in normal tissues, it may be feasible to develop specific inhibitors targeting the enzyme as anti-tumor agents which should have a minimal risk of adverse reaction...
  12. doi request reprint Dysregulation of PRMT1 and PRMT6, Type I arginine methyltransferases, is involved in various types of human cancers
    Masanori Yoshimatsu
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Int J Cancer 128:562-73. 2011
    ..In summary, our results suggest that dysregulation of PRMT1 and PRMT6 can be involved in human carcinogenesis and that these Type I arginine methyltransferases are good therapeutic targets for various types of cancer...
  13. doi request reprint Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells
    Hyun Soo Cho
    Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo, Japan
    Cancer Res 71:655-60. 2011
    ..Taken together, our results comprise a novel cell cycle regulatory mechanism mediated by methylation/demethylation dynamics, and they reveal the significance of LSD1 overexpression in human carcinogenesis...
  14. ncbi request reprint SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation
    Ryuji Hamamoto
    Section of Hematology Oncology, Department of Medicine, The University of Chicago, 5841 S Maryland Ave, MC2115 Chicago, IL 60637, United States Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan Electronic address
    Cancer Lett 351:126-33. 2014
    ..Our study reveals a novel mechanism for human carcinogenesis via methylation of HSP90AB1 by SMYD2, and additional functional studies may assist in developing novel strategies for cancer therapy. ..