Yukihide Tomari

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Perspective: machines for RNAi
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 19:517-29. 2005
  2. pmc Sorting of Drosophila small silencing RNAs
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 130:299-308. 2007
  3. ncbi request reprint Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    Christian Matranga
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell 123:607-20. 2005
  4. ncbi request reprint A protein sensor for siRNA asymmetry
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1377-80. 2004
  5. pmc Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein
    Klaus Forstemann
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 3:e236. 2005
  6. ncbi request reprint RISC assembly defects in the Drosophila RNAi mutant armitage
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 116:831-41. 2004
  7. ncbi request reprint The RNA-induced silencing complex is a Mg2+-dependent endonuclease
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Curr Biol 14:787-91. 2004
  8. ncbi request reprint MicroRNA biogenesis: drosha can't cut it without a partner
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 15:R61-4. 2005
  9. pmc Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1
    Klaus Forstemann
    Gene Center and Munich Center for Integrated Protein Science CiPS M, Ludwig Maximilians Universitat Munchen, Feodor Lynen Str 25, D 81377 Munich, Germany
    Cell 130:287-97. 2007
  10. ncbi request reprint piRNAs--the ancient hunters of genome invaders
    Julia Verena Hartig
    Gene Center of the Ludwig Maximilians University, D 81377 Munchen, Germany
    Genes Dev 21:1707-13. 2007

Detail Information

Publications10

  1. ncbi request reprint Perspective: machines for RNAi
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Genes Dev 19:517-29. 2005
    ..Here, we review our current understanding of how small RNAs are produced, how they are loaded into protein complexes, and how they repress gene expression...
  2. pmc Sorting of Drosophila small silencing RNAs
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 130:299-308. 2007
    ..Thus, in flies small-RNA duplexes are actively sorted into Argonaute-containing complexes according to their intrinsic structures...
  3. ncbi request reprint Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexes
    Christian Matranga
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cell 123:607-20. 2005
    ..For siRNAs, virtually all RISC is assembled through this cleavage-assisted mechanism. In contrast, passenger-strand cleavage is not important for the incorporation of miRNAs that derive from mismatched duplexes...
  4. ncbi request reprint A protein sensor for siRNA asymmetry
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Science 306:1377-80. 2004
    ..Thus, R2D2 is both a protein sensor for siRNA thermodynamic asymmetry and a licensing factor for entry of authentic siRNAs into the RNAi pathway...
  5. pmc Normal microRNA maturation and germ-line stem cell maintenance requires Loquacious, a double-stranded RNA-binding domain protein
    Klaus Forstemann
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Biol 3:e236. 2005
    ..Thus, every known Drosophila RNase-III endonuclease is paired with a dsRBD protein that facilitates its function in small RNA biogenesis...
  6. ncbi request reprint RISC assembly defects in the Drosophila RNAi mutant armitage
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell 116:831-41. 2004
    ..Our results suggest that armi is required for RISC maturation...
  7. ncbi request reprint The RNA-induced silencing complex is a Mg2+-dependent endonuclease
    Dianne S Schwarz
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA 01605 USA
    Curr Biol 14:787-91. 2004
    ..Thus, the RISC-component that mediates endonucleolytic cleavage of the target RNA remains to be identified...
  8. ncbi request reprint MicroRNA biogenesis: drosha can't cut it without a partner
    Yukihide Tomari
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Curr Biol 15:R61-4. 2005
    ....
  9. pmc Drosophila microRNAs are sorted into functionally distinct argonaute complexes after production by dicer-1
    Klaus Forstemann
    Gene Center and Munich Center for Integrated Protein Science CiPS M, Ludwig Maximilians Universitat Munchen, Feodor Lynen Str 25, D 81377 Munich, Germany
    Cell 130:287-97. 2007
    ..Thus, the two members of the Drosophila Ago subclade of Argonaute proteins are functionally specialized, but specific small RNA classes are not restricted to associate with Ago1 or Ago2...
  10. ncbi request reprint piRNAs--the ancient hunters of genome invaders
    Julia Verena Hartig
    Gene Center of the Ludwig Maximilians University, D 81377 Munchen, Germany
    Genes Dev 21:1707-13. 2007
    ..We summarize the recent literature on piRNA biogenesis and function with an emphasis on work in Drosophila, where genetics and biochemistry have met very successfully...