Chihiro Tohda

Summary

Affiliation: University of Toyama
Country: Japan

Publications

  1. pmc Kihi-to, a herbal traditional medicine, improves Abeta(25-35)-induced memory impairment and losses of neurites and synapses
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    BMC Complement Altern Med 8:49. 2008
  2. pmc Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice
    Chihiro Tohda
    Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Sci Rep 2:535. 2012
  3. doi request reprint Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Japan
    Int J Neurosci 121:641-8. 2011
  4. doi request reprint Current and future therapeutic strategies for functional repair of spinal cord injury
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 930 0194 Toyama, Japan
    Pharmacol Ther 132:57-71. 2011
  5. pmc Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Br J Pharmacol 157:1427-40. 2009
  6. ncbi request reprint [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Insitute of Natural Medicine, University of Toyama, Toyama City, Japan
    Yakugaku Zasshi 128:1159-67. 2008
  7. doi request reprint Hyperactivity, memory deficit and anxiety-related behaviors in mice lacking the p85alpha subunit of phosphoinositide-3 kinase
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 9300194, Japan
    Brain Dev 31:69-74. 2009
  8. pmc Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus
    C Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Br J Pharmacol 149:532-41. 2006
  9. ncbi request reprint Learning deficits and agenesis of synapses and myelinated axons in phosphoinositide-3 kinase-deficient mice
    Chihiro Tohda
    Divisions of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Neurosignals 15:293-306. 2006
  10. ncbi request reprint Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration
    Tomoharu Kuboyama
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    Eur J Neurosci 23:1417-26. 2006

Collaborators

Detail Information

Publications38

  1. pmc Kihi-to, a herbal traditional medicine, improves Abeta(25-35)-induced memory impairment and losses of neurites and synapses
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    BMC Complement Altern Med 8:49. 2008
    ..The effect of Kihi-to on memory deficit has not been examined. Thus, the goal of the present study is to determine the in vivo and in vitro effects of Kihi-to on memory, neurite growth and synapse reconstruction...
  2. pmc Diosgenin is an exogenous activator of 1,25D₃-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice
    Chihiro Tohda
    Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Sci Rep 2:535. 2012
    ..This is the first study to demonstrate that the exogenous stimulator diosgenin activates the 1,25D₃-MARRS pathway, which may be a very critical signaling target for anti-AD therapy...
  3. doi request reprint Kamikihi-to (KKT) rescues axonal and synaptic degeneration associated with memory impairment in a mouse model of Alzheimer's disease, 5XFAD
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Japan
    Int J Neurosci 121:641-8. 2011
    ..In conclusion, KKT improved object recognition memory deficit in an AD model 5XFAD mice. Restoration of degenerated axons and synapses may be associated with the memory recovery by KKT...
  4. doi request reprint Current and future therapeutic strategies for functional repair of spinal cord injury
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 930 0194 Toyama, Japan
    Pharmacol Ther 132:57-71. 2011
    ..corrected]...
  5. pmc Sominone enhances neurite outgrowth and spatial memory mediated by the neurotrophic factor receptor, RET
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Br J Pharmacol 157:1427-40. 2009
    ..We aimed to identify receptors or associated molecules of sominone, and to investigate the effects of sominone on memory in normal mice...
  6. ncbi request reprint [Overcoming several neurodegenerative diseases by traditional medicines: the development of therapeutic medicines and unraveling pathophysiological mechanisms]
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Insitute of Natural Medicine, University of Toyama, Toyama City, Japan
    Yakugaku Zasshi 128:1159-67. 2008
    ..To clarify key events in overcoming neurodegeneration, we are now studying the molecular targets and signal cascades of sominone...
  7. doi request reprint Hyperactivity, memory deficit and anxiety-related behaviors in mice lacking the p85alpha subunit of phosphoinositide-3 kinase
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 9300194, Japan
    Brain Dev 31:69-74. 2009
    ..Therefore, these behavioral phenotypes can be analyzed in a relationship with losses of synapses and myelinated axons in the brain, which resulted from deficiencies in PI3K activity...
  8. pmc Promotion of axonal maturation and prevention of memory loss in mice by extracts of Astragalus mongholicus
    C Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Br J Pharmacol 149:532-41. 2006
    ..This study aimed to explore effects of drugs that can facilitate the regeneration of neurites and the reconstruction of synapses even in severely damaged neurons...
  9. ncbi request reprint Learning deficits and agenesis of synapses and myelinated axons in phosphoinositide-3 kinase-deficient mice
    Chihiro Tohda
    Divisions of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Neurosignals 15:293-306. 2006
    ....
  10. ncbi request reprint Withanoside IV and its active metabolite, sominone, attenuate Abeta(25-35)-induced neurodegeneration
    Tomoharu Kuboyama
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    Eur J Neurosci 23:1417-26. 2006
    ..These data suggest that orally administrated withanoside IV may ameliorate neuronal dysfunction in Alzheimer's disease and that the active principle after metabolism is sominone...
  11. ncbi request reprint Abeta(25-35)-induced memory impairment, axonal atrophy, and synaptic loss are ameliorated by M1, A metabolite of protopanaxadiol-type saponins
    Chihiro Tohda
    1Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Neuropsychopharmacology 29:860-8. 2004
    ..M1 was shown to be effective in vitro and in vivo, indicating that Ginseng drugs containing ppd-type saponins may reactivate neuronal function in AD by p.o. administration...
  12. ncbi request reprint Axonal and dendritic extension by protopanaxadiol-type saponins from ginseng drugs in SK-N-SH cells
    Chihiro Tohda
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Jpn J Pharmacol 90:254-62. 2002
    ..Especially, longer neurites were mainly positive for phosphorylated NF-H. These results suggest that protopanaxadiol-type saponins enhance axonal and dendritic formation activity...
  13. doi request reprint Active components from Siberian ginseng (Eleutherococcus senticosus) for protection of amyloid β(25-35)-induced neuritic atrophy in cultured rat cortical neurons
    Yanjing Bai
    Division of Pharmacognosy, Institute of Natural Medicine, University of Toyama, Toyama, 930 0194, Japan
    J Nat Med 65:417-23. 2011
    ..Among them, eleutheroside B, eleutheroside E and isofraxidin showed obvious protective effects against Aβ(25-35)-induced atrophies of axons and dendrites at 1 and 10 μM...
  14. ncbi request reprint Metabolite 1 of protopanaxadiol-type saponins, an axonal regenerative factor, stimulates teneurin-2 linked by PI3-kinase cascade
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Sugitani, Toyama, Japan
    Neuropsychopharmacology 31:1158-64. 2006
    ..In addition, treatment with PI3-kinase inhibitor also reduced M1-induced axonal extension. These results suggest that M1 induces axonal outgrowth through the teneurin-2-PI3-kinase cascade...
  15. ncbi request reprint Repair of amyloid beta(25-35)-induced memory impairment and synaptic loss by a Kampo formula, Zokumei-to
    Chihiro Tohda
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Brain Res 990:141-7. 2003
    ..The present results suggest that memory impairment and synaptic loss in AD patients may be improved by treatment with ZMT, even after such impairment has already progressed...
  16. ncbi request reprint Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha
    Tomoharu Kuboyama
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Neuroreport 13:1715-20. 2002
    ..These results suggest that axons are predominantly extended by withanolide A, and dendrites by withanosides IV and VI...
  17. pmc A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte-secreted vimentin
    Kiyoshi Teshigawara
    Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Br J Pharmacol 168:903-19. 2013
    ..In this study, we investigated the effects of denosomin on functional recovery in SCI mice and elucidated the mechanism though which denosomin induces axonal growth in the injured spinal cord...
  18. ncbi request reprint Withanoside IV improves hindlimb function by facilitating axonal growth and increase in peripheral nervous system myelin level after spinal cord injury
    Natsuki Nakayama
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    Neurosci Res 58:176-82. 2007
    ..These results suggest that oral administration of withanoside IV may ameliorate locomotor functions by facilitating both axonal regrowth and increase in PNS myelin level...
  19. ncbi request reprint Search for natural products related to regeneration of the neuronal network
    Chihiro Tohda
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Neurosignals 14:34-45. 2005
    ..Trigonelline, a constituent of coffee beans, demonstrated the regeneration of dendrites and axons, in addition to memory improvement...
  20. ncbi request reprint Dammarane-type Saponins from Panax japonicus and their neurite outgrowth activity in SK-N-SH cells
    Kun Zou
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Japan
    J Nat Prod 65:1288-92. 2002
    ..Ginsenosides Rb(1) and Rb(3) and notoginsenosides R(4) (6) and Fa (7) showed significant neurite outgrowth enhancing activities in human neuroblastoma SK-N-SH cells...
  21. doi request reprint Sominone improves memory impairments and increases axonal density in Alzheimer's disease model mice, 5XFAD
    Eri Joyashiki
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    Int J Neurosci 121:181-90. 2011
    ..These results suggest that memory deficits in AD may be improved by sominone independently of reducing amyloid plaques and neuroinflammation...
  22. pmc Neuritic regeneration and synaptic reconstruction induced by withanolide A
    Tomoharu Kuboyama
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Br J Pharmacol 144:961-71. 2005
    ..WL-A is therefore an important candidate for the therapeutic treatment of neurodegenerative diseases, as it is able to reconstruct neuronal networks...
  23. ncbi request reprint Characterization of anti-neurodegenerative effects of Polygala tenuifolia in Abeta(25-35)-treated cortical neurons
    Rie Naito
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyoma, Japan
    Biol Pharm Bull 29:1892-6. 2006
    ..By characterization of PT effects on neuronal morphological plasticity and cell damage, usefulness as well as an insufficiency of PT as an anti-dementia drug was clarified...
  24. doi request reprint Icariin improves memory impairment in Alzheimer's disease model mice (5xFAD) and attenuates amyloid β-induced neurite atrophy
    Takuya Urano
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama 930 0194, Japan
    Phytother Res 24:1658-63. 2010
    ..improved spatial memory impairment in 5xFAD mice. These novel findings suggest that icariin may improve memory dysfunction in AD and have a potential to extend neurites even when amyloid β-induced neurite atrophy has already occurred...
  25. ncbi request reprint Inhibitory effects of Eleutherococcus senticosus extracts on amyloid beta(25-35)-induced neuritic atrophy and synaptic loss
    Chihiro Tohda
    Division of Biofunctional Evaluation, Research Center for Ethnomedicine, Institute of Natural Medicine, University of Toyama, Toyama, Japan
    J Pharmacol Sci 107:329-39. 2008
    ..In conclusion, extracts of E. senticosus protect against neuritic atrophy and cell death under Abeta treatment, and one of active constituents may be eleutheroside B...
  26. doi request reprint Synthesis of dihydrofuran-fused perhydrophenanthrenes having a phenolic hydroxyl group as a novel anti-Alzheimer's disease agent
    Kenji Sugimoto
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Bioorg Med Chem Lett 22:449-52. 2012
    ..We could reveal that a new methoxy derivative having a phenolic hydroxyl group exerted the most significant effects on the dendritic and axonal extensions in the damaged neurons, among DFs examined in this study...
  27. pmc Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration
    Tomoharu Kuboyama
    Laboratory for Neuronal Growth Mechanisms, RIKEN Brain Science Institute, Wako, Saitama 351 0198, Japan Division of Neuromedical Science, Institute of Natural Medicine, University of Toyama, Toyama, Toyama 930 0194, Japan
    Exp Neurol 248:157-69. 2013
    ..These results point to the importance of adhesion dynamics in restoring endball migration and suggest a potential therapeutic target for axon tract repair. ..
  28. doi request reprint Structure-activity-relationship studies on dihydrofuran-fused perhydrophenanthrenes as an anti-Alzheimer's disease agent
    Kenji Sugimoto
    Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Bioorg Med Chem 21:4459-71. 2013
    ..The necessity of the cyano group on 10b position was also proved in this structure-activity-relationship study. ..
  29. ncbi request reprint Comprehensive identifying method for localized mRNAs in single neuronal axons
    Chihiro Tohda
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Biochem Biophys Methods 57:57-63. 2003
    ..This method appears to be useful to identify mRNAs in axons inclusively, sequence-independently, and even at low expression levels...
  30. ncbi request reprint Gamma-aminobutyric acid specifically inhibits progression of tubular fibrosis and atrophy in nephrectomized rats
    Sumiyo Sasaki
    Institute of Natural Medicine, University of Toyama, Japan
    Biol Pharm Bull 30:687-91. 2007
    ..These results suggest that GABA may have a beneficial effect on renal function in nephrectomized rats by inhibiting fibrosis and atrophy primarily in tubuli, and that it ameliorates losses of renal function in renal failure...
  31. ncbi request reprint Protective effect of grape seed polyphenols against high glucose-induced oxidative stress
    Hajime Fujii
    Institute of Natural Medicine, University of Toyama
    Biosci Biotechnol Biochem 70:2104-11. 2006
    ....
  32. doi request reprint Synthesis of long-chain fatty acid derivatives as a novel anti-Alzheimer's agent
    Hong Yan Zhang
    Division of Natural Products Chemistry, Institute of Natural Medicine, University of Toyama, Sugitani 2630, Toyama 930 0194, Japan
    Bioorg Med Chem Lett 24:604-8. 2014
    ..Both fatty acids 10 and 16 possess two (Z)-double bonds at the n-3 and n-14 positions, which might be important for the neurite outgrowth activity. ..
  33. doi request reprint Synthesis of sominone and its derivatives based on an RCM strategy: discovery of a novel anti-Alzheimer's disease medicine candidate "denosomin"
    Yuji Matsuya
    Graduate School of Medicine and Pharmaceutical Sciences and Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Org Lett 11:3970-3. 2009
    ....
  34. pmc Diosgenin-induced cognitive enhancement in normal mice is mediated by 1,25D₃-MARRS
    Chihiro Tohda
    Division of Neuromedical Science, Department of Bioscience, Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Sci Rep 3:3395. 2013
    ..Our in vivo data indicate that diosgenin is a memory-enhancing drug and that enhancement by diosgenin is mediated by 1,25D₃-MARRS-triggered axonal growth...
  35. ncbi request reprint Influence of amla (Emblica officinalis Gaertn.) on hypercholesterolemia and lipid peroxidation in cholesterol-fed rats
    Hyun Ju Kim
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:413-8. 2005
    ..These results suggest that amla may be effective for hypercholesterolemia and prevention of atherosclerosis...
  36. ncbi request reprint Dammarane-type triterpene saponins from Panax japonicus
    Kun Zou
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    J Nat Prod 65:346-51. 2002
    ..Their structures were elucidated by chemical and spectroscopic means...
  37. ncbi request reprint Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities
    Jing Zhao
    Department of Metabolic Engineering, Toyama Medical and Pharmaceutical University, Sugitani, Japan
    Chem Pharm Bull (Tokyo) 50:760-5. 2002
    ....
  38. ncbi request reprint Effects of curcuma drugs on vasomotion in isolated rat aorta
    Yohei Sasaki
    Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
    Biol Pharm Bull 26:1135-43. 2003
    ..Therefore, all Curcuma drugs tested in the present study can be effective for vasodilation. Moreover, the drug derived from C. zedoaria has potential to cure Oketsu with its various acting points...