Tadatsugu Taniguchi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint IRF family of transcription factors as regulators of host defense
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Annu Rev Immunol 19:623-55. 2001
  2. ncbi request reprint IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
  3. ncbi request reprint IRF-1: the transcription factor linking the interferon response and oncogenesis
    T Taniguchi
    Department of Immunology, Faculty of Medicine, University of Tokyo Hongo, Japan
    Biochim Biophys Acta 1333:M9-17. 1997
  4. ncbi request reprint Regulation of the interferon system, immune response and oncogenesis by the transcription factor interferon regulatory factor-1
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
    Eur Cytokine Netw 9:43-8. 1998
  5. ncbi request reprint A weak signal for strong responses: interferon-alpha/beta revisited
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Rev Mol Cell Biol 2:378-86. 2001
  6. ncbi request reprint The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors
    Tadatsugu Taniguchi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, 113 0033, Tokyo, Japan
    Curr Opin Immunol 14:111-6. 2002
  7. pmc Signaling crosstalk between RANKL and interferons in osteoclast differentiation
    Hiroshi Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
    Arthritis Res 4:S227-32. 2002
  8. pmc Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression
    Hideyuki Yanai
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 104:3402-7. 2007
  9. ncbi request reprint Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:243-9. 2005
  10. ncbi request reprint Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:1035-40. 2005

Collaborators

Detail Information

Publications58

  1. ncbi request reprint IRF family of transcription factors as regulators of host defense
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Annu Rev Immunol 19:623-55. 2001
    ..Their functional roles, through interactions with their own or other members of the family of transcription factors, are becoming clearer in the regulation of host defense, such as innate and adaptive immune responses and oncogenesis...
  2. ncbi request reprint IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
    ..Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7...
  3. ncbi request reprint IRF-1: the transcription factor linking the interferon response and oncogenesis
    T Taniguchi
    Department of Immunology, Faculty of Medicine, University of Tokyo Hongo, Japan
    Biochim Biophys Acta 1333:M9-17. 1997
  4. ncbi request reprint Regulation of the interferon system, immune response and oncogenesis by the transcription factor interferon regulatory factor-1
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Japan
    Eur Cytokine Netw 9:43-8. 1998
    ..IRF-1 may be a prototypical example of a transcription factor which can selectively modulate distinct sets of genes depending on the cell type and/or nature of the cellular stimuli, so as to evoke appropriate response in each...
  5. ncbi request reprint A weak signal for strong responses: interferon-alpha/beta revisited
    T Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Rev Mol Cell Biol 2:378-86. 2001
    ..What is the purpose of the constitutive weak interferon-alpha/beta signal?..
  6. ncbi request reprint The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors
    Tadatsugu Taniguchi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, 113 0033, Tokyo, Japan
    Curr Opin Immunol 14:111-6. 2002
    ..This mechanism is mediated by transcription factors of the IFN regulatory factor family and, in fact, may have evolved to render the system more robust in antiviral responses...
  7. pmc Signaling crosstalk between RANKL and interferons in osteoclast differentiation
    Hiroshi Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
    Arthritis Res 4:S227-32. 2002
    ..Collectively, these studies revealed novel aspects of the two types of IFN, beyond their original roles in the immune response, and may offer a molecular basis for the treatment of bone diseases...
  8. pmc Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression
    Hideyuki Yanai
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 104:3402-7. 2007
    ..These results, together with the dual regulation of IRF5 gene expression by IFN signaling and p53, may provide a new link in the transcriptional network underlying antiviral immunity and tumor suppression...
  9. ncbi request reprint Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:243-9. 2005
    ..Thus, our study identifies IRF-5 as a new, principal downstream regulator of the TLR-MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses...
  10. ncbi request reprint Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:1035-40. 2005
    ..Thus, our study offers insights into the regulation of TLR9 signalling in space, potentially suggesting a new avenue for therapeutic intervention...
  11. pmc Negative regulation of Toll-like-receptor signaling by IRF-4
    Hideo Negishi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 102:15989-94. 2005
    ..This study may provide an insight into the complex regulatory mechanisms of MyD88 signaling by IRFs...
  12. pmc Essential contribution of IRF3 to intestinal homeostasis and microbiota-mediated Tslp gene induction
    Hideo Negishi
    Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Meguro ku, Tokyo 153 8505, Japan
    Proc Natl Acad Sci U S A 109:21016-21. 2012
    ..This newly identified intestinal gene regulatory mechanism, wherein IRF3 activated by microbiota-derived nucleic acids plays a critical role in intestinal homeostasis, may have clinical implication in colonic inflammatory disorders...
  13. pmc Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
    Zhichao Wang
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:5477-82. 2008
    ..These results in toto provide insights into the mechanism of DAI activation and reveal the complex regulatory mechanisms underlying DNA-mediated protective and pathologic immune responses...
  14. pmc A selective contribution of the RIG-I-like receptor pathway to type I interferon responses activated by cytosolic DNA
    Myoung Kwon Choi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 106:17870-5. 2009
    ..Our study may provide insights into the complexity of host defense mechanisms that thwart immune evasion by DNA-containing pathogens...
  15. ncbi request reprint Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling in terminal differentiation of osteoclasts
    Hiroshi Takayanagi
    Department of Immunology, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Japan
    Dev Cell 3:889-901. 2002
    ..Thus, NFATc1 may represent a master switch for regulating terminal differentiation of osteoclasts, functioning downstream of RANKL...
  16. ncbi request reprint Interplay between interferon and other cytokine systems in bone metabolism
    Hiroshi Takayanagi
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Immunol Rev 208:181-93. 2005
    ....
  17. pmc Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 101:15416-21. 2004
    ..Thus, we propose that this molecular complex may function as a cytoplasmic transductional-transcriptional processor...
  18. ncbi request reprint The antirheumatic drug leflunomide inhibits osteoclastogenesis by interfering with receptor activator of NF-kappa B ligand-stimulated induction of nuclear factor of activated T cells c1
    Makoto Urushibara
    Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 50:794-804. 2004
    ..This study was undertaken to determine whether leflunomide has a direct action on the osteoclast lineage and to gain insights into the molecular basis for the bone-protective effect of leflunomide...
  19. pmc Negative regulation of IFN-alpha/beta signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells
    Kenya Honda
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 101:2416-21. 2004
    ....
  20. ncbi request reprint The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and TH1 versus TH-17 differentiation of CD4+ T cells
    Shin ichi Kano
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Immunol 9:34-41. 2008
    ..Because both IL-12 and IL-23 bind to and transmit signals through IL-12Rbeta1, our data suggest that distinct thresholds of IL-12Rbeta1 expression are required for T(H)1 versus T(H)-17 differentiation...
  21. doi request reprint Cross-interference of RLR and TLR signaling pathways modulates antibacterial T cell responses
    Hideo Negishi
    Department of Molecular Immunology, Institute of Industrial Science, University of Tokyo, Tokyo, Japan
    Nat Immunol 13:659-66. 2012
    ..The innate immune receptor cross-interference we describe may have implications for infection-associated clinical episodes...
  22. ncbi request reprint DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 448:501-5. 2007
    ....
  23. pmc Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
    Kenya Honda
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 100:10872-7. 2003
    ..The immune system may have acquired the selective utilization of this cytokine system, which is essential for innate antiviral immunity, to effectively couple with the induction of adaptive immunity...
  24. doi request reprint HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses
    Hideyuki Yanai
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 462:99-103. 2009
    ..These findings may have implications for understanding the evolution of the innate immune system and for the treatment of immunological disorders...
  25. ncbi request reprint Stat1-mediated cytoplasmic attenuation in osteoimmunology
    Hiroshi Takayanagi
    Department of Cellular Physiological Chemistry, Graduate School, Tokyo Medical and Dental University, Yushima 1 5 45, Bunkyo ku, Tokyo 113 8549, Japan
    J Cell Biochem 94:232-40. 2005
    ....
  26. pmc Stat1 functions as a cytoplasmic attenuator of Runx2 in the transcriptional program of osteoblast differentiation
    Sunhwa Kim
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Genes Dev 17:1979-91. 2003
    ..Our study provides a unique example in which a latent transcription factor attenuates the activity of another transcription factor in the cytoplasm, and reveals a new regulatory mechanism in bone remodeling...
  27. pmc A cell-type-specific requirement for IFN regulatory factor 5 (IRF5) in Fas-induced apoptosis
    Arnaud Couzinet
    Departments of Immunology and Molecular Pathology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:2556-61. 2008
    ..Thus, these findings reveal a cell-type-specific function for IRF5 in the complex regulatory mechanism of death-receptor-induced apoptosis...
  28. doi request reprint IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension
    Kensuke Tsushima
    Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    FASEB J 25:1531-43. 2011
    ..Thus, our present study reveals a hitherto unrecognized function of IRF3 in cardiac remodeling, providing new insight into the progression of hypertension-induced cardiac pathogenesis...
  29. pmc Cell type-dependent proapoptotic role of Bcl2L12 revealed by a mutation concomitant with the disruption of the juxtaposed Irf3 gene
    Akira Nakajima
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 106:12448-52. 2009
    ..Thus, our present study revealed, on the one hand, a cell type-dependent proapoptotic function of Bcl2L12 and, on the other hand, confirmed the essential role of IRF3 in type I IFN response...
  30. ncbi request reprint Cooperation between MyD88 and TRIF pathways in TLR synergy via IRF5 activation
    Xinshou Ouyang
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Tokyo, Japan
    Biochem Biophys Res Commun 354:1045-51. 2007
    ..Thus, our findings offer a mechanistic insight into TLR synergy, revealing the hitherto unknown cross talk between the MyD88 and TRIF pathways for a robust TLR-mediated activation of the immune system...
  31. pmc Evidence for licensing of IFN-gamma-induced IFN regulatory factor 1 transcription factor by MyD88 in Toll-like receptor-dependent gene induction program
    Hideo Negishi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 103:15136-41. 2006
    ..Thus, our present study places IRF1 as an additional member participating in MyD88 signaling and provides a mechanistic insight into the enhancement of the TLR-dependent gene induction program by IFN-gamma...
  32. pmc A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity
    Hideo Negishi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:20446-51. 2008
    ..Taken together, our results indicate a critical cooperation of the RIG-I/MDA5-type I IFN and the TLR3-type II IFN signaling axes for efficient innate antiviral immune responses...
  33. doi request reprint Critical role for constitutive type I interferon signaling in the prevention of cellular transformation
    Hui Min Chen
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 100:449-56. 2009
    ....
  34. ncbi request reprint Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    Takako Koga
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 428:758-63. 2004
    ..These results reveal that RANKL and M-CSF are not sufficient to activate the signals required for osteoclastogenesis...
  35. doi request reprint Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling
    Tatsuaki Mizutani
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Exp Hematol 36:255-64. 2008
    ....
  36. ncbi request reprint Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence
    Akinori Takaoka
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 424:516-23. 2003
    ..Our study reveals a hitherto unrecognized link between p53 and IFN-alpha/beta in tumour suppression and antiviral immunity, which may have therapeutic implications...
  37. pmc Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus
    David A Savitsky
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0031, Japan
    Proc Natl Acad Sci U S A 107:10154-9. 2010
    ..By demonstrating a B-cell-intrinsic role, this study places IRF5 in a context that may have implications for understanding the pathogenesis of human SLE...
  38. doi request reprint Regulation of the cytosolic DNA-sensing system in innate immunity: a current view
    Hideyuki Yanai
    Department of Immunology, The University of Tokyo, Bunkyo ku, Japan
    Curr Opin Immunol 21:17-22. 2009
    ..Here, we summarize our current understanding of how cytosolic DNA receptors contribute to the regulation of innate immune responses and discuss the complexity of the cytosolic DNA-sensing system as well as its future prospects...
  39. ncbi request reprint Regulation of the type I IFN induction: a current view
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Int Immunol 17:1367-78. 2005
    ..The understanding of the regulatory mechanisms of IFN-alpha/beta gene induction by TLRs and viruses is an emerging theme, for which much new insight has been gained over the past few years...
  40. pmc Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways
    Tsukasa Shibue
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    EMBO J 25:4952-62. 2006
    ..These findings offer a new insight into differential cellular responses induced by p53, and may have therapeutic implications in cancer...
  41. ncbi request reprint Wild-type measles virus infection in human CD46/CD150-transgenic mice: CD11c-positive dendritic cells establish systemic viral infection
    Masashi Shingai
    Department of Immunology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan
    J Immunol 175:3252-61. 2005
    ..Although these results may not simply reflect human MV infection, the huCD150/huCD46 TG mice may serve as a useful model for the analysis of MV-dependent modulation of mDC response...
  42. ncbi request reprint New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Sci 94:405-11. 2003
    ....
  43. ncbi request reprint Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock
    Shinya Sakaguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 306:860-6. 2003
    ..Finally, the IRF-3-deficient mice show resistance to LPS-induced endotoxin shock. These results place IRF-3 as a molecule central to LPS/TLR4 signaling...
  44. ncbi request reprint Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Immunity 25:349-60. 2006
    ..Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system...
  45. doi request reprint The IRF family transcription factors in immunity and oncogenesis
    Tomohiko Tamura
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Annu Rev Immunol 26:535-84. 2008
    ..Moreover, the role of several IRF family members in the regulation of the cell cycle and apoptosis has important implications for understanding susceptibility to and progression of several cancers...
  46. pmc Suppression of immune responses by nonimmunogenic oligodeoxynucleotides with high affinity for high-mobility group box proteins (HMGBs)
    Hideyuki Yanai
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 108:11542-7. 2011
    ..We discuss our findings in relation to the critical role of HMGBs in initiating immune responses and the possible use of these ni-ODNs in therapeutic interventions...
  47. doi request reprint Regulation of immunity and oncogenesis by the IRF transcription factor family
    David Savitsky
    Department of Immunology, Faculty of Medicine, Graduate School of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Immunol Immunother 59:489-510. 2010
    ..In this review, we provide an update on the current knowledge of their roles in immune responses, immune cell development, and regulation of oncogenesis...
  48. ncbi request reprint RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta
    Hiroshi Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 416:744-9. 2002
    ..Our study places the IFN-beta system in a new context, and may offer a molecular basis for the treatment of bone diseases...
  49. pmc Integral role of Noxa in p53-mediated apoptotic response
    Tsukasa Shibue
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Dev 17:2233-8. 2003
    ....
  50. ncbi request reprint BH3-only proteins: integrated control point of apoptosis
    Tsukasa Shibue
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Int J Cancer 119:2036-43. 2006
    ..In particular, we focus on the overlapping and individual roles of 2 BH3-only proteins, Puma and Noxa, in the context of the apoptotic response induced by the tumor suppressor p53...
  51. doi request reprint Therapeutic potential of proapoptotic molecule Noxa in the selective elimination of tumor cells
    Saori Suzuki
    Department of Immunology, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Cancer Sci 100:759-69. 2009
    ..Thus, our results suggest a mechanism wherein Noxa, but not Puma, selectively induces apoptosis in human tumor cells. These data provide a new prospect for cancer therapy by the Noxa-mediated selective elimination of malignant cells...
  52. doi request reprint Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth
    Atsushi Matsuda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 411:7-13. 2011
    ..Thus, these mutant mice and cells may provide new tools with which to study the mechanisms underlying the regulation of cell cycle and oncogenesis...
  53. doi request reprint Interferon regulatory factor family of transcription factors and regulation of oncogenesis
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Sci 99:467-78. 2008
    ..In the present review article, we aim at summarizing our current knowledge of the roles of IRF in host defense, with special emphasis on their involvement in the regulation of oncogenesis...
  54. doi request reprint Induction of colonic regulatory T cells by indigenous Clostridium species
    Koji Atarashi
    Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Science 331:337-41. 2011
    ....
  55. ncbi request reprint IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nat Rev Immunol 6:644-58. 2006
    ....
  56. ncbi request reprint 25 years after the dawn of cytokine molecular biology: roles of IRF transcription factors in toll-like receptor-mediated gene-expression program
    Tadatsugu Taniguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Harvey Lect 101:75-87. 2005
  57. ncbi request reprint Detection of an up-regulation of a group of chemokine genes in murine cardiac allograft in the absence of interferon-gamma by means of DNA microarray
    Akio Saiura
    Department of Hepato Biliary Pancreatic and Transplantation Surgery, The University of Tokyo, Tokyo, Japan
    Transplantation 73:1480-6. 2002
    ..To bring the alternative pathway during allograft rejection into more precise focus, we investigated the gene expression profile in murine cardiac allografts in IFN-gamma-/- mice by means of DNA microarray...
  58. ncbi request reprint Toll-like receptor signaling and IRF transcription factors
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Japan
    IUBMB Life 58:290-5. 2006
    ....