Yoshiya Tanaka

Summary

Affiliation: University of Occupational and Environmental Health
Country: Japan

Publications

  1. doi request reprint Intensive treatment and treatment holiday of TNF-inhibitors in rheumatoid arthritis
    Yoshiya Tanaka
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Curr Opin Rheumatol 24:319-26. 2012
  2. pmc Low levels of 1,5-anhydro-D-glucitol are associated with vascular endothelial dysfunction in type 2 diabetes
    Keiichi Torimoto
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushyu shi 807 8555, Japan
    Cardiovasc Diabetol 13:99. 2014
  3. pmc C5a promotes migration, proliferation, and vessel formation in endothelial cells
    Ryuji Kurihara
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Inflamm Res 59:659-66. 2010
  4. pmc IL-17 inhibits chondrogenic differentiation of human mesenchymal stem cells
    Masahiro Kondo
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka, Japan Pharmacology Research Laboratories I, Research Division, Mitsubishi Tanabe Pharma Corporation, Aoba ku, Yokohama, Kanagawa, Japan
    PLoS ONE 8:e79463. 2013
  5. ncbi request reprint Effects of tofacitinib on lymphocytes in rheumatoid arthritis: relation to efficacy and infectious adverse events
    Koshiro Sonomoto
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
    Rheumatology (Oxford) 53:914-8. 2014
  6. ncbi request reprint Is it possible to withdraw biologics from therapy in rheumatoid arthritis?
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan Electronic address
    Clin Ther 35:2028-35. 2013
  7. ncbi request reprint Discontinuation of biologics in patients with rheumatoid arthritis
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupation and Environmental Health, Japan
    Clin Exp Rheumatol 31:S22-7. 2013
  8. pmc Efficacy of combination of Ezetimibe 10 mg and rosuvastatin 2.5 mg versus rosuvastatin 5 mg monotherapy for hypercholesterolemia in patients with type 2 diabetes
    Keiichi Torimoto
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushyu shi 807 8555, Japan
    Lipids Health Dis 12:137. 2013
  9. ncbi request reprint Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study
    Yoshiya Tanaka
    The First Department of Internal Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    Mod Rheumatol 23:1045-52. 2013
  10. doi request reprint JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Mod Rheumatol 23:415-24. 2013

Collaborators

Detail Information

Publications159 found, 100 shown here

  1. doi request reprint Intensive treatment and treatment holiday of TNF-inhibitors in rheumatoid arthritis
    Yoshiya Tanaka
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Curr Opin Rheumatol 24:319-26. 2012
    ..We here document whether 'treatment holiday' of TNF inhibitors is possible in RA patients, after maintaining low disease activity by intensive treatment with TNF inhibitors...
  2. pmc Low levels of 1,5-anhydro-D-glucitol are associated with vascular endothelial dysfunction in type 2 diabetes
    Keiichi Torimoto
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushyu shi 807 8555, Japan
    Cardiovasc Diabetol 13:99. 2014
    ..Here, we investigated the relationship between vascular endothelial dysfunction and blood levels of 1,5-anhydro-D-glucitol (1,5-AG), a marker of both postprandial hyperglycemia and fluctuations in blood glucose...
  3. pmc C5a promotes migration, proliferation, and vessel formation in endothelial cells
    Ryuji Kurihara
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan
    Inflamm Res 59:659-66. 2010
    ..The goal of this paper is to investigate the effects of activated complement C5a on vascular endothelium during vessel formation...
  4. pmc IL-17 inhibits chondrogenic differentiation of human mesenchymal stem cells
    Masahiro Kondo
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Fukuoka, Japan Pharmacology Research Laboratories I, Research Division, Mitsubishi Tanabe Pharma Corporation, Aoba ku, Yokohama, Kanagawa, Japan
    PLoS ONE 8:e79463. 2013
    ..Here we investigated the effects of IL-17, a key cytokine in chronic inflammation, on chondrogenic differentiation of human MSCs...
  5. ncbi request reprint Effects of tofacitinib on lymphocytes in rheumatoid arthritis: relation to efficacy and infectious adverse events
    Koshiro Sonomoto
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
    Rheumatology (Oxford) 53:914-8. 2014
    ..To assess the effects of tofacitinib on T lymphocytes in RA patients with a special focus on efficacy and infectious adverse events (iAEs)...
  6. ncbi request reprint Is it possible to withdraw biologics from therapy in rheumatoid arthritis?
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan Electronic address
    Clin Ther 35:2028-35. 2013
    ..Clinical remission is perceived as a realistic primary goal, and its maintenance leads to structural and functional remission...
  7. ncbi request reprint Discontinuation of biologics in patients with rheumatoid arthritis
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupation and Environmental Health, Japan
    Clin Exp Rheumatol 31:S22-7. 2013
    ..The combination of early treatment with TNF inhibitors and MTX plus tight control of inflammation provide the best chance of a biologic-free remission or at least the possibility of 'biologic treatment holidays'. ..
  8. pmc Efficacy of combination of Ezetimibe 10 mg and rosuvastatin 2.5 mg versus rosuvastatin 5 mg monotherapy for hypercholesterolemia in patients with type 2 diabetes
    Keiichi Torimoto
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushyu shi 807 8555, Japan
    Lipids Health Dis 12:137. 2013
    ..Therefore, this study was performed to examine the effects of these two regimens on LDL-C and lipoproteins...
  9. ncbi request reprint Prevention of joint destruction by tacrolimus in patients with early rheumatoid arthritis: a post hoc analysis of a double-blind, randomized, placebo-controlled study
    Yoshiya Tanaka
    The First Department of Internal Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu, 807 8555, Japan
    Mod Rheumatol 23:1045-52. 2013
    ....
  10. doi request reprint JAK inhibitor tofacitinib for treating rheumatoid arthritis: from basic to clinical
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Mod Rheumatol 23:415-24. 2013
    ..Taken together, an orally available kinase inhibitor tofacitinib targeting JAK-mediated signals would be expected to be a new option for RA treatment...
  11. doi request reprint Next stage of RA treatment: is TNF inhibitor-free remission a possible treatment goal?
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, 1 1 Iseigaoka, Kitakyushu 807 8555, Japan
    Ann Rheum Dis 72:ii124-7. 2013
    ....
  12. pmc Relationship between fluctuations in glucose levels measured by continuous glucose monitoring and vascular endothelial dysfunction in type 2 diabetes mellitus
    Keiichi Torimoto
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushyu shi, 807 8555, Japan
    Cardiovasc Diabetol 12:1. 2013
    ..We hypothesized that fluctuation in blood glucose levels correlate with vascular endothelial dysfunction and that this relationship can be assessed using common bedside medical devices...
  13. pmc Steroid psychosis in a polyarteritis nodosa patient successfully treated with risperidone: tracking serum brain-derived neurotrophic factor levels longitudinally
    Reiji Yoshimura
    Department of Psychiatry, University of Occupational and Environmental Health, Iseigaoka, Yahatanishi ku, Kitakyushu, Fukuoka 8078555, Japan
    Ann Gen Psychiatry 11:2. 2012
    ..We found that corticosteroid lowered serum BDNF levels, and improvement of psychiatric symptoms was intact with the serum BDNF levels seen in the patients...
  14. pmc Golimumab in combination with methotrexate in Japanese patients with active rheumatoid arthritis: results of the GO-FORTH study
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu City, Japan
    Ann Rheum Dis 71:817-24. 2012
    ..To assess the efficacy and safety of golimumab + methotrexate (MTX) in Japanese patients with active rheumatoid arthritis (RA)...
  15. doi request reprint Structural damages disturb functional improvement in patients with rheumatoid arthritis treated with etanercept
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu 807 8555, Japan
    Mod Rheumatol 22:186-94. 2012
    ..In conclusion, higher HAQ and mTSS at baseline inhibits HAQ-DI improvement within 1 year of etanercept treatment, and the cutoff point necessary for mTSS to improve physical functions in patients with RA was 55.5...
  16. doi request reprint In vitro and in vivo analysis of a JAK inhibitor in rheumatoid arthritis
    Y Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Kitakyushu, 807 8555, Japan
    Ann Rheum Dis 71:i70-4. 2012
    ..Thus, an orally available tofacitinib in combination with MTX was efficacious and had a manageable safety profile. Tofacitinib at 5 and 10 mg twice a day appears suitable for further evaluation to optimise the treatment of RA...
  17. pmc Suppressive effect of azithromycin on Plasmodium berghei mosquito stage development and apicoplast replication
    Shoichi Shimizu
    Department of Immunology and Parasitology, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushu, Japan
    Malar J 9:73. 2010
    ..This study evaluated the transmission-blocking effect of AZM using a rodent malaria model...
  18. pmc Clinical significance in the number of involved lymph nodes in patients that underwent surgery for pathological stage III-N2 non-small cell lung cancer
    Takeshi Hanagiri
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807, Japan
    J Cardiothorac Surg 6:144. 2011
    ..This study investigated whether the number of involved lymph nodes is associated with the prognosis in patients that underwent surgery for pathological stage (p-stage) III/N2 NSCLC...
  19. pmc Small GTP-binding protein Rho-mediated signaling promotes proliferation of rheumatoid synovial fibroblasts
    Shingo Nakayamada
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan
    Arthritis Res Ther 7:R476-84. 2005
    ..A rational design of future therapeutic strategies for RA synovitis could perhaps include the exploitation of the Rho pathway to directly reduce the growth of synovial cells...
  20. pmc Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis
    Wolfgang Hueber
    Department of Medicine, Division of Immunology and Rheumatology, Stanford University, Stanford, CA 94305, USA
    Arthritis Res Ther 11:R76. 2009
    ..Since no clinical or laboratory tests are available to predict response to anti-TNF therapies, great need exists for predictive biomarkers...
  21. ncbi request reprint T cell integrin activation by chemokines in inflammation
    Y Tanaka
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Arch Immunol Ther Exp (Warsz) 48:443-50. 2000
    ..The present review documents the relevance of cytoplasmic signaling and cytoskeletal assembly to integrin-mediated adhesion induced by chemokines during inflammatory processes...
  22. ncbi request reprint Osteoblasts and osteoclasts in bone remodeling and inflammation
    Yoshiya Tanaka
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu 807 8555, Japan
    Curr Drug Targets Inflamm Allergy 4:325-8. 2005
    ..Based on an improved understanding of immune signals, investigation of the suppression of cell functions may lead to improved understanding and better treatment of diseases of bone metabolism and osteoporosis...
  23. ncbi request reprint A multicenter phase I/II trial of rituximab for refractory systemic lupus erythematosus
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu 807 8555, Japan
    Mod Rheumatol 17:191-7. 2007
    ..Rituximab therapy appears to be safe for the treatment of active SLE patients and holds significant therapeutic promise, at least for the majority of patients experiencing profound B-cell depletion...
  24. ncbi request reprint Treatment of inflammatory immunologic disease 4. B cell targeting therapy using the anti-CD20 antibody rituximab in inflammatory autoimmune diseases
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Intern Med 46:1313-5. 2007
  25. pmc Retrospective clinical study on the notable efficacy and related factors of infliximab therapy in a rheumatoid arthritis management group in Japan: one-year clinical outcomes (RECONFIRM-2)
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Mod Rheumatol 18:146-52. 2008
    ..2%, respectively. In conclusion, we reconfirmed the clinical efficacy of infliximab and demographic factors related to the efficacy over a 54-week study period in 410 Japanese patients with RA using DAS28-CRP and EULAR response criteria...
  26. ncbi request reprint [B cell targeting therapy using the anti-CD20 antibody in autoimmune diseases]
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Yakugaku Zasshi 129:675-9. 2009
    ..Therefore, targeting B-cells may have potential interests by bringing about a breakthrough in the treatment of RA, SLE and other autoimmune diseases...
  27. pmc Discontinuation of infliximab after attaining low disease activity in patients with rheumatoid arthritis: RRR (remission induction by Remicade in RA) study
    Y Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Kitakyushu 807 8555 Japan
    Ann Rheum Dis 69:1286-91. 2010
    ..Discontinuation of TNF inhibitors after acquisition of low disease activity (LDA) is important for safety and economic reasons...
  28. doi request reprint Phenotypic changes of lymphocytes in patients with systemic lupus erythematosus who are in longterm remission after B cell depletion therapy with rituximab
    Shigeru Iwata
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Yahata Nishi, Kitakyushu 807 8555, Japan
    J Rheumatol 38:633-41. 2011
    ..We investigated longitudinally the differentiation and phenotypic changes of peripheral B cells and T cells in patients with SLE after rituximab treatment...
  29. doi request reprint Phase II study of tofacitinib (CP-690,550) combined with methotrexate in patients with rheumatoid arthritis and an inadequate response to methotrexate
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, Iseigaoka, Yahatanishi, Kitakyushu, Japan
    Arthritis Care Res (Hoboken) 63:1150-8. 2011
    ....
  30. ncbi request reprint Severe hypercalcemia and hypernatremia associated with calcipotriol for treatment of psoriasis
    Chie Kawahara
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, 1 1 Iseigaoka, Yahatanishi ku, 807 8555, Kitakyushu, Japan
    J Bone Miner Metab 22:159-62. 2004
  31. ncbi request reprint [Migration of cells in allergic inflammation]
    Yoshiya Tanaka
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
    Arerugi 52:477-80. 2003
  32. ncbi request reprint H-Ras signals to cytoskeletal machinery in induction of integrin-mediated adhesion of T cells
    Y Tanaka
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, Japan
    J Immunol 163:6209-16. 1999
    ....
  33. ncbi request reprint Distinct phenotype of leukemic T cells with various tissue tropisms
    Y Tanaka
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Yahatanishi ku, Kitakyushu
    J Immunol 158:3822-9. 1997
    ....
  34. ncbi request reprint Constitutive up-regulation of integrin-mediated adhesion of tumor-infiltrating lymphocytes to osteoblasts and bone marrow-derived stromal cells
    Y Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu
    Cancer Res 58:4138-45. 1998
    ..Our data also indicated that interactions between TILs and osteoblasts/stromal cells lead to the secretion by the latter of the osteoclastogenic cytokine interleukin 6...
  35. ncbi request reprint H-Ras/mitogen-activated protein kinase pathway inhibits integrin-mediated adhesion and induces apoptosis in osteoblasts
    Yoshiya Tanaka
    First Department of Internal Medicine, University of Occupational and Environmental Health School of Medicine, Kitakyushu 807 8555, Japan
    J Biol Chem 277:21446-52. 2002
    ....
  36. ncbi request reprint Activation of leukocyte function-associated antigen-1 on adult T-cell leukemia cells
    Y Tanaka
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu
    Leuk Lymphoma 36:15-23. 1999
    ..These events result in a strong adhesion of ATL cells to the endothelium and spontaneous transendothelial migration...
  37. doi request reprint Intracellular galectin-9 activates inflammatory cytokines in monocytes
    Ai Matsuura
    First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Genes Cells 14:511-21. 2009
    ..Our results indicate that galectin-9 is a LPS-responsive factor, and further demonstrate that intracellular galectin-9 transactivates inflammatory cytokine genes in monocytes through direct physical interaction with NF-IL6...
  38. ncbi request reprint Small GTPase Rho signaling is involved in beta1 integrin-mediated up-regulation of intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation
    Fumihiko Hirai
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu 807 8555, Japan
    Biochem Biophys Res Commun 356:279-85. 2007
    ..Thus, Rho-mediated signaling in osteoblasts seems to introduce major biases to bone resorption...
  39. pmc Clinical, radiographic and functional effectiveness of tocilizumab for rheumatoid arthritis patients--REACTION 52-week study
    Tsutomu Takeuchi
    Department of Internal Medicine, Division of Rheumatology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rheumatology (Oxford) 50:1908-15. 2011
    ..To evaluate the effectiveness and safety of tocilizumab in RA patients in clinical practice...
  40. doi request reprint Tacrolimus, a calcineurin inhibitor, overcomes treatment unresponsiveness mediated by P-glycoprotein on lymphocytes in refractory rheumatoid arthritis
    Katsunori Suzuki
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan
    J Rheumatol 37:512-20. 2010
    ..It also inhibits functions of P-glycoprotein, which is involved in drug resistance. We examined the mechanisms of early response to 2-week tacrolimus treatment in patients with RA...
  41. doi request reprint Dopamine D2-like receptor signaling suppresses human osteoclastogenesis
    Kentaro Hanami
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Bone 56:1-8. 2013
    ..These findings indicate that dopaminergic signaling plays an important role in bone homeostasis via direct effects upon osteoclast differentiation and further suggest that the clinical use of neuroleptics is likely to affect bone mass. ..
  42. ncbi request reprint Beta1 integrin/focal adhesion kinase-mediated signaling induces intercellular adhesion molecule 1 and receptor activator of nuclear factor kappaB ligand on osteoblasts and osteoclast maturation
    Shingo Nakayamada
    First and Second Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, 807 8555, Japan
    J Biol Chem 278:45368-74. 2003
    ..We here propose that beta1 integrin/FAK-mediated signaling on osteoblasts could be involved in ICAM-1- and RANKL-dependent osteoclast maturation...
  43. ncbi request reprint beta1 integrin-mediated signaling induces intercellular adhesion molecule 1 and Fas on rheumatoid synovial cells and Fas-mediated apoptosis
    Shingo Nakayamada
    University of Occupational and Environmental Health, Kitakyushu, Japan
    Arthritis Rheum 48:1239-48. 2003
    ..However, the relevance of beta1 integrin to inflammatory processes in RA remains unclear. We examined the role of beta1 integrin-mediated signaling in RA...
  44. ncbi request reprint A case of life-threatening refractory polychondritis successfully treated with combined intensive immunosuppressive therapy with methotrexate
    Kunihiro Yamaoka
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata nishi ku, Kitakyushu 807 8555, Japan
    Mod Rheumatol 17:144-7. 2007
    ..This case illustrates the potentially fatal sudden onset of airway inflammation that can occur with this disorder, and the effectiveness of methotrexate...
  45. doi request reprint Human mesenchymal stem cells inhibit osteoclastogenesis through osteoprotegerin production
    Koichi Oshita
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Fukuoka, Japan
    Arthritis Rheum 63:1658-67. 2011
    ..Since bone destruction caused by activated osteoclasts occurs in RA, we undertook the present study to investigate the effect of MSCs on osteoclast function and differentiation in order to evaluate their potential use in RA therapy...
  46. ncbi request reprint Advanced glycation end products induce calcification of vascular smooth muscle cells through RAGE/p38 MAPK
    Takahisa Tanikawa
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Vasc Res 46:572-80. 2009
    ..We demonstrate that advanced glycation end products (AGEs) induce calcification of vascular smooth muscle cells through the receptor for AGE (RAGE)/p38 mitogen-activated protein kinase (MAPK) signaling pathway...
  47. ncbi request reprint Constitutive association of MyD88 to IRAK in HTLV-I-transformed T cells
    Takamitsu Mizobe
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Exp Hematol 35:1812-22. 2007
    ..In this study, we investigated whether MyD88, an adaptor protein of Toll-like receptor (TLR) signaling, contributes to constitutive NF-kappaB activation in HTLV-I-transformed T cells...
  48. ncbi request reprint [Rheumatoid arthritis and osteoporosis: trends in their treatments]
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
    Nihon Rinsho 64:2359-66. 2006
    ..Thus, it is a clinical trend that physicians treat joint destruction as an inflammatory disease and osteoporosis as a metabolic disease...
  49. ncbi request reprint Leflunomide inhibits PDK1/Akt pathway and induces apoptosis of human mast cells
    Norifumi Sawamukai
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Immunol 179:6479-84. 2007
    ..These results indicate a new way of controlling mast cells and may therefore be the basis for innovative approaches to the treatment of various diseases related to mast cells...
  50. ncbi request reprint Abatacept inhibits radiographic progression in patients with rheumatoid arthritis: a retrospective analysis of 6 months of abatacept treatment in routine clinical practice. The ALTAIR study
    Satoshi Kubo
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Fukuoka 807 8555, Japan
    Mod Rheumatol 24:42-51. 2014
    ..Our objectives in this study were to determine the inhibitory effects of abatacept on joint damage and its clinical efficacy and safety in patients with rheumatoid arthritis (RA)...
  51. ncbi request reprint Antihypertensive and metabolic effects of high-dose olmesartan and telmisartan in type 2 diabetes patients with hypertension
    Tadashi Arao
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Endocr J 60:563-70. 2013
    ..Because there was a correlation between the percent changes of HOMA-IR and hs-CRP, these effects of olmesartan might be mediated by an anti-inflammatory action...
  52. ncbi request reprint The JAK inhibitor tofacitinib regulates synovitis through inhibition of interferon-γ and interleukin-17 production by human CD4+ T cells
    Keisuke Maeshima
    University of Occupational and Environmental Health, Japan
    Arthritis Rheum 64:1790-8. 2012
    ..The aim of this study was to examine the effects of tofacitinib in vitro and in vivo in RA, in order to elucidate the role of JAK in the disease process...
  53. ncbi request reprint Fragmented hyaluronan induces transcriptional up-regulation of the multidrug resistance-1 gene in CD4+ T cells
    Shizuyo Tsujimura
    First Department of Internal Medicine and Department of Molecular Biology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    J Biol Chem 281:38089-97. 2006
    ..Our findings imply that CD4+ T cell activation by fragmented hyaluronan, induced by characteristic extracellular matrix changes in inflammation, tumors, and other conditions, results in P-glycoprotein-mediated multidrug resistance...
  54. ncbi request reprint Macrophage inflammatory protein-1alpha induces hypercalcemia in adult T-cell leukemia
    Yosuke Okada
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu, Japan
    J Bone Miner Res 19:1105-11. 2004
    ..We propose that serum MIP-1alpha is a clinical hallmark for hypercalcemia in ATL...
  55. ncbi request reprint Induction of RANKL expression and osteoclast maturation by the binding of fibroblast growth factor 2 to heparan sulfate proteoglycan on rheumatoid synovial fibroblasts
    Kazuhisa Nakano
    University of Occupational and Environmental Health, Kitakyushu, Japan
    Arthritis Rheum 50:2450-8. 2004
    ..The aim of this study was to clarify the relevance of RA synovial fibroblasts (RASFs) and fibroblast growth factor 2 (FGF-2), which is produced abundantly by RASFs, to the osteoclastogenesis and bone resorption in RA...
  56. pmc Efficacy of rituximab (anti-CD20) for refractory systemic lupus erythematosus involving the central nervous system
    Mikiko Tokunaga
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka Yahata nishi, Kitakyushu 807 8555 Japan
    Ann Rheum Dis 66:470-5. 2007
    ..A standard treatment for NPSLE is not available. This report describes the clinical and laboratory tests of 10 patients with NPSLE before and after rituximab treatment, including changes in lymphocyte phenotypes...
  57. ncbi request reprint [Secondary osteoporosis due to systemic autoimmune diseases and rheumatic diseases]
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Nihon Rinsho 62:677-82. 2004
  58. ncbi request reprint [Biochemical markers of bone turnover. New aspect. Therapy of rheumatoid arthritis for bone metabolic marker]
    Yosuke Okada
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
    Clin Calcium 19:1186-90. 2009
    ..In this article, we described our findings that TNF-alphablocking therapy decreased urinary crosslinked N-telopeptide of type I collagen and increased serum bone alkaline phosphatase in RA patients...
  59. ncbi request reprint [Adhesion molecules in the context with bone remodeling and osteoporosis]
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Nihon Rinsho 62:125-30. 2004
  60. ncbi request reprint Activation signal transduction by beta1 integrin in T cells from patients with systemic lupus erythematosus
    Shingo Nakayamada
    University of Occupational and Environmental Health, School of Medicine, Fukuoka, Japan
    Arthritis Rheum 56:1559-68. 2007
    ..We undertook this study to perform a quantitative and functional analysis of beta1 integrin-mediated signaling to T cells in patients with SLE...
  61. doi request reprint Advanced glycation end products increase endothelial permeability through the RAGE/Rho signaling pathway
    Akiko Hirose
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Yahatanishi ku, Kitakyushyu, Japan
    FEBS Lett 584:61-6. 2010
    ..We also showed that RhoA and RAGE spontaneously formed a complex. These findings suggest that activation of RAGE/Rho is involved in AGE-BSA-induced hyperpermeability through gap formation and actin reorganization in diabetes...
  62. ncbi request reprint Dermal mast cell density in fingers reflects severity of skin sclerosis in systemic sclerosis
    Sonosuke Yukawa
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Kitakyushu, Fukuoka, 807 8555, Japan
    Mod Rheumatol 23:1151-7. 2013
    ..Although several reports have implied the involvement of mast cells in SSc based on examination of forearm skin specimens, there have been no studies that examined digital skin specimens...
  63. ncbi request reprint [Angioimmunoblastic T-cell lymphoma accompanied by pure red cell aplasia]
    Takamitsu Mizobe
    First Department of Internal Medicine, University of Occupational and Environmental Health
    Rinsho Ketsueki 46:211-6. 2005
    ..Remission was also accompanied by normalization of the Coombs tests, suggesting that autoimmune mechanisms in AILT may contribute to the development of PRCA...
  64. doi request reprint Intracellular HMGB1 transactivates the human IL1B gene promoter through association with an Ets transcription factor PU.1
    Fumihiko Mouri
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Eur J Haematol 80:10-9. 2008
    ..1-deficient murine EL4 thymoma cells. Thus, our data raise the possibility of a novel mechanism which sustains and amplifies inflammatory reactions through physical interaction of PU.1 with intracellular HMGB1 in macrophages/monocytes...
  65. ncbi request reprint Alendronate protects premenopausal women from bone loss and fracture associated with high-dose glucocorticoid therapy
    Yosuke Okada
    First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Rheumatol 35:2249-54. 2008
    ....
  66. ncbi request reprint [Recent progress in clinical trials for rheumatic diseases]
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
    Nihon Rinsho 67:619-25. 2009
    ..The prospects are here...
  67. doi request reprint Successful treatment of osteomalacia caused by renal tubular acidosis associated with Sjögren's syndrome
    Sunao Yamamoto
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Mod Rheumatol 23:401-5. 2013
    ..Here we report the successful amelioration of bone lesions through a multidisciplinary approach that improved renal tubular acidosis, with a special focus on treatment of the underlying inflammatory disorder with glucocorticoids...
  68. ncbi request reprint Iatrogenic osteomalacia: report of two cases
    Sunao Yamamoto
    First Department of Internal Medicine, University of Occupational and Environmental Health, Japan
    J UOEH 35:25-31. 2013
    ..For therapy, she was treated with 1 μg/day oral alfacalcidol.Two months after initiating treatment, the pain improved...
  69. ncbi request reprint Amplification of Toll-like receptor-mediated signaling through spleen tyrosine kinase in human B-cell activation
    Shigeru Iwata
    First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    J Allergy Clin Immunol 129:1594-601.e2. 2012
    ..B cells are activated by combined signals through the B-cell receptor (BCR) and CD40. However, the underlying mechanisms by which BCR signals synergize with Toll-like receptor (TLR) signaling in human B cells remain unclear...
  70. ncbi request reprint Marked improvement of calcinosis in adult dermatomyositis with etidronate therapy
    Hiroko Mori
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    J Bone Miner Metab 30:114-8. 2012
    ..We propose etidronate as a beneficial and effective therapy for calcinosis with osteoporosis...
  71. doi request reprint Efficacy of combination therapy of anti-TNF-α antibody infliximab and methotrexate in refractory entero-Behçet's disease
    Shigeru Iwata
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu, 807 8555, Japan
    Mod Rheumatol 21:184-91. 2011
    ....
  72. ncbi request reprint Imatinib mesylate-sensitive blast crisis immediately after discontinuation of imatinib mesylate therapy in chronic myelogenous leukemia: report of two cases
    Takehiro Higashi
    First Department Internal Medicine, School of Medicine, University of Occupational and Environmental Health, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Am J Hematol 76:275-8. 2004
    ..Our report suggests the possibility that withdrawal of imatinib mesylate may lead to proliferation of blast clones even in patients showing good responses to imatinib mesylate without signs of disease progression...
  73. ncbi request reprint Engagement of CD44 up-regulates Fas ligand expression on T cells leading to activation-induced cell death
    Kazuhisa Nakano
    Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Apoptosis 12:45-54. 2007
    ..We therefore propose that the engagement of CD44 on T cells can eliminate autoreactive T cells by expression of FasL and FasL-mediated AICD...
  74. ncbi request reprint Galectin-9 induces osteoblast differentiation through the CD44/Smad signaling pathway
    Rena Tanikawa
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    Biochem Biophys Res Commun 394:317-22. 2010
    ..Because Smad1 is phosphorylated by BMP receptors, we propose that formation of the CD44/BMP receptor complex induced by galectin-9 may provide a trigger for the activation of Smads...
  75. ncbi request reprint Transcriptional regulation of multidrug resistance-1 gene by interleukin-2 in lymphocytes
    Shizuyo Tsujimura
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Yahata Nishi, Kitakyushu, Japan
    Genes Cells 9:1265-73. 2004
    ....
  76. ncbi request reprint Glycated albumin and cross-linking of CD44 induce scavenger receptor expression and uptake of oxidized LDL in human monocytes
    Hirofumi Kishikawa
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Biochem Biophys Res Commun 339:846-51. 2006
    ..g., hyaluronan) and glycated albumin induced the differentiation of resting monocytes into foam macrophages through the induction of MSRs, implying that CD44 could be involved in atherosclerotic lesions of those such as diabetic patients...
  77. ncbi request reprint Hepatocyte growth factor enhances adhesion of breast cancer cells to endothelial cells in vitro through up-regulation of CD44
    Shinichiro Mine
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health Japan, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu 807 8555, Japan
    Exp Cell Res 288:189-97. 2003
    ..These results suggest that CD44 may confer the metastatic properties of breast cancer cells and, therefore, could be used as a target in future molecular cancer therapy...
  78. ncbi request reprint [Active arthritis due to cryoglobulinemia based on HCV infection in a patient with RA improvement of arthritis with IFN-alpha]
    Shizuyo Tsujimura
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 27:48-53. 2004
    ..Administration of IFN-alpha resulted in the disappearance of HCV-RNA and cryoglobulin followed by amelioration of arthritis without exacerbation of RA...
  79. pmc Effectiveness and safety of adalimumab in Japanese patients with rheumatoid arthritis: retrospective analyses of data collected during the first year of adalimumab treatment in routine clinical practice (HARMONY study)
    Tsutomu Takeuchi
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mod Rheumatol 22:327-38. 2012
    ..ADA therapy is highly effective for reducing disease activity, improving physical function, and limiting radiographic progression. It is generally safe and well tolerated by Japanese RA patients in routine clinical practice...
  80. ncbi request reprint [Biologics: current therapeutic strategies for rheumatoid arthritis]
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Nihon Rinsho 65:1179-84. 2007
    ..Herein I review the evidence-based medicine that addresses these issues and document an era of anti-cytokine therapeutics which is beginning to emerge...
  81. ncbi request reprint Induction of hyperadiponectinemia following long-term treatment of patients with rheumatoid arthritis with infliximab (IFX), an anti-TNF-alpha antibody
    Keiko Nishida
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Kitakyushu, Japan
    Endocr J 55:213-6. 2008
    ....
  82. ncbi request reprint Low molecular weight hyaluronan increases the Uptaking of oxidized LDL into monocytes
    Takahiro Tabata
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Endocr J 54:685-93. 2007
    ..Thus, we propose that engagement of CD44 with low molecular weight hyaluronan is centrally involved in the inflammatory pathogenesis of athelosclerotic plaques through migration of monocytes and foamed macrophage differentiation...
  83. ncbi request reprint [CD20 antibody for the treatment of systemic autoimmune diseases]
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Nihon Rinsho 63:728-33. 2005
  84. ncbi request reprint Monocyte chemoattractant protein-1 induces scavenger receptor expression and monocyte differentiation into foam cells
    Takahiro Tabata
    First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi, Kitakyushu, 807 8555, Japan
    Biochem Biophys Res Commun 305:380-5. 2003
    ....
  85. ncbi request reprint [Successful treatment of intravenous cyclophosphamide pulse therapy for lupus myelitis with urinary disturbance and acute confusional state]
    Mikiko Tokunaga
    The First Department of Internal Medicine, University of Occupational and Environmental Hearth, Japan, School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 27:338-44. 2004
    ..We here propose IV-CY as an invaluable choice for the treatment of not only active lupus myelitis but also neurogenic bladder resisted for steroid...
  86. ncbi request reprint Etanercept overcomes P-glycoprotein-induced drug resistance in lymphocytes of patients with intractable rheumatoid arthritis
    Shizuyo Tsujimura
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahata Nishi, Kitakyushu, 807 8555, Japan
    Mod Rheumatol 20:139-46. 2010
    ..None of the patients experienced any severe adverse effects. Etanercept is useful for overcoming P-gp-mediated treatment resistance in intractable RA patients who have to discontinue infliximab or are intolerant to MTX...
  87. ncbi request reprint Attempt to correct abnormal signal transduction in T lymphocytes from systemic lupus erythematosus patients
    Yuko Fujii
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan, 1 1 Iseigaoka, Yahatanishi ku, Kitakyushu 807 8555, Japan
    Autoimmun Rev 5:143-4. 2006
    ..This time, analysis of abnormal TCR signaling in SLE patients and attempt to correct the impaired IL-2 production by replenishing missing signaling molecules are to be discussed...
  88. doi request reprint [Secondary osteoporosis UPDATE. Rheumatoid arthritis and bone damage: trends in treatment]
    Yoshiya Tanaka
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
    Clin Calcium 20:735-42. 2010
    ..Furthermore, anti-RANKL antibody denosumab possesses a potential to inhibit joint destruction as well as systemic and GC-mediated osteoporosis...
  89. doi request reprint Dopamine induces IL-6-dependent IL-17 production via D1-like receptor on CD4 naive T cells and D1-like receptor antagonist SCH-23390 inhibits cartilage destruction in a human rheumatoid arthritis/SCID mouse chimera model
    Kazuhisa Nakano
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807 8555, Japan
    J Immunol 186:3745-52. 2011
    ....
  90. ncbi request reprint Constitutive tyrosine and serine phosphorylation of STAT4 in T-cells transformed with HTLV-I
    Takehiro Higashi
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Genes Cells 10:1153-62. 2005
    ....
  91. doi request reprint Mast cell-derived tryptase inhibits apoptosis of human rheumatoid synovial fibroblasts via rho-mediated signaling
    Norifumi Sawamukai
    University of Occupational and Environmental Health, Kitakyushu, Japan, and University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Arthritis Rheum 62:952-9. 2010
    ..This study was undertaken to elucidate a role for mast cells in RA by investigating the antiapoptotic effects of tryptase, a major product of mast cells, on RA synovial fibroblasts (RASFs)...
  92. ncbi request reprint Serum hyaluronan concentration as a marker of angiopathy in patients with diabetes mellitus
    Shinichiro Mine
    Department of Internal Medicine, Mitsubishi Chemical Hospital, Kitakyushu, Japan
    Endocr J 53:761-6. 2006
    ..Our data suggest that serum HA level correlates with poor blood glucose control and diabetic angiopathy and that it could be used as a marker of diabetic angiopathy...
  93. ncbi request reprint [Targeting CD20 in rheumatoid arthritis]
    Kazuyoshi Saito
    The First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health
    Nihon Rinsho 65:1243-9. 2007
    ....
  94. ncbi request reprint Stimulation of beta1 integrin down-regulates ICAM-1 expression and ICAM-1-dependent adhesion of lung cancer cells through focal adhesion kinase
    M Yasuda
    Second Department of Surgery, School of Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu
    Cancer Res 61:2022-30. 2001
    ..Our results suggest that such processes can lead to the escape of lung cancer cells in vivo from immunological surveillance...
  95. ncbi request reprint [CD20 antibody for treatment of rheumatoid arthritis]
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Japan
    Nihon Rinsho 63:544-8. 2005
  96. ncbi request reprint Functional cooperation of cyclin C and c-Myc in mediating homotypic cell adhesion via very late antigen-4 activation and vascular cell adhesion molecule-1 induction
    Z J Liu
    Department of Biochemistry and of Laboratory Medicine, Kobe University, School of Medicine, Kobe, Japan
    Blood 92:4700-11. 1998
    ..Our results provide a novel role for cyclin C and c-Myc in the regulation of cell adhesion through distinct mechanisms...
  97. ncbi request reprint [Paradigm shift in the treatment of rheumatoid arthritis by biologics]
    Yoshiya Tanaka
    First Department of Internal Medicine, School of Medicine, University of Occupational and Environmental Health, Kitakyusyu 807 8555
    Rinsho Byori 56:309-15. 2008
    ..In this review, how to use TNF inhibitors for the treatment of RA will also be discussed from domestic as well as global evidence...
  98. ncbi request reprint [Case of pulmonary infection with Mycobacterium chelonae in healthy breast-feeding woman]
    Katsunori Suzuki
    Department of Medicine, Health Insurance Nogata Chuou Hospital, Japan
    Kekkaku 82:759-63. 2007
    ..There are no signs of recurrence after completion of the treatment for 12 months...
  99. ncbi request reprint [Efficacy of anti-cytokines and anti-RANKL antibody for treatment of RA and osteoporosis]
    Yosuke Okada
    University of Occupational and Environmental Health, School of Medicine, The First Department of Internal Medicine
    Clin Calcium 17:1762-8. 2007
    ....
  100. ncbi request reprint Growth suppression of human mast cells expressing constitutively active c-kit receptors by JNK inhibitor SP600125
    Bin Wang
    The First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan
    Genes Cells 11:983-92. 2006
    ..The results obtained from the present study suggest the possibility that JNK/c-Jun may be a therapeutic target in diseases associated with mutations in the catalytic domain of c-kit...
  101. ncbi request reprint Abnormal intracellular distribution of NFAT1 in T lymphocytes from patients with systemic lupus erythematosus and characteristic clinical features
    Yuko Fujii
    The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, 1 1 Iseigaoka, Yahatanishi, Kitakyushu, Fukuoka 807 8555, Japan
    Clin Immunol 119:297-306. 2006
    ..In vitro cyclosporin A treatment suggested autonomously activated Ca2+/Cn pathway in lupus T lymphocytes. Considering these results, NFAT1 might be presenting the clinical heterogeneity in SLE...