E Tanaka

Summary

Affiliation: University of Tsukuba
Country: Japan

Publications

  1. ncbi How useful is the "cocktail approach" for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Ibaraki ken 305 8575, Japan
    J Clin Pharm Ther 28:157-65. 2003
  2. ncbi Clinically significant pharmacokinetic drug interactions with psychoactive drugs: antidepressants and antipsychotics and the cytochrome P450 system
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Japan
    J Clin Pharm Ther 24:7-16. 1999
  3. ncbi Trimethadione metabolism and microsomal monooxygenases in untreated and phenobarbital-treated rhesus monkeys
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120:317-20. 1998
  4. ncbi In vivo age-related changes in hepatic drug-oxidizing capacity in humans
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 23:247-55. 1998
  5. ncbi Pharmacokinetic interactions between acute alcohol ingestion and single doses of benzodiazepines, and tricyclic and tetracyclic antidepressants -- an update
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Japan
    J Clin Pharm Ther 23:331-6. 1998
  6. ncbi Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 23:403-16. 1998
  7. ncbi Clinically significant pharmacokinetic drug interactions between antiepileptic drugs
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 24:87-92. 1999
  8. ncbi Chlorzoxazone: a probe drug whose metabolism can be used to monitor toluene exposure in rats
    D Mizuno
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Arch Toxicol 74:139-44. 2000
  9. ncbi Cytochrome P450 2E1: its clinical and toxicological role
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki ken 305 8575, Japan
    J Clin Pharm Ther 25:165-75. 2000
  10. ncbi Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Ibaraki ken 305 8575, Japan
    J Clin Pharm Ther 25:325-32. 2000

Detail Information

Publications60

  1. ncbi How useful is the "cocktail approach" for evaluating human hepatic drug metabolizing capacity using cytochrome P450 phenotyping probes in vivo?
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Ibaraki ken 305 8575, Japan
    J Clin Pharm Ther 28:157-65. 2003
    ..Despite current limitations, the cocktail method for obtaining information about multiple CYP activities in a single experimental session is likely to be more widely used as a screening or phenotyping method for humans in the future...
  2. ncbi Clinically significant pharmacokinetic drug interactions with psychoactive drugs: antidepressants and antipsychotics and the cytochrome P450 system
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Japan
    J Clin Pharm Ther 24:7-16. 1999
    ..In addition, genotyping for these drugs may be also useful in preventing side-effects...
  3. ncbi Trimethadione metabolism and microsomal monooxygenases in untreated and phenobarbital-treated rhesus monkeys
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 120:317-20. 1998
    ..These findings suggest that plasma DMO/TMO ratio in a single blood sampling after TMO administration is very useful for determination the degree of hepatic induction in clinical study...
  4. ncbi In vivo age-related changes in hepatic drug-oxidizing capacity in humans
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 23:247-55. 1998
    ..Further study of the changes in P450 with age is warranted to help prevent adverse reactions and to guide us in tailoring therapy better for the individual patient...
  5. ncbi Pharmacokinetic interactions between acute alcohol ingestion and single doses of benzodiazepines, and tricyclic and tetracyclic antidepressants -- an update
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Japan
    J Clin Pharm Ther 23:331-6. 1998
    ..However, since changes in the pharmacogenetic metabolism of benzodiazepines and tricyclic and tetracyclic antidepressants are mainly governed by CYP2C19 and CYP2D6, caution is needed when used together with alcohol...
  6. ncbi Clinically important pharmacokinetic drug-drug interactions: role of cytochrome P450 enzymes
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 23:403-16. 1998
    ..In the future, it may help to identify individuals at greatest risk of drug interactions and adverse events...
  7. ncbi Clinically significant pharmacokinetic drug interactions between antiepileptic drugs
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 24:87-92. 1999
    ....
  8. ncbi Chlorzoxazone: a probe drug whose metabolism can be used to monitor toluene exposure in rats
    D Mizuno
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Arch Toxicol 74:139-44. 2000
    ..729, P < 0.001). In conclusion, these results demonstrate that CZX is a very good probe for monitoring induction in toluene-treated rats...
  9. ncbi Cytochrome P450 2E1: its clinical and toxicological role
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki ken 305 8575, Japan
    J Clin Pharm Ther 25:165-75. 2000
    ..In the future, methods for fully analysing the function of CYP2E1 using knockout mice will be established. This article reviews recent advances in our understanding of the role of human CYP2E1 in drug metabolism...
  10. ncbi Update: the clinical importance of acetaminophen hepatotoxicity in non-alcoholic and alcoholic subjects
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Ibaraki ken 305 8575, Japan
    J Clin Pharm Ther 25:325-32. 2000
    ..The acetaminophen-alcohol interaction is complex, because acute and chronic ethanol have opposite effects. This review also considers physiological and clinical changes, as well as the diagnosis and treatment of acetaminophen poisoning...
  11. ncbi The clinical importance of conventional and quantitative liver function tests in liver transplantation
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki ken 305 8575, Japan
    J Clin Pharm Ther 25:411-9. 2000
    ..or with histological evaluation, is thought to be desirable for deciding whether a liver transplantation should be carried out or not...
  12. ncbi Determination of plasma bromvalerylurea and its main metabolite by a simple high-performance liquid chromatographic method and quantitation of bromide by energy dispersive X-ray spectrometry in carbon tetrachloride-intoxicated rats
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan
    J Chromatogr B Biomed Sci Appl 759:361-6. 2001
    ..However, there was no difference in the plasma levels of bromide between CCl4-treated rats and control rats. rights reserved...
  13. ncbi Preliminary study of the in vitro interaction between alcohol, high-dose flunitrazepam and its three metabolites using human liver microsomes
    Einosuke Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki-ken 305-8575, Japan
    Basic Clin Pharmacol Toxicol 96:88-90. 2005
  14. ncbi Toxicological interactions between alcohol and benzodiazepines
    Einosuke Tanaka
    Department of Legal Medicine, Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Toxicol Clin Toxicol 40:69-75. 2002
    ..g., disease, age) and external (e.g., environment, diet) factors. Fatal poisoning involving coadministration of alcohol and benzodiazepine, especially triazolam, continues to be a serious problem...
  15. ncbi Premedication medicines do not cause drug metabolic interaction with propofol using human liver microsomes in vitro
    Einosuke Tanaka
    Institute of Community Medicine, University of Tsukuba, 305 8575, Tsukuba shi, Ibaraki Ken, Japan
    Eur J Clin Pharmacol 60:565-8. 2004
    ....
  16. ncbi Toxicological interactions involving psychiatric drugs and alcohol: an update
    E Tanaka
    Department of Forensic Medicine, Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 28:81-95. 2003
    ..g. dose, timing of ingestion, gastrointestinal absorption, distribution and elimination) factors. Cases of fatal poisoning involving coadministration of psychiatric drugs, alcohol and other drugs prompted this review...
  17. ncbi A study of the in vitro interaction between ethanol, and triazolam and its two metabolites using human liver microsomes
    Einosuke Tanaka
    Department of Legal Medicine, Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Forensic Med 12:245-8. 2005
    ..Ethanol is used as a social drug worldwide. Sometimes, toxic interactions occur following combined administration of these two drugs. In this study, we have investigated the interaction between alcohol and triazolam in vitro...
  18. ncbi A fatal poisoning with 5-methoxy-N,N-diisopropyltryptamine, Foxy
    Einosuke Tanaka
    Department of Legal Medicine, University of Tsukuba, Ibaraki 305 8575, Japan
    Forensic Sci Int 163:152-4. 2006
    ..The level of 5-MeO-DIPT, 5-OH-DIPT and 5-MeO-NIPT in blood and urine was 0.412, 0.327 and 0.020 microg/ml, and 1.67, 27.0 and 0.32 microg/ml, respectively. These blood and urine levels were higher than published data for such poisoning...
  19. ncbi Effects of premedication medicines on the formation of the CYP3A4-dependent metabolite of ropivacaine, 2', 6'-Pipecoloxylidide, on human liver microsomes in vitro
    Einosuke Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki ken 305 8575, Japan
    Basic Clin Pharmacol Toxicol 98:181-3. 2006
    ..8 microM and 250 microM, respectively). The results show lack of interaction between ropivacaine and seven premedication medicines within the therapeutic range of ropivacaine using human liver microsomes in vitro...
  20. ncbi Simultaneous determination of three local anesthetic drugs from the pipecoloxylidide group in human serum by high-performance liquid chromatography
    Einosuke Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki ken 305 8575, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 834:213-6. 2006
    ..This method may be useful in clinical and forensic applications for the determination or identification of the local anesthetic drugs: bupivacaine, mepivacaine or ropivacaine...
  21. ncbi Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography
    Einosuke Tanaka
    Department of Legal Medicine, Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Ibaraki ken 305 8575, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 854:116-20. 2007
    ..This sensitive and selective method offers the opportunity for simultaneous screening and quantification of almost all phenothiazines available in Japan for the purposes of clinical and forensic applications...
  22. ncbi Involvement of cytochrome P450 2C9, 2E1 and 3A4 in trimethadione N-demethylation in human microsomes
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Ibaraki Ken, Japan
    J Clin Pharm Ther 28:493-6. 2003
    ..In this study, we determined the percentage contribution of the three CYPs (CYP2C9, CYP2E1 and CYP3A4) to TMO N-demethylation...
  23. ncbi Metabolic interaction between ethanol, high-dose alprazolam and its two main metabolites using human liver microsomes in vitro
    Einosuke Tanaka
    Department of Legal Medicine, Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Forensic Leg Med 14:348-51. 2007
    ..Toxic levels may be reached by simultaneous administration of ethanol and high-dose alprazolam...
  24. ncbi Comparison of hepatic drug-oxidizing activity after simultaneous administration of two probe drugs, caffeine and trimethadione, to human subjects
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Pharmacol Toxicol 72:31-3. 1993
    ..05); paraxanthine r = -0.68 (P < 0.05); theophylline r = -0.65 (P < 0.05). These findings suggest that caffeine and trimethadione metabolism in healthy subjects is mediated by only in part by a form(s) of P450 enzymes involved...
  25. ncbi Influence of partial hepatectomy in dogs on trimethadione metabolism and microsomal monooxygenases
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Xenobiotica 25:1301-10. 1995
    ..6. The data presented above do not reveal any relationship between P4502B11 induction and liver regeneration. The reason for such a change is unknown, therefore further investigation needs to be carried out...
  26. ncbi Trimethadione tolerance test for the quantitative assessment of liver function in rats
    A Ishikawa
    Department of Surgery, University of Tsukuba, Ibaraki, Japan
    J Gastroenterol Hepatol 6:363-7. 1991
    ..The results suggest that the quantitative functional changes of the remnant liver after hepatectomy in both CCl4-treated and untreated rats can be estimated pre-operatively by the TMO tolerance test...
  27. ncbi A study of the in vitro interaction between lidocaine and premedications using human liver microsomes
    A Nagashima
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 30:185-8. 2005
    ....
  28. ncbi Effect of E-5110, a novel non-steroidal anti-inflammatory drug, on trimethadione metabolism as an indicator of hepatic drug-oxidizing capacity in beagle dog
    Z Daling
    Eisai Research Laboratories, Eisai, CO, Ltd, Ibaraki Ken, Japan
    Xenobiotica 24:215-20. 1994
    ..6. Results of both the in vivo and in vitro studies of the effects of E-5110 treatment in dog on TMO indicate that these effects may be attributed to the induction of CYP2B and 3A...
  29. ncbi Trimethadione metabolism in patients with normal liver and in patients with chronic liver disease
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Pharmacobiodyn 10:499-502. 1987
    ....
  30. ncbi Induction of cytochrome P-450 and related drug-oxidizing activities in muscone (3-methylcyclopentadecanone)-treated rats
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan
    Biochem Pharmacol 36:4263-7. 1987
    ..This type of induction of the hepatic metabolizing enzymes was similar to that seen after treatment with a prototype drug, phenobarbital...
  31. ncbi Trimethadione tolerance test for one-point estimation of the severity of liver damage in cirrhotic patients
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Japan
    Int J Clin Pharmacol Ther Toxicol 29:333-6. 1991
    ..10, which was 16% of the normal level, by the TMO tolerance test. These findings suggest that the TMO tolerance test is a useful indicator of the hepatic parenchymal function in cirrhotic patients...
  32. ncbi Sex-related differences in hepatic drug-oxidizing capacity of streptozotocin-induced diabetic rats
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan
    J Pharmacobiodyn 11:416-23. 1988
    ..In conclusion, our study showed that the effect of STZ-induced diabetes on drug metabolism varies with the sex and the drugs used. Insulin normalized all these diabetic changes...
  33. ncbi A simplified approach for evaluation of hepatic drug-oxidizing activity with a simultaneous determination of caffeine and trimethadione and their demethylated metabolites in rats with a selective cytochrome P-450 inducer
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Biopharm Drug Dispos 13:263-72. 1992
    ....
  34. ncbi Trimethadione metabolism, a useful indicator for assessing hepatic drug-oxidizing capacity
    M Nakamura
    Institute of Community Medicine, University of Tsukuba, Japan
    Biochem Pharmacol 47:247-51. 1994
    ....
  35. ncbi Dual effects of a novel thienodiazepine platelet-activating factor antagonist, on drug-oxidizing enzymes in beagle dog
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Xenobiotica 24:293-300. 1994
    ..However, aniline hydroxylase activity was not significantly changed. 5. Content of P450 2B was significantly increased in E-6123 treated dog, while that of 3A was not.(ABSTRACT TRUNCATED AT 250 WORDS)..
  36. ncbi Changes in the enzymatic activities of beagle liver during maturation as assessed both in vitro and in vivo
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Xenobiotica 28:795-802. 1998
    ..3. The results of these in vivo and in vitro studies suggest that changes in enzyme activity are due to differences in P450 isoenzymes during development...
  37. ncbi Changes in caffeine, lidocaine and trimethadione metabolism in carbon tetrachloride-intoxicated rats as assessed by a "cocktail" study
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Pharmacol Toxicol 75:150-3. 1994
    ..These findings suggest that each probe drug, metabolized by different or partially overlapping P450, is useful in evaluating drug-oxidizing capacity in liver disease...
  38. ncbi The metabolism and excretion of trimethadione in patients with percutaneous transhepatic biliary drainage and renal dysfunction
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Pharmacobiodyn 12:145-8. 1989
    ..These results suggest that metabolism and urinary and biliary excretion of TMO are not changed in patients with PTBD and renal dysfunction...
  39. ncbi Simplified test for determination of drug-oxidizing capacity in rats with chemical-induced liver injury using caffeine and trimethadione as model drugs
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Pharmacol Toxicol 70:177-80. 1992
    ..74 to 0.96; P less than 0.01) with the ratio of theobromine/caffeine, paraxanthine/caffeine and theophylline/caffeine after 1, 2 and 4 hr) of caffeine administration.(ABSTRACT TRUNCATED AT 250 WORDS)..
  40. ncbi Chlorzoxazone: a probe drug the metabolism of which can be used to monitor one-point blood sampling in the carbon tetrachloride-intoxicated rat
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Japan
    Hum Exp Toxicol 20:381-5. 2001
    ..909, P<0.01). In conclusion, these results from this study demonstrate that CZX is a good probe for monitoring the inhibition of metabolism in rats due to CCl4 treatment...
  41. ncbi Plasma lidocaine concentrations during continuous thoracic epidural anesthesia after clonidine premedication in children
    S Inomata
    Department of Anesthesiology, University of Tsukuba, Tsukuba shi, Ibaraki Ken, Japan
    Anesth Analg 93:1147-51. 2001
    ..Additionally, perhaps an additional margin of safety regarding lidocaine toxicity is gained through the use of oral clonidine in children who will receive epidural lidocaine...
  42. ncbi In vivo and in vitro trimethadione oxidation activity of the liver from various animal species including mouse, hamster, rat, rabbit, dog, monkey and human
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Hum Exp Toxicol 18:12-6. 1999
    ..965, P < 0.001). These results show that TMO is a probe agent with metabolic and pharmacokinetic characteristics making it attractive for the in vivo and in vitro characterization of metabolic activity in various animal species...
  43. ncbi In vivo function tests of hepatic drug-oxidizing capacity in patients with liver disease
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Japan
    J Clin Pharm Ther 22:237-49. 1997
    ..The future use of these tests needs to be discussed in terms of potential clinical implications...
  44. ncbi Trimethadione metabolism as a probe drug to estimate hepatic oxidizing capacity in rats
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan
    Comp Biochem Physiol C 104:205-7. 1993
    ..4. This finding suggests that TMO may be used as a probe drug in the rapid determination of the functional reserve mass of the liver as well as the hepatic oxidizing capacity...
  45. ncbi Simultaneous determination of twelve benzodiazepines in human serum using a new reversed-phase chromatographic column on a 2-microns porous microspherical silica gel
    E Tanaka
    Department of Legal Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Chromatogr B Biomed Appl 682:173-8. 1996
    ..These results show that a new ODS filler with a particle size of 2 microns was more sensitive, provided better separation and was more rapid than that with conventional ODS filler...
  46. ncbi The effect of roxatidine acetate and cimetidine on hepatic drug clearance assessed by simultaneous administration of three model substrates
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Japan
    Br J Clin Pharmacol 28:171-4. 1989
    ..ICG clearance was not changed significantly by either pretreatment. The results of this study show that roxatidine acetate does not impair the metabolism of three model substrates used to assess hepatic drug clearance...
  47. ncbi Comparison of trimethadione and antipyrine as indicators of oxidative drug metabolizing capacity in man
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Japan
    Eur J Clin Pharmacol 36:629-32. 1989
    ..762 and 0.772, respectively. The findings suggest that TMO metabolism and the formation of NORA in healthy subjects are mediated by a closely related form(s) of the cytochrome P-450 system...
  48. ncbi Trimethadione tolerance tests for the assessment of feasible size of hepatic resection in patients with hepatocellular carcinoma
    A Ishikawa
    Department of Surgery, University of Tsukuba, Ibaraki, Japan
    J Gastroenterol Hepatol 8:426-32. 1993
    ....
  49. ncbi Trimethadione as a probe drug to estimate hepatic oxidizing capacity in humans
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 115:211-6. 1996
    ..This finding suggests that TMO may be used as a probe drug in the rapid determination of the functional reserve mass of the liver as well as hepatic drug-oxidizing capacity in humans in vivo...
  50. ncbi Clinical significance of the trimethadione tolerance test in chronic hepatitis: a useful indicator of hepatic drug metabolizing capacity
    M Abei
    Department of Gastroenterology, University of Tsukuba, Ibaraki, Japan
    J Gastroenterol 30:478-84. 1995
    ....
  51. ncbi Improved method for the determination of trimethadione and its demethylated metabolite, dimethadione, in human serum by gas chromatography
    E Tanaka
    Institute of Community Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Chromatogr 584:267-9. 1992
    ..This improved method is reliable in terms of sensitivity, selectivity and reproducibility for the simultaneous determination of both compounds in human serum...
  52. ncbi Propofol inhibits lidocaine metabolism in human and rat liver microsomes
    Shinichi Inomata
    Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan
    J Anesth 17:246-50. 2003
    ..On the other hand, lidocaine did not change propofol metabolism. CONCLUSION: Propofol possesses a dose-dependent inhibitory effect on the metabolism of lidocaine in both human and rat CYP systems in vitro...
  53. ncbi Effect of propofol on ropivacaine metabolism in human liver microsomes
    Yoshiko Osaka
    Graduate School, University of Tsukuba, Tsukuba, Japan
    J Anesth 20:60-3. 2006
    ..The IC50 of propofol was 34.9 micromol.l(-1). Propofol shows a competitive inhibitory effect on the metabolism of ropivacaine (i.e., PPX production mediated by CYP3A4) in human CYP systems in vitro...
  54. ncbi The clinical importance of the trimethadione tolerance test as a method for quantitative assessment of hepatic functional reserve in patients with biliary atresia
    H Nakamura
    Institute of Clinical Medicine, University of Tsukuba, Ibaraki Ken, Japan
    J Clin Pharm Ther 26:417-24. 2001
    ..The trimethadione (TMO) tolerance test was performed to evaluate its usefulness in the assessment of hepatic functional reserve in patients with biliary atresia...
  55. ncbi CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia
    Shinichi Inomata
    Departments of Anesthesiology, Legal Medicine, and Pharmaceutical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Clin Pharmacol Ther 78:647-55. 2005
    ..The objective of this study was to investigate the effects of polymorphism in CYP2C19 and the effects of CYP3A4 messenger ribonucleic acid (mRNA) content in blood on recovery from general anesthesia and on diazepam pharmacokinetics...
  56. ncbi Effects of clonidine on lidocaine metabolism in human or rat liver microsomes
    Shinichi Inomata
    Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba 305-8575, Japan
    J Anesth 17:281-3. 2003
  57. ncbi Induction of cytochrome P450 isozymes in rat renal microsomes by cyclosporin A
    M Nakamura
    Institute of Community Medicine, University of Tsukuba, Ibaraki, Japan
    Biochem Pharmacol 48:1743-6. 1994
    ..The specific induction of CYP4A2 may be related to CsA-induced nephrotoxicity and elevated blood pressure, because omega-hydroxyarachidonic acid is a potent vasoconstrictor...
  58. ncbi A novel constitutive model of skeletal muscle taking into account anisotropic damage
    D Ito
    Japan Automobile Research Institute, Karima, Tsukuba, Ibaraki, Japan
    J Mech Behav Biomed Mater 3:85-93. 2010
    ..The model can predict non-linear mechanical properties and breaking points...
  59. ncbi Simultaneous determination of flunitrazepam and 7-aminoflunitrazepam in human serum by ion trap gas chromatography-tandem mass spectrometry
    Masaru Terada
    Course of Social Medicine, Department of Legal Medicine, Osaka University Graduate School of Medicine F3, Suita Shi, Osaka 565 0871, Japan
    Leg Med (Tokyo) 5:S96-S100. 2003
    ..8 V), respectively. The detection limits of full scan EI mass spectrometry and tandem mass spectrometry for FNZ and 7-AFNZ in human serum were ca. 200 ng/ml, 60 ng/ml, 15 ng/ml and 1 ng/ml, respectively...
  60. ncbi The specific mitochondrial DNA polymorphism found in Klinefelter's syndrome
    Haruna Oikawa
    Department of Legal Medicine, Institute of Community Medicine, University of Tsukuba, Tennodai 1-1-1, Tsukuba City, Ibaraki 305-8575, Japan
    Biochem Biophys Res Commun 297:341-5. 2002
    ..Our data indicate that possible interaction of the sex chromosome and the mtDNA exists, and suggests that the specific mtDNA haplotype could cause the abnormal cell to fertilize and reproduce itself...