Hajime Takizawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, School of Medicine, Tokyo University, Bunkyo ku, Tokyo 113, Japan
    Am J Physiol Lung Cell Mol Physiol 278:L906-13. 2000
  2. ncbi request reprint Bronchial epithelial cells in allergic reactions
    Hajime Takizawa
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Curr Drug Targets Inflamm Allergy 4:305-11. 2005
  3. ncbi request reprint Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-kappa B-dependent pathway
    Hajime Takizawa
    Departments of Laboratory Medicine and Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Am J Physiol Lung Cell Mol Physiol 284:L1055-62. 2003
  4. ncbi request reprint Diesel exhaust particles and their effect on induced cytokine expression in human bronchial epithelial cells
    Hajime Takizawa
    The Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Curr Opin Allergy Clin Immunol 4:355-9. 2004
  5. ncbi request reprint Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
  6. ncbi request reprint Diesel exhaust particles activate human bronchial epithelial cells to express inflammatory mediators in the airways: a review
    H Takizawa
    The Department of Laboratory Medicine, Nippon Medical School, Tokyo, Japan
    Respirology 5:197-203. 2000
  7. doi request reprint Nrf2 is closely related to allergic airway inflammatory responses induced by low-dose diesel exhaust particles in mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Clin Immunol 137:234-41. 2010
  8. ncbi request reprint Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Clin Immunol 128:366-73. 2008
  9. doi request reprint The effects of oxidative stress induced by prolonged low-dose diesel exhaust particle exposure on the generation of allergic airway inflammation differ between BALB/c and C57BL/6 mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Immunopharmacol Immunotoxicol 31:230-7. 2009
  10. doi request reprint Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/c and C57BL/6 strains
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Exp Lung Res 34:125-39. 2008

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Increased expression of inflammatory mediators in small-airway epithelium from tobacco smokers
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, School of Medicine, Tokyo University, Bunkyo ku, Tokyo 113, Japan
    Am J Physiol Lung Cell Mol Physiol 278:L906-13. 2000
    ..Our results also suggested that this new ultrathin bronchofiberscope promised a good approach for the evaluation of cellular changes in the small airways...
  2. ncbi request reprint Bronchial epithelial cells in allergic reactions
    Hajime Takizawa
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Curr Drug Targets Inflamm Allergy 4:305-11. 2005
    ..These findings strongly suggest that BEC are actively involved as regulators of allergic inflammatory responses, and become a target for therapeutic intervention...
  3. ncbi request reprint Diesel exhaust particles upregulate eotaxin gene expression in human bronchial epithelial cells via nuclear factor-kappa B-dependent pathway
    Hajime Takizawa
    Departments of Laboratory Medicine and Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Am J Physiol Lung Cell Mol Physiol 284:L1055-62. 2003
    ..These findings suggested that DEP stimulated eotaxin gene expression via NF-kappaB-dependent, but STAT6-independent, pathways...
  4. ncbi request reprint Diesel exhaust particles and their effect on induced cytokine expression in human bronchial epithelial cells
    Hajime Takizawa
    The Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Curr Opin Allergy Clin Immunol 4:355-9. 2004
    ..It is also important to compare responses to DEP exposure between healthy and susceptible populations...
  5. ncbi request reprint Increased expression of transforming growth factor-beta1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD)
    H Takizawa
    Department of Laboratory Medicine and Respiratory Medicine, Tokyo University, School of Medicine, 7 3 1Hongo, Bunkyo ku, Tokyo 113, Japan
    Am J Respir Crit Care Med 163:1476-83. 2001
    ..Our study showed a close link between smoking and expression of TGF-beta1 in small airways. Our results also suggested that small airway epithelial cells might be involved in obstructive changes found in smokers and patients with COPD...
  6. ncbi request reprint Diesel exhaust particles activate human bronchial epithelial cells to express inflammatory mediators in the airways: a review
    H Takizawa
    The Department of Laboratory Medicine, Nippon Medical School, Tokyo, Japan
    Respirology 5:197-203. 2000
    ..We studied the effect of DEP on the production of inflammatory cytokines and mediators including IL-8 and granulocyte macrophage colony stimulating factor (GM-CSF) by human airway epithelial cells in vitro...
  7. doi request reprint Nrf2 is closely related to allergic airway inflammatory responses induced by low-dose diesel exhaust particles in mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Clin Immunol 137:234-41. 2010
    ....
  8. ncbi request reprint Disruption of Nrf2 enhances susceptibility to airway inflammatory responses induced by low-dose diesel exhaust particles in mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Clin Immunol 128:366-73. 2008
    ..These results strongly suggest that DEP-induced oxidative stress and host antioxidant responses play some role in the development of DEP-induced airway inflammation...
  9. doi request reprint The effects of oxidative stress induced by prolonged low-dose diesel exhaust particle exposure on the generation of allergic airway inflammation differ between BALB/c and C57BL/6 mice
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Immunopharmacol Immunotoxicol 31:230-7. 2009
    ..Our results contribute more information to the search for genetic susceptibility factors in the response to DEP, and may thus assist in the discovery of new biomarkers for DEP-related disease...
  10. doi request reprint Airway inflammatory responses to oxidative stress induced by prolonged low-dose diesel exhaust particle exposure from birth differ between mouse BALB/c and C57BL/6 strains
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Exp Lung Res 34:125-39. 2008
    ....
  11. doi request reprint C-reactive protein modulates human lung fibroblast migration
    Kazuhiko Kikuchi
    Department of Respiratory Medicine, University of Tokyo, Tokyo, Japan
    Exp Lung Res 35:48-58. 2009
    ..In summary, this study demonstrates that CRP directly modulates human lung fibroblasts migration. Thus, CRP may contribute to regulation of wound healing and may be endogenous antifibrotic factor acting on lung fibrosis...
  12. ncbi request reprint Airway inflammatory responses to oxidative stress induced by low-dose diesel exhaust particle exposure differ between mouse strains
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Exp Lung Res 33:227-44. 2007
    ..Low-dose DEP exposure induces airway inflammatory responses that differ among strains, and these differences may be caused by differences in sensitivity to oxidative stress...
  13. ncbi request reprint Inhalation of diesel exhaust for three months affects major cytokine expression and induces bronchus-associated lymphoid tissue formation in murine lungs
    Kumiko Hiramatsu
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Exp Lung Res 29:607-22. 2003
    ..These findings suggest that DE may provoke immunological responses by acting as a foreign body in the lung, and that even low-level exposure may induce allergic reactions...
  14. ncbi request reprint Repeated exposure to low-dose diesel exhaust after allergen challenge exaggerates asthmatic responses in mice
    Aki Matsumoto
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Clin Immunol 121:227-35. 2006
    ....
  15. doi request reprint Procaterol inhibits lung fibroblast migration
    Tadashi Kohyama
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Inflammation 32:387-92. 2009
    ..Procaterol, which is prescribed mainly for treatment of bronchial asthma, might be a useful drug for inhibiting lung fibrosis following injuries to the lung...
  16. doi request reprint EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: importance in IL-8 transcription
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo 113 8602, Japan
    Pulm Pharmacol Ther 26:318-24. 2013
    ..EM and EM703 might contribute to chemical prevention of the risk of pulmonary diseases induced by oxidative stress from environmental pollutant, such as DEP...
  17. ncbi request reprint Methotrexate induces interleukin-8 production by human bronchial and alveolar epithelial cells
    Yasuhiro Yamauchi
    Department of Respiratory Medicine, University of Tokyo, Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Sci (Lond) 106:619-25. 2004
    ..These results suggest that MTX activates bronchial and alveolar epithelial cells to induce IL-8 production through p38 MAPK, which might play an important role as one of the mechanisms of MTX-induced lung inflammation...
  18. ncbi request reprint Potential action of IL-4 and IL-13 as fibrogenic factors on lung fibroblasts in vitro
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 132:168-76. 2003
    ..We hypothesized that these cytokines would stimulate fibroblast proliferation in association with decreased prostaglandin E(2) (PGE(2))...
  19. doi request reprint Simultaneous stimulation with TGF-β1 and TNF-α induces epithelial mesenchymal transition in bronchial epithelial cells
    Sumiko Kamitani
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine, Tokyo, Japan
    Int Arch Allergy Immunol 155:119-28. 2011
    ..TGF-β1, which is a potent inducer of EMT, is thought to be related to the pathogenesis of airway remodeling. We investigated whether TGF-β1 and/or TNF-α induce EMT in bronchial epithelial cells...
  20. ncbi request reprint The effects of inhalation of diesel exhaust on murine mycobacterial infection
    Kumiko Hiramatsu
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Exp Lung Res 31:405-15. 2005
    ..These results indicate that long-term DE exposure may increase pulmonary mycobacterial burden...
  21. doi request reprint Tumor necrosis factor-alpha enhances both epithelial-mesenchymal transition and cell contraction induced in A549 human alveolar epithelial cells by transforming growth factor-beta1
    Yasuhiro Yamauchi
    Department of Respiratory Medicine, The University of Tokyo, Tokyo, Japan
    Exp Lung Res 36:12-24. 2010
    ..In conclusion, TNF-alpha enhances not only EMT but also cell contraction induced by TGF-beta1. EMT might contribute to tissue fibrosis through induction of cell contraction...
  22. pmc Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation
    Masashi Desaki
    Department of Respiratory Medicine, University of Tokyo Graduate School of Medicine Kitasato Medical Institute, Tokyo, Japan
    Antimicrob Agents Chemother 48:1581-5. 2004
    ..Taken together, these data suggest EM has an anti-inflammatory action, presumably via an interaction with the NF-kappaB signaling pathway in the downstream of the dissociation from IkappaB, resulting in the inhibition of NF-kappaB...
  23. doi request reprint Clarithromycin inhibits fibroblast migration
    Tadashi Kohyama
    Department of Respiratory Medicine, The University of Tokyo, Graduate School of Medicine, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    Respir Med 102:1769-76. 2008
    ..The aim of the current study was to investigate the effect of 14-membered ring macrolide clarithromycin (CAM) on migration induced by human plasma fibronectin (HFn) or on contraction of human fetal lung fibroblasts (HFL-1)...
  24. ncbi request reprint Role of oxidative stresses induced by diesel exhaust particles in airway inflammation, allergy and asthma: their potential as a target of chemoprevention
    Ying Ji Li
    Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
    Inflamm Allergy Drug Targets 9:300-5. 2010
    ..Therefore, chemoprevention against DEPs health effects in susceptible individuals may become a choice for future environmental protection policy...
  25. pmc Mechanic's hands revisited: is this sign still useful for diagnosis in patients with lung involvement of collagen vascular diseases?
    Erei Sohara
    Department of Respiratory Medicine, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka City, Tokyo 181 8611, Japan
    BMC Res Notes 7:303. 2014
    ..The aim of this study was to clarify the relevance of "mechanic's hands" to collagen vascular diseases including various skin lesions and interstitial pneumonia...
  26. ncbi request reprint Breakthrough Invasive Candida glabrata in Patients on Micafungin: a Novel FKS Gene Conversion Correlated with Sequential Elevation of MIC
    Takeshi Saraya
    Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan
    J Clin Microbiol 52:2709-12. 2014
    ..015 to 4 μg/ml). A novel mutation identified in micafungin-resistant strains at bp 262 of FKS2 (containing a deletion of F659 [F659del]) was inserted into the homologous region in FKS1. ..
  27. pmc Methicillin-resistant Staphylococcus aureus enterocolitis sequentially complicated with septic arthritis: a case report and review of the literature
    Yukari Ogawa
    Department of Respiratory Medicine, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    BMC Res Notes 7:21. 2014
    ..Although most reports describing patients infected with methicillin-resistant Staphylococcus aureus enterocolitis have been published in Japan, this concept remains a matter of debate and diagnostic criteria have not yet been defined...
  28. pmc High-resolution computed tomography findings for patients with drug-induced pulmonary toxicity, with special reference to hypersensitivity pneumonitis-like patterns in gemcitabine-induced cases
    Masaki Tamura
    Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan
    Oncologist 18:454-9. 2013
    ....
  29. ncbi request reprint Cytomegalovirus pneumonia in a patient with interstitial pneumonia and Nocardia asiatica presenting as cavitary lung lesions
    Takeshi Saraya
    Department of Respiratory Medicine, Kyorin University School of Medicine, Japan
    Intern Med 52:593-7. 2013
    ..Following CMV pneumonia, cavitary lesions again occurred in the patient's lungs that were thought to be the first case of cavitary lesions caused by Nocardia asiatica infection...
  30. doi request reprint Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells
    Yu Mikami
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Japan
    Biochem Biophys Res Commun 428:451-7. 2012
    ..In summary, LIGHT enhanced TGF-β1-induced EMT but also induced EMT via the Erk1/2 pathway by itself, without TGF-β1 signaling. LIGHT may contribute to the pathogenesis of airway fibrosis through enhancement of EMT...
  31. doi request reprint Histamine stimulates human lung fibroblast migration
    Tadashi Kohyama
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Mol Cell Biochem 337:77-81. 2010
    ..This study demonstrated that histamine has the potential to stimulate human lung fibroblast migration, and thus may contribute to regulation of wound healing and the development of fibrotic disorders of the lung...
  32. ncbi request reprint Long-term inhalation of diesel exhaust affects cytokine expression in murine lung tissues: comparison between low- and high-dose diesel exhaust exposure
    Yoshinobu Saito
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Exp Lung Res 28:493-506. 2002
    ..These results suggest that DE alters immunological responses in the lung and may increase susceptibility to pathogens, and that increased IL-4 expression by low-dose DE exposure may induce allergic reaction such as asthma...
  33. doi request reprint Serial quantification of procalcitonin (PCT) predicts clinical outcome and prognosis in patients with community-acquired pneumonia (CAP)
    Masaki Tamura
    Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo 181 8612, Japan
    J Infect Chemother 20:97-103. 2014
    ..006), and this positively correlated with disease severity scores for all patients (PCT vs. PSI: R = 0.380, P < 0.001; PCT vs...
  34. ncbi request reprint Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor
    Masafumi Horie
    1Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    Exp Lung Res 40:222-36. 2014
    ..Histamine is a potent mediator of allergic inflammation, substantially involved in asthmatic pathophysiology...
  35. doi request reprint Mycoplasma pneumoniae extract induces an IL-17-associated inflammatory reaction in murine lung: implication for mycoplasmal pneumonia
    Daisuke Kurai
    Department of Respiratory Medicine, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka shi, Tokyo, 181 8611, Japan
    Inflammation 36:285-93. 2013
    ..05). Further, significantly more neutrophils were recruited to the lungs of the RI group (P < 0.05). These observations suggest that IL-17 is involved in the prolonged induction of neutrophils in mice treated with Mp extract...
  36. ncbi request reprint Leukotriene D4 potentiates fibronectin-induced migration of human lung fibroblasts
    Jun Kato
    The Department of Respiratory Medicine, University of Tokyo, Graduate School of Medicine, Tokyo, Japan
    Clin Immunol 117:177-81. 2005
    ..These findings suggest that LTD4 has a potential to augment fibroblast chemotaxis, and to contribute to regulation of the wound healing and following remodeling in fibrotic processes of the lung...
  37. ncbi request reprint Cytokine responsiveness in cultured human small airway epithelial cells in relation to lung transplantation
    Kuniharu Miyajima
    The First Department of Surgery, Tokyo Medical University, Tokyo, Japan
    Ann Thorac Cardiovasc Surg 11:374-81. 2005
    ..In this study we evaluated intercellular adhesion molecule-1 (ICAM-1) expression on SAEC stimulated with several inflammatory cytokines and compared it with that on large airway epithelial cells (LAEC)...
  38. pmc A case of malignant peritoneal mesothelioma revealed with limitation of PET-CT in the diagnosis of thoracic metastasis
    Takeshi Saraya
    Departments of Respiratory Medicine, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka City, Tokyo, Japan
    J Thorac Dis 5:E11-6. 2013
    ..The present case demonstrated the some of the limitations of PET-CT in the diagnosis of malignant mesothelioma, which failed to detect pleural involvement despite aggressive invasion by this tumor...
  39. ncbi request reprint [Role of inflammatory cells in the development of airway inflammation]
    Hajime Takizawa
    Department of Respiratory Medicine, Tokyo University
    Nihon Rinsho 61:2107-12. 2003
    ..However, their role in the pathogenesis of inflammatory changes remains unelucidated. Further studies are necessary for the new development of treatment for this progressive lung disease...
  40. doi request reprint Hyperoxia exaggerates bacterial dissemination and lethality in Pseudomonas aeruginosa pneumonia
    Yoshiaki Kikuchi
    Department of Microbiology and Infectious Diseases, Toho University School of Medicine, 5 21 16 Ohmorinishi, Ohtaku, Tokyo, Japan
    Pulm Pharmacol Ther 22:333-9. 2009
    ..aeruginosa pneumonia. Our data identify the potential of macrolides to protect individuals with P. aeruginosa pneumonia in the setting of hyperoxia...
  41. ncbi request reprint Role of interferon-gamma in the development of murine bronchus-associated lymphoid tissues induced by silica in vivo
    Masashi Desaki
    Department of Respiratory Medicine, Graduate School of Medicine, Instutute of Medical Science, University of Tokyo, Tokyo, Japan
    Toxicol Appl Pharmacol 185:1-7. 2002
    ..These results suggest that IFN-gamma has an inhibitory effect on the development of BALT and may be involved in small airway disease in silicotic lung...
  42. ncbi request reprint Invasive tracheobronchial aspergillosis in a patient with systemic lupus erythematosus-dermatomyositis overlap syndrome
    Mitsuru Sada
    Department of Respiratory Medicine, Kyorin University School of Medicine, Japan
    Intern Med 52:2149-53. 2013
    ..This case of aspergillosis should thus be recognized as an extremely rare presentation of an Aspergillus infection. ..
  43. ncbi request reprint Interferon-gamma inhibits hepatocyte growth factor-stimulated cell proliferation of human bronchial epithelial cells: upregulation of p27(kip1) cyclin-dependent kinase inhibitor
    Kazutaka Takami
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Am J Respir Cell Mol Biol 26:231-8. 2002
    ....
  44. doi request reprint Fluorodeoxyglucose (FDG) uptake in pulmonary rheumatoid nodules diagnosed by video-assisted thoracic surgery lung biopsy: two case reports and a review of the literature
    Takeshi Saraya
    Department of Respiratory Medicine, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Mod Rheumatol 23:393-6. 2013
    ..These cases show that rheumatoid nodules with an enhanced inflammatory process, such as vasculitis, can appear false-positive for malignancy on FDG-PET/CT scan images...
  45. ncbi request reprint Clinical implications of the immunomodulatory effects of macrolides
    Jun Tamaoki
    First Department of Medicine, Tokyo Women s Medical University, 8 1 Kawada cho, Shiinjuku, Tokyo, Japan
    Am J Med 117:5S-11S. 2004
    ..In patients with DPB, the anti-inflammatory effects lead to a significant increase in survival. Further work is needed to characterize the clinical benefits of macrolides in patients with other chronic inflammatory airway diseases...
  46. ncbi request reprint Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model
    Satoshi Ishii
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    J Immunol 172:7095-102. 2004
    ..These results indicate an important role for PAF receptor, downstream of the eosinophilic inflammatory cascade, in regulating airway responsiveness after sensitization and aeroallergen challenge...
  47. pmc Familial summer-type hypersensitivity pneumonitis in Japan: two case reports and review of the literature
    Akira Nakajima
    Department of Respiratory Medicine, Kyorin University School of Medicine, 6 20 2 Shinkawa, 181 8611, Mitaka City, Tokyo, Japan
    BMC Res Notes 6:371. 2013
    ..The incidence of summer-type hypersensitivity pneumonitis is higher in the summer season, especially in Japan, due to the influence of the hot and humid environment and the common style of wood house or old concrete condominiums...
  48. pmc The saw-tooth sign as a clinical clue for intrathoracic central airway obstruction
    Akira Nakajima
    Departments of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan
    BMC Res Notes 5:388. 2012
    ....
  49. ncbi request reprint Effects of diesel exhaust on murine alveolar macrophages and a macrophage cell line
    Yoshinobu Saito
    Fourth Department of Internal Medicine, Nippon Medical School, Tokyo, Japan
    Exp Lung Res 28:201-17. 2002
    ..Longer exposure of DE may therefore suppress the host defense in the lung and may increase susceptibility to lung infections such as mycobacterial infection...
  50. ncbi request reprint Future treatment for COPD: targeting oxidative stress and its related signal
    Hiroo Wada
    Department of Respiratory Medicine, Kyorin University School of Medicine, 6 20 2 Shinkawa, Mitaka, Tokyo 181 8611, Japan
    Recent Pat Inflamm Allergy Drug Discov 7:1-11. 2013
    ....
  51. pmc Impact of air pollution on allergic diseases
    Hajime Takizawa
    Department of Respiratory Medicine, Kyorin University School of Medicine, Tokyo, Japan
    Korean J Intern Med 26:262-73. 2011
    ....
  52. ncbi request reprint A novel snake venom vascular endothelial growth factor (VEGF) predominantly induces vascular permeability through preferential signaling via VEGF receptor-1
    Hiroyuki Takahashi
    Division of Genetics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 279:46304-14. 2004
    ..TfsvVEGF is thus a potent inducing factor selective for vascular permeability through preferential signaling via VEGFR-1. These data strongly indicate the importance of VEGFR-1 signaling in vascular permeability...
  53. doi request reprint Black pleural effusion
    Takeshi Saraya
    Department of Respiratory Medicine, Kyorin University School of Medicine, Mitaka City, Tokyo, Japan
    Am J Med 126:641.e1-6. 2013
    ..Black pleural effusions are extremely rare and have been reported in patients with infection, malignancy, and hemorrhage. However, no review articles appear to have focused on this rare clinical presentation...
  54. pmc High-resolution CT findings of patients with pulmonary nocardiosis
    Naoki Tsujimoto
    Kyorin University School of Medicine, Department of Respiratory Medicine, Mitaka, Tokyo, Japan
    J Thorac Dis 4:577-82. 2012
    ..Opportunistic pulmonary infection with Nocardia species is rare in humans, and only a few studies have radiologically analyzed patients with pulmonary nocardiosis using high-resolution computed tomography (HRCT)...
  55. ncbi request reprint Voltage-gated sodium channel expressed in cultured human smooth muscle cells: involvement of SCN9A
    Taisuke Jo
    Department of Cardiovascular, Respiratory Medicine and Gastroenterology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    FEBS Lett 567:339-43. 2004
    ..These results provide novel evidence that TTX-sensitive Na(+) channel expressed in cultured hSMCs is mainly composed of Na(v)1.7...
  56. ncbi request reprint [Immunological tests: Anti-neutrophil cytoplasmic antibody]
    Hajime Takizawa
    Department of Respiratory Medicine, University of Tokyo
    Nihon Rinsho 63:624-6. 2005
  57. ncbi request reprint Novel therapeutic strategies for fibrotic lung disease: a review with a focus on epithelial-mesenchymal transition
    Satoshi Noguchi
    Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Recent Pat Inflamm Allergy Drug Discov 8:9-18. 2014
    ..We also describe recent patents that could develop into novel therapeutics. ..
  58. pmc Guillain-Barré syndrome in two patients with respiratory failure and a review of the Japanese literature
    Erei Sohara
    Departments of Respiratory Medicine, Kyorin University School of Medicine, Mitaka, Tokyo, Japan
    J Thorac Dis 4:601-7. 2012
    ....
  59. ncbi request reprint Alpha-1 antitrypsin deficiency with severe pulmonary emphysema
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Tokyo
    Intern Med 43:223-6. 2004
    ..We report an additional case of AAT deficiency with severe emphysema that is genetically determined as S(iiyama) variant by allele-specific polymerase chain reaction (PCR) analysis...
  60. ncbi request reprint A case of pulmonary veno-occlusive disease associated with systemic sclerosis
    Akira Saito
    Department of Respiratory Medicine, Graduate School of Medicine, University of Tokyo, Japan
    Respirology 8:383-5. 2003
    ..The patient died 7 months later and at autopsy the lungs showed prominent thickening of the interlobular septa and small branches of pulmonary veins showed intimal thickening...
  61. ncbi request reprint [Effect of EM703, a new macrolide derivative, on activation of transcription factors derived from the airway epithelial cells]
    Shinji Dezaki
    Jpn J Antibiot 57:120-2. 2004
  62. ncbi request reprint Acute eosinophilic pneumonia: possible role of hyperreactivity of airway epithelial cells
    Hajime Takizawa
    Intern Med 41:917. 2002
  63. doi request reprint Ym1 and Ym2 expression in a mouse model exposed to diesel exhaust particles
    Hyun Mi Song
    Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, Korea
    Environ Toxicol 23:110-6. 2008
    ..Chitinase may play a role in regulating allergic diseases...
  64. pmc Additive effect of diesel exhaust particulates and ozone on airway hyperresponsiveness and inflammation in a mouse model of asthma
    An Soo Jang
    Department of Internal Medicine, Soonchunhyang University Hospital, Bucheon, Korea
    J Korean Med Sci 20:759-63. 2005
    ..Co-exposure of ozone and DEP has additive effect on airway hyperresponsiveness by modulation of IL-4 and IFN-gamma suggesting that DEP amplify Th2 immune response...
  65. ncbi request reprint [Bronchial asthma]
    Hajime Takizawa
    Nihon Naika Gakkai Zasshi 92:1244-7. 2003
  66. ncbi request reprint [Exhaled nitric oxide (NO), carbon monoxide (CO)]
    Hajime Takizawa
    Department of Respiratory Medicine, Tokyo University School of Medicine
    Nihon Rinsho 62:282-4. 2004
  67. ncbi request reprint Prostacyclin analogs inhibit fibroblast migration
    Tadashi Kohyama
    Pulmonary and Critical Care Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 5125, USA
    Am J Physiol Lung Cell Mol Physiol 283:L428-32. 2002
    ..Such an effect may contribute to the regulation of fibroblasts in wound healing and could contribute to the pathogenesis of diseases characterized by abnormal tissue repair remodeling...
  68. ncbi request reprint PDE4 inhibitors attenuate fibroblast chemotaxis and contraction of native collagen gels
    Tadashi Kohyama
    University of Nebraska Medical Center, Omaha 68198 5125, USA
    Am J Respir Cell Mol Biol 26:694-701. 2002
    ..In summary, these in vitro results suggest that PDE4 inhibitors may be able to suppress fibroblast activity and, thus, have the potential to block the development of progressive fibrosis...
  69. ncbi request reprint [Keypoints in the treatment of bronchial asthma using the guideline as a reference]
    Hajime Takizawa
    Nihon Naika Gakkai Zasshi 96:2822-8. 2007