Junko Takita

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. doi request reprint Frequent inactivation of A20 in B-cell lymphomas
    Motohiro Kato
    Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 459:712-6. 2009
  2. doi request reprint Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene
    Junko Takita
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan
    Eur J Haematol 83:149-53. 2009
  3. doi request reprint Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma
    Junko Takita
    Department of Cell Therapy and Transplantation, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 102:1645-50. 2011
  4. ncbi request reprint Mutation and expression analyses of the MET and CDKN2A genes in rhabdomyosarcoma with emphasis on MET overexpression
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 46:348-58. 2007
  5. doi request reprint Oncogenic mutations of ALK kinase in neuroblastoma
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Nature 455:971-4. 2008
  6. ncbi request reprint Aberrations of the CHK2 gene are rare in pediatric solid tumors
    Yu Yan Chen
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int J Mol Med 16:85-91. 2005
  7. doi request reprint Hepatoblastoma in a patient with sotos syndrome
    Motohiro Kato
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pediatr 155:937-9. 2009
  8. doi request reprint Interstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma
    Kan Takahashi
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Brain Dev 33:353-6. 2011
  9. ncbi request reprint Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors
    Kazuko Obana
    Department of Pediatric Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int J Oncol 23:1151-7. 2003
  10. ncbi request reprint Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 45:583-91. 2006

Collaborators

Detail Information

Publications31

  1. doi request reprint Frequent inactivation of A20 in B-cell lymphomas
    Motohiro Kato
    Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 459:712-6. 2009
    ....
  2. doi request reprint Acute megakaryoblastic leukemia in a child with the MLL-AF4 fusion gene
    Junko Takita
    Department of Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan
    Eur J Haematol 83:149-53. 2009
    ..To our knowledge, MLL-AF4 as well as t(4;11)(q21:q23) has not been reported in adult and childhood AMKL. Thus, our case provides new insight into the molecular mechanisms of MLL-AF4-associated leukemia...
  3. doi request reprint Aberrations of NEGR1 on 1p31 and MYEOV on 11q13 in neuroblastoma
    Junko Takita
    Department of Cell Therapy and Transplantation, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 102:1645-50. 2011
    ..In addition, the findings suggest a possible prognostic value for NEGR1 in neuroblastoma...
  4. ncbi request reprint Mutation and expression analyses of the MET and CDKN2A genes in rhabdomyosarcoma with emphasis on MET overexpression
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 46:348-58. 2007
    ..Our data suggest that MET plays a role in the progression of RMS...
  5. doi request reprint Oncogenic mutations of ALK kinase in neuroblastoma
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, Tokyo 113 8655, Japan
    Nature 455:971-4. 2008
    ..We anticipate that our findings will provide new insights into the pathogenesis of advanced neuroblastoma and that ALK-specific kinase inhibitors might improve its clinical outcome...
  6. ncbi request reprint Aberrations of the CHK2 gene are rare in pediatric solid tumors
    Yu Yan Chen
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int J Mol Med 16:85-91. 2005
    ..These results suggest that aberrations of the CHK2 gene are rare in pediatric solid tumors...
  7. doi request reprint Hepatoblastoma in a patient with sotos syndrome
    Motohiro Kato
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pediatr 155:937-9. 2009
    ..Genome-wide analysis of copy number alterations showed a gain of chromosome 2, uniparental disomy of 18q, and microdeletion of 5q35...
  8. doi request reprint Interstitial deletion of 13q14.13-q32.3 presenting with Arima syndrome and bilateral retinoblastoma
    Kan Takahashi
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Brain Dev 33:353-6. 2011
    ..13 to 13q32.3 and involving the RB1 gene. This patient is the first case of Arima syndrome, or a Joubert syndrome-related disorder, that showed linkage to chromosome 13q...
  9. ncbi request reprint Aberrations of p16INK4A, p14ARF and p15INK4B genes in pediatric solid tumors
    Kazuko Obana
    Department of Pediatric Surgery, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    Int J Oncol 23:1151-7. 2003
    ..Our results suggest that abnormal expression of the p16 and/or p14ARF may be associated with a poor prognosis in these 3 tumors...
  10. ncbi request reprint Mutations of the PTPN11 and RAS genes in rhabdomyosarcoma and pediatric hematological malignancies
    Yuyan Chen
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 45:583-91. 2006
    ..Our data suggest that mutations of PTPN11 as well as RAS play a role in the pathogenesis of not only myeloid hematological malignancies but also a subset of RMS malignancies...
  11. doi request reprint A complex t(1;22;11)(q44;q13;q23) translocation causing MLL-p300 fusion gene in therapy-related acute myeloid leukemia
    Hiroaki Ohnishi
    Department of Laboratory Medicine, Kyorin University, Mitaka, Tokyo, Japan
    Eur J Haematol 81:475-80. 2008
    ..Considering that the MLL-CBP fusion gene is also found almost exclusively in therapy-related leukemia, the association of MLL-p300 and MLL-CBP with therapy-related leukemia rather than de novo leukemia is thereby suggested...
  12. ncbi request reprint Gene expression profiling and identification of novel prognostic marker genes in neuroblastoma
    Junko Takita
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 40:120-32. 2004
    ..02). Therefore, the BIRC, CDKN2D, and SMARCD3 genes are possible candidates for being novel prognostic markers for NB...
  13. doi request reprint Oncogenic mutations of ALK in neuroblastoma
    Seishi Ogawa
    Cancer Genomics Project, The University of Tokyo, Tokyo, Japan
    Cancer Sci 102:302-8. 2011
    ....
  14. doi request reprint Whole-genome profiling of chromosomal aberrations in hepatoblastoma using high-density single-nucleotide polymorphism genotyping microarrays
    Makoto Suzuki
    Department of General Surgical Science, Graduate School of Medicine, Gunma University Graduate School, 3 39 15 Showa, Maebashi, Gunma, Japan
    Cancer Sci 99:564-70. 2008
    ..The expression patterns of IGF2 and H19 were opposite between genes with and without the UPD. This difference in the expression patterns might influence the clinical features of HBL...
  15. doi request reprint A novel SOS1 mutation in Costello/CFC syndrome affects signaling in both RAS and PI3K pathways
    Munkhtuya Tumurkhuu
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan
    J Recept Signal Transduct Res 33:124-8. 2013
    ..Previously, we found a novel mutation of the SOS1 gene (T158A) in a patient with Costello/CFC overlapping phenotype...
  16. doi request reprint Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array
    Riki Nishimura
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 104:856-64. 2013
    ..These findings enhance our understanding of the genetic mechanisms underlying RMS pathogenesis and support further studies for therapeutic development of RMS. ..
  17. doi request reprint Comprehensive genetic analysis of overlapping syndromes of RAS/RAF/MEK/ERK pathway
    Munkhtuya Tumurkhuu
    Department of Developmental Medical Sciences, Institute of International Health, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Pediatr Int 52:557-62. 2010
    ..Each of these syndromes has a wide spectrum of molecular etiology. The aim of the present study was to conduct a comprehensive genetic analysis of RAS/RAF/MEK/ERK pathway in these syndromes...
  18. ncbi request reprint In vitro drug resistance to imatinib and mutation of ABL gene in childhood Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia
    Hiroyuki Kawaguchi
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Japan
    Leuk Lymphoma 46:273-6. 2005
    ..A missense mutation of T to C (Y253H) of the ABL gene was identified in the resistant clone, suggesting that this mutation may play an etiological role in the rapid loss of drug sensitivity...
  19. doi request reprint Mutational analyses of the ATP6V1B1 and ATP6V0A4 genes in patients with primary distal renal tubular acidosis
    Kenichiro Miura
    Department of Pediatrics, Faculty of Medicine, The University of Tokyo, Tokyo, Japan
    Nephrol Dial Transplant 28:2123-30. 2013
    ..Mutations in the ATP6V1B1 and the ATP6V0A4 genes cause primary autosomal-recessive distal renal tubular acidosis (dRTA). Large deletions of either gene in patients with dRTA have not been described...
  20. doi request reprint The effect of the order of total body irradiation and chemotherapy on graft-versus-host disease
    Motohiro Kato
    Department of Hematology Oncology, Saitama Children s Medical Center, Saitama Departments of Pediatrics Cell Therapy and Transplantation Medicine, University of Tokyo, Tokyo, Japan
    J Pediatr Hematol Oncol 36:e9-e12. 2014
    ....
  21. ncbi request reprint Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma
    Yu Yan Chen
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Oncol 23:737-44. 2003
    ..These results suggest that KIF1Ba in addition to KIF1Bbeta may not be a candidate tumor suppressor gene for NB...
  22. ncbi request reprint AML1/RUNX1 mutations are infrequent, but related to AML-M0, acquired trisomy 21, and leukemic transformation in pediatric hematologic malignancies
    Takeshi Taketani
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 38:1-7. 2003
    ..These results suggest that AML1 mutations in pediatric hematologic malignancies are infrequent, but are possibly related to AML-M0, acquired trisomy 21, and leukemic transformation. These patients may have a poor clinical outcome...
  23. ncbi request reprint A family of episodic ataxia type 2: no evidence of genetic linkage to the CACNA1A gene
    Hiroyuki Hirose
    Department of Pediatrics, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Mol Med 11:187-9. 2003
    ..This suggests that the cause of EA2 can be heterogeneous, that is, defects of genes other than CACNA1A might be the cause of EA2...
  24. doi request reprint Early occurrence of nephrotic syndrome associated with cord blood stem cell transplantation
    Kenichiro Miura
    Department of Pediatrics, Graduate School of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    Clin Exp Nephrol 16:180-2. 2012
    ..To our knowledge, this is the earliest occurrence of NS after HSCT. Hematologists and nephrologists should be aware that this condition may occur even in early periods after HSCT...
  25. ncbi request reprint The kinesin superfamily protein Rab6KIFL is not involved in the pathophysiology of Charcot-Marie-Tooth disease type 4C
    Michiaki Nagura
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Int J Mol Med 11:45-7. 2003
    ..No mutation in Rab6KIFL gene was found in this family. Further investigation is necessary to identify the causative gene for CMT4C...
  26. doi request reprint Comparison of intravenous with oral busulfan in allogeneic hematopoietic stem cell transplantation with myeloablative conditioning regimens for pediatric acute leukemia
    Motohiro Kato
    Department of Cell Therapy and Transplantation Medicine, The University of Tokyo, Tokyo, Japan Department of Pediatrics, The University of Tokyo, Tokyo, Japan Department of Hematology Oncology, Saitama Children s Medical Center, Saitama, Japan Electronic address
    Biol Blood Marrow Transplant 19:1690-4. 2013
    ..3% ± 2.5% with oral-BU (P = .51). Furthermore, multivariate analysis showed no significant survival advantage with iv-BU. In conclusion, iv-BU failed to show a significant survival advantage in children with acute leukemia...
  27. pmc ADORA2A polymorphism predisposes children to encephalopathy with febrile status epilepticus
    Mayu Shinohara
    Department of Developmental Medical Sciences, Graduate School of Medicine, University of Tokyo, Japan
    Neurology 80:1571-6. 2013
    ..However, its pathogenesis remains unclear. In this study, we clarified that genetic variation in the adenosine A2A receptor (ADORA2A), whose activation is involved in excitotoxicity, may be a predisposing factor of AESD...
  28. doi request reprint Imaging findings of upper abdominal involvement by acute megakaryoblastic leukaemia
    Shiori Amemiya
    Department of Radiology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Pediatr Radiol 38:457-61. 2008
    ..With the association of splenic lesion and lymphadenopathy, the imaging findings were considered indicative of a haematological disorder...
  29. doi request reprint A case with sacrococcygeal primitive myxoid mesenchymal tumor of infancy: a case report and review of the literature
    Atsuro Saito
    Departments of Pediatrics Radiology Organ Pathology, Shimane University Faculty of Medicine Division of Blood Transfusion, Shimane University Hospital Department of Digestive and General Surgery, Shimane University School of Medicine, Shimane Department of Cell Therapy and Transplantation Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    J Pediatr Hematol Oncol 35:e280-2. 2013
    ..A diagnosis of primitive myxoid mesenchymal tumor of infancy should be considered in cases of soft tissue tumors in infants that show prominent vascularity but little contrast enhancement on MRI or CT. ..
  30. ncbi request reprint Lack of aberrations of the BMP4, BMP2, and PTX1 genes in a patient with pituitary hypoplasia, os odontoideum, renal dysplasia, and right leg anomalies
    Masahiro Goto
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Japan
    Int J Mol Med 10:293-7. 2002
    ..We did not find any non-sense mutations although 5 polymorphisms of these genes were found. This constellation of findings may represent a new entity of congenital combined pituitary hormone deficiency...
  31. ncbi request reprint Aberrations of the hSNF5/INI1 gene are restricted to malignant rhabdoid tumors or atypical teratoid/rhabdoid tumors in pediatric solid tumors
    Kaoru Uno
    Department of Pediatrics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Genes Chromosomes Cancer 34:33-41. 2002
    ..These results suggest that alterations of the hSNF5/INI1 gene were restricted to MRTs or AT/RTs in pediatric solid tumors...