M M Taketo

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice
    Leigh Anne D Miller
    Division of Developmental Biology, Department of Ophthalmology, Children s Hospital Research Foundation, The University of Cincinnati, Cincinnati, OH 45229 3039, USA
    BMC Dev Biol 6:14. 2006
  2. ncbi request reprint Cyclooxygenase-2 inhibitors in tumorigenesis (Part II)
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo, Japan
    J Natl Cancer Inst 90:1609-20. 1998
  3. ncbi request reprint COX-2 and colon cancer
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Inflamm Res 47:S112-6. 1998
  4. ncbi request reprint Cyclooxygenase-2 inhibitors in tumorigenesis (part I)
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo, Japan
    J Natl Cancer Inst 90:1529-36. 1998
  5. ncbi request reprint Mapping of eight testis-specific genes to mouse chromosomes
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Genomics 46:138-42. 1997
  6. ncbi request reprint Gastro-intestinal tumorigenesis in Smad4 mutant mice
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Cytokine Growth Factor Rev 11:147-57. 2000
  7. ncbi request reprint Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1)
    T Ito
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Gene 244:55-63. 2000
  8. ncbi request reprint Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
    M Sonoshita
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Nat Med 7:1048-51. 2001
  9. ncbi request reprint Mapping of six germ-cell-specific genes to mouse chromosomes
    M Matsui
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Mamm Genome 8:873-4. 1997
  10. ncbi request reprint Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice
    K Takaku
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Japan
    Cancer Res 59:6113-7. 1999

Collaborators

Detail Information

Publications38

  1. pmc Optic cup and facial patterning defects in ocular ectoderm beta-catenin gain-of-function mice
    Leigh Anne D Miller
    Division of Developmental Biology, Department of Ophthalmology, Children s Hospital Research Foundation, The University of Cincinnati, Cincinnati, OH 45229 3039, USA
    BMC Dev Biol 6:14. 2006
    ..Consistent with this, Wnt signaling gain of function in the ocular region ectoderm results in a suppression of lens fate...
  2. ncbi request reprint Cyclooxygenase-2 inhibitors in tumorigenesis (Part II)
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo, Japan
    J Natl Cancer Inst 90:1609-20. 1998
    ..This Part II (of a two-part review) focuses on the growing clinical and experimental evidence that NSAIDS and COX-2 inhibitors can influence the risk of colon (and possibly of other) cancers...
  3. ncbi request reprint COX-2 and colon cancer
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Inflamm Res 47:S112-6. 1998
    ..The results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis, and indicate that COX-2-selective inhibitors can be a new class of therapeutic agents for colorectal polyposis and cancer...
  4. ncbi request reprint Cyclooxygenase-2 inhibitors in tumorigenesis (part I)
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo, Japan
    J Natl Cancer Inst 90:1529-36. 1998
    ..This Part I (of a two-part review) focuses on the discovery of the COXs; their biochemical, molecular, and structural properties; and on the discovery of isozyme-specific inhibitors of COX activity...
  5. ncbi request reprint Mapping of eight testis-specific genes to mouse chromosomes
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Genomics 46:138-42. 1997
    ..Three novel genes encoding testis-specific proteins A2 (Tsga2), A8 (Tsga8), and A12 (Tsga12) were mapped to chromosomes 3, X, and 10, respectively...
  6. ncbi request reprint Gastro-intestinal tumorigenesis in Smad4 mutant mice
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan
    Cytokine Growth Factor Rev 11:147-57. 2000
    ..These results indicate that mutations in SMAD4 play a significant role in the malignant progression of colorectal tumors...
  7. ncbi request reprint Gene structure and chromosome mapping of mouse transcription elongation factor S-II (Tcea1)
    T Ito
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Tokyo, Japan
    Gene 244:55-63. 2000
    ..Linkage analysis showed that Tcea1 and Tcea1-ps1 are mapped on mouse chromosomes 1 and 15, respectively. Relationships between Tcea1 and S-II cDNAs isolated so far are discussed...
  8. ncbi request reprint Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(Delta 716) knockout mice
    M Sonoshita
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan
    Nat Med 7:1048-51. 2001
    ....
  9. ncbi request reprint Mapping of six germ-cell-specific genes to mouse chromosomes
    M Matsui
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Japan
    Mamm Genome 8:873-4. 1997
  10. ncbi request reprint Gastric and duodenal polyps in Smad4 (Dpc4) knockout mice
    K Takaku
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Japan
    Cancer Res 59:6113-7. 1999
    ..In addition, foci of adenocarcinoma with signet ring cells are also found. These results are consistent with a recent report that germ-line SMAD4 mutations are found in a subset of familial juvenile polyposis...
  11. ncbi request reprint Suppression of intestinal polyposis in Apc(delta 716) knockout mice by an additional mutation in the cytosolic phospholipase A(2) gene
    K Takaku
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Hongo, Tokyo 113 0033, Japan
    J Biol Chem 275:34013-6. 2000
    ..These results suggest that in the colon, group X sPLA(2) supplies arachidonic acid in both the normal epithelium and the polyps even in the absence of cPLA(2)...
  12. ncbi request reprint Gene organization and chromosome mapping of the testis-specific S-II
    T Ito
    Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Mamm Genome 9:915-7. 1998
  13. pmc Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype
    M Matsui
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Japan
    Proc Natl Acad Sci U S A 97:9579-84. 2000
    ..Accordingly, this mutant mouse should provide a useful animal model for investigation of human diseases that are affected in the peripheral cholinergic functions...
  14. ncbi request reprint Genomic structure and chromosomal location of the mouse macrophage C-type lectin gene
    M Tsuiji
    Laboratory of Cancer Biology and Molecular Immunology, The University of Tokyo, Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Immunogenetics 50:67-70. 1999
  15. ncbi request reprint Retrovirus integration site Mintb encoding the mouse homolog of hnRNP U
    M Matsui
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, 113 0033, Japan
    J Biochem 125:1104-14. 1999
    ..Northern and in situ hybridization analyses revealed that gene R was abundantly expressed in the testis, especially in the pachytene spermatocytes and round spermatids...
  16. ncbi request reprint Chemoprevention of intestinal polyposis in the Apcdelta716 mouse by rofecoxib, a specific cyclooxygenase-2 inhibitor
    M Oshima
    Tsukuba Research Institute, Banya Pharmaceutical Co, Ltd, Japan
    Cancer Res 61:1733-40. 2001
    ..This study showing the inhibition of polyposis in the Apcdelta716 mouse suggests that the specific COX-2 inhibitor rofecoxib (Vioxx) has potential as a chemopreventive agent in human intestinal and colon cancer...
  17. ncbi request reprint Gastrointestinal tumorigenesis in Smad4 (Dpc4) mutant mice
    M M Taketo
    Department of Pharmacology, Graduate School of Medicine Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501 Japan
    Hum Cell 13:85-95. 2000
    ..These results indicate that mutations in SMAD4 play a significant role in the malignant progression of colorectal tumors...
  18. pmc Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin gene
    N Harada
    Banyu Tsukuba Research Institute Merck, Tsukuba 300 2611, Japan
    EMBO J 18:5931-42. 1999
    ..Some nascent microadenomas were also found in the colon. These results present experimental genetic evidence that activation of the Wnt signaling pathway can cause intestinal and colonic tumors...
  19. pmc Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas
    H Takeda
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Br J Cancer 90:701-4. 2004
    ..These results suggest that PGE(2) produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas...
  20. ncbi request reprint Effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine on intestinal polyp development in Apc delta 716 knockout mice
    M Oshima
    Banyu Tsukuba Research Institute Merck, Tsukuba, Japan
    Mol Carcinog 15:11-7. 1996
    ..These results suggest that PhIP affects intestinal polyp development by accelerating the growth rate of microadenomas. It is also possible that high doses of N-OH-PhIP increase the frequency of Apc gene LOH...
  21. ncbi request reprint Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes
    K Takaku
    Banyu Tsukuba Research Institute Merck, Japan
    Cell 92:645-56. 1998
    ..These results indicate that mutations in DPC4 (SMAD4) play a significant role in the malignant progression of colorectal tumors...
  22. ncbi request reprint Morphological and molecular processes of polyp formation in Apc(delta716) knockout mice
    H Oshima
    Banyu Tsukuba Research Institute Merck, Japan
    Cancer Res 57:1644-9. 1997
    ..These results suggest that early adenomas in the Apc(delta716) polyps are very similar to the normal proliferating cells of the crypt except for the lack of directed migration along the crypt-villus axis...
  23. ncbi request reprint Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2)
    M Oshima
    Banyu Tsukuba Research Institute Merck, Okubo, Japan
    Cell 87:803-9. 1996
    ..These results provide direct genetic evidence that COX-2 plays a key role in tumorigenesis and indicate that COX-2-selective inhibitors can be a novel class of therapeutic agents for colorectal polyposis and cancer...
  24. ncbi request reprint Wnt signaling and gastrointestinal tumorigenesis in mouse models
    M M Taketo
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo, Kyoto, Japan
    Oncogene 25:7522-30. 2006
    ....
  25. pmc Development of spontaneous tumours and intestinal lesions in Fhit gene knockout mice
    T Fujishita
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Br J Cancer 91:1571-4. 2004
    ..These results suggest that Fhit plays important roles in systemic tumour suppression and in the integrity of mucosal structure of the intestines...
  26. ncbi request reprint Somatic activation of beta-catenin bypasses pre-TCR signaling and TCR selection in thymocyte development
    F Gounari
    Department of Pathology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA
    Nat Immunol 2:863-9. 2001
    ..Although active beta-catenin induced differentiation in the absence of TCRs, its action was associated with reduced proliferation and survival when compared to developmental changes induced by the pre-TCR or the alpha beta TCR...
  27. ncbi request reprint CDX2 expression in the stomach with intestinal metaplasia and intestinal-type cancer: Prognostic implications
    H Seno
    Department of Pharmacology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    Int J Oncol 21:769-74. 2002
    ..These results collectively indicate that CDX2 expression in gastric cancer tissues can be a novel prognostic marker for patient survival...
  28. pmc Cytokeratins 8 and 19 in the mouse placental development
    Y Tamai
    Banyu Tsukuba Research Institute Merck, Tsukuba, Ibaraki 300 2611, Japan
    J Cell Biol 151:563-72. 2000
    ..These results indicate that K19 and K8 cooperate in ensuring the normal development of placental tissues...
  29. pmc Targeted deletion of keratins 18 and 19 leads to trophoblast fragility and early embryonic lethality
    M Hesse
    Institut fur Genetik, Abteilung Molekulargenetik and Bonner Forum Biomedizin, Universitat Bonn, 53117 Bonn, Anatomisches Institut, Universitat Bonn, 53115 Bonn, Germany
    EMBO J 19:5060-70. 2000
    ..Our data also offer a rationale to explore the involvement of keratin mutations in early abortions during human pregnancies...
  30. ncbi request reprint Early embryonic lethality caused by targeted disruption of the mouse thioredoxin gene
    M Matsui
    Department of Biological Responses, Kyoto University, Japan
    Dev Biol 178:179-85. 1996
    ..These results indicate that Txn expression is essential for early differentiation and morphogenesis of the mouse embryo...
  31. ncbi request reprint TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    M Oshima
    Banyu Tsukuba Research Institute Merck, Okubo, Japan
    Dev Biol 179:297-302. 1996
    ..Some chimeric mice showed several types of congenital anomalies, suggesting that TGF-beta II is important for normal development in a variety of organs...
  32. ncbi request reprint Suppression of intestinal polyp development by low-fat and high-fiber diet in Apc(delta716) knockout mice
    K Hioki
    Central Institute for Experimental Animals, Kawasaki, Japan
    Carcinogenesis 18:1863-5. 1997
    ..This is likely to be due to a decreased frequency of loss of heterozygosity, rather than a retarded growth of the polyp adenomas...
  33. ncbi request reprint Estrogen-induced tumorigenesis in the pituitary gland of TGF-beta(+/-) knockout mice
    N Shida
    Department of Neurosurgery, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai 980, Japan
    Biochim Biophys Acta 1407:79-83. 1998
    ..Histological examination of the pituitary glands found 38 adenomas in 14 Tgfbr2(+/-) mice but only one tumor in ten wild type mice. Pituitary tumorigenesis is greatly accelerated in Tgfbr2(+/-) mice by estrogen treatment...
  34. ncbi request reprint Impaired extrapyramidal function caused by the targeted disruption of retinoid X receptor RXRgamma1 isoform
    Y Saga
    Banyu Tsukuba Research Institute Merck Tsukuba, Ibaraki, 300 33 Japan
    Genes Cells 4:219-28. 1999
    ..In contrast to the widespread expression of RXRalpha and RXRbeta, the expression of RXRgamma is restricted to particular tissues in which RXRgamma1 is the major isoform expressed in the mouse corpus striatum...
  35. ncbi request reprint Colonic hamartoma development by anomalous duplication in Cdx2 knockout mice
    Y Tamai
    Banyu Tsukuba Research Institute Merck, Ibaraki, Japan
    Cancer Res 59:2965-70. 1999
    ....
  36. ncbi request reprint Effects of docosahexaenoic acid (DHA) on intestinal polyp development in Apc delta 716 knockout mice
    M Oshima
    Banyu Tsukuba Research Institute Merck, Japan
    Carcinogenesis 16:2605-7. 1995
    ..This is the first demonstration that DHA inhibits intestinal polyposis induced by an Apc mutation at both its formation and growth...
  37. ncbi request reprint Involvement of caspase 3 in apoptotic death of cortical neurons evoked by DNA damage
    E Keramaris
    Neuroscience Research Institute, University of Ottawa, Ontario, Canada
    Mol Cell Neurosci 15:368-79. 2000
    ..This suggests that the requirement for caspase 3 in death of neurons evoked by DNA damage may differ depending upon the developmental state of the cell...
  38. ncbi request reprint Chromosomal instability by beta-catenin/TCF transcription in APC or beta-catenin mutant cells
    K Aoki
    Department of Pharmacology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Oncogene 26:3511-20. 2007
    ..These results collectively indicate that beta-catenin/TCF-mediated transcription itself increases CIN through dysregulation of G2/M progression...