Kei Takenaka

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells
    Kei Takenaka
    Division of Cancer Genomics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 353:501-8. 2007
  2. ncbi request reprint Phospholipase Cdelta4: from genome structure to physiological function
    Kiyoko Fukami
    Department of Biochemistry, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8039, Japan
    Adv Enzyme Regul 43:87-106. 2003
  3. ncbi request reprint Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels
    Yoshiaki Kise
    Division of Cancer Genomics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 351:78-84. 2006
  4. pmc Phospholipase Cdelta1 is required for skin stem cell lineage commitment
    Yoshikazu Nakamura
    Department of Biochemistry, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    EMBO J 22:2981-91. 2003
  5. pmc Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling
    Kei Takenaka
    Department of Biochemistry, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Cell Biol 23:7329-38. 2003
  6. ncbi request reprint Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition
    Takashi Kanematsu
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 281:22180-9. 2006
  7. ncbi request reprint Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface
    Akiko Mizokami
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 27:1692-701. 2007

Collaborators

  • Tadaomi Takenawa
  • Takafumi Inoue
  • K Fukami
  • Y Shirakata
  • Takashi Kanematsu
  • Akiko Mizokami
  • Junichi Nabekura
  • Stephen J Moss
  • Keiichi I Nakayama
  • Masato Hirata
  • Yoshiaki Kise
  • Yoshikazu Nakamura
  • Hitoshi Ishibashi
  • Eiki Kominami
  • Tsuneyuki Yamamoto
  • Taku Yamaguchi
  • Isei Tanida
  • Hiroaki Miki
  • Atsushi Yasunaga
  • Akiko Kuratani
  • Yoshito Mizoguchi
  • Tohru Tezuka
  • Jasmina N Jovanovic
  • Tadashi Yamamoto
  • Josef T Kittler
  • Nobuaki Yoshida
  • Shin ichi Nishikawa
  • Koji Hashimoto
  • Haiyan Yu
  • Yuki Kataoka

Detail Information

Publications7

  1. ncbi request reprint GSK3beta positively regulates Hedgehog signaling through Sufu in mammalian cells
    Kei Takenaka
    Division of Cancer Genomics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 353:501-8. 2007
    ..These results strongly suggest that GSK3beta phosphorylates Sufu to positively regulate Hedgehog signaling in mammalian cells...
  2. ncbi request reprint Phospholipase Cdelta4: from genome structure to physiological function
    Kiyoko Fukami
    Department of Biochemistry, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8039, Japan
    Adv Enzyme Regul 43:87-106. 2003
  3. ncbi request reprint Fused kinase is stabilized by Cdc37/Hsp90 and enhances Gli protein levels
    Yoshiaki Kise
    Division of Cancer Genomics, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 351:78-84. 2006
    ..This growth inhibition is partially rescued by expression of ectopic Gli1, suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells...
  4. pmc Phospholipase Cdelta1 is required for skin stem cell lineage commitment
    Yoshikazu Nakamura
    Department of Biochemistry, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    EMBO J 22:2981-91. 2003
    ..From these results, we conclude that PLCdelta(1) is required for skin stem cell lineage commitment...
  5. pmc Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling
    Kei Takenaka
    Department of Biochemistry, The Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    Mol Cell Biol 23:7329-38. 2003
    ..These mice had a stronger T-cell-independent antigen response. These results indicate that PLC-L2 is a novel negative regulator of BCR signaling and immune responses...
  6. ncbi request reprint Modulation of GABA(A) receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition
    Takashi Kanematsu
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science and Station for Collaborative Research, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 281:22180-9. 2006
    ..Together, the results suggest that PRIP plays an important role in BDNF-dependent regulation of GABA(A) receptors by mediating the specific association between beta subunits of these receptors with protein phosphatases...
  7. ncbi request reprint Phospholipase C-related inactive protein is involved in trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface
    Akiko Mizokami
    Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, and Station for Collaborative Research, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 27:1692-701. 2007
    ..These results suggest that PRIP is implicated in the trafficking of gamma2 subunit-containing GABA(A) receptors to the cell surface, probably by acting as a bridging molecule between GABARAP and the receptors...