M Takekawa

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. pmc p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
    M Takekawa
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    EMBO J 19:6517-26. 2000
  2. ncbi request reprint [Stress-responsive MAP kinases]
    Mutsuhiro Takekawa
    Tanpakushitsu Kakusan Koso 47:1379-89. 2002
  3. pmc Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta
    Mutsuhiro Takekawa
    Division of Molecular Cell Signaling, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    EMBO J 21:6473-82. 2002
  4. ncbi request reprint Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation
    M Itoh
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
    Mol Endocrinol 16:2382-92. 2002
  5. ncbi request reprint Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
    H Fujimoto
    1Department of Genome Sciences, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Cell Death Differ 13:1170-80. 2006
  6. ncbi request reprint MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells
    T Shonai
    Department of Radiology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    Cell Death Differ 9:963-71. 2002
  7. ncbi request reprint Analysis of gene expression during maturation of immature dendritic cells derived from peripheral blood monocytes
    T Matsunaga
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Scand J Immunol 56:593-601. 2002
  8. doi request reprint Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
    Kyoko Arimoto
    Department of Molecular Cell Signaling, Institute of Medical Sciences, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Cell Biol 10:1324-32. 2008
  9. pmc A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway
    Kazuo Tatebayashi
    Division of Molecular Cell Signaling, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    EMBO J 22:3624-34. 2003
  10. pmc Stimulus-specific distinctions in spatial and temporal dynamics of stress-activated protein kinase kinase kinases revealed by a fluorescence resonance energy transfer biosensor
    Taichiro Tomida
    Institute of Medical Sciences, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 29:6117-27. 2009

Collaborators

Detail Information

Publications18

  1. pmc p53-inducible wip1 phosphatase mediates a negative feedback regulation of p38 MAPK-p53 signaling in response to UV radiation
    M Takekawa
    First Department of Internal Medicine, Sapporo Medical University, School of Medicine, S 1, W 16, Chuo Ku, Sapporo 060 8543, Japan
    EMBO J 19:6517-26. 2000
    ..These results suggest that p53-dependent expression of Wip1 mediates a negative feedback regulation of p38-p53 signaling and contributes to suppression of the UV-induced apoptosis...
  2. ncbi request reprint [Stress-responsive MAP kinases]
    Mutsuhiro Takekawa
    Tanpakushitsu Kakusan Koso 47:1379-89. 2002
  3. pmc Smad-dependent GADD45beta expression mediates delayed activation of p38 MAP kinase by TGF-beta
    Mutsuhiro Takekawa
    Division of Molecular Cell Signaling, Institute of Medical Science, The University of Tokyo, 4 6 1, Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    EMBO J 21:6473-82. 2002
    ..Thus TGF-beta-induced p38 activation, mediated by GADD45beta expression, may play an important role in the biological effects of TGF-beta...
  4. ncbi request reprint Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation
    M Itoh
    First Department of Internal Medicine, Sapporo Medical University School of Medicine, Sapporo, 060 8543, Japan
    Mol Endocrinol 16:2382-92. 2002
    ..Taken together, these findings suggest that JNK-mediated phosphorylation of the GR-Ser226 enhances GR nuclear export and may contribute to termination of GR-mediated transcription...
  5. ncbi request reprint Regulation of the antioncogenic Chk2 kinase by the oncogenic Wip1 phosphatase
    H Fujimoto
    1Department of Genome Sciences, Faculty of Medical Sciences, Graduate School of Medicine, Kobe University, 7 5 1, Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    Cell Death Differ 13:1170-80. 2006
    ....
  6. ncbi request reprint MEK/ERK pathway protects ionizing radiation-induced loss of mitochondrial membrane potential and cell death in lymphocytic leukemia cells
    T Shonai
    Department of Radiology, Sapporo Medical University School of Medicine, S 1, W 16, Chuo Ku, Sapporo, 060 8543, Japan
    Cell Death Differ 9:963-71. 2002
    ..Our data enlighten an anti-apoptotic function of MEK/ERK pathway against IR-induced apoptosis, thereby implying its contribution to radioresistance...
  7. ncbi request reprint Analysis of gene expression during maturation of immature dendritic cells derived from peripheral blood monocytes
    T Matsunaga
    First Department of Internal Medicine, Sapporo Medical University, Sapporo, Japan
    Scand J Immunol 56:593-601. 2002
    ..PSMA3 was also induced in the DCs stimulated with immune complex. These findings might contribute to our understanding of DC maturation and the effectiveness of DC-based vaccines...
  8. doi request reprint Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
    Kyoko Arimoto
    Department of Molecular Cell Signaling, Institute of Medical Sciences, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Nat Cell Biol 10:1324-32. 2008
    ..Thus, type 1 conditions suppress activation of the MTK1-SAPK pathway and apoptosis induced by type 2 stress. These findings may be relevant to the problem of hypoxia-induced resistance to cancer chemotherapy...
  9. pmc A docking site determining specificity of Pbs2 MAPKK for Ssk2/Ssk22 MAPKKKs in the yeast HOG pathway
    Kazuo Tatebayashi
    Division of Molecular Cell Signaling, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    EMBO J 22:3624-34. 2003
    ..Thus, the docking site contributes to both the efficiency and specificity of signaling. During these analyses, we also found a nuclear export signal and a possible nuclear localization signal in Pbs2...
  10. pmc Stimulus-specific distinctions in spatial and temporal dynamics of stress-activated protein kinase kinase kinases revealed by a fluorescence resonance energy transfer biosensor
    Taichiro Tomida
    Institute of Medical Sciences, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 29:6117-27. 2009
    ..These observations revealed previously unknown heterogeneity in SAPK responses and supplied answers to the question of the cellular location in which various stresses induce stimulus-specific SAPK responses...
  11. ncbi request reprint Conserved docking site is essential for activation of mammalian MAP kinase kinases by specific MAP kinase kinase kinases
    Mutsuhiro Takekawa
    Division of Molecular Cell Signaling, Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell 18:295-306. 2005
    ..Synthetic DVD oligopeptides inhibited specific MAPKK activation, both in vitro and in vivo, demonstrating the critical importance of the DVD docking in MAPK signaling...
  12. pmc Activation of MTK1/MEKK4 by GADD45 through induced N-C dissociation and dimerization-mediated trans autophosphorylation of the MTK1 kinase domain
    Zenshi Miyake
    Institute of Medical Sciences, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 27:2765-76. 2007
    ..Constitutively active MTK1 mutants induced the same events, but in the absence of GADD45...
  13. ncbi request reprint Usage of tautomycetin, a novel inhibitor of protein phosphatase 1 (PP1), reveals that PP1 is a positive regulator of Raf-1 in vivo
    Shinya Mitsuhashi
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    J Biol Chem 278:82-8. 2003
    ..Furthermore, a physical interaction between PP1C and Raf-1 was also observed. These data strongly suggest that PP1 positively regulates Raf-1 in vivo...
  14. pmc GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNgamma production in T cells
    Hongbo Chi
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT, USA
    EMBO J 23:1576-86. 2004
    ..During Th1 differentiation, the GADD45beta/GADD45gamma/MEKK4 pathway appears to integrate upstream signals transduced by both T cell receptor and IL12/STAT4, leading to augmented IFNgamma production in a process independent of STAT4...
  15. pmc Characterization of a novel low-molecular-mass dual-specificity phosphatase-3 (LDP-3) that enhances activation of JNK and p38
    Kentaro Takagaki
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita 15, Nishi 7, Kita ku, Sapporo 060 0815, Japan
    Biochem J 383:447-55. 2004
    ..4 M sorbitol. By screening with a variety of stimuli, we found that LDP-3 specifically enhances the osmotic stress-induced activation of JNK and p38...
  16. ncbi request reprint A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurring substitution that affects substrate specificity
    Koji Nakamura
    Division of Biochemical Oncology and Immunology, Institute for Genetic Medicine, Hokkaido University, Kita ku, Sapporo 060 0815, Japan
    J Biochem 132:463-70. 2002
    ..We first found that VHR inhibits the activation of p38 as well as ERK and JNK, with similar efficiency. Under the conditions used, LDP-2 specifically suppressed JNK activation...
  17. pmc NF-kappaB inhibits TNF-induced accumulation of ROS that mediate prolonged MAPK activation and necrotic cell death
    Sachiko Sakon
    Department of Immunology, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo, Japan
    EMBO J 22:3898-909. 2003
    ..or prolonged MAPK activation in wild-type MEFs, indicating that TRAF-mediated NF-kappaB activation normally suppresses the TNF-induced ROS accumulation that subsequently induces prolonged MAPK activation and necrotic cell death..
  18. pmc Regulation of MTK1/MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding
    Hiroaki Mita
    Dana Farber Cancer Institute and Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 22:4544-55. 2002
    ..These MTK1 mutants are constitutively active, in both yeast and mammalian cells. A model of MTK1 autoinhibition by the N-terminal inhibitory domain and activation by GADD45 binding is presented...