Shu Takeda

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Common endocrine control of body weight, reproduction, and bone mass
    Shu Takeda
    Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Nutr 23:403-11. 2003
  2. doi request reprint Molecular bases of the sympathetic regulation of bone mass
    Shu Takeda
    Department of Orthopaedic Surgery, Graduate School, 21st Century Center of Excellence Program, Tokyo Medical and Dental University 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Bone 42:837-40. 2008
  3. doi request reprint Osteoporosis: a neuroskeletal disease?
    Shu Takeda
    Department of Orthopaedic Surgery, Tokyo Medical and Dental School Graduate School, Tokyo, Japan
    Int J Biochem Cell Biol 41:455-9. 2009
  4. doi request reprint Central control of bone remodelling
    S Takeda
    Department of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Neuroendocrinol 20:802-7. 2008
  5. ncbi request reprint Central control of bone remodeling
    Shu Takeda
    Department of Orthopedics, 21st Century Center of Excellence COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Biochem Biophys Res Commun 328:697-9. 2005
  6. ncbi request reprint Central control of bone remodeling by neuromedin U
    Shingo Sato
    Department of Orthopaedic Surgery, Graduate School, 21st Century Center of Excellence Program, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Nat Med 13:1234-40. 2007
  7. doi request reprint The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease
    Shingo Sato
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 58:2764-75. 2008
  8. pmc Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor
    Ryo Hanyu
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 113 8510 Tokyo, Japan
    Proc Natl Acad Sci U S A 109:7433-8. 2012
  9. doi request reprint Vitamin E decreases bone mass by stimulating osteoclast fusion
    Koji Fujita
    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Nat Med 18:589-94. 2012
  10. pmc A microRNA regulatory mechanism of osteoblast differentiation
    Hiroyuki Inose
    Department of Orthopedics, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 106:20794-9. 2009

Detail Information

Publications41

  1. ncbi request reprint Common endocrine control of body weight, reproduction, and bone mass
    Shu Takeda
    Department of Molecular and Human Genetics and Bone Disease Program of Texas, Baylor College of Medicine, Houston, Texas 77030, USA
    Annu Rev Nutr 23:403-11. 2003
    ..Sympathomimetics administered to mice decreased bone formation and bone mass. Conversely, beta-blockers increased bone formation and bone mass and blunted the bone loss induced by ovariectomy...
  2. doi request reprint Molecular bases of the sympathetic regulation of bone mass
    Shu Takeda
    Department of Orthopaedic Surgery, Graduate School, 21st Century Center of Excellence Program, Tokyo Medical and Dental University 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Bone 42:837-40. 2008
    ..We also discussed the antagonistic role played by two beta adrenergic receptors in this regulation and the relevance of these results obtained through studies of model organisms to human physiology and pathology...
  3. doi request reprint Osteoporosis: a neuroskeletal disease?
    Shu Takeda
    Department of Orthopaedic Surgery, Tokyo Medical and Dental School Graduate School, Tokyo, Japan
    Int J Biochem Cell Biol 41:455-9. 2009
    ..Namely, like all other homeostatic functions, bone remodelling is under the control of the hypothalamus, and osteoporosis is considered to be a neuroskeletal disease...
  4. doi request reprint Central control of bone remodelling
    S Takeda
    Department of Orthopaedic Surgery, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Neuroendocrinol 20:802-7. 2008
    ..This review summarises the genetic, molecular and physiological bases for the central control of bone remodelling and discusses the future directions of this new research field of neuroskeletal biology...
  5. ncbi request reprint Central control of bone remodeling
    Shu Takeda
    Department of Orthopedics, 21st Century Center of Excellence COE Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
    Biochem Biophys Res Commun 328:697-9. 2005
    ..Mice deficient for catecholamines have high bone mass. beta-Receptor agonists decreased bone mass, and conversely, treatment by beta-blockers increased bone mass...
  6. ncbi request reprint Central control of bone remodeling by neuromedin U
    Shingo Sato
    Department of Orthopaedic Surgery, Graduate School, 21st Century Center of Excellence Program, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo 113 8519, Japan
    Nat Med 13:1234-40. 2007
    ..Given the existence of inhibitors and activators of NMU action, our results may influence the treatment of diseases involving low bone mass, such as osteoporosis...
  7. doi request reprint The distinct role of the Runx proteins in chondrocyte differentiation and intervertebral disc degeneration: findings in murine models and in human disease
    Shingo Sato
    Tokyo Medical and Dental University, Tokyo, Japan
    Arthritis Rheum 58:2764-75. 2008
    ....
  8. pmc Anabolic action of parathyroid hormone regulated by the β2-adrenergic receptor
    Ryo Hanyu
    Department of Molecular Pharmacology, Medical Research Institute, Tokyo Medical and Dental University, 113 8510 Tokyo, Japan
    Proc Natl Acad Sci U S A 109:7433-8. 2012
    ..These data implicate an unexpected functional interaction between PTHR and β(2)AR, two G protein-coupled receptors from distinct families, which control bone formation and PTH anabolism...
  9. doi request reprint Vitamin E decreases bone mass by stimulating osteoclast fusion
    Koji Fujita
    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    Nat Med 18:589-94. 2012
    ..These results show that serum vitamin E is a determinant of bone mass through its regulation of osteoclast fusion...
  10. pmc A microRNA regulatory mechanism of osteoblast differentiation
    Hiroyuki Inose
    Department of Orthopedics, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8519, Japan
    Proc Natl Acad Sci U S A 106:20794-9. 2009
    ..Finally, transgenic mice expressing miR-206 in osteoblasts developed a low bone mass phenotype due to impaired osteoblast differentiation. Our data show that miRNA is a regulator of osteoblast differentiation...
  11. ncbi request reprint Leptin regulation of bone resorption by the sympathetic nervous system and CART
    Florent Elefteriou
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Nature 434:514-20. 2005
    ..Our study establishes that leptin-regulated neural pathways control both aspects of bone remodelling, and demonstrates that integrity of sympathetic signalling is necessary for the increase in bone resorption caused by gonadal failure...
  12. ncbi request reprint Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system
    Hisataka Kondo
    Department of Molecular Pharmacology, Tokyo Medical and Dental University, Japan
    J Biol Chem 280:30192-200. 2005
    ..These observations indicated that sympathetic nervous tone mediates unloading-induced bone loss through suppression of bone formation by osteoblasts and enhancement of resorption by osteoclasts...
  13. pmc Runx2 haploinsufficiency ameliorates the development of ossification of the posterior longitudinal ligament
    Makiko Iwasaki
    Department of Orthopedic Surgery, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS ONE 7:e43372. 2012
    ..Collectively, this study demonstrated that Runx2 is expressed in an OPLL-like region, and its elevation is a prerequisite for developing the complete OPLL-like phenotype in a mouse model of OPLL...
  14. pmc Maf promotes osteoblast differentiation in mice by mediating the age-related switch in mesenchymal cell differentiation
    Keizo Nishikawa
    Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo, Japan
    J Clin Invest 120:3455-65. 2010
    ..This study identifies a transcriptional mechanism for an age-related switch in cell fate determination and may provide a molecular basis for novel therapeutic strategies against age-related bone diseases...
  15. doi request reprint [Effect of obesity on bone metabolism]
    Shu Takeda
    Tokyo Medical and Dental University Graduate School, Department of Orthopedics
    Clin Calcium 18:632-7. 2008
    ..As a result, it has been generally believed that obesity leads to an increase in bone mass. However, recent observations revealed that excessive fat mass may not protect against osteoporotic fractures...
  16. ncbi request reprint Monosodium glutamate-sensitive hypothalamic neurons contribute to the control of bone mass
    Florent Elefteriou
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Endocrinology 144:3842-7. 2003
    ..It also indicates that NPY deficiency does not affect bone mass...
  17. pmc Sympathetic control of bone mass regulated by osteopontin
    Masashi Nagao
    Department of Molecular Pharmacology, Medical Research Institute, and Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, 113 8510 Tokyo, Japan
    Proc Natl Acad Sci U S A 108:17767-72. 2011
    ..Our results indicate that OPN plays a critical role in sympathetic tone regulation of bone mass and that this OPN regulation is taking place through modulation of the β2-adrenergic receptor/cAMP signaling system...
  18. pmc Runx1 and Runx2 cooperate during sternal morphogenesis
    Ayako Kimura
    Department of Orthopaedics, Graduate School, Tokyo Medical and Dental University, Tokyo 113 8519, Japan
    Development 137:1159-67. 2010
    ..Collectively, these results show that Runx1 and Runx2 cooperatively regulate sternal morphogenesis and the commitment of mesenchymal cells to become chondrocytes through the induction of Sox5 and Sox6...
  19. ncbi request reprint Estrogen prevents bone loss via estrogen receptor alpha and induction of Fas ligand in osteoclasts
    Takashi Nakamura
    Institute of Molecular and Cellular Biosciences, University of Tokyo, Yayoi 1 1 1, Bunkyo ku, Tokyo 113 0032, Japan
    Cell 130:811-23. 2007
    ..Our results support a model in which estrogen regulates the life span of mature osteoclasts via the induction of the Fas/FasL system, thereby providing an explanation for the osteoprotective function of estrogen as well as SERMs...
  20. ncbi request reprint Leptin regulates bone formation via the sympathetic nervous system
    Shu Takeda
    Department of Molecular and Human Genetics, One Baylor Plaza, Houston, TX 77030, USA
    Cell 111:305-17. 2002
    ..None of these manipulations affects body weight. This study demonstrates a leptin-dependent neuronal regulation of bone formation with potential therapeutic implications for osteoporosis...
  21. doi request reprint [Genomic approaches to bone and joint diseases. Control of bone remodeling by hormones and neuronal pathways]
    Shu Takeda
    Tokyo Medical and Dental University, Department of Orthopedics
    Clin Calcium 18:216-21. 2008
    ..Furthermore, other neuropeptides, such as cocaine- and amphetamine-regulated transcript or neuromedin U, have been shown to be intimately involved in bone remodeling...
  22. doi request reprint Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development
    Dai Suzuki
    Department of Biochemistry, Showa University, Hatanodai, Shinagawa, Tokyo, Japan
    Dev Biol 335:396-406. 2009
    ..Our findings from Rac1 conditional mutants indicate crucial roles for Rac1 in limb bud morphogenesis, especially interdigital programmed cell death...
  23. ncbi request reprint [Central control of bone metabolism]
    Shu Takeda
    Department of Orthopedics, Center of Excellence Program for Frontier Research on Molecular Destruction and Reconstruction of Tooth and Bone, Tokyo Medical and Dental University
    Clin Calcium 15:797-804. 2005
    ..Thus, leptin regulates not only bone formation but bone resorption centrally...
  24. ncbi request reprint Interleukin-11 as a stimulatory factor for bone formation prevents bone loss with advancing age in mice
    Yasuhiro Takeuchi
    Division of Endocrinology and Nephrology, Department of Medicine, University of Tokyo School of Medicine, Japan
    J Biol Chem 277:49011-8. 2002
    ..These results indicate that IL-11 is a stimulatory factor for osteoblastogenesis and bone formation to conserve cortical bone, possibly by enhancing BMP actions in bone. IL-11 may be a new therapeutic target for senile osteoporosis...
  25. ncbi request reprint Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability
    Satoru Kamekura
    Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 54:2462-70. 2006
    ..By producing instability in mouse knee joints, we attempted to determine the involvement of runt-related transcription factor 2 (RUNX-2), which is required for chondrocyte hypertrophy, in the development of osteoarthritis (OA)...
  26. ncbi request reprint Co-overexpression of GDNF and GFRalpha1 induces neural differentiation in neural progenitor cells in comparison to bone marrow stromal cells
    Yukiko Nojiri
    Section of Orthopaedic and Spinal Surgery, Tokyo Medical and Dental University Graduate School, 1 5 45 Yushima, Bunkyoku, Tokyo, 113 8519, Japan
    J Med Dent Sci 55:121-8. 2008
    ..These results suggest that augmentation of both GDNF and GFRalpha1 could have positive effects during neural tissue repair...
  27. ncbi request reprint Role of central leptin signaling in renal macrophage infiltration
    Miyako Tanaka
    Department of Molecular Medicine and Metabolism, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    Endocr J 57:61-72. 2010
    ....
  28. pmc The Role of Individual Domains and the Significance of Shedding of ATP6AP2/(pro)renin Receptor in Vacuolar H(+)-ATPase Biogenesis
    Kenichiro Kinouchi
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e78603. 2013
    ..The V-ATPase assembly occurs prior to its delivery to the trans-Golgi network and hence shedding of ATP6AP2/PRR would not affect the biogenesis of active V-ATPase. ..
  29. doi request reprint Enhancement of fracture healing by electrical stimulation in the comminuted intraarticular fracture of distal radius
    Kazuhiro Kohata
    Department of Orthopedic Surgery, Kawakita General Hospital, Tokyo, Japan Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
    Biomed Mater Eng 23:485-93. 2013
    ....
  30. doi request reprint The effects of risedronate administered in combination with a proton pump inhibitor for the treatment of osteoporosis
    Soichiro Itoh
    Department of Orthopaedic Surgery, Kawakita General Hospital, 1 7 3 Asagaya kita, Suginami ku, Tokyo 166 8588, Japan
    J Bone Miner Metab 31:206-11. 2013
    ..It is expected that risedronate administration in combination with a PPI may be more effective not only for treating osteoporosis but also improving physical fitness than treatment with risedronate alone...
  31. ncbi request reprint [Statins as possible therapeutic tools for osteoporosis]
    Yasuhiro Takeuchi
    Division of Endocrinology and Nephrology, Department of Medicine, University of Tokyo School of Medicine, Tokyo, Japan
    Clin Calcium 14:302-7. 2004
    ..Here we briefly review the role of statins in bone metabolism through the survey of clinical observations...
  32. ncbi request reprint Effect of acute changes of serum phosphate on fibroblast growth factor (FGF)23 levels in humans
    Nobuaki Ito
    Division of Nephrology and Endocrinology, Department of Internal Medicine, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Bone Miner Metab 25:419-22. 2007
    ..However, FGF23 did not change by these maneuvers. It is concluded that acute changes of serum phosphate do not modify FGF23 levels in the healthy human...
  33. ncbi request reprint Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass
    P Ducy
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Cell 100:197-207. 2000
    ..This study identifies leptin as a potent inhibitor of bone formation acting through the central nervous system and therefore describes the central nature of bone mass control and its disorders...
  34. ncbi request reprint Central control of bone formation
    S Takeda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    J Bone Miner Metab 19:195-8. 2001
    ..This finding also has therapeutic implications...
  35. pmc Serum leptin level is a regulator of bone mass
    F Elefteriou
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, Houston, TX 77030, USA
    Proc Natl Acad Sci U S A 101:3258-63. 2004
    ..Taken together, these results indicate that adipocyte-derived circulating leptin is a determinant of bone formation and suggests that leptin antiosteogenic function is conserved in vertebrates...
  36. pmc Continuous expression of Cbfa1 in nonhypertrophic chondrocytes uncovers its ability to induce hypertrophic chondrocyte differentiation and partially rescues Cbfa1-deficient mice
    S Takeda
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA
    Genes Dev 15:467-81. 2001
    ..These results identify Cbfa1 as a hypertrophic chondrocyte differentiation factor and provide a genetic argument for a common regulation of osteoblast and chondrocyte differentiation mediated by Cbfa1...
  37. ncbi request reprint ED-71, a novel vitamin D analog, promotes bone formation and angiogenesis and inhibits bone resorption after bone marrow ablation
    N Okuda
    Section of Orthopeadic Surgery, Department of Molecular Regulation of Supportive Tissue, Division of Bio Matrix, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Bone 40:281-92. 2007
    ..In this paper, we clearly demonstrate that ED-71 is an orally administered small molecular weight compound with an anabolic effect on bone metabolism...
  38. ncbi request reprint Ghrelin directly regulates bone formation
    Nobuhiro Fukushima
    Molecular Genetics, Institute of Life Science, Kurume University, Kurume, Fukuoka, Japan
    J Bone Miner Res 20:790-8. 2005
    ..Ghrelin and its receptor, GHS-R1a, were identified in osteoblasts, and ghrelin promoted both proliferation and differentiation. Furthermore, ghrelin increased BMD in rats. Our results show that ghrelin directly affects bone formation...
  39. ncbi request reprint [Control of bone remodeling by leptin and sympathetic nervous system]
    Shu Takeda
    Department of Orthopedics 21COE, Tokyo Medical and Dental University Graduate School
    Nihon Rinsho 65:105-9. 2007
  40. ncbi request reprint [Leptin and beta-blockers in bone metabolism]
    Shu Takeda
    Department of Endocrinology and Metabolism, Mishuku Hospital
    Clin Calcium 14:241-7. 2004
    ..Administration of beta-blockers in mice led to an increase in bone mass. Moreover, recent report showing that beta-blockers reduce the risk of fracture suggests their therapeutic application for osteoporosis...
  41. ncbi request reprint [The role of PPAR gamma for the osteoblastic differentiation]
    Shu Takeda
    Department of Endocrinology and Metabolism, Mishuku Hospital
    Nihon Rinsho 62:789-93. 2004