A Takeda

Summary

Affiliation: University of Shizuoka
Country: Japan

Publications

  1. ncbi request reprint Zinc transport from the striatum and substantia nigra
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
    Brain Res Bull 47:103-6. 1998
  2. doi request reprint Zinc signaling in the hippocampus and its relation to pathogenesis of depression
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Mol Neurobiol 44:166-74. 2011
  3. doi request reprint Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol
    A Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Surugaku, Shizuoka 422 8526, Japan
    Neuroscience 171:443-50. 2010
  4. doi request reprint Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurotoxicology 30:712-7. 2009
  5. doi request reprint Abnormal Ca2+ mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Epilepsy Res 83:73-80. 2009
  6. pmc Insight into glutamate excitotoxicity from synaptic zinc homeostasis
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Alzheimers Dis 2011:491597. 2010
  7. pmc Enhanced susceptibility to spontaneous seizures of noda epileptic rats by loss of synaptic zn(2+)
    Atsushi Takeda
    Department of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka, Japan
    PLoS ONE 8:e71372. 2013
  8. doi request reprint Synaptic Zn(2+) homeostasis and its significance
    Atsushi Takeda
    Department of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Metallomics 5:417-23. 2013
  9. doi request reprint Zinc signaling in the hippocampus and its relation to pathogenesis of depression
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Trace Elem Med Biol 26:80-4. 2012
  10. doi request reprint Proposed glucocorticoid-mediated zinc signaling in the hippocampus
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Shizuoka 422 8526, Japan
    Metallomics 4:614-8. 2012

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Zinc transport from the striatum and substantia nigra
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
    Brain Res Bull 47:103-6. 1998
    ....
  2. doi request reprint Zinc signaling in the hippocampus and its relation to pathogenesis of depression
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Mol Neurobiol 44:166-74. 2011
    ..This paper summarizes that hippocampal Zn²⁺ signaling serves to maintain healthy brain and that glucocorticoid signaling, which is responsive to zinc homeostasis in the living body, is linked to the pathophysiology of depression...
  3. doi request reprint Impairment of recognition memory and hippocampal long-term potentiation after acute exposure to clioquinol
    A Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Surugaku, Shizuoka 422 8526, Japan
    Neuroscience 171:443-50. 2010
    ..The CQ-mediated attenuation of dentate gyrus LTP, which may be associated with the transient lack of zinc release from zincergic neurons, seems to be involved in the impairment of the long-term memory...
  4. doi request reprint Unique response of zinc in the hippocampus to behavioral stress and attenuation of subsequent mossy fiber long-term potentiation
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurotoxicology 30:712-7. 2009
    ..It is likely that the facilitated zinc influx by tail suspension, which seems to be linked to glutamate signaling, is involved in attenuation of subsequent mossy fiber LTP...
  5. doi request reprint Abnormal Ca2+ mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Epilepsy Res 83:73-80. 2009
    ..It is likely that abnormal Ca(2+) mobilization in neurons is involved in seizure susceptibility in zinc-deficient animals...
  6. pmc Insight into glutamate excitotoxicity from synaptic zinc homeostasis
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Int J Alzheimers Dis 2011:491597. 2010
    ..This paper summarizes the role of Zn(2+) signaling in glutamate excitotoxicity, which is involved in Alzheimer's disease, to understand the significance of synaptic Zn(2+) homeostasis in the pathophysiology of Alzheimer's disease...
  7. pmc Enhanced susceptibility to spontaneous seizures of noda epileptic rats by loss of synaptic zn(2+)
    Atsushi Takeda
    Department of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka, Japan
    PLoS ONE 8:e71372. 2013
    ....
  8. doi request reprint Synaptic Zn(2+) homeostasis and its significance
    Atsushi Takeda
    Department of Bioorganic Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Metallomics 5:417-23. 2013
    ..Synaptic Zn(2+) homeostasis is affected by the enhanced glutamatergic (zincergic) neuron activity. This paper summarizes the significance of synaptic Zn(2+) homeostasis in zincergic neuron activity...
  9. doi request reprint Zinc signaling in the hippocampus and its relation to pathogenesis of depression
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    J Trace Elem Med Biol 26:80-4. 2012
    ....
  10. doi request reprint Proposed glucocorticoid-mediated zinc signaling in the hippocampus
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Shizuoka 422 8526, Japan
    Metallomics 4:614-8. 2012
    ..This paper analyzes the actions of glucocorticoid-mediated Zn(2+) signal in the hippocampus under stressful circumstances and its significance in both hippocampal function and dysfunction...
  11. doi request reprint Therapeutic effect of Yokukansan on social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res Bull 87:551-5. 2012
    ..These results suggest that Yokukansan ameliorates social isolation-induced aggressive behavior of zinc-deficient and pair-fed mice through the action against glutamatergic neurotransmitter system and other neurotransmitter systems...
  12. doi request reprint Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Neurochem Int 60:394-9. 2012
    ..The present study suggests that corticosterone-mediated increase in postsynaptic Zn(2+) signal in the cytosolic compartment is involved in the attenuation of CA1 LTP after exposure to acute stress...
  13. ncbi request reprint Responsiveness to kainate in young rats after 2-week zinc deprivation
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
    Biometals 19:565-72. 2006
    ..The alteration of calcium signaling seems to be involved in the susceptibility in zinc deficiency...
  14. ncbi request reprint Zinc release in the lateral nucleus of the amygdala by stimulation of the entorhinal cortex
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Brain Res 1118:52-7. 2006
    ..The present study suggested that zinc is released in the lateral nucleus of the amygdala by depolarization of the entorhinal neurons. In the lateral nucleus, zinc released may suppress the increase in presynaptic calcium signal...
  15. ncbi request reprint Response of hippocampal mossy fiber zinc to excessive glutamate release
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Neurochem Int 50:322-7. 2007
    ..These results suggest that zinc released from mossy fibers attenuates the increase in intracellular calcium signal in mossy fiber synapses and postsynaptic CA3 neurons after excessive inputs to dentate granular cells...
  16. ncbi request reprint Anxiety-like behavior of young rats after 2-week zinc deprivation
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Behav Brain Res 177:1-6. 2007
    ....
  17. ncbi request reprint Role of zinc influx via AMPA/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Neurosci Res 85:1310-7. 2007
    ..The present study indicates that the increase in free calcium levels via the metabotropic glutamate receptor pathway is inversely related to free zinc levels in CA3 pyramidal cells...
  18. ncbi request reprint Negative modulation of presynaptic activity by zinc released from Schaffer collaterals
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka, Japan
    J Neurosci Res 85:3666-72. 2007
    ..These results suggest that zinc attenuates excitation of Schaffer collateral synapses elicited with glutamate via suppression of presynaptic activity...
  19. ncbi request reprint Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Neurochem Int 52:241-6. 2008
    ....
  20. ncbi request reprint Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurochem Int 49:746-50. 2006
    ..These results suggest that GABAergic neurotransmitter system is critically impaired in the amygdala of young rats after 4-week zinc deprivation...
  21. ncbi request reprint Response of extracellular zinc in the ventral hippocampus against novelty stress
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Neurochem 99:670-6. 2006
    ..The zinc uptake may be involved in the response to painless psychological stress or in the cognitive processes...
  22. ncbi request reprint [Essential trace metals and brain function]
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Yakugaku Zasshi 124:577-85. 2004
    ..The homeostasis of trace metals in the brain is important for brain function and also for the prevention of brain diseases...
  23. ncbi request reprint Zinc homeostasis in the hippocampus of zinc-deficient young adult rats
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Neurochem Int 46:221-5. 2005
    ..It is likely that zinc-requiring systems in the nucleus are more responsive to zinc deficiency than vesicular zinc. This responsiveness appears to be involved in the transient learning impairment...
  24. ncbi request reprint Enhanced excitability of hippocampal mossy fibers and CA3 neurons under dietary zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Epilepsy Res 63:77-84. 2005
    ..The alteration of hippocampal calcium homeostasis seems to enhance excitability of dentate granular cells in zinc deficiency, following by an enhanced excitability of postsynaptic structures in CA3 neurons...
  25. ncbi request reprint Change of zinc uptake under growth arrest and apoptosis
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Anticancer Res 24:3869-74. 2004
    ..The present study demonstrates that zinc uptake is involved not only in the process of cell proliferation, but also in the process of apoptosis...
  26. ncbi request reprint Involvement of unusual glutamate release in kainate-induced seizures in zinc-deficient adult rats
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Epilepsy Res 66:137-43. 2005
    ..These results suggest that GABA can be excessively released in zinc-deficient adult rats. An unusual glutamate release may be involved in the enhanced susceptibility to kainate-induced seizures in zinc-deficient adult rats...
  27. ncbi request reprint Increase in hippocampal cell death after treatment with kainate in zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Neurochem Int 47:539-44. 2005
    ..Synaptically released zinc may be less involved in kainate-induced hippocampal cell death in zinc deficiency...
  28. ncbi request reprint Zinc release from Schaffer collaterals and its significance
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Brain Res Bull 68:442-7. 2006
    ..These results suggest that zinc released from Schaffer collaterals suppressively modulates presynaptic and postsynaptic calcium signaling in the CA1, followed by the suppression of glutamate release...
  29. ncbi request reprint Region-specific loss of zinc in the brain in pentylentetrazole-induced seizures and seizure susceptibility in zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Epilepsy Res 70:41-8. 2006
    ..These results suggest that the decrease in zinc concentration in the hippocampus in zinc deficiency does not influence susceptibility to pentylentetrazole-induced seizures...
  30. doi request reprint Enhancement of hippocampal mossy fiber activity in zinc deficiency and its influence on behavior
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biometals 21:545-52. 2008
    ..This decrease seems to be also involved in neuropsychological behavior in zinc deficiency...
  31. doi request reprint Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Life Sci 82:909-14. 2008
    ..The changes in neurotransmitter homeostasis, probably via the increase in serum corticosterone, seem to be linked to aggressive behavior elicited by social isolation in zinc deficiency...
  32. doi request reprint Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Neurosci Res 86:2906-11. 2008
    ..Targeting molecules of zinc in mossy fiber LTP seem to be different between during and after LTP induction because of the differential synaptic activity between them...
  33. pmc Transient increase in Zn2+ in hippocampal CA1 pyramidal neurons causes reversible memory deficit
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, Suruga ku, Shizuoka, Japan
    PLoS ONE 6:e28615. 2011
    ..The present study indicates that the transient increase in cytosolic Zn(2+) in CA1 pyramidal neurons reversibly impairs object recognition memory...
  34. doi request reprint Involvement of N-methyl-D-aspartate receptor subunits in zinc-mediated modification of CA1 long-term potentiation in the developing hippocampus
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, Shizuoka, Japan
    J Neurosci Res 90:551-8. 2012
    ..It is likely that the changes in expression of NMDA receptor subunits are involved in the zinc-mediated modification of CA1 LTP in the developing hippocampus...
  35. doi request reprint Significance of serum glucocorticoid and chelatable zinc in depression and cognition in zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Behav Brain Res 226:259-64. 2012
    ..These results suggest that the chronic increase in serum glucocorticoid level is involved in the increase in depression-like behavior rather than the decrease in chelatable zinc after 4-week zinc deficiency...
  36. doi request reprint Unique induction of CA1 LTP components after intake of theanine, an amino acid in tea leaves and its effect on stress response
    Atsushi Takeda
    Graduate School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka, 422 8526, Japan
    Cell Mol Neurobiol 32:41-8. 2012
    ..This study is the first to indicate that theanine intake modifies the mechanism of CA1 LTP induction...
  37. doi request reprint Facilitated neurogenesis in the developing hippocampus after intake of theanine, an amino acid in tea leaves, and object recognition memory
    Atsushi Takeda
    Graduate School of Pharmaceutical Sciences, University of Shizuoka, Global COE, Shizuoka, Japan
    Cell Mol Neurobiol 31:1079-88. 2011
    ..3% theanine administration facilitates neurogenesis in the developing hippocampus followed by enhanced recognition memory. Theanine intake may be of benefit to the postnatal development of hippocampal function...
  38. doi request reprint Differential effects of zinc influx via AMPA/kainate receptor activation on subsequent induction of hippocampal CA1 LTP components
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Brain Res 1354:188-95. 2010
    ..Zinc influx via AMPA/kainate receptor activation may differentially act on subsequent induction of CA1 LTP components...
  39. doi request reprint Increases in extracellular zinc in the amygdala in acquisition and recall of fear experience and their roles in response to fear
    A Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neuroscience 168:715-22. 2010
    ..The present paper demonstrates that zinc released in the lateral amygdala may participate in emotional behavior in response to fear...
  40. doi request reprint Zinc differentially acts on components of long-term potentiation at hippocampal CA1 synapses
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Brain Res 1323:59-64. 2010
    ..The present study suggests that zinc differentially acts on CA1 LTP components...
  41. doi request reprint Insight into zinc signaling from dietary zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, University of Shizuoka, Yada, Suruga ku, Japan
    Brain Res Rev 62:33-44. 2009
    ....
  42. doi request reprint Facilitation of zinc influx via AMPA/kainate receptor activation in the hippocampus
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE 21, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurochem Int 55:376-82. 2009
    ..It is likely that zinc influx is persistently facilitated via stress-induced glutamatergic neuron activation...
  43. doi request reprint Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar concentrations of zinc
    A Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neuroscience 158:585-91. 2009
    ..It is likely that Zn(2+) taken up during LTP induction potentiates CA1 LTP via NMDA receptor activation...
  44. doi request reprint Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan
    Atsushi Takeda
    Department of Medical Biochemistry, University of Shizuoka, 52 1 Yada, Suruga ku, Shizuoka 422 8526, Japan
    Neurochem Int 53:230-5. 2008
    ..The enhanced exocytosis in zinc deficiency is a possible mechanism on abnormal increase in extracellular glutamate in the hippocampus induced with high K(+)...
  45. doi request reprint Suppressive effect of Yokukansan on excessive release of glutamate and aspartate in the hippocampus of zinc-deficient rats
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    Nutr Neurosci 11:41-6. 2008
    ..The present study demonstrates that Yokukansan is a possible medicine for prevention or cure of neurological diseases associated with excitotoxicity...
  46. ncbi request reprint Release of amino acids by zinc in the hippocampus
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res Bull 63:253-7. 2004
    ..Zinc seems to modulate glutamatergic synapses multifunctionally in the hippocampus, because glutamine, serine, aspartate, and glycine are involved in synaptic neurotransmission...
  47. ncbi request reprint In vivo stimulation-induced release of manganese in rat amygdala
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res 811:147-51. 1998
    ..The results suggest that the role of manganese ions in the amygdala, and probably in the olfactory system, is dynamically linked to neural signalling processes...
  48. ncbi request reprint Influence of manganese on the release of neurotransmitters in rat striatum
    A Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res 965:279-82. 2003
    ..These results suggest that manganese released into the synaptic cleft in a calcium- and impulse-dependent manner may influence GABA release in the striatum...
  49. ncbi request reprint Possible involvement of plasma histidine in differential brain permeability to zinc and cadmium
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharnaceutical Sciences, University of Shizuoka, Japan
    Biometals 15:371-5. 2002
    ..These results suggest that the avid binding of cadmium to plasma proteins is related to brain impermeability to this metal...
  50. ncbi request reprint Influence of iron-saturation of plasma transferrin in iron distribution in the brain
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526 Shizuoka, Japan
    Neurochem Int 41:223-8. 2002
    ..Transferrin-bound iron may be responsible for the fraction of iron in circulation that enters the brain...
  51. ncbi request reprint Abnormal iron delivery to the bone marrow in neonatal hypotransferrinemic mice
    Atsushi Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
    Biometals 15:33-6. 2002
    ..However, the iron seems to be unavailable for the production of hemoglobin. These results suggest that transferrin-dependent iron uptake by erythroid cells in the bone marrow is essential for the development of erythrocytes...
  52. ncbi request reprint Zinc homeostasis and functions of zinc in the brain
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Biometals 14:343-51. 2001
    ..Therefore, zinc homeostasis in the brain is closely related to neuronal activity. Even in adult animals and probably adult humans, adequate zinc supply is important for brain functions and prevention of neurological diseases...
  53. ncbi request reprint Abnormal iron accumulation in the brain of neonatal hypotransferrinemic mice
    A Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Brain Res 912:154-61. 2001
    ..It is likely that the management of iron is different in the brain of HP mice...
  54. ncbi request reprint Zinc-65 imaging of rat brain tumors
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422 8526, Japan
    Cancer Res 61:5065-9. 2001
    ..It is likely that zinc uptake is more specific for brain tumors than is FDG uptake, which suggests that there is great potential for the use of (69m)Zn, a short half-life gamma emitter, in the diagnosis of brain tumors...
  55. ncbi request reprint Zinc homeostasis in the brain of adult rats fed zinc-deficient diet
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Neurosci Res 63:447-52. 2001
    ..The hippocampal formation may be the most responsive to dietary zinc deprivation in the adult brain. The present finding demonstrates that zinc homeostasis in the brain is altered by chronically dietary zinc deprivation...
  56. ncbi request reprint Movement of zinc and its functional significance in the brain
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res Brain Res Rev 34:137-48. 2000
    ..Therefore, zinc homeostasis in the presynaptic vesicle is important for the function of zinc-containing glutaminergic neurons...
  57. ncbi request reprint Manganese influences the levels of neurotransmitters in synapses in rat brain
    A Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Neuroscience 114:669-74. 2002
    ..The present findings demonstrate that manganese released into the synaptic cleft may influence synaptic neurotransmission...
  58. ncbi request reprint 65Zn localization in rat brain after intracerebroventricular injection of 65Zn-histidine
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Brain Res 863:241-4. 2000
    ..These results suggest an enhancement by histidine on zinc uptake in the brain parenchyma via the CSF...
  59. ncbi request reprint Influence of transferrin on manganese uptake in rat brain
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Neurosci Res 59:542-52. 2000
    ..It is likely that Tf-bound Mn in the CSF is less readily transported into the brain parenchymal cells than the non-Tf-bound form. These results suggest that Mn is transported into the brain efficiently via a Tf-independent uptake system...
  60. ncbi request reprint 109Cd transport in rat brain
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
    Brain Res Bull 49:453-7. 1999
    ..These results suggest that Cd cannot easily move in the brain extracelular space, and is taken up into the brain parenchyma...
  61. ncbi request reprint Role of zinc released by stimulation in rat amygdala
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Neurosci Res 57:405-10. 1999
    ..The olfactory sensation was temporarily disturbed by the perfusion. These results suggest that vesicular zinc is essential to the function of the amygdala, e.g., olfactory function...
  62. ncbi request reprint Release of zinc from the brain of El (epilepsy) mice during seizure induction
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, 422 8526, Japan
    Brain Res 828:174-8. 1999
    ..The decrease in actively functioning zinc in the brain may be associated with the increase in susceptibility to seizure in the El mouse...
  63. ncbi request reprint Release of glutamate and GABA in the hippocampus under zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    J Neurosci Res 72:537-42. 2003
    ..The present study suggests that the excitability of hippocampal glutamatergic neurons is enhanced by dietary zinc deficiency...
  64. ncbi request reprint Susceptibility to kainate-induced seizures under dietary zinc deficiency
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka, Japan
    J Neurochem 85:1575-80. 2003
    ..The present results demonstrate an enhanced release of glutamate associated with a decrease in GABA concentrations as a possible mechanism for the increased seizure susceptibility under zinc deficiency...
  65. ncbi request reprint Involvement of amygdalar extracellular zinc in rat behavior for passive avoidance
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Neurosci Lett 358:119-22. 2004
    ..On the other hand, the behavior during perfusion with ZnEDTA was more rapidly developed than that with vehicle only. These results suggest that amygdalar extracellular zinc is involved in the behavior for passive avoidance...
  66. ncbi request reprint Elimination of zinc-65 from the brain under kainate-induced seizures
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Biometals 17:141-4. 2004
    ..These results demonstrate that kainate-induced seizures are linked to decreased zinc concentrations in the brain...
  67. ncbi request reprint Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Neurosci Res 75:225-9. 2004
    ..Zinc seems to be an inhibitory neuromodulator of glutamate release...
  68. ncbi request reprint Zinc movement in the brain under kainate-induced seizures
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Epilepsy Res 54:123-9. 2003
    ..The present study suggests that the excessive release of zinc and glutamate from the neuron terminals under kainate-induced seizures is associated with the loss of zinc from the brain...
  69. ncbi request reprint Manganese uptake into rat brain during development and aging
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Neurosci Res 56:93-8. 1999
    ..In the 5-day-old brain, 54Mn was relatively concentrated in the hippocampal CA3 and dentate gyrus and the pons. In the aging brain, 54Mn was relatively concentrated in the inferior colliculi, olivary nuclei and red nuclei...
  70. ncbi request reprint Inhibitory function of zinc against excitation of hippocampal glutamatergic neurons
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Epilepsy Res 57:169-74. 2003
    ..The increase in glutamate concentration in the entorhinal cortex during perfusion of the CA1 with 50 microM glutamate was inhibited by the addition of zinc in the CA1. Zinc seems to be an inhibitory neuromodulator of glutamate release...
  71. ncbi request reprint Relationship between brain zinc and transient learning impairment of adult rats fed zinc-deficient diet
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka, Japan
    Brain Res 859:352-7. 2000
    ..These results suggest that the decrease of vesicular zinc in the hippocampal formation and cerebral cortex is involved in the transient learning impairment of adults rats...
  72. ncbi request reprint Cadmium toxicity in synaptic neurotransmission in the brain
    A Minami
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, 422-8526, Shizuoka, Japan
    Brain Res 894:336-9. 2001
    ..These results suggest that cadmium released from the amygdalar neuron terminals affect the degree and balance of excitation-inhibition in synaptic neurotransmission...
  73. ncbi request reprint Suppressive effect of Saiko-ka-ryukotsu-borei-to, a herbal medicine, on excessive release of glutamate in the hippocampus
    Haruna Tamano
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res Bull 64:273-7. 2004
    ..These results suggest that Saiko-ka-ryukotsu-borei-to is a useful drug for prevention or cure of excitotoxicity of glutamate...
  74. ncbi request reprint Relationship between zinc and neurotransmitters released into the amygdalar extracellular space
    Akira Minami
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res 936:91-4. 2002
    ..It is likely that vesicular zinc modulates GABA release in the amygdala. The modulation of GABAergic neuron activity by zinc may be important for the functions of the amygdala...
  75. ncbi request reprint Zinc transport in the rat olfactory system
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Neurosci Lett 225:69-71. 1997
    ..These results suggest that Zn is intraneuronally transported along the olfactory tract. Zn may be taken up by the piriform neurons after release from the secondary olfactory neuron terminals and transported to the entorhinal area...
  76. ncbi request reprint Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation
    Akira Minami
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan
    J Neurosci Res 83:167-76. 2006
    ..The present study demonstrates that zinc released from mossy fibers may be a negative-feedback factor against presynaptic activity during tetanic stimulation...
  77. doi request reprint Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation
    Haruna Tamano
    Department of Medical Biochemistry, University of Shizuoka, Japan
    Neurochem Int 55:536-41. 2009
    ....
  78. ncbi request reprint Distribution of trace elements in the brain of EL (epilepsy) mice
    Maki Hirate
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Epilepsy Res 51:109-16. 2002
    ..These results suggest that alteration of homeostasis of zinc, cobalt and selenium in the brain may be involved in the susceptibility, development or termination of seizures in EL mice...
  79. doi request reprint Zinc-mediated attenuation of hippocampal mossy fiber long-term potentiation induced by forskolin
    Masaki Ando
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Suruga ku, Shizuoka, Japan
    Neurochem Int 57:608-14. 2010
    ..The significance of endogenous zinc uptake by mossy fibers is discussed focused on tetanus-induced mossy fiber LTP...
  80. ncbi request reprint [Function and toxicity of trace metals in the central nervous system]
    Atsushi Takeda
    School of Pharmaceutical Sciences, University of Shizuoka
    Clin Calcium 14:45-9. 2004
    ..The homeostasis of trace metals in the brain is important for brain function and also prevention of brain diseases...
  81. ncbi request reprint Manganese action in brain function
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, 422 8526, Shizuoka, Japan
    Brain Res Brain Res Rev 41:79-87. 2003
    ..Understanding the movement and action of manganese in synapses may be important to clarify the function and toxicity of manganese in the brain...
  82. ncbi request reprint Manganese concentration in rat brain: manganese transport from the peripheral tissues
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
    Neurosci Lett 242:45-8. 1998
    ..These results suggest that the delivery of Mn from the liver to the brain is not involved in preferential Mn accumulation in the basal nuclei under physiological condition. This delivery may be important for brain function...
  83. ncbi request reprint Zinc distribution in the brain of Nagase analbuminemic rat and enlargement of the ventricular system
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Brain Res 769:193-5. 1997
    ..A most interesting observation was that the cerebral ventricles were considerably enlarged in NAR...
  84. ncbi request reprint Tumor cell growth is inhibited by suppressing metallothionein-I synthesis
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Yada, Japan
    Cancer Lett 116:145-9. 1997
    ..On the other hand, control ODN did not inhibit the cell growth appreciably. These results indicate that MT-I expression may be necessary for the growth and survival of these tumor cells...
  85. ncbi request reprint Elevation of hepatic levels of metallothionein during experimental carcinogenesis
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Biol Trace Elem Res 41:157-64. 1994
    ..This type of elevation of hepatic MT level was also observed in lung metastasis-induced mice. On the other hand, in rats with pancreatitis caused by the administration of deoxycholate, the hepatic level of MT rose only transiently...
  86. ncbi request reprint Preferential uptake of zinc, manganese, and rubidium in rat brain tumor
    Haruna Tamano
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Nucl Med Biol 29:505-8. 2002
    ..It is likely that rubidium and manganese, in addition to zinc, are preferentially taken up by tumors in the brain...
  87. ncbi request reprint Alteration of zinc concentrations in the brain implanted with C6 glioma
    Atsushi Takeda
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan
    Brain Res 965:170-3. 2003
    ..These results suggest that zinc taken up in the tumor may be utilized for tumor cell proliferation and that there is greater potential in the use of 69mZn, a short-half life gamma-emitter, for evaluation of the viability of brain tumors...
  88. ncbi request reprint Chemical form of tumor-tropic 99mTc-DL-homocysteine
    A Takeda
    Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    Int J Rad Appl Instrum A 40:565-8. 1989
    ..Although an uncertainty remains on the valency of Tc in 99mTc-Hcy molecule and the accurate molecular size of this complex, its putative chemical form is described...
  89. doi request reprint Dynamic action of neurometals at the synapse
    Haruna Tamano
    Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Global COE, 52 1 Yada, Suruga ku, Shizuoka, Japan
    Metallomics 3:656-61. 2011
    ..This paper summarizes the action of metals in synaptic neurotransmission focused on calcium signaling at glutamatergic synapses...
  90. ncbi request reprint Plasma membrane ion permeability induced by mutant alpha-synuclein contributes to the degeneration of neural cells
    Katsutoshi Furukawa
    Laboratory of Neurosciences, Gerontology Research Center, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    J Neurochem 97:1071-7. 2006
    ..These findings suggest that the high membrane ion permeability caused by mutant alpha-synuclein may contribute to the degeneration of neurons in PD...
  91. ncbi request reprint Quantification of neutral cysteine protease bleomycin hydrolase and its localization in rat tissues
    Yayoi Kamata
    Laboratory of Biochemistry, Faculty of Arts and Sciences, Sagami Women s University, Sagamihara, Kanagawa 228 8533, Japan
    J Biochem 141:69-76. 2007
    ..These results suggest that BH may play ubiquitous and unique roles in rat tissues...
  92. doi request reprint Serine 129 phosphorylation of alpha-synuclein induces unfolded protein response-mediated cell death
    Naoto Sugeno
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai, Miyagi 980 8574, Japan
    J Biol Chem 283:23179-88. 2008
    ..Taken together, it seems plausible that alpha-synuclein toxicity is dependent on the phosphorylation at Ser(129) that induces the UPRs, possibly triggered by the disturbed endoplasmic reticulum-Golgi trafficking...
  93. ncbi request reprint Downregulation of the NbNACa1 gene encoding a movement-protein-interacting protein reduces cell-to-cell movement of Brome mosaic virus in Nicotiana benthamiana
    Masanori Kaido
    Laboratory of Plant Pathology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Mol Plant Microbe Interact 20:671-81. 2007
    ..From these results, we propose that NbNACa1 is involved in BMV cell-to-cell movement through the regulation of BMV MP localization to the plasmodesmata...
  94. ncbi request reprint Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies
    Akihiko Nunomura
    Department of Psychiatry and Neurology, Asahikawa Medical College, Higashi 2 1 1 1, Midorigaoka, Asahikawa 078 8510, Japan
    Neuroreport 13:2035-9. 2002
    ....
  95. ncbi request reprint Alpha-synuclein facilitates the toxicity of oxidized catechol metabolites: implications for selective neurodegeneration in Parkinson's disease
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryomachi, Aobaku, Sendai, Miyagi 980 8574, Japan
    FEBS Lett 580:2147-52. 2006
    ..This cellular model may reconstitute the pathological metabolism of alpha-S in the synucleinopathy and provide a useful tool to explore possible pathomechanisms of nigral degeneration in PD...
  96. ncbi request reprint Role of Neu4L sialidase and its substrate ganglioside GD3 in neuronal apoptosis induced by catechol metabolites
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, Sendai, Miyagi 980 8574, Japan
    FEBS Lett 581:406-12. 2007
    ..Neu4L and its substrate GD3 may act as key molecules in the mitochondrial apoptotic pathway in neuronal cells...
  97. ncbi request reprint Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells
    Takafumi Hasegawa
    Department of Neurology, Tohoku University School of Medicine, 1 1 Seiryo machi, Aoba ku, Sendai, Miyagi, 980 8574, Japan
    Brain Res 1013:51-9. 2004
    ..This cellular model will enable better understanding of the molecular pathomechanisms of synucleinopathy...
  98. ncbi request reprint Upregulated expression of transforming growth factor-beta, type IV collagen, and plasminogen activator inhibitor-1 mRNA are decreased after release of unilateral ureteral obstruction
    Yukihiko Ogata
    Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Japan
    Tohoku J Exp Med 197:159-68. 2002
    ..Decreased PAI-1 expression in the post-obstructed kidney may contribute to the degradation of extracellular matrix proteins and recovery of tubulointerstitial fibrosis, at least partly, after release of ureteral obstruction...
  99. ncbi request reprint Heme catabolism and heme oxygenase in neurodegenerative disease
    Atsushi Takeda
    Department of Neurology, Tohoku University School of Medicine, Sendai 980 8574, Japan
    Antioxid Redox Signal 6:888-94. 2004
    ..This places heme oxygenase at the center of disease pathogenesis and offers a novel therapeutic approach targeted at either the causes or consequences of enzyme induction...
  100. ncbi request reprint Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease
    Akihiko Nunomura
    Department of Psychiatry and Neurology, Asahikawa Medical College, Asahikawa 078 8510, Japan
    Neurobiol Dis 17:108-13. 2004
    ..These results suggest that oxidative stress is an early event involved in the pathological cascade of FAD...