Hiroshi Takayanagi


Affiliation: University of Tokyo
Country: Japan


  1. Hayashi M, Nakashima T, Yoshimura N, Okamoto K, Tanaka S, Takayanagi H. Autoregulation of Osteocyte Sema3A Orchestrates Estrogen Action and Counteracts Bone Aging. Cell Metab. 2019;: pubmed publisher
    ..We further show that serum levels of SEMA3A decreased with age or after menopause in humans. Thus, we provide a mechanistic insight into the estrogen action and a promising therapeutic approach to protect against bone-related aging. ..
  2. Inoue M, Okamoto K, Terashima A, Nitta T, Muro R, Negishi Koga T, et al. Arginine methylation controls the strength of γc-family cytokine signaling in T cell maintenance. Nat Immunol. 2018;: pubmed publisher
    ..Thus, arginine methylation regulates strength of signaling via γc-family cytokines by facilitating the expression of signal-transducing components. ..
  3. Terashima A, Takayanagi H. Overview of Osteoimmunology. Calcif Tissue Int. 2018;102:503-511 pubmed publisher
  4. Komatsu N, Takayanagi H. Arthritogenic T cells in autoimmune arthritis. Int J Biochem Cell Biol. 2015;58:92-6 pubmed publisher
    ..Further analysis on the molecular basis and antigen-specificity of arthritogenic Th17 cell subsets will be helpful to establish novel therapeutic approaches and clarify how self-tolerance breaks down in autoimmune arthritis. ..
  5. Komatsu N, Takayanagi H. Regulatory T cells in Arthritis. Prog Mol Biol Transl Sci. 2015;136:207-15 pubmed publisher
    ..Here, we summarize our understanding of the role of Treg cells in arthritis based on recent human and murine studies. ..
  6. Terashima A, Okamoto K, Nakashima T, Akira S, Ikuta K, Takayanagi H. Sepsis-Induced Osteoblast Ablation Causes Immunodeficiency. Immunity. 2016;44:1434-43 pubmed publisher
  7. Sumiya E, Negishi Koga T, Nagai Y, Suematsu A, Suda T, Shinohara M, et al. Phosphoproteomic analysis of kinase-deficient mice reveals multiple TAK1 targets in osteoclast differentiation. Biochem Biophys Res Commun. 2015;463:1284-90 pubmed publisher
    ..Thus, TAK1 functions as a critical regulator of the phosophorylation status of various cellular proteins that govern osteoclastogenesis. ..
  8. Takaba H, Morishita Y, Tomofuji Y, Danks L, Nitta T, Komatsu N, et al. Fezf2 Orchestrates a Thymic Program of Self-Antigen Expression for Immune Tolerance. Cell. 2015;163:975-87 pubmed publisher
    ..Thus, two independent factors, Fezf2 and Aire, permit the expression of TRAs in the thymus to ensure immune tolerance. ..
  9. Ono T, Takayanagi H. Osteoimmunology in Bone Fracture Healing. Curr Osteoporos Rep. 2017;15:367-375 pubmed publisher
    ..Accumulating evidence has begun to reveal the deeper picture of bone fracture healing. Further studies are required for the development of novel therapeutic strategies for bone fracture. ..

More Information


  1. Nitta T, Kochi Y, Muro R, Tomofuji Y, Okamura T, Murata S, et al. Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol. 2017;2: pubmed publisher
    ..Our findings suggest that, in addition to the MHC haplotype, proteasome variations influence T cell repertoire selection and may contribute to the difference in individual susceptibility to autoimmunity. ..
  2. Takaba H, Takayanagi H. The Mechanisms of T Cell Selection in the Thymus. Trends Immunol. 2017;38:805-816 pubmed publisher
    ..Here, we discuss novel findings on the transcriptional mechanisms of tissue restricted-antigen expression in the medullary thymic epithelial cells and its effects on T cell selection. ..
  3. Tsukasaki M, Komatsu N, Nagashima K, Nitta T, Pluemsakunthai W, Shukunami C, et al. Host defense against oral microbiota by bone-damaging T cells. Nat Commun. 2018;9:701 pubmed publisher
    ..Thus, bone-damaging T cells, which may have developed to stop local infection by inducing tooth loss, function as a double-edged sword by protecting against pathogens while also inducing skeletal tissue degradation. ..
  4. Nakamura H, Nakashima T, Hayashi M, Izawa N, Yasui T, Aburatani H, et al. Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell-cell fusion. Biochem Biophys Res Commun. 2014;455:305-11 pubmed publisher
    ..This study demonstrates that Pcdh7 plays a key role in osteoclastogenesis by promoting cell-cell fusion. ..
  5. Guerrini M, Okamoto K, Komatsu N, Sawa S, Danks L, Penninger J, et al. Inhibition of the TNF Family Cytokine RANKL Prevents Autoimmune Inflammation in the Central Nervous System. Immunity. 2015;43:1174-85 pubmed publisher
    ..Pharmacological inhibition of RANKL prevented the development of EAE without affecting the peripheral immune response, indicating that RANKL is a potential therapeutic target for treating autoimmune diseases in the CNS. ..
  6. Nagashima K, Sawa S, Nitta T, Prados A, Koliaraki V, Kollias G, et al. Targeted deletion of RANKL in M cell inducer cells by the Col6a1-Cre driver. Biochem Biophys Res Commun. 2017;493:437-443 pubmed publisher
    ..This study demonstrates that Col6a1-Cre driver mice are as useful as Twist2-Cre driver mice for functional analyses of GALT-resident mesenchymal cells, including MCi cells. ..