Research Topics
Genomes and Genes
| Kiyoshi TakatsuSummaryAffiliation: University of Tokyo Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Interleukin-5 regulates genes involved in B-cell terminal maturationKeisuke Horikawa
Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
Immunology 118:497-508. 2006..Taken together, preferential Aid and Blimp-1 expression plays a critical role in IL-5-induced immunoglobulin-secreting cell differentiation and micro to gamma 1 CSR in CD38-activated B cells...- IL-5 and eosinophiliaKiyoshi Takatsu
Department of Immunobiology and Pharmacological Genetics, University of Toyama, Toyama 930 0194, Japan
Curr Opin Immunol 20:288-94. 2008..We will emphasize that IL-5 plays a pivotal role in the innate and acquired immune response and eosinophilia... - The immunogenic peptide for Th1 developmentKiyoshi Takatsu
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Minato, Japan
Int Immunopharmacol 3:783-800. 2003..Peptide-25 has a potent adjuvant activity in both humoral and cell-mediated immune responses that is mediated by Th1 cells. We would propose to designate Peptide-25 as "Th1-inducing peptide"... - [Allergic inflammation and immune response: role of cytokine]Kiyoshi Takatsu
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
Arerugi 54:1245-9. 2005 - [Allergic inflammation and eosinophils: trials, tribulations and enigma of IL-5, eosinophils and asthma]Kiyoshi Takatsu
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
Arerugi 54:48-52. 2005 - Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 productionYumiko Tsukamoto
Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
Mol Immunol 46:1278-88. 2009..IL-4 may be required for the induction of DNA repair system together with AID for the completion of CSR... - Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signalsHaruyuki Ariga
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Immunology 122:210-21. 2007.... - The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cellsYoshinori Nagai
Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
Int Immunol 24:389-400. 2012..These responses contributed to TLR4-mediated anti-apoptotic responses in MZ B cells. Thus, RP105 contributes in a unique way to the TLR4-dependent survival, proliferation and plasma cell generation of MZ B cells... - The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammationYasuharu Watanabe
Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan
Diabetes 61:1199-209. 2012..Thus, the RP105/MD-1 complex is a major mediator of adipose tissue inflammation independent of TLR4 signaling and may represent a novel therapeutic target for obesity-associated metabolic disorders... - APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferationMasanori Iseki
Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Biochem Biophys Res Commun 330:1005-13. 2005..Thus, APS appears to play novel negative regulatory roles in BCR signaling, actin reorganization pathways, and control of compartment sizes of B-lineage cells... - A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responsesKoichiro Takahashi
Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
J Exp Med 204:2963-76. 2007..These results suggest that PRAT4A regulates the subcellular distribution and response of multiple TLRs and is required for both innate and adaptive immune responses... - Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) miceSumiyo Sasaki
Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
Mol Immunol 49:611-20. 2012..This correlation suggests that sMD-1 may contribute to pathogenesis in this autoimmune disease model... - Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, LnkHitoshi Takizawa
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
Blood 107:2968-75. 2006..Transient inhibition of Lnk or Lnk-mediated pathways could be a potent approach to augment engraftment of HSCs/HPCs without obvious side effects... - Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunityMasashi Ikutani
Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama 930 0194, Japan
J Immunol 188:703-13. 2012..These newly identified innate IL-5-producing cells thus play a role in tumor surveillance through lung eosinophils and may contribute to development of novel immunotherapies for cancer... - Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signalsHitoshi Takizawa
Division of Immunology, Department of Microbiology and Immunology, The University of Tokyo, Tokyo, Japan
Exp Hematol 36:897-906. 2008..However, the mechanism regulating platelet release from MKs is not well understood. Here, we investigated a role of Lnk/Sh2b3, an intracellular adaptor protein, in megakaryopoiesis... - Augmented induction of CD8+ cytotoxic T-cell response and antitumour resistance by T helper type 1-inducing peptideTakeshi Kikuchi
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Immunology 117:47-58. 2006..These phenomena were not achieved by immunization with OVA alone. Peptide-25-reactive Th1 cells counteractivated dendritic cells in the presence of Peptide-25 leading them to activate and present OVA peptide to CD8(+) cytotoxic T cells... - Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor alpha chain geneByoung gon Moon
Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
Cell Immunol 228:110-8. 2004..These results suggest involvement of IL-5 in enhanced B-1 cell activation, autoantibody production, and development of autoimmune disease in Lyn-deficient mice... - Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transductionJun Seita
Laboratory of Stem Cell Therapy, Center for Experimental Medicine, University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
Proc Natl Acad Sci U S A 104:2349-54. 2007..In general, likewise, the fate of stem cells may be determined by combinational changes in multiple signal transduction pathways... - IL-5-induced hypereosinophilia suppresses the antigen-induced immune response via a TGF-beta-dependent mechanismKazuyuki Nakagome
Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
J Immunol 179:284-94. 2007..Therefore, hypereosinophilia could reveal an immunosuppressive effect in the early stage of Ag-induced immune response... - The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic modelToshiki Tamura
Division of Immunology, Institute of Medical Science, University of Tokyo, Japan
Int Immunol 16:1691-9. 2004..These results imply that interaction between Peptide-25/I-Ab and TCR may primarily influence determination of the fate of naive CD4+ T cells in their differentiation towards the Th1 subset... - The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig productionByoung gon Moon
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
J Immunol 172:6020-9. 2004..Our results illuminate the role of IL-5 in the homeostatic proliferation and survival of mature B-1 cells and in IgA production in the mucosal tissues... - Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cellsAtsuko Itakura
Division of Immunology, Department of Immunology and Microbiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Int Arch Allergy Immunol 140:8-16. 2006..In this study, we investigated the role of interleukin (IL)-5, which has broad effects on both eosinophils and B-1 cells, in elicitation of CS... - A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4Yasutaka Wakabayashi
Division of Infectious Genetics, University of Tokyo, Japan
J Immunol 177:1772-9. 2006..PRAT4A knockdown down-regulated cell surface TLR4/MD-2 on dendritic cells. These results demonstrate a novel mechanism regulating TLR4/MD-2 expression on the cell surface... - CpG ODN mediated prevention from ovalbumin-induced anaphylaxis in mouse through B cell pathwayWen Xu
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Int Immunopharmacol 8:351-61. 2008..These results imply a B cell-intrinsic, T cell-independent mechanism by which CpG ODN directly acts on B cells and inhibits IgE and IgG1 production leading to cause prevention from allergic symptoms... - The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranesYoshinori Nagai
Divisions of Infectious Genetics and Immunology, Institute of Medical Science, University of Tokyo, Japan
J Immunol 174:7043-9. 2005..These results demonstrate that a signal via RP105 is uniquely important for regulating TLR-dependent Ab production to microbial membranes... - Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domainsMasanori Iseki
Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
Mol Cell Biol 24:2243-50. 2004..After BCR stimulation, F-actin contents were lower in APS(-/-) B-1 cells than in wild-type B-1 cells. Our results indicate that APS might have a novel regulatory role in actin reorganization and control of B-1 cell compartment size... - Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient miceHideo Ema
Laboratory of Stem Cell Therapy, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Dev Cell 8:907-14. 2005..Lnk appears to control HSC numbers by negatively regulating HSC self-renewal signaling... - Interleukin 5 in the link between the innate and acquired immune responseKiyoshi Takatsu
Department of Immunobiology and Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama 930 0194, Japan
Adv Immunol 101:191-236. 2009.... - [Role of interleukin-5 in immune regulation and inflammation]Kiyoshi Takatsu
Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
Nippon Rinsho 62:1941-51. 2004..No significant changes in airway hyper-responsiveness and peak flow recordings between the anti-IL-5 and placebo-treated groups were reported. At this moment, the role of IL-5 and eosinophil in allergic inflammation remains uncertain... - Requirement of 8-mercaptoguanosine as a costimulus for IL-4-dependent mu to gamma1 class switch recombination in CD38-activated B cellsYumiko Tsukamoto
Division of Immunology, Department of Immunology and Microbiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108, Japan
Biochem Biophys Res Commun 336:625-33. 2005..Furthermore, our data suggest the requirement of additional molecules in addition to AID for CSR... - Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed miceShiho Fujisaka
The First Department of Internal Medicine, University of Toyama, Toyama, Japan
Endocrinology 152:1789-99. 2011..In conclusion, telmisartan improves insulin sensitivity and modulates adipose tissue macrophage polarization to an antiinflammatory M2 state in high-fat-fed mice... - Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different mannerHiroe Honda
1 Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
J Leukoc Biol 91:967-76. 2012.... - Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gammaAi Kariyone
Division of Immunology, Department of Microbiology and Immunology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan
Int Immunol 15:1183-94. 2003.... - Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cellsIkuo Yana
Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
J Cell Sci 120:1607-14. 2007.... - Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor proteinSatoshi Takaki
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
J Immunol 170:703-10. 2003..Our results illuminate the novel negative regulatory mechanism mediated by the Lnk adaptor protein in controlling lymphocyte production and function... - Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, LnkSatoshi Takaki
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
J Exp Med 195:151-60. 2002..These observations indicate that Lnk plays critical roles in the expansion and function of early hematopoietic progenitors, and provide useful clues for the amplification of hematopoietic progenitor cells... - Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexesMasayuki Hirano
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
Int Immunol 16:747-57. 2004..We propose a model in which Btk regulates gene transcription in B cells by activating BAM and the SWI/SNF transcriptional complex via TFII-I activation... - Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assemblyChiyomi Kubo-Akashi
Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Shirokanedai 4 6 1, Minato ku, Tokyo 108 8639, Japan
Biochem Biophys Res Commun 315:356-62. 2004..Our results suggest potential roles of APS in controlling actin cytoskeleton and magnitude of degranulation in mast cells... - Interleukin-5 and IL-5 receptor in health and diseasesKiyoshi Takatsu
Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
Proc Jpn Acad Ser B Phys Biol Sci 87:463-85. 2011.... - Analysis of Trichophyton antigen-induced contact hypersensitivity in mouseTomoya Nakamura
Department of R and D Center, Ikeda Mohando Co, Ltd, Toyama, Japan
J Dermatol Sci 66:144-53. 2012..Since Trichophyton cannot colonize mice, guinea pigs were used in previous experiments on Trichophyton infection. However, it is difficult to perform immunological and genetic analyses in guinea pigs... - Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndromeKeisuke Otsubo
Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
Clin Immunol 141:111-20. 2011..These results suggest that genetically altered FOXP3 can drive the generation of functionally immature Treg cells, but that intact FOXP3 is necessary for the complete function of Treg cells... - NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytesHiroaki Kaku
Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
Int Immunol 14:1055-64. 2002..These results indicate an essential role for NF-kappaB proteins in the induction of germline gamma1 transcripts by CD38-ligated murine B cells giving rise to IL-5-induced IgG1 production... - PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transductionHarumi Suzuki
Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160 8582, Japan
Nat Immunol 4:280-6. 2003..Our results indicate that PI3K and Btk have unique roles in proximal BCR signaling and that they have a common target further downstream in the activation of NF-kappaB... - SH2-B is required for both male and female reproductionSatoshi Ohtsuka
Division of Molecular Genetics, Institute of Life Science, Kurume University, Kurume 839 0861, USA
Mol Cell Biol 22:3066-77. 2002..SH2-B(-/-) cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a critical role in the IGF-I-mediated reproductive pathway in mice... - Memory Th1 cells augment tumor-specific CTL following transcutaneous peptide immunizationAkihiro Hosoi
Department of Immunotherapeutics Medinet, Graduate School of Medicine, The University of Tokyo, Japan
Cancer Res 68:3941-9. 2008..Therefore, concomitant activation of Ag85B- or peptide-25-specific mTh1 cells together with tumor-specific CTL by TCI might augment antitumor immune responses in a sizeable fraction of patients... - Critical role of IL-5 in antigen-induced pulmonary eosinophilia, but not in lymphocyte activationNobuhiro Matsumoto
Third Department of Internal Medicine, Miyazaki Medical College, Japan
Int Arch Allergy Immunol 130:209-15. 2003..We conclude that IL-5 appears to be required for the accumulation of eosinophils and AHR in the inflammatory lung. However, IL-5 does not play a critical role in the accumulation of activated CD4+ T cells in the inflammatory lung... - Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cellsDianne Emslie
Immunology Division, The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
J Exp Med 205:409-21. 2008..IL-5 augments ASC differentiation in vitro, and we show that IL-5 directly activates the plasma cell differentiation program by enhancing blimp1 expression... - Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiencyHiroko Saito
Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
J Immunol 168:3017-23. 2002.... - Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in miceMohamed El-Malky
Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences, Kawasumi-1, Mizuho, Nagoya 467-8601, Japan
Parasitol Int 52:71-9. 2003..The present study suggests that eosinophils are capable of attacking adult nematodes in the intestinal epithelia, probably in conjunction with secretory IgA, although they are not enough for the complete worm expulsion... - Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activationMiki Hara-Yokoyama
Department of Hard Tissue Engineering, Biochemistry, Division of Bio Matrix, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8549, Japan
Int Immunopharmacol 8:59-70. 2008..The antibodies will be useful tools to analyze the conformational change of CD38 in the process of triggering B cell survival and the activation signal... - Identification of eosinophil lineage-committed progenitors in the murine bone marrowHiromi Iwasaki
Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
J Exp Med 201:1891-7. 2005..The newly identified EoPs could be the cellular target in the treatment of a variety of disorders mediated by eosinophils... - Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsivenessHiromasa Inoue
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
J Exp Med 201:73-82. 2005..These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma... - Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupusXiangshu Wen
Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
Eur J Immunol 34:2740-9. 2004..Thus, this model may provide a clue to the pathogenesis of both SLE and B-CLL... - The order of expression of transcription factors directs hierarchical specification of hematopoietic lineagesHiromi Iwasaki
Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
Genes Dev 20:3010-21. 2006..We propose that the order of expression of key transcription factors is critical for their interplay to selectively drive lineage specification programs, by which stem cells could generate multiple lineage cells in a hierarchical manner... - Role of cytokines in allergic airway inflammationHiroshi Nakajima
Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
Int Arch Allergy Immunol 142:265-73. 2007..In this review, we discuss the role of individual cytokines in the pathogenesis of asthma... - Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in miceHiroyuki Tanaka
Department of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
Am J Respir Cell Mol Biol 31:62-8. 2004..These findings demonstrated that eosinophils are involved in allergen-induced subepithelial and peribronchial fibrosis probably by producing a fibrogenic factor, TGF-beta1... - Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptorsKeisuke Horikawa
Immunogenomics Laboratory, The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra 0200, Australia
J Exp Med 204:759-69. 2007.... - Nasal cholera toxin elicits IL-5 and IL-5 receptor alpha-chain expressing B-1a B cells for innate mucosal IgA antibody responsesKosuke Kataoka
Department of Pediatric Dentistry, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
J Immunol 178:6058-65. 2007.... - Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor proteinIkuo Nobuhisa
Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
Mol Cell Biol 23:8486-94. 2003..Furthermore, aorta cells of E11.5 Lnk homozygous mutant mice also showed enhanced hematopoietic colony-forming activity. Thus, Lnk is a negative regulator of hematopoiesis in the AGM region... - Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivoAndrea J Wolf
Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Immunol 179:2509-19. 2007..These results indicate that Mtb targets DC migration and Ag presentation in vivo to promote persistent infection... - Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungsAndrea J Wolf
Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 205:105-15. 2008.... - Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishmentYoshinori Nagai
Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
Immunity 24:801-12. 2006..Thus, the preferential pathogen-mediated stimulation of myeloid differentiation pathways may provide a means for rapid replenishment of the innate immune system during infection... - An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivityAtsuko Itakura
Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8013, USA
J Immunol 175:7170-8. 2005.... - Increased insulin sensitivity and hypoinsulinemia in APS knockout miceAsako Minami
Division of Molecular Genetics, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan
Diabetes 52:2657-65. 2003..APS(-/-) mice also showed increased serum levels of leptin and adiponectin, which might explain the increased insulin sensitivity of adipocytes...