Kiyoshi Takatsu

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint [Allergic inflammation and eosinophils: trials, tribulations and enigma of IL-5, eosinophils and asthma]
    Kiyoshi Takatsu
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
    Arerugi 54:48-52. 2005
  2. pmc Interleukin-5 regulates genes involved in B-cell terminal maturation
    Keisuke Horikawa
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 118:497-508. 2006
  3. doi request reprint IL-5 and eosinophilia
    Kiyoshi Takatsu
    Department of Immunobiology and Pharmacological Genetics, University of Toyama, Toyama 930 0194, Japan
    Curr Opin Immunol 20:288-94. 2008
  4. ncbi request reprint The immunogenic peptide for Th1 development
    Kiyoshi Takatsu
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Minato, Japan
    Int Immunopharmacol 3:783-800. 2003
  5. ncbi request reprint [Allergic inflammation and immune response: role of cytokine]
    Kiyoshi Takatsu
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
    Arerugi 54:1245-9. 2005
  6. doi request reprint Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production
    Yumiko Tsukamoto
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Mol Immunol 46:1278-88. 2009
  7. doi request reprint The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells
    Yoshinori Nagai
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    Int Immunol 24:389-400. 2012
  8. pmc Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals
    Haruyuki Ariga
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 122:210-21. 2007
  9. pmc The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation
    Yasuharu Watanabe
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan
    Diabetes 61:1199-209. 2012
  10. ncbi request reprint APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation
    Masanori Iseki
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 330:1005-13. 2005

Detail Information

Publications66

  1. ncbi request reprint [Allergic inflammation and eosinophils: trials, tribulations and enigma of IL-5, eosinophils and asthma]
    Kiyoshi Takatsu
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
    Arerugi 54:48-52. 2005
  2. pmc Interleukin-5 regulates genes involved in B-cell terminal maturation
    Keisuke Horikawa
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 118:497-508. 2006
    ..Taken together, preferential Aid and Blimp-1 expression plays a critical role in IL-5-induced immunoglobulin-secreting cell differentiation and micro to gamma 1 CSR in CD38-activated B cells...
  3. doi request reprint IL-5 and eosinophilia
    Kiyoshi Takatsu
    Department of Immunobiology and Pharmacological Genetics, University of Toyama, Toyama 930 0194, Japan
    Curr Opin Immunol 20:288-94. 2008
    ..We will emphasize that IL-5 plays a pivotal role in the innate and acquired immune response and eosinophilia...
  4. ncbi request reprint The immunogenic peptide for Th1 development
    Kiyoshi Takatsu
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Minato, Japan
    Int Immunopharmacol 3:783-800. 2003
    ..Peptide-25 has a potent adjuvant activity in both humoral and cell-mediated immune responses that is mediated by Th1 cells. We would propose to designate Peptide-25 as "Th1-inducing peptide"...
  5. ncbi request reprint [Allergic inflammation and immune response: role of cytokine]
    Kiyoshi Takatsu
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo
    Arerugi 54:1245-9. 2005
  6. doi request reprint Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production
    Yumiko Tsukamoto
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Mol Immunol 46:1278-88. 2009
    ..IL-4 may be required for the induction of DNA repair system together with AID for the completion of CSR...
  7. doi request reprint The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells
    Yoshinori Nagai
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    Int Immunol 24:389-400. 2012
    ..These responses contributed to TLR4-mediated anti-apoptotic responses in MZ B cells. Thus, RP105 contributes in a unique way to the TLR4-dependent survival, proliferation and plasma cell generation of MZ B cells...
  8. pmc Instruction of naive CD4+ T-cell fate to T-bet expression and T helper 1 development: roles of T-cell receptor-mediated signals
    Haruyuki Ariga
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 122:210-21. 2007
    ....
  9. pmc The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation
    Yasuharu Watanabe
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama, Japan
    Diabetes 61:1199-209. 2012
    ..Thus, the RP105/MD-1 complex is a major mediator of adipose tissue inflammation independent of TLR4 signaling and may represent a novel therapeutic target for obesity-associated metabolic disorders...
  10. ncbi request reprint APS, an adaptor molecule containing PH and SH2 domains, has a negative regulatory role in B cell proliferation
    Masanori Iseki
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 330:1005-13. 2005
    ..Thus, APS appears to play novel negative regulatory roles in BCR signaling, actin reorganization pathways, and control of compartment sizes of B-lineage cells...
  11. pmc A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
    Koichiro Takahashi
    Division of Infectious Genetics, The Institute of Medical Science, The University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    J Exp Med 204:2963-76. 2007
    ..These results suggest that PRAT4A regulates the subcellular distribution and response of multiple TLRs and is required for both innate and adaptive immune responses...
  12. ncbi request reprint Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein, Lnk
    Hitoshi Takizawa
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo, 108 8639, Japan
    Blood 107:2968-75. 2006
    ..Transient inhibition of Lnk or Lnk-mediated pathways could be a potent approach to augment engraftment of HSCs/HPCs without obvious side effects...
  13. pmc Lnk negatively regulates self-renewal of hematopoietic stem cells by modifying thrombopoietin-mediated signal transduction
    Jun Seita
    Laboratory of Stem Cell Therapy, Center for Experimental Medicine, University of Tokyo, 4 6 1 Shirokanedai, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 104:2349-54. 2007
    ..In general, likewise, the fate of stem cells may be determined by combinational changes in multiple signal transduction pathways...
  14. ncbi request reprint Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals
    Hitoshi Takizawa
    Division of Immunology, Department of Microbiology and Immunology, The University of Tokyo, Tokyo, Japan
    Exp Hematol 36:897-906. 2008
    ..However, the mechanism regulating platelet release from MKs is not well understood. Here, we investigated a role of Lnk/Sh2b3, an intracellular adaptor protein, in megakaryopoiesis...
  15. doi request reprint Serum soluble MD-1 levels increase with disease progression in autoimmune prone MRL(lpr/lpr) mice
    Sumiyo Sasaki
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    Mol Immunol 49:611-20. 2012
    ..This correlation suggests that sMD-1 may contribute to pathogenesis in this autoimmune disease model...
  16. doi request reprint Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity
    Masashi Ikutani
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama 930 0194, Japan
    J Immunol 188:703-13. 2012
    ..These newly identified innate IL-5-producing cells thus play a role in tumor surveillance through lung eosinophils and may contribute to development of novel immunotherapies for cancer...
  17. ncbi request reprint IL-5-induced hypereosinophilia suppresses the antigen-induced immune response via a TGF-beta-dependent mechanism
    Kazuyuki Nakagome
    Department of Allergy and Rheumatology, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Immunol 179:284-94. 2007
    ..Therefore, hypereosinophilia could reveal an immunosuppressive effect in the early stage of Ag-induced immune response...
  18. pmc Augmented induction of CD8+ cytotoxic T-cell response and antitumour resistance by T helper type 1-inducing peptide
    Takeshi Kikuchi
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Immunology 117:47-58. 2006
    ..These phenomena were not achieved by immunization with OVA alone. Peptide-25-reactive Th1 cells counteractivated dendritic cells in the presence of Peptide-25 leading them to activate and present OVA peptide to CD8(+) cytotoxic T cells...
  19. ncbi request reprint Abrogation of autoimmune disease in Lyn-deficient mice by the deletion of IL-5 receptor alpha chain gene
    Byoung gon Moon
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo 108 8639, Japan
    Cell Immunol 228:110-8. 2004
    ..These results suggest involvement of IL-5 in enhanced B-1 cell activation, autoantibody production, and development of autoimmune disease in Lyn-deficient mice...
  20. ncbi request reprint The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production
    Byoung gon Moon
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    J Immunol 172:6020-9. 2004
    ..Our results illuminate the role of IL-5 in the homeostatic proliferation and survival of mature B-1 cells and in IgA production in the mucosal tissues...
  21. ncbi request reprint The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model
    Toshiki Tamura
    Division of Immunology, Institute of Medical Science, University of Tokyo, Japan
    Int Immunol 16:1691-9. 2004
    ..These results imply that interaction between Peptide-25/I-Ab and TCR may primarily influence determination of the fate of naive CD4+ T cells in their differentiation towards the Th1 subset...
  22. ncbi request reprint Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B-cell priming and not impairment in antigen presentation
    Nurlaely Mida Rachmawati
    Division of Immunology, Department of Biomolecular Sciences, Saga University Faculty of Medicine, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Int Immunol 25:117-28. 2013
    ..These results provide important information concerning the regulatory mechanisms of antibody production, especially in endotoxin-tolerant states...
  23. ncbi request reprint Quantification of self-renewal capacity in single hematopoietic stem cells from normal and Lnk-deficient mice
    Hideo Ema
    Laboratory of Stem Cell Therapy, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Dev Cell 8:907-14. 2005
    ..Lnk appears to control HSC numbers by negatively regulating HSC self-renewal signaling...
  24. ncbi request reprint A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4
    Yasutaka Wakabayashi
    Division of Infectious Genetics, University of Tokyo, Japan
    J Immunol 177:1772-9. 2006
    ..PRAT4A knockdown down-regulated cell surface TLR4/MD-2 on dendritic cells. These results demonstrate a novel mechanism regulating TLR4/MD-2 expression on the cell surface...
  25. doi request reprint CpG ODN mediated prevention from ovalbumin-induced anaphylaxis in mouse through B cell pathway
    Wen Xu
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunopharmacol 8:351-61. 2008
    ..These results imply a B cell-intrinsic, T cell-independent mechanism by which CpG ODN directly acts on B cells and inhibits IgE and IgG1 production leading to cause prevention from allergic symptoms...
  26. ncbi request reprint Interleukin 5 plays an essential role in elicitation of contact sensitivity through dual effects on eosinophils and B-1 cells
    Atsuko Itakura
    Division of Immunology, Department of Immunology and Microbiology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Int Arch Allergy Immunol 140:8-16. 2006
    ..In this study, we investigated the role of interleukin (IL)-5, which has broad effects on both eosinophils and B-1 cells, in elicitation of CS...
  27. ncbi request reprint The radioprotective 105/MD-1 complex links TLR2 and TLR4/MD-2 in antibody response to microbial membranes
    Yoshinori Nagai
    Divisions of Infectious Genetics and Immunology, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 174:7043-9. 2005
    ..These results demonstrate that a signal via RP105 is uniquely important for regulating TLR-dependent Ab production to microbial membranes...
  28. pmc Increased numbers of B-1 cells and enhanced responses against TI-2 antigen in mice lacking APS, an adaptor molecule containing PH and SH2 domains
    Masanori Iseki
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    Mol Cell Biol 24:2243-50. 2004
    ..After BCR stimulation, F-actin contents were lower in APS(-/-) B-1 cells than in wild-type B-1 cells. Our results indicate that APS might have a novel regulatory role in actin reorganization and control of B-1 cell compartment size...
  29. doi request reprint Interleukin 5 in the link between the innate and acquired immune response
    Kiyoshi Takatsu
    Department of Immunobiology and Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, Toyama 930 0194, Japan
    Adv Immunol 101:191-236. 2009
    ....
  30. ncbi request reprint [Role of interleukin-5 in immune regulation and inflammation]
    Kiyoshi Takatsu
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo
    Nihon Rinsho 62:1941-51. 2004
    ..No significant changes in airway hyper-responsiveness and peak flow recordings between the anti-IL-5 and placebo-treated groups were reported. At this moment, the role of IL-5 and eosinophil in allergic inflammation remains uncertain...
  31. pmc Activation and regulation of the pattern recognition receptors in obesity-induced adipose tissue inflammation and insulin resistance
    Yasuharu Watanabe
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Science for Research, University of Toyama, 2630 Sugitani, Toyama shi, Toyama 930 0194, Japan
    Nutrients 5:3757-78. 2013
    ....
  32. ncbi request reprint Requirement of 8-mercaptoguanosine as a costimulus for IL-4-dependent mu to gamma1 class switch recombination in CD38-activated B cells
    Yumiko Tsukamoto
    Division of Immunology, Department of Immunology and Microbiology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108, Japan
    Biochem Biophys Res Commun 336:625-33. 2005
    ..Furthermore, our data suggest the requirement of additional molecules in addition to AID for CSR...
  33. doi request reprint Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice
    Shiho Fujisaka
    The First Department of Internal Medicine, University of Toyama, Toyama, Japan
    Endocrinology 152:1789-99. 2011
    ..In conclusion, telmisartan improves insulin sensitivity and modulates adipose tissue macrophage polarization to an antiinflammatory M2 state in high-fat-fed mice...
  34. doi request reprint Glycyrrhizin and isoliquiritigenin suppress the LPS sensor toll-like receptor 4/MD-2 complex signaling in a different manner
    Hiroe Honda
    Toyama Prefectural Institute for Pharmaceutical Research, Toyama, Japan
    J Leukoc Biol 91:967-76. 2012
    ....
  35. ncbi request reprint Immunogenicity of Peptide-25 of Ag85B in Th1 development: role of IFN-gamma
    Ai Kariyone
    Division of Immunology, Department of Microbiology and Immunology, Center for Experimental Medicine, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 15:1183-94. 2003
    ....
  36. ncbi request reprint Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells
    Ikuo Yana
    Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Cell Sci 120:1607-14. 2007
    ....
  37. pmc Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk
    Satoshi Takaki
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo 108 8639, Japan
    J Exp Med 195:151-60. 2002
    ..These observations indicate that Lnk plays critical roles in the expansion and function of early hematopoietic progenitors, and provide useful clues for the amplification of hematopoietic progenitor cells...
  38. ncbi request reprint Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein
    Satoshi Takaki
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    J Immunol 170:703-10. 2003
    ..Our results illuminate the novel negative regulatory mechanism mediated by the Lnk adaptor protein in controlling lymphocyte production and function...
  39. ncbi request reprint Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions: APS-deficiency causes augmented degranulation and reduced actin assembly
    Chiyomi Kubo-Akashi
    Division of Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Shirokanedai 4 6 1, Minato ku, Tokyo 108 8639, Japan
    Biochem Biophys Res Commun 315:356-62. 2004
    ..Our results suggest potential roles of APS in controlling actin cytoskeleton and magnitude of degranulation in mast cells...
  40. ncbi request reprint Bruton's tyrosine kinase (Btk) enhances transcriptional co-activation activity of BAM11, a Btk-associated molecule of a subunit of SWI/SNF complexes
    Masayuki Hirano
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Int Immunol 16:747-57. 2004
    ..We propose a model in which Btk regulates gene transcription in B cells by activating BAM and the SWI/SNF transcriptional complex via TFII-I activation...
  41. doi request reprint Analysis of Trichophyton antigen-induced contact hypersensitivity in mouse
    Tomoya Nakamura
    Department of R and D Center, Ikeda Mohando Co, Ltd, Toyama, Japan
    J Dermatol Sci 66:144-53. 2012
    ..Since Trichophyton cannot colonize mice, guinea pigs were used in previous experiments on Trichophyton infection. However, it is difficult to perform immunological and genetic analyses in guinea pigs...
  42. pmc Interleukin-5 and IL-5 receptor in health and diseases
    Kiyoshi Takatsu
    Department of Immunobiology and Pharmacological Genetics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan
    Proc Jpn Acad Ser B Phys Biol Sci 87:463-85. 2011
    ....
  43. doi request reprint Identification of FOXP3-negative regulatory T-like (CD4(+)CD25(+)CD127(low)) cells in patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome
    Keisuke Otsubo
    Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Clin Immunol 141:111-20. 2011
    ..These results suggest that genetically altered FOXP3 can drive the generation of functionally immature Treg cells, but that intact FOXP3 is necessary for the complete function of Treg cells...
  44. ncbi request reprint NF-kappaB is required for CD38-mediated induction of C(gamma)1 germline transcripts in murine B lymphocytes
    Hiroaki Kaku
    Division of Immunology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Japan
    Int Immunol 14:1055-64. 2002
    ..These results indicate an essential role for NF-kappaB proteins in the induction of germline gamma1 transcripts by CD38-ligated murine B cells giving rise to IL-5-induced IgG1 production...
  45. ncbi request reprint PI3K and Btk differentially regulate B cell antigen receptor-mediated signal transduction
    Harumi Suzuki
    Department of Microbiology and Immunology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Nat Immunol 4:280-6. 2003
    ..Our results indicate that PI3K and Btk have unique roles in proximal BCR signaling and that they have a common target further downstream in the activation of NF-kappaB...
  46. pmc Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor alpha chain expression on activated B cells
    Dianne Emslie
    Immunology Division, The Walter and Eliza Hall Institute, Parkville, Victoria 3050, Australia
    J Exp Med 205:409-21. 2008
    ..IL-5 augments ASC differentiation in vitro, and we show that IL-5 directly activates the plasma cell differentiation program by enhancing blimp1 expression...
  47. pmc Regulation of hematopoietic development in the aorta-gonad-mesonephros region mediated by Lnk adaptor protein
    Ikuo Nobuhisa
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Mol Cell Biol 23:8486-94. 2003
    ..Furthermore, aorta cells of E11.5 Lnk homozygous mutant mice also showed enhanced hematopoietic colony-forming activity. Thus, Lnk is a negative regulator of hematopoiesis in the AGM region...
  48. ncbi request reprint Nasal cholera toxin elicits IL-5 and IL-5 receptor alpha-chain expressing B-1a B cells for innate mucosal IgA antibody responses
    Kosuke Kataoka
    Department of Pediatric Dentistry, Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Immunol 178:6058-65. 2007
    ....
  49. ncbi request reprint Critical role of IL-5 in antigen-induced pulmonary eosinophilia, but not in lymphocyte activation
    Nobuhiro Matsumoto
    Third Department of Internal Medicine, Miyazaki Medical College, Japan
    Int Arch Allergy Immunol 130:209-15. 2003
    ..We conclude that IL-5 appears to be required for the accumulation of eosinophils and AHR in the inflammatory lung. However, IL-5 does not play a critical role in the accumulation of activated CD4+ T cells in the inflammatory lung...
  50. ncbi request reprint Intraepithelial infiltration of eosinophils and their contribution to the elimination of adult intestinal nematode, Strongyloides venezuelensis in mice
    Mohamed El-Malky
    Department of Molecular Parasitology, Nagoya City University Graduate School of Medical Sciences, Kawasumi 1, Mizuho, Nagoya 467 8601, Japan
    Parasitol Int 52:71-9. 2003
    ..The present study suggests that eosinophils are capable of attacking adult nematodes in the intestinal epithelia, probably in conjunction with secretory IgA, although they are not enough for the complete worm expulsion...
  51. pmc SH2-B is required for both male and female reproduction
    Satoshi Ohtsuka
    Division of Molecular Genetics, Institute of Life Science, Kurume University, Kurume 839 0861, USA
    Mol Cell Biol 22:3066-77. 2002
    ..SH2-B(-/-) cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a critical role in the IGF-I-mediated reproductive pathway in mice...
  52. ncbi request reprint Pathogenesis of murine experimental allergic rhinitis: a study of local and systemic consequences of IL-5 deficiency
    Hiroko Saito
    Asthma Research Group, Division of Clinical Immunology and Allergy, Department of Medicine, McMaster University, Hamilton, Ontario, Canada
    J Immunol 168:3017-23. 2002
    ....
  53. ncbi request reprint Role of interleukin-5 and eosinophils in allergen-induced airway remodeling in mice
    Hiroyuki Tanaka
    Department of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan
    Am J Respir Cell Mol Biol 31:62-8. 2004
    ..These findings demonstrated that eosinophils are involved in allergen-induced subepithelial and peribronchial fibrosis probably by producing a fibrogenic factor, TGF-beta1...
  54. ncbi request reprint Transgene-mediated hyper-expression of IL-5 inhibits autoimmune disease but increases the risk of B cell chronic lymphocytic leukemia in a model of murine lupus
    Xiangshu Wen
    Department of Pathology, Juntendo University School of Medicine, Tokyo, Japan
    Eur J Immunol 34:2740-9. 2004
    ..Thus, this model may provide a clue to the pathogenesis of both SLE and B-CLL...
  55. pmc Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness
    Hiromasa Inoue
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Exp Med 201:73-82. 2005
    ..These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma...
  56. pmc Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors
    Keisuke Horikawa
    Immunogenomics Laboratory, The Australian Phenomics Facility, The John Curtin School of Medical Research, The Australian National University, Canberra 0200, Australia
    J Exp Med 204:759-69. 2007
    ....
  57. ncbi request reprint Role of cytokines in allergic airway inflammation
    Hiroshi Nakajima
    Department of Molecular Genetics, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Int Arch Allergy Immunol 142:265-73. 2007
    ..In this review, we discuss the role of individual cytokines in the pathogenesis of asthma...
  58. ncbi request reprint Mycobacterium tuberculosis infects dendritic cells with high frequency and impairs their function in vivo
    Andrea J Wolf
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Immunol 179:2509-19. 2007
    ..These results indicate that Mtb targets DC migration and Ag presentation in vivo to promote persistent infection...
  59. pmc The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages
    Hiromi Iwasaki
    Center for Cellular and Molecular Medicine, Kyushu University Hospital, Fukuoka, Japan
    Genes Dev 20:3010-21. 2006
    ..We propose that the order of expression of key transcription factors is critical for their interplay to selectively drive lineage specification programs, by which stem cells could generate multiple lineage cells in a hierarchical manner...
  60. ncbi request reprint Alteration of enzymatic properties of cell-surface antigen CD38 by agonistic anti-CD38 antibodies that prolong B cell survival and induce activation
    Miki Hara-Yokoyama
    Department of Hard Tissue Engineering, Biochemistry, Division of Bio Matrix, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8549, Japan
    Int Immunopharmacol 8:59-70. 2008
    ..The antibodies will be useful tools to analyze the conformational change of CD38 in the process of triggering B cell survival and the activation signal...
  61. pmc Initiation of the adaptive immune response to Mycobacterium tuberculosis depends on antigen production in the local lymph node, not the lungs
    Andrea J Wolf
    Division of Infectious Diseases, Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 205:105-15. 2008
    ....
  62. pmc Identification of eosinophil lineage-committed progenitors in the murine bone marrow
    Hiromi Iwasaki
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:1891-7. 2005
    ..The newly identified EoPs could be the cellular target in the treatment of a variety of disorders mediated by eosinophils...
  63. doi request reprint Memory Th1 cells augment tumor-specific CTL following transcutaneous peptide immunization
    Akihiro Hosoi
    Department of Immunotherapeutics Medinet, Graduate School of Medicine, The University of Tokyo, Japan
    Cancer Res 68:3941-9. 2008
    ..Therefore, concomitant activation of Ag85B- or peptide-25-specific mTh1 cells together with tumor-specific CTL by TCI might augment antitumor immune responses in a sizeable fraction of patients...
  64. ncbi request reprint Increased insulin sensitivity and hypoinsulinemia in APS knockout mice
    Asako Minami
    Division of Molecular Genetics, Institute for Enzyme Research, University of Tokushima, Tokushima, Japan
    Diabetes 52:2657-65. 2003
    ..APS(-/-) mice also showed increased serum levels of leptin and adiponectin, which might explain the increased insulin sensitivity of adipocytes...
  65. ncbi request reprint An hour after immunization peritoneal B-1 cells are activated to migrate to lymphoid organs where within 1 day they produce IgM antibodies that initiate elicitation of contact sensitivity
    Atsuko Itakura
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8013, USA
    J Immunol 175:7170-8. 2005
    ....
  66. pmc Toll-like receptors on hematopoietic progenitor cells stimulate innate immune system replenishment
    Yoshinori Nagai
    Immunobiology and Cancer Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA
    Immunity 24:801-12. 2006
    ..Thus, the preferential pathogen-mediated stimulation of myeloid differentiation pathways may provide a means for rapid replenishment of the innate immune system during infection...