Akinori Takaoka

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Interferon signalling network in innate defence
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Microbiol 8:907-22. 2006
  2. ncbi request reprint IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
  3. ncbi request reprint Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:243-9. 2005
  4. pmc Negative regulation of Toll-like-receptor signaling by IRF-4
    Hideo Negishi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 102:15989-94. 2005
  5. ncbi request reprint Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:1035-40. 2005
  6. pmc Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression
    Hideyuki Yanai
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 104:3402-7. 2007
  7. pmc Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
    Zhichao Wang
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:5477-82. 2008
  8. pmc Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
    Kenya Honda
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 100:10872-7. 2003
  9. doi request reprint Critical role for constitutive type I interferon signaling in the prevention of cellular transformation
    Hui Min Chen
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 100:449-56. 2009
  10. ncbi request reprint DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 448:501-5. 2007

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Interferon signalling network in innate defence
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Cell Microbiol 8:907-22. 2006
    ..Further comprehensive understanding of IFN signalling may offer a better direction to unravelling the complex signalling networks in the host defence system, and may contribute to their more effective therapeutic applications...
  2. ncbi request reprint IRF-7 is the master regulator of type-I interferon-dependent immune responses
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:772-7. 2005
    ..Thus, all elements of IFN responses, whether the systemic production of IFN in innate immunity or the local action of IFN from plasmacytoid dendritic cells in adaptive immunity, are under the control of IRF-7...
  3. ncbi request reprint Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:243-9. 2005
    ..Thus, our study identifies IRF-5 as a new, principal downstream regulator of the TLR-MyD88 signalling pathway and a potential target of therapeutic intervention to control harmful immune responses...
  4. pmc Negative regulation of Toll-like-receptor signaling by IRF-4
    Hideo Negishi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 102:15989-94. 2005
    ..This study may provide an insight into the complex regulatory mechanisms of MyD88 signaling by IRFs...
  5. ncbi request reprint Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 434:1035-40. 2005
    ..Thus, our study offers insights into the regulation of TLR9 signalling in space, potentially suggesting a new avenue for therapeutic intervention...
  6. pmc Role of IFN regulatory factor 5 transcription factor in antiviral immunity and tumor suppression
    Hideyuki Yanai
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 104:3402-7. 2007
    ..These results, together with the dual regulation of IRF5 gene expression by IFN signaling and p53, may provide a new link in the transcriptional network underlying antiviral immunity and tumor suppression...
  7. pmc Regulation of innate immune responses by DAI (DLM-1/ZBP1) and other DNA-sensing molecules
    Zhichao Wang
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 105:5477-82. 2008
    ..These results in toto provide insights into the mechanism of DAI activation and reveal the complex regulatory mechanisms underlying DNA-mediated protective and pathologic immune responses...
  8. pmc Selective contribution of IFN-alpha/beta signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection
    Kenya Honda
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Japan
    Proc Natl Acad Sci U S A 100:10872-7. 2003
    ..The immune system may have acquired the selective utilization of this cytokine system, which is essential for innate antiviral immunity, to effectively couple with the induction of adaptive immunity...
  9. doi request reprint Critical role for constitutive type I interferon signaling in the prevention of cellular transformation
    Hui Min Chen
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Cancer Sci 100:449-56. 2009
    ....
  10. ncbi request reprint DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 448:501-5. 2007
    ....
  11. doi request reprint IRF3 regulates cardiac fibrosis but not hypertrophy in mice during angiotensin II-induced hypertension
    Kensuke Tsushima
    Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    FASEB J 25:1531-43. 2011
    ..Thus, our present study reveals a hitherto unrecognized function of IRF3 in cardiac remodeling, providing new insight into the progression of hypertension-induced cardiac pathogenesis...
  12. ncbi request reprint Regulation of the type I IFN induction: a current view
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Int Immunol 17:1367-78. 2005
    ..The understanding of the regulatory mechanisms of IFN-alpha/beta gene induction by TLRs and viruses is an emerging theme, for which much new insight has been gained over the past few years...
  13. pmc Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 101:15416-21. 2004
    ..Thus, we propose that this molecular complex may function as a cytoplasmic transductional-transcriptional processor...
  14. ncbi request reprint Integration of interferon-alpha/beta signalling to p53 responses in tumour suppression and antiviral defence
    Akinori Takaoka
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 424:516-23. 2003
    ..Our study reveals a hitherto unrecognized link between p53 and IFN-alpha/beta in tumour suppression and antiviral immunity, which may have therapeutic implications...
  15. ncbi request reprint Type I interferon [corrected] gene induction by the interferon regulatory factor family of transcription factors
    Kenya Honda
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Immunity 25:349-60. 2006
    ..Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system...
  16. pmc Differential contribution of Puma and Noxa in dual regulation of p53-mediated apoptotic pathways
    Tsukasa Shibue
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo, Japan
    EMBO J 25:4952-62. 2006
    ..These findings offer a new insight into differential cellular responses induced by p53, and may have therapeutic implications in cancer...
  17. ncbi request reprint [Class II cytokine receptors and their ligands]
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo
    Nihon Rinsho 63:193-201. 2005
  18. ncbi request reprint Essential role of IRF-3 in lipopolysaccharide-induced interferon-beta gene expression and endotoxin shock
    Shinya Sakaguchi
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Biochem Biophys Res Commun 306:860-6. 2003
    ..Finally, the IRF-3-deficient mice show resistance to LPS-induced endotoxin shock. These results place IRF-3 as a molecule central to LPS/TLR4 signaling...
  19. pmc Integral role of Noxa in p53-mediated apoptotic response
    Tsukasa Shibue
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Genes Dev 17:2233-8. 2003
    ....
  20. doi request reprint Interferon regulatory factor family of transcription factors and regulation of oncogenesis
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Sci 99:467-78. 2008
    ..In the present review article, we aim at summarizing our current knowledge of the roles of IRF in host defense, with special emphasis on their involvement in the regulation of oncogenesis...
  21. ncbi request reprint New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism
    Akinori Takaoka
    Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Bunkyo ku, Tokyo 113 0033, Japan
    Cancer Sci 94:405-11. 2003
    ....
  22. ncbi request reprint The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors
    Tadatsugu Taniguchi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, 113 0033, Tokyo, Japan
    Curr Opin Immunol 14:111-6. 2002
    ..This mechanism is mediated by transcription factors of the IFN regulatory factor family and, in fact, may have evolved to render the system more robust in antiviral responses...
  23. ncbi request reprint Comparing antibody and small-molecule therapies for cancer
    Kohzoh Imai
    Sapporo Medical University, South 1, West 17, Chuo Ku, Sapporo, 060 8556, Japan
    Nat Rev Cancer 6:714-27. 2006
    ..We discuss and compare the distinctive properties of these two therapeutic strategies so as to provide a better view for the development of new drugs and the future direction of cancer therapy...
  24. doi request reprint Cytosolic DNA recognition for triggering innate immune responses
    Akinori Takaoka
    Division of Signaling in Cancer and Immunology, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Adv Drug Deliv Rev 60:847-57. 2008
    ..In addition, we also discuss the issue of self vs. non-self DNA recognition by DAI (DLM-1/ZBP1) and other DNA sensors in terms of the possible involvement in autoimmune abnormalities...
  25. ncbi request reprint Interplay between interferon and other cytokine systems in bone metabolism
    Hiroshi Takayanagi
    Department of Cell Signaling, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Immunol Rev 208:181-93. 2005
    ....