Yukitoshi Takahashi

Summary

Affiliation: University of Tokyo
Country: Japan

Publications

  1. ncbi request reprint Genetic variations of immunoregulatory genes associated with Rasmussen syndrome
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, 886 Urushiyama, Aoi ward, Shizuoka, Japan Department of Pediatrics, Gifu University School of Medicine, Yanagido, Gifu, Japan Electronic address
    Epilepsy Res 107:238-43. 2013
  2. doi request reprint Immunomodulatory therapy versus surgery for Rasmussen syndrome in early childhood
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, Shizuoka, Japan
    Brain Dev 35:778-85. 2013
  3. ncbi request reprint Open study of pranlukast add-on therapy in intractable partial epilepsy
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, 886 Urushiyama, Aoi ku, Shizuoka 420 8688, Japan
    Brain Dev 35:236-44. 2013
  4. ncbi request reprint Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua
    Y Takahashi
    Department of Pediatrics, Gifu Prefectural Gifu Hospital, Japan
    Neurology 61:891-6. 2003
  5. pmc Vaccination and infection as causative factors in Japanese patients with Rasmussen syndrome: molecular mimicry and HLA class I
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, 886 Urushiyama Aoi ku, Shizuoka 420 8688, Japan
    Clin Dev Immunol 13:381-7. 2006
  6. ncbi request reprint Effectiveness of broadcasting guidelines for photosensitive seizure prevention
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka MIND, Japan
    Neurology 62:990-3. 2004
  7. ncbi request reprint A substantial number of Rasmussen syndrome patients have increased IgG, CD4+ T cells, TNFalpha, and Granzyme B in CSF
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 50:1419-31. 2009
  8. ncbi request reprint Autoantibodies and cell-mediated autoimmunity to NMDA-type GluRepsilon2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 46:152-8. 2005
  9. doi request reprint Risk factors for hyperammonemia in pediatric patients with epilepsy
    Yoshiaki Yamamoto
    Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 54:983-9. 2013
  10. doi request reprint Influence of CYP2C19 polymorphism and concomitant antiepileptic drugs on serum clobazam and N-desmethyl clobazam concentrations in patients with epilepsy
    Yoshiaki Yamamoto
    Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Ulushiyama, Aoi ku, Japan
    Ther Drug Monit 35:305-12. 2013

Detail Information

Publications83

  1. ncbi request reprint Genetic variations of immunoregulatory genes associated with Rasmussen syndrome
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, 886 Urushiyama, Aoi ward, Shizuoka, Japan Department of Pediatrics, Gifu University School of Medicine, Yanagido, Gifu, Japan Electronic address
    Epilepsy Res 107:238-43. 2013
    ..To elucidate the genetic predisposition of Rasmussen syndrome (RS)...
  2. doi request reprint Immunomodulatory therapy versus surgery for Rasmussen syndrome in early childhood
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, Shizuoka, Japan
    Brain Dev 35:778-85. 2013
    ..We suggest a new treatment strategy for RS using early immunomodulatory therapy: initiation of regular steroid pulse therapy after early diagnosis indicated by biomarkers, then switching to tacrolimus therapy after several months. ..
  3. ncbi request reprint Open study of pranlukast add-on therapy in intractable partial epilepsy
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, 886 Urushiyama, Aoi ku, Shizuoka 420 8688, Japan
    Brain Dev 35:236-44. 2013
    ..Further investigations by double-blind control study and animal models are warranted...
  4. ncbi request reprint Autoantibodies to NMDA receptor in patients with chronic forms of epilepsia partialis continua
    Y Takahashi
    Department of Pediatrics, Gifu Prefectural Gifu Hospital, Japan
    Neurology 61:891-6. 2003
    ..Antibody-mediated and cytotoxic T cell-mediated pathogenicity have been implicated as the autoimmune pathophysiologic mechanisms in Rasmussen's encephalitis...
  5. pmc Vaccination and infection as causative factors in Japanese patients with Rasmussen syndrome: molecular mimicry and HLA class I
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, 886 Urushiyama Aoi ku, Shizuoka 420 8688, Japan
    Clin Dev Immunol 13:381-7. 2006
    ..1 (A*2402 + B*5201). Some alleles and haplotypes of HLA class I may be the risk factors in Japanese patients. Cross-reactivity of cytotoxic T lymphocytes may contribute to the processes leading from infection to the involvement of CNS...
  6. ncbi request reprint Effectiveness of broadcasting guidelines for photosensitive seizure prevention
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka MIND, Japan
    Neurology 62:990-3. 2004
    ..They show that the guidelines successfully control TV images to protect many photosensitive persons from harmful TV emissions...
  7. ncbi request reprint A substantial number of Rasmussen syndrome patients have increased IgG, CD4+ T cells, TNFalpha, and Granzyme B in CSF
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 50:1419-31. 2009
    ..We studied the immunologic molecules in cerebrospinal fluid (CSF) and discussed their evolutional changes in pediatric patients with Rasmussen syndrome (RS)...
  8. ncbi request reprint Autoantibodies and cell-mediated autoimmunity to NMDA-type GluRepsilon2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 46:152-8. 2005
    ..To evaluate antibody-mediated and cytotoxic T cell-mediated pathogenicity that has been implicated as the autoimmune pathophysiological mechanism in Rasmussen's encephalitis...
  9. doi request reprint Risk factors for hyperammonemia in pediatric patients with epilepsy
    Yoshiaki Yamamoto
    Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 54:983-9. 2013
    ..To identify risk factors for hyperammonemia in pediatric patients with epilepsy...
  10. doi request reprint Influence of CYP2C19 polymorphism and concomitant antiepileptic drugs on serum clobazam and N-desmethyl clobazam concentrations in patients with epilepsy
    Yoshiaki Yamamoto
    Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Ulushiyama, Aoi ku, Japan
    Ther Drug Monit 35:305-12. 2013
    ....
  11. doi request reprint Lamotrigine is favourable for startle-induced seizures
    Hiroko Ikeda
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epileptic Disord 13:277-83. 2011
    ..The addition of LTG treatment dramatically improved the lives of the patients presented here and should be considered as an option for startle-induced seizures...
  12. doi request reprint Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome
    Dezhi Cao
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 53:1140-5. 2012
    ..Then we assessed the efficacy of stiripentol (STP) monotherapy versus STP and clobazam (CLB) combination therapy to prevent hyperthermia-induced seizures in Scn1a(RX/+) mice...
  13. doi request reprint Self-induced seizures presumably by peri-orbital somatosensory self-stimulation: a report of two cases
    Rumiko Takayama
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoiku, Shizuoka, Japan
    Brain Dev 34:685-90. 2012
    ..In patients with serial seizures preceded by peculiar behaviors, we need to consider the possibility of self-induced seizures, even if they have a history of West syndrome and severe psychomotor retardation...
  14. doi request reprint Retrospective multiinstitutional study of the prevalence of early death in Dravet syndrome
    Masako Sakauchi
    Department of Pediatrics, Tokyo Women s Medical University, Tokyo, Japan
    Epilepsia 52:1144-9. 2011
    ..A questionnaire survey was conducted in Japan to investigate the causes and prevalence of death related to Dravet syndrome...
  15. ncbi request reprint [Acute limbic encephalitis and NMDA type-glutamate receptor]
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
    Rinsho Shinkeigaku 48:926-9. 2008
    ..These autoantibodies in both groups included epitopes to n-terminal of GluRepsilon2. Antibodies against NMDAR complex (Dalmau's method) in CSF were detected in 90.9% (10/11) of NHAE-OT patients...
  16. doi request reprint Cutaneous adverse drug reaction in patients with epilepsy after acute encephalitis
    Yukiko Mogami
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
    Brain Dev 34:496-503. 2012
    ..RANTES may be a biomarker for susceptibility to CARs in EAE patients...
  17. ncbi request reprint [Efficacy of repeated adrenocorticotropic hormone therapy in patients with intractable epileptic spasms]
    Mariko Ikegami
    Department of Pediatrics, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorder, Shizuoka
    No To Hattatsu 45:281-7. 2013
    ..We examined the effectiveness of repeated adrenocorticotropic hormone (ACTH) therapy in short-term and long-term seizure control in patients with intractable epileptic spasms...
  18. ncbi request reprint [Effectiveness of topiramate in eleven patients with Dravet syndrome]
    Hiroka Takahashi
    Department of Pediatrics, National Epilepsy Center Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka
    No To Hattatsu 42:273-6. 2010
    ..In the present study, TPM was useful as an adjunctive therapy to reduce the frequency of convulsive seizures in patients with Dravet syndrome. A large-scale efficacy study of TPM for Dravet syndrome is warranted...
  19. ncbi request reprint [Autoantibodies against glutamate receptors in patients with encephalitis]
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
    Rinsho Shinkeigaku 47:848-51. 2007
    ..However, no patients with widespread encephalitis had autoantibodies to the extracellular N epitope in acute stages. These data may suggest that GluR autoimmunity contributes to the onset of localized encephalitis...
  20. ncbi request reprint Serum matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 levels in non-herpetic acute limbic encephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    J Neurol 256:1846-50. 2009
    ..001) but did not differ in patients with NHALE in the acute and convalescent stages. Our preliminary study suggests that the prolonged imbalance of MMP-9 and TIMP-1 is associated with the pathogenesis of NHALE...
  21. doi request reprint Temporal changes in brain MRI findings in Rasmussen syndrome
    Etsuko Yamazaki
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epileptic Disord 13:229-39. 2011
    ..In the present study, we examined the status and evolutionary changes in MRI lesions to identify the MRI characteristics of RS...
  22. ncbi request reprint [Antibodies to glutamate receptor in limbic encephalitis]
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Aoi ku, Shizuoka, Japan
    Brain Nerve 62:827-37. 2010
    ..Pathophysiology of antibodies against NR is estimated to cause internalization of NR on surface of neurons, resulting in inhibition of NR function...
  23. ncbi request reprint Influence of concomitant antiepileptic drugs on plasma lamotrigine concentration in adult Japanese epilepsy patients
    Yoshiaki Yamamoto
    Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
    Biol Pharm Bull 35:487-93. 2012
    ..94, 0.94, 0.90, and 0.91, respectively. In the clinical setting, these findings can help to estimate LTG concentrations and predict the inducing or inhibiting effects of concomitant AEDs...
  24. ncbi request reprint [Rasmussen encephalitis and non-herpetic acute limbic encephalitis]
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
    Rinsho Shinkeigaku 48:163-72. 2008
    ..4 years old, autoantibodies against NAE were around 59 years old, autoantibodies against Hu were around 61.5 years old. These data suggest that autoantibodies related with NHALE have age-dependent heterogeneity...
  25. doi request reprint HLA class I markers in Japanese patients with carbamazepine-induced cutaneous adverse reactions
    Hiroko Ikeda
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 51:297-300. 2010
    ..These data may suggest that HLA-B*5901 is one of the candidate markers for CBZ-induced SJS in Japanese...
  26. ncbi request reprint Long-term course of Dravet syndrome: a study from an epilepsy center in Japan
    Rumiko Takayama
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 55:528-38. 2014
    ..This study attempted to clarify the long-term course of Dravet syndrome (DS)...
  27. doi request reprint PCDH19-related female-limited epilepsy: further details regarding early clinical features and therapeutic efficacy
    Norimichi Higurashi
    Department of Pediatrics, School of Medicine, Fukuoka University, 7 45 1, Nanakuma, Jonan ku, Fukuoka 814 0180, Japan
    Epilepsy Res 106:191-9. 2013
    ..Our data will facilitate early diagnosis and development of a treatment strategy for better clinical management of patients with PCDH19-related epilepsy...
  28. ncbi request reprint Stiripentol open study in Japanese patients with Dravet syndrome
    Yushi Inoue
    Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 50:2362-8. 2009
    ..To survey the treatment situation of Dravet syndrome in Japan and to compare this result with effectiveness of stiripentol (STP) add-on therapy in an open-label multicenter study...
  29. ncbi request reprint Focal encephalopathy with recurrent episodes of epileptic status and cluster mimicking hemiconvulsion-hemiplegia-epilepsy syndrome
    Rie Miyata
    Department of Pediatrics, Tokyo Kita Social Insurance Hospital, Tokyo, Japan
    Brain Dev 34:360-3. 2012
    ..In such cases, immunohistochemistry using the patient's sera may be useful for the investigation of the pathogenesis of the illness...
  30. ncbi request reprint Influence of uridine diphosphate glucuronosyltransferase 2B7 -161C>T polymorphism on the concentration of valproic acid in pediatric epilepsy patients
    Kazuyuki Inoue
    Department of Clinical Pharmacology and Genetics, School of Pharmaceutical Sciences, University of Shizuoka and Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, National Epilepsy Center, Shizuoka, Japan
    Ther Drug Monit 36:406-9. 2014
    ..This study aimed to examine the relationships between plasma VPA concentrations and the -161C>T single nucleotide polymorphism in uridine diphosphate glucuronosyltransferase (UGT) 2B7 genes in pediatric epilepsy patients...
  31. ncbi request reprint Interaction between sulthiame and clobazam: sulthiame inhibits the metabolism of clobazam, possibly via an action on CYP2C19
    Yoshiaki Yamamoto
    Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, 886 Urushiyama, Shizuoka 420 8688, Japan Department of Clinical Pharmaceutics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, 52 1 Yada, Shizuoka 422 8526, Japan Electronic address
    Epilepsy Behav 34:124-6. 2014
    ..During combination therapy with STM and CLB in patients with CYP2C19 intermediate or extensive metabolizer phenotypes, monitoring of DMCLB concentrations may be helpful in ascertaining CLB-related adverse effects...
  32. ncbi request reprint Cerebrospinal fluid levels of cytokines in non-herpetic acute limbic encephalitis: comparison with herpes simplex encephalitis
    Takashi Ichiyama
    Department of Pediatrics, Yamaguchi University Graduate School of Medicine, 1 1 1 Minamikogushi, Ube, Yamaguchi 755 8505, Japan
    Cytokine 44:149-53. 2008
    ..Recently, non-herpetic acute limbic encephalitis (NHALE) was identified as a new subgroup of limbic encephalitis. The immunological pathophysiology of NHALE is still unclear...
  33. doi request reprint Risk factors for hyperammonemia associated with valproic acid therapy in adult epilepsy patients
    Yoshiaki Yamamoto
    Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, 886, Urushiyama, Aoi ku, Shizuoka shi, Shizuoka 420 8688 Japan
    Epilepsy Res 101:202-9. 2012
    ..5). Regimens containing multiple inducers were associated with an increased risk of hyperammonemia. Identification of risk factors for hyperammonemia associated with VPA therapy can help to minimize side effects during its clinical use...
  34. ncbi request reprint Acute cerebellar ataxia and consecutive cerebellitis produced by glutamate receptor delta2 autoantibody
    Takashi Shiihara
    Department of Pediatrics, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    Brain Dev 29:254-6. 2007
    ..Furthermore, glutamate receptor delta2 autoantibody was detected in serum and cerebro-spinal fluid. Thus, we believe that the glutamate receptor delta2 autoantibody may play a role in cerebellar ataxia and consecutive cerebellitis...
  35. doi request reprint Nationwide survey (incidence, clinical course, prognosis) of Rasmussen's encephalitis
    Ayako Muto
    Department of Pediatrics, Tokyo Women s Medical University, Tokyo, Japan
    Brain Dev 32:445-53. 2010
    ..We performed a nationwide survey of RE to assess the clinical picture, treatment effect, and prognosis of Japanese RE patients...
  36. ncbi request reprint [Symptoms and clinical course of epilepsy with myoclonic absences]
    Hiroko Ikeda
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka
    No To Hattatsu 43:14-8. 2011
    ..Patients with long MA duration or MA status epilepticus were prone to be refractory to medication. EMA can be divided into two subgroups based on the seizure outcome, favorable and unfavorable. Further large-scale study is required...
  37. ncbi request reprint Electroclinical features of epilepsy in patients with juvenile type dentatorubral-pallidoluysian atrophy
    Kiyoshi Egawa
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Epilepsia 49:2041-9. 2008
    ..To clarify the electroclinical characteristics of epileptic seizures in patients with juvenile type dentatorubral-pallidoluysian atrophy (DRPLA)...
  38. doi request reprint SLC2A1 gene analysis of Japanese patients with glucose transporter 1 deficiency syndrome
    Natsuko Hashimoto
    Department of Pediatrics, Osaka University Graduate School of Medicine, Osaka, Japan
    J Hum Genet 56:846-51. 2011
    ..Changes in regulatory sequences in the promoter region or genes other than SLC2A1 might be responsible for onset of Glut1-DS in the other four patients (33%) without SLC2A1 mutation...
  39. doi request reprint Mortality in Dravet syndrome: search for risk factors in Japanese patients
    Masako Sakauchi
    Department of Pediatrics, Tokyo Women s Medical University, Tokyo, Japan
    Epilepsia 52:50-4. 2011
    ..Neither the treatment nor the number of seizures was associated with any cause of mortality. Factors leading to a fatal outcome are difficult to predict...
  40. ncbi request reprint MR imaging and 1H-MR spectroscopy of a case of van der Knaap disease
    Hideyuki Morita
    Department of Pediatrics, Gifu Prefectral Gifu Hospital, 4 6 1, Noishiki, Gifu 500 8717, Japan
    Brain Dev 28:466-9. 2006
    ..These findings suggest that demyelination progresses slowly in van der Knaap disease and that MRS with long and short TE is useful for the evaluation of neural metabolization associated with van der Knaap disease...
  41. ncbi request reprint A common variable immunodeficient patient who developed acute disseminated encephalomyelitis followed by the Lennox-Gastaut syndrome
    Masashi Kondo
    Department of Pediatrics, Graduate School of Medicine, Gifu University, Gifu, Japan
    Pediatr Allergy Immunol 16:357-60. 2005
    ..We suspect that a genetic defect in the immune system of our patient might also be associated with the neurologic disorders of ADEM and the Lennox-Gastaut syndrome...
  42. doi request reprint Chronic myoclonia of subcortical origin with antiglutamate receptor antibodies
    Muneaki Matsuo
    Department of Pediatrics, Faculty of Medicine, Saga University, Saga, Japan
    J Child Neurol 22:1393-6. 2007
    ..The patient's symptoms have now been stable with clonazepam treatment for 2 years. The left thalamus was suspected to have been the region at least partly responsible for the patient's symptoms...
  43. doi request reprint Interstitial duplication of 2q32.1-q33.3 in a patient with epilepsy, developmental delay, and autistic behavior
    Daisuke Usui
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Am J Med Genet A 161:1078-84. 2013
    ..This result is in agreement with our previous study, in which we observed that duplicated segments as interstitial duplications are generally inserted in the tandem configuration...
  44. doi request reprint Clinical and radiological features of Japanese patients with a severe phenotype due to CASK mutations
    Jun ichi Takanashi
    Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan
    Am J Med Genet A 158:3112-8. 2012
    ..The male patient showed a more severe clinical phenotype. These uniform clinical and radiological features should facilitate an early diagnosis and be useful for medical care of females with ID and MICPCH associated with CASK mutations...
  45. doi request reprint Late delirious behavior with 2009 H1N1 influenza: mild autoimmune-mediated encephalitis?
    Jun ichi Takanashi
    Department of Pediatrics, Kameda Medical Center, Kamogawa, Japan
    Pediatrics 129:e1068-71. 2012
    ..This study indicates that 2009 H1N1 influenza has a tendency to cause late-onset and long-standing delirious behavior, at least in Japanese children. Mild autoimmune-mediated encephalitis should be considered as an underlying cause...
  46. ncbi request reprint A patient with epilepsia partialis continua with anti-glutamate receptor epsilon 2 antibodies
    Akira Kumakura
    Department of Pediatrics, Shiga Medical Center for Children, Moriyama, Shiga, Japan
    Pediatr Neurol 29:160-3. 2003
    ..Therefore, anti-glutamate receptor epsilon 2 subunit antibodies are not specific for chronic progressive epilepsia partialis continua of childhood and Rasmussen's encephalitis...
  47. ncbi request reprint [Development of rapid genotyping methods for single nucleotide polymorphisms of cytochrome P450 2C9 (CYP2C9) and cytochrome P450 2C19 (CYP2C19) and their clinical application in pediatric patients with epilepsy]
    Yoshiaki Yamamoto
    Department of Clinical Research, National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka, Japan
    Yakugaku Zasshi 131:809-15. 2011
    ....
  48. ncbi request reprint A case of acute encephalitis with refractory, repetitive partial seizures, presenting autoantibody to glutamate receptor Gluepsilon2
    Hiromichi Ito
    Department of Pediatrics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3 18 15, Kuramoto Cho, Tokushima 770 8503, Japan
    Brain Dev 27:531-4. 2005
    ..In this case, a combination of mild hypothermia therapy, steroid pulse therapy, and massive gamma-globulin therapy was effective...
  49. ncbi request reprint Acute cerebellitis following hemolytic streptococcal infection
    Hiromasa Uchizono
    Department of Pediatrics, Mie University Graduate School of Medicine, Tsu City, Japan
    Pediatr Neurol 49:497-500. 2013
    ..Acute cerebellitis is a rare inflammatory syndrome in children, with either infectious or autoimmune etiologies...
  50. ncbi request reprint Association of acute cerebellar ataxia and human papilloma virus vaccination: a case report
    Chihiro Yonee
    Department of Pediatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima City, Kagoshima, Japan
    Neuropediatrics 44:265-7. 2013
    ..We report the case of a patient who developed symptoms of acute cerebellar ataxia (ACA) after administration of the human papilloma virus (HPV)-16/18 vaccine...
  51. ncbi request reprint An immunologic case study of acute encephalitis with refractory, repetitive partial seizures
    Hiroyuki Wakamoto
    Department of Pediatrics, Ehime Prefectural Central Hospital, Ehime, Japan
    Brain Dev 34:763-7. 2012
    ..NK cell dysfunction may be the underlying abnormality in this AERRPS case, which might have contributed to the production of GluR autoantibodies...
  52. ncbi request reprint A case of acute cerebellitis accompanied by autoantibodies against glutamate receptor delta2
    Tomoyuki Shimokaze
    Department of Pediatrics, Yamagata Prefectural Shinjo Hospital, Shinjo, Japan
    Brain Dev 29:224-6. 2007
    ..Early steroid treatment for acute cerebellitis might have been effective to prevent the progress of the disease and improve the prognosis...
  53. ncbi request reprint [Diagnostic and therapeutic scheme of autoimmune mediated encephalitis/encephalopathy]
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
    Rinsho Shinkeigaku 52:836-9. 2012
    ..Antibodies to TPO can be the marker for diagnosis, and thereafter, confirmation of antibodies to NAE is necessary for definitive diagnosis...
  54. ncbi request reprint Acute encephalopathy with refractory status epilepticus: bilateral mesial temporal and claustral lesions, associated with a peripheral marker of oxidative DNA damage
    Takashi Shiihara
    Department of Pediatrics, Yamagata University School of Medicine, 2 2 2 Iida nishi, Yamagata 990 9585, Japan
    J Neurol Sci 250:159-61. 2006
    ..Serial measurements of oxidative stress markers in acute encephalitis, encephalopathy, or status epilepticus could clarify the relationships between acute brain damage and free radicals...
  55. ncbi request reprint Detection of DNA of six human herpesviruses in the cerebrospinal fluid of immunocompetent non-herpetic acute limbic encephalitis patients
    Tetsushi Yoshikawa
    Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Aichi, Japan
    Microbiol Immunol 54:471-4. 2010
    ..EBV DNA was detected in one CSF sample. The EBV DNA-positive patient was a 36-year-old woman who presented with fever, headache, mild somnolence, and the typical neuroimaging findings...
  56. ncbi request reprint Serial MR imaging and 1H-MR spectroscopy of unidentified bright objects in a case of neurofibromatosis type 1
    Atsushi Imamura
    Department of Pediatrics, Gifu Prefectural Gifu Hospital, 4 6 1 Noishiki, Gifu 500 8717, Japan
    Brain Dev 27:595-7. 2005
    ..The longitudinal follow-up using MR image and 1H-MRS was useful for metabolic evaluation of UBO in patients with NF1...
  57. ncbi request reprint [Antibodies to the glutamate receptor]
    Yukitoshi Takahashi
    National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Japan
    Brain Nerve 65:345-53. 2013
    ..Antibodies to metabotropic GluRs have been detected using cell-based assays in patients with Hodgkin's lymphoma. Passive transfer of the IgG fraction from patients having antibodies to metabotropic GluR1 causes ataxia in mice...
  58. ncbi request reprint Mutations of sodium channel alpha subunit type 1 (SCN1A) in intractable childhood epilepsies with frequent generalized tonic-clonic seizures
    Tateki Fujiwara
    National Epilepsy Centre, Shizuoka Medical Institute of Neurological Disorders, Shizuoka, Japan
    Brain 126:531-46. 2003
    ..Here we suggest that SMEI and ICEGTC represent a continuum with minor phenotypic and genotypic differences...
  59. ncbi request reprint [Intrathecal glutamate receptor antibodies in a patient with elderly-onset refractory epilepsy]
    Yuji Tanaka
    First Department of Internal Medicine, School of Medicine, Gifu University, Department of Neurology, Gifu Prefectural Gifu Hospital
    Rinsho Shinkeigaku 43:345-9. 2003
    ..The glutamate receptor antibodies may play a role in late-onset refractory epilepsy, and may be an autoimmune factor in paraneoplstic neurologic syndrome presenting with epilepsy...
  60. ncbi request reprint [Non-herpetic acute limbic encephalitis-like manifestation in a case of Hashimoto's encephalopathy with positive autoantibodies against ionotropic glutamate receptor epsilon2]
    Akihiro Shindo
    Department of Neurology, Mie University Graduate School of Medicine
    Rinsho Shinkeigaku 47:629-34. 2007
    ..A final diagnosis of Hashimoto's encephalopathy associated with GluRepsilon2 antibody was made. The present case suggests that NHALE-like clinical manifestation can be produced by autoimmune-mediated encephalopathies...
  61. ncbi request reprint Encephalitis of unknown etiology with anti-GluR epsilon2 autoantibody, showing divergent neuroradiologic and clinical findings
    Masaki Miyazaki
    Eur Neurol 57:111-3. 2007
  62. ncbi request reprint A chronic progressive case of enteroviral limbic encephalitis associated with autoantibody to glutamate receptor epsilon2
    Hideto Nakajima
    Eur Neurol 57:238-40. 2007
  63. ncbi request reprint [Subacute encephalitis with anti-glutamate receptor antibodies presented with epilepsia partialis continua]
    Motomi Arai
    Rinsho Shinkeigaku 45:610-2. 2005
    ..While he had no motor dysfunctions, he had loss of spontaneity and memory impairment. This report suggests that EPC might be the initial symptom of subacute encephalitis with a possible autoimmune mechanism...
  64. ncbi request reprint [A case of chronic cerebellitis with anti-glutamate receptor delta 2 antibody]
    Nobuyoshi Sugiyama
    Division of Neurology, Saitama Children s Medical Center, Iwatsuki, Saitama
    No To Hattatsu 36:60-3. 2004
    ..Serum and CSF anti-glutamate receptor delta 2 antibodies were detected in the serum and CSF. We diagnosed him as having chronic cerebellitis associated with anti-glutamate receptor delta 2 antibody...
  65. doi request reprint Epitope of autoantibodies to N-methyl-D-aspartate receptor heteromers in paraneoplastic limbic encephalitis
    Yukitoshi Takahashi
    Ann Neurol 64:110-1; author reply 111-2. 2008
  66. ncbi request reprint [Subacute encephalitis associated with anti-glutamate receptor antibodies: serial studies of MRI, 1H-MRS and SPECT]
    Shiro Yamamoto
    Cerebrovascular Division, Department of Medicine, Yodogawa Christian Hospital
    Rinsho Shinkeigaku 48:196-201. 2008
    ..This report suggests that MRI, 1H-MRS and SPECT studies were useful in understanding the pathogenesis of encephalitis associated with glutamate receptor antibodies...
  67. ncbi request reprint Mutations in the NHLRC1 gene are the common cause for Lafora disease in the Japanese population
    Shweta Singh
    Department of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India
    J Hum Genet 50:347-52. 2005
    ..Our study, in addition to documenting the genetic and molecular heterogeneity observed for LD, suggests that mutations in the NHLRC1 gene may be a common cause of LD in the Japanese population...
  68. ncbi request reprint Acute limbic encephalitis: a new entity?
    Yoko Mochizuki
    Department of Pathology, Tokyo Metropolitan Neurological Hospital, 2 6 1 Musashidai, Fuchu shi, Tokyo 183 0042, Japan
    Neurosci Lett 394:5-8. 2006
    ..HSV-1, -2 and human herpes virus-6 were negative immunohistochemically. We believe that our autopsy case may contribute to understanding the neuropathological background of non-herpetic acute limbic encephalitis...
  69. ncbi request reprint "Burst and slow complexes" in nonconvulsive epileptic status
    Akio Ikeda
    Department of Neurology, Kyoto University School of Medicine, Japan
    Epileptic Disord 8:61-4. 2006
    ..CSF and serum were positive for autoantibodies to NMDA receptors. The "burst and slow complexes" reported here are considered to be an atypical EEG pattern of a generalized epileptic phenomenon...
  70. ncbi request reprint Acute encephalitis with refractory, repetitive partial seizures: case reports of this unusual post-encephalitic epilepsy
    Yoshiaki Saito
    Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36 1 Nishi cho, Yonago 683 8504, Japan
    Brain Dev 29:147-56. 2007
    ..We also hypothesize that a prolonged inflammatory process exists in the cerebral cortex with AERRPS, and may be pivotal in the epileptogenesis...
  71. ncbi request reprint Reflex seizures in patients with malformations of cortical development and refractory epilepsy
    Andre Palmini
    Porto Alegre Epilepsy Surgery Program, Hospital Sao Lucas, Pontificia Universidade Catolica do Rio Grande do Sul PUCRS, Porto Alegre, Brazil
    Epilepsia 46:1224-34. 2005
    ..We sought to characterize reflex seizures in patients with MCDs and refractory epilepsy...
  72. ncbi request reprint [A case of non-herpetic acute encephalitis with autoantibodies for ionotropic glutamate receptor delta2 and epsilon2]
    Yuichi Hayashi
    Department of Neurology and Geriatrics, Division of Neurosciences, Gifu University Graduate School of Medicine
    Rinsho Shinkeigaku 45:657-62. 2005
    ..This is the first report of MRI-positive non-herpetic acute encephalitis with autoantibodies to GluRdelta2 and epsilon2...
  73. ncbi request reprint Refractory epilepsy accompanying acute encephalitis with multifocal cortical lesions: possible autoimmune etiology
    Tohru Okanishi
    Division of Child Neurology, Institute of Neurological Sciences, Faculty of Medicine, Tottori University, 36 1 Yonago 683 8504, Japan
    Brain Dev 29:590-4. 2007
    ..We discuss the etiological significance of the multifocal lesions, which are unusual findings on neuroimaging of AERRPS...
  74. doi request reprint Steroid-responsive chronic cerebellitis with positive glutamate receptor delta 2 antibody
    Masaya Kubota
    Department of Pediatrics Pediatric Neurology, Metropolitan Hachioji Children s Hospital, Hachioji City, Tokyo, Japan plala or jp
    J Child Neurol 23:228-30. 2008
    ..Because the cerebellum is strongly involved in language acquisition as well as motor development, treatment must facilitate time for language learning while reducing the side effects of the corticosteroid therapy...
  75. ncbi request reprint [A 16-year-old boy with meningoencephalitis with auto-antibody against glutamate receptor]
    Shiho Tomioka
    Department of Pediatrics, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka
    No To Hattatsu 40:42-6. 2008
    ..These clinical features were quite different from those observed for cases of Rasmussen's encephalitis...
  76. ncbi request reprint [A case of myoclonic astatic epilepsy with autoantibody for glutamate receptor epsilon 2]
    Anzu Takahashi
    Department of Pediatrics, Shimane University Faculty of Medicine, Izumo, Shimane
    No To Hattatsu 40:38-41. 2008
    ..To our knowledge, there have been no previous reports of MAE in which autoantibody to GluR epsilon 2 was positive. It is suggested that autoimmunity in this case was associated with the pathogenesis of MAE...
  77. ncbi request reprint [Effect of tacrolimus in a case of autoimmune encephalitis]
    Keiko Hirano
    Department of Pediatric Neurology, Shizuoka Children s Hospital, Shizuoka
    No To Hattatsu 39:436-9. 2007
    ..There were few reports describing tacrolimus therapy for encephalitis. Tacrolimus may be effective for selected patients with recurrent encephalitis in which an autoimmune mechanism is considered as the pathogenesis...
  78. ncbi request reprint [Autoimmune encephalitis with anti-glutamate receptor antibody presenting as epilepsia partialis continua and action myoclonus: a case report]
    Yuji Kato
    Department of Neurology, Saitama Medical University
    Rinsho Shinkeigaku 47:429-33. 2007
    ..This is the first report of autoimmune encephalitis with anti-glutamate receptor antibody presenting as low level of 5-HIAA in the CSF. Tandospirone was effective for action myoclonus...
  79. ncbi request reprint Paraneoplastic limbic encephalitis caused by ovarian teratoma with autoantibodies to glutamate receptor
    Sadahisa Okamoto
    Department of Neurology, Graduate School of Medical Sciences, Kumamoto University
    Intern Med 46:1019-22. 2007
    ..However, after the treatment, an ovarian tumor was discovered, and we detected autoantibodies to GluR in the CSF. A possible association between the ovarian teratoma and GluR is suggested...
  80. ncbi request reprint [Successful use of methylprednisolone therapy in a case of non-herpetic acute encephalitis with antibodies against ionotropic glutamate receptor epsilon2 and delta2]
    Yuko Wada
    Department of Neurology, Nishi Kobe Medical Center, Kouji dai, Nishi ku, Kobe, Hyogo 651 2273, Japan
    Brain Nerve 59:527-32. 2007
    ..This case report indicates that high-dose IV methylprednisolone therapy may be an affective treatment for non-herpetic acute limbic encephalitis, possibly associated with autoimmune mechanisms...
  81. ncbi request reprint [A case of non-herpetic acute limbic encephalitis in childhood--comparison with acute encephalitis with refractory repetitive partial seizures (AERRPS)]
    Masashiro Kikuchi
    Department of Pediatrics, Hitachi General Hospital, Hitachi, Ibaraki
    No To Hattatsu 39:221-5. 2007
    ..We assume that a part of AERRPS belongs to the category of parainfectious limbic encephalitis with repetitive seizures...
  82. ncbi request reprint Limbic encephalitis with autoantibodies against the glutamate receptor epsilon 2 mimicking temporal lobe epilepsy
    Aihide Yoshino
    Psychiatry Clin Neurosci 61:335. 2007
  83. ncbi request reprint [A case of glioblastoma misdiagnosed initially due to positive finding of anti-glutamate receptor antibody]
    Taku Rokutanda
    Department of Neurology, Stroke Center, Saiseikai Kumamoto Hospital
    Rinsho Shinkeigaku 48:497-500. 2008
    ..We suggest that patients with autoantibodies against GluRepsilon2 should be carefully diagnosed with limbic encephalopathy associated with autoimmune mechanisms even if radiological findings are typical of the disease...