Tsutomu Takahashi

Summary

Affiliation: University of Toyama
Country: Japan

Publications

  1. doi request reprint Amygdala and insula volumes prior to illness onset in bipolar disorder: a magnetic resonance imaging study
    Andreas Bechdolf
    Department of Psychiatry, University of Cologne, Germany
    Psychiatry Res 201:34-9. 2012
  2. doi request reprint Volumetric MRI study of the insular cortex in individuals with current and past major depression
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria 3053, Australia
    J Affect Disord 121:231-8. 2010
  3. doi request reprint Midline brain structures in patients with current and remitted major depression
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1058-63. 2009
  4. doi request reprint Midline brain structures in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:842-6. 2009
  5. doi request reprint Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Arch Gen Psychiatry 66:366-76. 2009
  6. ncbi request reprint Olfactory sulcus morphology in established bipolar affective disorder
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Electronic address
    Psychiatry Res 222:114-7. 2014
  7. doi request reprint The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan Department of Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 51:166-71. 2014
  8. doi request reprint Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Electronic address
    Schizophr Res 153:18-24. 2014
  9. doi request reprint Longitudinal MRI study of the midline brain regions in first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    Psychiatry Res 212:150-3. 2013
  10. doi request reprint Altered depth of the olfactory sulcus in first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 40:167-72. 2013

Detail Information

Publications85

  1. doi request reprint Amygdala and insula volumes prior to illness onset in bipolar disorder: a magnetic resonance imaging study
    Andreas Bechdolf
    Department of Psychiatry, University of Cologne, Germany
    Psychiatry Res 201:34-9. 2012
    ..If these findings are confirmed, they suggest that imaging investigations could help to distinguish people who will subsequently develop bipolar disorder from those who will not, at least in symptomatically enriched samples...
  2. doi request reprint Volumetric MRI study of the insular cortex in individuals with current and past major depression
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria 3053, Australia
    J Affect Disord 121:231-8. 2010
    ..Nevertheless, it remains largely unknown whether MDD patients exhibit morphologic changes of the insular cortex, and whether such changes reflect state or trait markers of the disorder...
  3. doi request reprint Midline brain structures in patients with current and remitted major depression
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1058-63. 2009
    ..Whether the AI length exhibits ongoing changes across the course of the illness remains to be determined in longitudinal studies...
  4. doi request reprint Midline brain structures in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:842-6. 2009
    ..These preliminary findings suggest that ongoing neuroimaging studies should further evaluate a potential involvement of midline brain structures in the pathogenesis of BPD...
  5. doi request reprint Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Australia
    Arch Gen Psychiatry 66:366-76. 2009
    ..It is unknown whether these progressive processes predate the onset of psychosis...
  6. ncbi request reprint Olfactory sulcus morphology in established bipolar affective disorder
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Electronic address
    Psychiatry Res 222:114-7. 2014
    ..Bipolar patients had significantly shallower olfactory sulci bilaterally compared to controls, suggesting that neurodevelopmental abnormalities contribute to the neurobiology of bipolar disorder. ..
  7. doi request reprint The polymorphism of YWHAE, a gene encoding 14-3-3epsilon, and orbitofrontal sulcogyral pattern in patients with schizophrenia and healthy subjects
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan Department of Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan Electronic address
    Prog Neuropsychopharmacol Biol Psychiatry 51:166-71. 2014
    ..These results suggest a possible role for the YWHAE genotype in the early development of the OFC sulcogyral pattern, but its effect alone is not likely to explain the altered sulcogyral pattern in schizophrenia...
  8. doi request reprint Altered depth of the olfactory sulcus in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Electronic address
    Schizophr Res 153:18-24. 2014
    ....
  9. doi request reprint Longitudinal MRI study of the midline brain regions in first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    Psychiatry Res 212:150-3. 2013
    ..The CSP showed no group difference. These results suggest a role for the AI as a possible neurodevelopmental marker of schizophrenia...
  10. doi request reprint Altered depth of the olfactory sulcus in first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 40:167-72. 2013
    ..These findings suggest that the olfactory sulcus depth, but not length, may be a static vulnerability marker of schizophrenia that reflects early neurodevelopmental abnormality...
  11. doi request reprint Longitudinal MRI study of the pituitary volume in chronic schizophrenia: a preliminary report
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Psychiatry Res 202:84-7. 2012
    ....
  12. ncbi request reprint Follow-up MRI study of the insular cortex in first-episode psychosis and chronic schizophrenia
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 108:49-56. 2009
    ....
  13. doi request reprint Diagnostic specificity of the insular cortex abnormalities in first-episode psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:651-7. 2009
    ..These findings suggest that the widespread volume reduction of the insular cortex is specific to established schizophrenia, implicating its role in the neurobiology of clinical characteristics associated with schizophrenia...
  14. ncbi request reprint Increased pituitary volume in schizophrenia spectrum disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria 3053, Australia
    Schizophr Res 108:114-21. 2009
    ....
  15. doi request reprint Insular cortex volume in established bipolar affective disorder: a preliminary MRI study
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Psychiatry Res 182:187-90. 2010
    ....
  16. ncbi request reprint Temporal lobe gray matter in schizophrenia spectrum: a volumetric MRI study of the fusiform gyrus, parahippocampal gyrus, and middle and inferior temporal gyri
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 87:116-26. 2006
    ....
  17. doi request reprint Prevalence of large cavum septi pellucidi in ultra high-risk individuals and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 105:236-44. 2008
    ..These findings suggest that the CSP is not a neurodevelopmental marker of psychosis and cast doubt over the notion that it plays a major role in the neurobiology of psychosis...
  18. doi request reprint Longitudinal volume changes of the pituitary gland in patients with schizotypal disorder and first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:177-83. 2011
    ..These findings suggest that the pituitary gland exhibits ongoing volume changes during the early course of the schizophrenia spectrum as a possible marker of state-related impairments...
  19. doi request reprint Adhesio interthalamica in individuals at high-risk for developing psychosis and patients with psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 32:1708-14. 2008
    ....
  20. ncbi request reprint Volume reduction of the left planum temporale gray matter associated with long duration of untreated psychosis in schizophrenia: a preliminary report
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 154:209-19. 2007
    ....
  21. doi request reprint Association between absence of the adhesio interthalamica and amygdala volume in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 162:101-11. 2008
    ....
  22. ncbi request reprint Prevalence of large cavum septi pellucidi and its relation to the medial temporal lobe structures in schizophrenia spectrum
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 31:1235-41. 2007
    ..These findings might reflect neurodevelopmental abnormalities in midline and associated limbic structures of the brain in schizophrenia spectrum...
  23. doi request reprint Insular cortex gray matter changes in individuals at ultra-high-risk of developing psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 111:94-102. 2009
    ..Whether these longitudinal changes are features of the disorder or related to treatment with antipsychotic medication remains to be determined...
  24. doi request reprint Superior temporal gyrus volume in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Psychiatry Res 182:73-6. 2010
    ..Our preliminary findings might reflect the neurobiological heterogeneity of the disorder...
  25. doi request reprint A follow-up MRI study of the superior temporal subregions in schizotypal disorder and first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 119:65-74. 2010
    ....
  26. doi request reprint Pituitary volume in patients with bipolar disorder and their first-degree relatives
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    J Affect Disord 124:256-61. 2010
    ..In addition, the contribution of genetic factors to the pituitary changes in BD remains largely unknown...
  27. doi request reprint An MRI study of the superior temporal subregions in patients with current and past major depression
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 34:98-103. 2010
    ....
  28. doi request reprint Midline brain abnormalities in established bipolar affective disorder
    Tsutomu Takahashi
    Department of Psychiatry, University of Melbourne and Melbourne Health, Melbourne Neuropsychiatry Centre, Victoria, Australia
    J Affect Disord 122:301-5. 2010
    ..Morphologic changes of cortico-limbic regions have been reported in bipolar disorder, but it remains unclear whether midline brain abnormalities relevant to cortico-limbic connectivity are also present...
  29. doi request reprint Superior temporal gyrus volume in antipsychotic-naive people at risk of psychosis
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, c o National Neuroscience Facility, 161 Barry Street, Carlton South, Victoria 3053, Australia
    Br J Psychiatry 196:206-11. 2010
    ..Morphological abnormalities of the superior temporal gyrus have been consistently reported in schizophrenia, but the timing of their occurrence remains unclear...
  30. ncbi request reprint A follow-up MRI study of the fusiform gyrus and middle and inferior temporal gyri in schizophrenia spectrum
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 35:1957-64. 2011
    ..Our findings suggest regional specificity of the progressive gray matter reduction in the temporal lobe structures, which might be specific to overt schizophrenia within the schizophrenia spectrum...
  31. doi request reprint Gray matter reduction of the superior temporal gyrus in patients with established bipolar I disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    J Affect Disord 123:276-82. 2010
    ..Functional abnormalities of the superior temporal gyrus (STG) have been implicated in the pathophysiology of bipolar disorder, but magnetic resonance imaging (MRI) studies of this region have yielded inconsistent findings...
  32. doi request reprint Insular cortex volume and impulsivity in teenagers with first-presentation borderline personality disorder
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1395-400. 2009
    ..Further studies are needed to clarify whether the potential relationship between the insular cortex volume and impulsivity is specific to BPD...
  33. doi request reprint Increased pituitary volume in patients with established bipolar affective disorder
    Tsutomu Takahashi
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Victoria, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 33:1245-9. 2009
    ..psychotic and nonpsychotic). Pituitary volume was larger in females than in males for both groups. These results support previous neuroendocrine findings that implicate HPA axis dysfunction in the core pathophysiological process of BD...
  34. doi request reprint An MRI study of the superior temporal subregions in first-episode patients with various psychotic disorders
    Tsutomu Takahashi
    Melbourne Neuropsychiatry Centre, Department of Psychiatry, University of Melbourne and Melbourne Health, Victoria, Australia
    Schizophr Res 113:158-66. 2009
    ..Our findings indicate that morphologic abnormalities of the STG gray matter are specific to schizophrenia among various psychotic disorders, implicating its role in the underlying pathophysiology of schizophrenia...
  35. ncbi request reprint The association of genotypic combination of the DRD3 and BDNF polymorphisms on the adhesio interthalamica and medial temporal lobe structures
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1236-42. 2008
    ....
  36. doi request reprint The Disrupted-in-Schizophrenia-1 Ser704Cys polymorphism and brain morphology in schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 172:128-35. 2009
    ..Our findings also suggest that the DISC1 genotype variation might have some relevance to the medication effect on brain morphology in schizophrenia...
  37. ncbi request reprint Bilateral volume reduction of the insular cortex in patients with schizophrenia: a volumetric MRI study
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 131:185-94. 2004
    ..The findings of this study suggest that there is a possible progressive loss of the gray matter volume of the bilateral insular cortices subsequent to the onset of schizophrenia...
  38. ncbi request reprint Lack of normal gender differences of the perigenual cingulate gyrus in schizophrenia spectrum disorders. A magnetic resonance imaging study
    Tsutomu Takahashi
    Dept of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 254:273-80. 2004
    ..These results suggest that both schizotypal and schizophrenia patients may share the same disruption of the normal pattern of gender differences of the perigenual cingulate gyrus...
  39. ncbi request reprint Differential contributions of prefrontal and temporolimbic pathology to mechanisms of psychosis
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Brain 128:2109-22. 2005
    ....
  40. ncbi request reprint Morphologic alterations of the parcellated superior temporal gyrus in schizophrenia spectrum
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 83:131-43. 2006
    ....
  41. ncbi request reprint Parietal lobe volume deficits in schizophrenia spectrum disorders
    Shi Yu Zhou
    Department of Neuropsychiatry, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 89:35-48. 2007
    ..The additional volume alterations in schizophrenia may support the notion that a deficit in the posterior parietal region is critical for the manifestation of overt psychotic symptoms...
  42. ncbi request reprint Volumetric magnetic resonance imaging study of the anterior cingulate gyrus in schizotypal disorder
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 252:268-77. 2002
    ..These results suggest that both schizotypal and schizophrenic subjects share, at least in part, the same cerebral asymmetry abnormalities...
  43. ncbi request reprint Increased pituitary volume in subjects at risk for psychosis and patients with first-episode schizophrenia
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    Psychiatry Clin Neurosci 67:540-8. 2013
    ..Enlarged pituitary gland has been reported in schizophrenia, possibly reflecting hypothalamic-pituitary-adrenal hyperactivity. The aim of the present study was to examine whether individuals at risk of psychosis also have similar changes...
  44. ncbi request reprint Volume reduction and altered sulco-gyral pattern of the orbitofrontal cortex in first-episode schizophrenia
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 121:55-65. 2010
    ..In addition, it remains elusive whether the OFC morphology in first-episode patients is related to their clinical features...
  45. doi request reprint The relationship between prefrontal brain volume and characteristics of memory strategy in schizophrenia spectrum disorders
    Mie Matsui
    Department of Neuropsychology, Graduate School of Medicine, University of Toyama, Toyama, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1854-62. 2008
    ..The findings for schizotypal patients suggest a compensation mechanism to remember the words using a serial processing strategy is at work when the inferior frontal gyrus cannot mediate semantic processing...
  46. ncbi request reprint Lack of normal structural asymmetry of the anterior cingulate gyrus in female patients with schizophrenia: a volumetric magnetic resonance imaging study
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 55:69-81. 2002
    ..These results suggest that gender may play an important role in the structural asymmetry anomalies in schizophrenia...
  47. ncbi request reprint Volumetric MRI study of the short and long insular cortices in schizophrenia spectrum disorders
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 138:209-20. 2005
    ..These results suggest that the volume reduction of the insular cortex may be specific to overt schizophrenia without topographically specific localization...
  48. ncbi request reprint Regional changes in brain gray and white matter in patients with schizophrenia demonstrated with voxel-based analysis of MRI
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Res 55:41-54. 2002
    ..Reduced white matter in the connecting bundles, which was first found in this study, may imply morphological substrates for abnormalities in the fronto-thalamic and fronto-temporolimbic connectivity in schizophrenia...
  49. ncbi request reprint Male-specific volume expansion of the human hippocampus during adolescence
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Cereb Cortex 15:187-93. 2005
    ..The possible relevance of these findings to progress in myelination and implications in psychiatric disorders were discussed...
  50. ncbi request reprint Volumetric analysis of sulci/gyri-defined in vivo frontal lobe regions in schizophrenia: Precentral gyrus, cingulate gyrus, and prefrontal region
    Shi Yu Zhou
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 139:127-39. 2005
    ....
  51. ncbi request reprint Volume reduction of the right anterior limb of the internal capsule in patients with schizotypal disorder
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 130:213-25. 2004
    ..Volume deficit confined to the right ALIC suggests that limited involvement of the fronto-thalamic connectivity may have some relevance to the sparing of schizotypal patients from the development of overt psychosis...
  52. ncbi request reprint Structural brain differences in patients with schizophrenia and schizotypal disorder demonstrated by voxel-based morphometry
    Yasuhiro Kawasaki
    Dept of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Eur Arch Psychiatry Clin Neurosci 254:406-14. 2004
    ....
  53. ncbi request reprint Bilateral volume reduction of the insular cortex in patients with schizophrenia: a volumetric MRI Study
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama 930 0194, Japan
    Psychiatry Res 132:187-96. 2004
    ..The findings of this study suggest that there is a possible progressive loss of the gray matter volume of the bilateral insular cortices subsequent to the onset of schizophrenia...
  54. ncbi request reprint Proton magnetic resonance spectroscopy of the inferior frontal gyrus and thalamus and its relationship to verbal learning task performance in patients with schizophrenia: a preliminary report
    Hirofumi Hagino
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Sugitani, Toyama, Japan
    Psychiatry Clin Neurosci 56:499-507. 2002
    ..These results support the notion of metabolic abnormalities in the left inferior frontal region related to verbal memory deficits in patients with schizophrenia...
  55. ncbi request reprint Volume reduction of the amygdala in patients with schizophrenia: a magnetic resonance imaging study
    Lisha Niu
    Department of Psychology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 132:41-51. 2004
    ..The results may be important for understanding the role of the amygdala in the pathophysiology of schizophrenia and the anatomical substrates of gender difference in the expressions of the illness...
  56. ncbi request reprint Prefrontal abnormalities in patients with simple schizophrenia: structural and functional brain-imaging studies in five cases
    Michio Suzuki
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 140:157-71. 2005
    ..It is also suggested that simple schizophrenia may occupy an extreme position of the schizophrenic continuum where the prefrontal deficits and negative symptoms are most purely manifested...
  57. doi request reprint Prevalence and length of the adhesio interthalamica in schizophrenia spectrum disorders
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan Core Research for Evolutional Science and Technology, Japan Science and Technology Corporation, Tokyo, Japan
    Psychiatry Res 164:90-4. 2008
    ..The AI was more often absent and shorter in both disorders than in controls, possibly reflecting common neurodevelopmental abnormalities in the schizophrenia spectrum...
  58. doi request reprint Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode psychosis: a longitudinal T2 relaxometry pilot study
    Stephen J Wood
    Melbourne Neuropsychiatry Centre, University of Melbourne, Australia
    Psychiatry Res 182:180-2. 2010
    ..There was an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a neuroprotective effect of E-EPA treatment. In addition, the smaller the increase in T(2), the greater the improvement in negative symptoms...
  59. doi request reprint Differentiation of first-episode schizophrenia patients from healthy controls using ROI-based multiple structural brain variables
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 34:10-7. 2010
    ..Brain morphometric measures from magnetic resonance imaging (MRI) have not been used to discriminate between first-episode patients with schizophrenia and healthy subjects...
  60. doi request reprint Grey and white matter abnormalities are associated with impaired spatial working memory ability in first-episode schizophrenia
    Luca Cocchi
    Department of Psychiatry, Melbourne Neuropsychiatry Centre, The University of Melbourne and Melbourne Health, Melbourne, Australia
    Schizophr Res 115:163-72. 2009
    ....
  61. ncbi request reprint Multiple structural brain measures obtained by three-dimensional magnetic resonance imaging to distinguish between schizophrenia patients and normal subjects
    Kazue Nakamura
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Schizophr Bull 30:393-404. 2004
    ..These findings support the view that schizophrenia patients have structural deviations in multiple brain areas and that a combination of structural brain measures can distinguish between patients and controls...
  62. pmc Classification of first-episode schizophrenia patients and healthy subjects by automated MRI measures of regional brain volume and cortical thickness
    Yoichiro Takayanagi
    Department of Neuropsychiatry, University of Toyama, Toyama, Japan
    PLoS ONE 6:e21047. 2011
    ....
  63. ncbi request reprint Perigenual cingulate gyrus volume in patients with schizophrenia: a magnetic resonance imaging study
    Tsutomu Takahashi
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Psychiatry 53:593-600. 2003
    ..Anterior cingulate gyrus abnormalities have been suggested to be involved in the pathophysiology of schizophrenia; however, little is known about morphologic changes in the perigenual cingulate gyrus in schizophrenia patients...
  64. ncbi request reprint Decreased volume and increased asymmetry of the anterior limb of the internal capsule in patients with schizophrenia
    Shi Yu Zhou
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, Toyama, Japan
    Biol Psychiatry 54:427-36. 2003
    ..The purpose of this study was to detect the volumetric changes in the ALIC in view of the putative abnormal frontothalamic connectivity in schizophrenia...
  65. doi request reprint Reduced white matter fractional anisotropy and clinical symptoms in schizophrenia: a voxel-based diffusion tensor imaging study
    Kazue Nakamura
    Department of Neuropsychiatry, University of Toyama Graduate School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 202:233-8. 2012
    ..These findings suggest widespread disruption of white matter integrity in schizophrenia, which could partly explain the severity of negative symptomatology...
  66. ncbi request reprint Multivariate voxel-based morphometry successfully differentiates schizophrenia patients from healthy controls
    Yasuhiro Kawasaki
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neuroimage 34:235-42. 2007
    ..These findings suggest that the characteristic distribution of gray matter changes may be of diagnostic value for schizophrenia...
  67. doi request reprint Association between the brain-derived neurotrophic factor Val66Met polymorphism and brain morphology in a Japanese sample of schizophrenia and healthy comparisons
    Tsutomu Takahashi
    Department of Neuropsychiatry, University of Toyama, 2630 Sugitani, Toyama 930 0194, Japan
    Neurosci Lett 435:34-9. 2008
    ....
  68. ncbi request reprint Quantification of lateral ventricular subdivisions in schizophrenia by high-resolution three-dimensional magnetic resonance imaging
    Takashi Yotsutsuji
    Department of Neuropsychiatry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Psychiatry Res 122:1-12. 2003
    ..Thus, the schizophrenia patients showed ventricular enlargement, particularly in the left temporal horn, being more severely affected in the male than in the female...
  69. ncbi request reprint Sex-related differences in the risk factor profile and medications of patients with atrial fibrillation recruited in J-TRACE
    Hiroshi Inoue
    Department of Internal Medicine, University of Toyama, Toyama, Japan
    Circ J 74:650-4. 2010
    ..Whether such a difference exists for Japanese patients with AF is unclear, so data from J-TRACE were used to investigate this issue...
  70. ncbi request reprint The Japan Thrombosis Registry for Atrial Fibrillation, Coronary or Cerebrovascular Events (J-TRACE): a nation-wide, prospective large cohort study; the study design
    Hideki Origasa
    Division of Biostatistics and Clinical Epidemiology, University of Toyama School of Medicine and Pharmaceutical Sciences, 2630 Sugitani, Toyama 930 0194, Japan
    Circ J 72:991-7. 2008
    ....
  71. pmc Developmental trajectories of amygdala and hippocampus from infancy to early adulthood in healthy individuals
    Akiko Uematsu
    Department of Psychology, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    PLoS ONE 7:e46970. 2012
    ..The sex differences and laterality during development of these two regions suggest that sex-related factors such as sex hormones and functional laterality might affect brain development...
  72. ncbi request reprint [Morphological study on brains of patients with schizophrenia--its application to the objective diagnosis]
    Michio Suzuki
    Seishin Shinkeigaku Zasshi 108:654-60. 2006
  73. ncbi request reprint [Pathological change of brain and premorbid vulnerability to stress in patients with schizophrenia]
    Michio Suzuki
    Seishin Shinkeigaku Zasshi 109:765-700. 2007
  74. ncbi request reprint Start-up behavior of viscoelastic fluid flow near a capillary entry
    Masataka Shirakashi
    Department of Mechanical Engineering, Nagaoka University of Technology, Niigata, Japan
    Ann N Y Acad Sci 972:81-6. 2002
    ..The transient behavior of the flow rate of the PAA-solution is attributed to the gradual development process of the flow field upstream from the entry...
  75. ncbi request reprint Comparison of magnetic resonance imaging and transesophageal echocardiography in detection of thrombus in the left atrial appendage
    Hideo Ohyama
    Second Department of Internal Medicine, Kagawa Medical University, 1750 1 Ikenobe, Miki cho, Kagawa 761 0793, Japan
    Stroke 34:2436-9. 2003
    ..A noninvasive technique of visualizing the left atrial appendage (LAA) and its thrombus in patients with atrial fibrillation would be of great interest. This study examined the utility of MRI for the assessment of thrombus in the LAA...
  76. ncbi request reprint Familial mediterranean fever medicated with an herbal medicine in Japan
    Masaki Komatsu
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Pediatr Int 46:81-4. 2004
  77. ncbi request reprint Recurrent URAT1 gene mutations and prevalence of renal hypouricemia in Japanese
    Tsutomu Takahashi
    Department of Pediatrics, Akita University School of Medicine, 1 1 1 Hondo, Akita shi, 010 8543, Akita, Japan
    Pediatr Nephrol 20:576-8. 2005
    ..In addition, we expect the prevalence of renal hypouricemia, 0.23%, from the analysis of serum urate levels in 1,730 Japanese children...
  78. ncbi request reprint A PTPN11 gene mutation (Y63C) causing Noonan syndrome is not associated with short stature in general population
    Ikuko Takahashi
    Department of Pediatrics, Akita University School of Medicine, Japan
    Tohoku J Exp Med 208:255-9. 2006
    ..However, c.188 A > G (Y63C) was not identified in 96 short individuals from the general population of 2,281 healthy adults. Thus, it is unlikely that PTPN11 is one of the genes underlying stature variations in the general population...
  79. ncbi request reprint [For the preparation for psychiatric specialist training programs: from a viewpoint of university hospitals]
    Masayoshi Kurachi
    Seishin Shinkeigaku Zasshi 108:925-30. 2006
  80. ncbi request reprint Significant decrease in tropoelastin gene expression in fibroblasts from a Japanese Costello syndrome patient with impaired elastogenesis and enhanced proliferation
    Yutaka Tatano
    Department of Medicinal Biotechnology, Institute for Medicinal Resources, Graduate School of Pharmaceutical Sciences, The University of Tokushima, Tokushima 770 8505
    J Biochem 140:193-200. 2006
    ....
  81. doi request reprint Smoking, fasting serum insulin, and obesity are the predictors of carotid atherosclerosis in relatively young subjects
    Takayuki Naya
    Department of Cardiorenal and Cerebrovascular Medicine, Division of Stroke, Kagawa University School of Medicine, Kagawa, Japan
    Angiology 58:677-84. 2007
    ....
  82. ncbi request reprint Novel mutation of methylmalonyl-CoA mutase gene causing the mut0 form of methylmalonic acidemia in a Japanese girl
    Chikako Oyama
    Department of Pediatrics, Akita University School of Medicine, Akita, Japan
    Pediatr Int 49:232-4. 2007
  83. ncbi request reprint Improvement of cerebral blood flow by olprinone, a phosphodiesterase-3 inhibitor, in mild heart failure
    Takashi Ueda
    Ueda Naika Clinic, Hyogo, Japan
    Cerebrovasc Dis 16:396-401. 2003
    ..65, p < 0.01). The percent increase in CBF was significantly greater in HF (13.7%) than in normal subjects (9.8%, p < 0.046). In patients with HF, the CBF of the cerebral cortex was decreased, but was increased by OL infusion...
  84. ncbi request reprint [Study on disease susceptibility to schizophrenia using brain MRI imaging]
    Michio Suzuki
    Seishin Shinkeigaku Zasshi 109:339-45. 2007
  85. ncbi request reprint Using related donors other than genotypically HLA-matched siblings in allogeneic hematopoietic stem cell transplantation for hematologic disease: a single institution experience in Japan
    Akira Tomonari
    Department of Hematology Oncology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan
    Int J Hematol 76:354-9. 2002
    ....